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Author

  • Leeanne McGurk
2011

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: Loss of ADAR1 in insects

Keegan, L. P., McGurk, L., Palavicini, J. P., Brindle, J., Paro, S., Li, X., Rosenthal, J. J. C. & O'Connell, M. A., 1 Sep 2011, In : Nucleic Acids Research. 39, 16, p. 7249-7262 14 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
57 Downloads (Pure)

Yeast informs Alzheimer's disease

McGurk, L. & Bonini, N. M., 2 Dec 2011, In : Science. 334, 6060, p. 1212-1213 2 p.

Research output: Contribution to journalShort survey

7 Citations (Scopus)
2012
Open Access
File
15 Citations (Scopus)
56 Downloads (Pure)
2015

Drosophila as an in vivo model for human neurodegenerative disease

McGurk, L., Berson, A. & Bonini, N. M., Oct 2015, In : Genetics. 201, 2, p. 377-402 26 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)
2018

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

McGurk, L., Mojsilovic-Petrovic, J., Van Deerlin, V. M., Shorter, J., Kalb, R. G., Lee, V. M., Trojanowski, J. Q., Lee, E. B. & Bonini, N. M., 29 Aug 2018, In : Acta Neuropathologica Communications. 6, 1, p. 1-15 15 p., 84.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
57 Downloads (Pure)

Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

McGurk, L., Gomes, E., Guo, L., Shorter, J. & Bonini, N. M., 26 Dec 2018, In : Biochemistry. 57, 51, p. 6923-6926 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

McGurk, L., Gomes, E., Guo, L., Mojsilovic-Petrovic, J., Tran, V., Kalb, R. G., Shorter, J. & Bonini, N. M., 6 Sep 2018, In : Molecular Cell. 71, 5, p. 703-717.e9 24 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2019

Poly(ADP-Ribosylation) in Age-Related Neurological Disease

McGurk, L., Rifai, O. M. & Bonini, N. M., Aug 2019, In : Trends in Genetics. 35, 8, p. 601-613 13 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2020

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

Deng, P., Khan, A., Jacobson, D., Sambrani, N., McGurk, L., Li, X., Jayasree, A., Hejatko, J., Shohat-Ophir, G., O'Connell, M. A., Li, J. B. & Keegan, L. P., 27 Mar 2020, In : Nature Communications. 11, 1, p. 1580 1580.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
33 Downloads (Pure)

First person - Leeanne McGurk

McGurk, L., Jun 2020, In : Journal of Cell Science. 133, 12, 2 p., jcs.248773.

Research output: Contribution to journalComment/debate

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

Khan, A., Paro, S., McGurk, L., Sambrani, N., Hogg, M. C., Brindle, J., Pennetta, G., Keegan, L. P. & O'Connell, M. A., 14 Feb 2020, In : BMC Biology. 18, 1, 16 p., 15.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
38 Downloads (Pure)

TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2

McGurk, L., Rifai, O. & Bonini, N. M., 23 Jun 2020, In : Journal of Cell Science. 133, 12

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
14 Downloads (Pure)