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• 2011

  Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: Loss of ADAR1 in insects

  Keegan, L. P., McGurk, L., Palavicini, J. P., Brindle, J., Paro, S., Li, X., Rosenthal, J. J. C. & O'Connell, M. A., 1 Sep 2011, In: Nucleic Acids Research. 39, 16, p. 7249-7262 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • RNA Editing
  • Insecta
  • Drosophila
  • Vertebrates
  • Crustacea
  36 Citations (Scopus)

  80 Downloads (Pure)

• Yeast informs Alzheimer's disease

  McGurk, L. & Bonini, N. M., 2 Dec 2011, In: Science. 334, 6060, p. 1212-1213 2 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Yeasts
  • Alzheimer Disease
  7 Citations (Scopus)
• 2014

  Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72

  McGurk, L., Lee, V. M., Trojanowksi, J. Q., Van Deerlin, V. M., Lee, E. B. & Bonini, N. M., 1 Sep 2014, In: Journal of Neuropathology and Experimental Neurology. 73, 9, p. 837-845 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Poly(A)-Binding Proteins
  • Amyotrophic Lateral Sclerosis
  • Inclusion Bodies
  • Motor Neurons
  • Sarcoma
  30 Citations (Scopus)

• Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

  Kim, H. J., Raphael, A. R., Ladow, E. S., Mcgurk, L., Weber, R. A., Trojanowski, J. Q., Lee, V. M. Y., Finkbeiner, S., Gitler, A. D. & Bonini, N. M., Feb 2014, In: Nature Genetics. 46, 2, p. 152-160 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic Lateral Sclerosis
  • Phosphorylation
  • Diptera
  • Ataxin-2
  • Carrier Proteins
  207 Citations (Scopus)
• 2018

  Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

  McGurk, L., Mojsilovic-Petrovic, J., Van Deerlin, V. M., Shorter, J., Kalb, R. G., Lee, V. M., Trojanowski, J. Q., Lee, E. B. & Bonini, N. M., 29 Aug 2018, In: Acta Neuropathologica Communications. 6, 1, p. 1-15 15 p., 84.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Poly Adenosine Diphosphate Ribose
  • Amyotrophic Lateral Sclerosis
  • veliparib
  • Spinal Cord
  • Nuclear RNA
  26 Citations (Scopus)

  71 Downloads (Pure)

• Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

  McGurk, L., Gomes, E., Guo, L., Shorter, J. & Bonini, N. M., 26 Dec 2018, In: Biochemistry. 57, 51, p. 6923-6926 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Poly Adenosine Diphosphate Ribose
  • Agglomeration
  • Prions
  • Biopolymers
  • DNA-Binding Proteins
  9 Citations (Scopus)

• Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

  McGurk, L., Gomes, E., Guo, L., Mojsilovic-Petrovic, J., Tran, V., Kalb, R. G., Shorter, J. & Bonini, N. M., 6 Sep 2018, In: Molecular Cell. 71, 5, p. 703-717.e9 24 p.

  Research output: Contribution to journal › Article › peer-review

  • Tankyrases
  • Poly Adenosine Diphosphate Ribose
  • Amyotrophic Lateral Sclerosis
  • Phosphorylation
  • Poly(ADP-ribose) Polymerases
  95 Citations (Scopus)
• 2020

  Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

  Deng, P., Khan, A., Jacobson, D., Sambrani, N., McGurk, L., Li, X., Jayasree, A., Hejatko, J., Shohat-Ophir, G., O'Connell, M. A., Li, J. B. & Keegan, L. P., 27 Mar 2020, In: Nature Communications. 11, 1, p. 1580 1580.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • editing
  • RNA Editing
  • Drosophila
  • Adenosine
  • brain
  7 Citations (Scopus)

  52 Downloads (Pure)

• First person - Leeanne McGurk

  McGurk, L., Jun 2020, In: Journal of Cell Science. 133, 12, 2 p., jcs.248773.

  Research output: Contribution to journal › Comment/debate › peer-review

• Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

  Khan, A., Paro, S., McGurk, L., Sambrani, N., Hogg, M. C., Brindle, J., Pennetta, G., Keegan, L. P. & O'Connell, M. A., 14 Feb 2020, In: BMC Biology. 18, 1, 16 p., 15.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Synaptic Membranes
  • adenosine deaminase
  • Adenosine Deaminase
  • autophagy
  • mutant
  3 Citations (Scopus)

  51 Downloads (Pure)

• TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2

  McGurk, L., Rifai, O. & Bonini, N. M., 23 Jun 2020, In: Journal of Cell Science. 133, 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tankyrases
  • Amyotrophic Lateral Sclerosis
  • Poly(ADP-ribose) Polymerases
  • RNA-Binding Proteins
  • DNA-Binding Proteins
  1 Citation (Scopus)

  19 Downloads (Pure)