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  • Michael Ashford
2012

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Meakin, P. J., Harper, A. J., Hamilton, D. L., Gallagher, J., McNeilly, A. D., Burgess, L. A., Vaanholt, L. M., Bannon, K. A., Latcham, J., Hussain, I., Speakman, J. R., Howlett, D. R. & Ashford, M. L. J., 1 Jan 2012, In : Biochemical Journal. 441, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)
131 Downloads (Pure)
2015

Mice lacking beta2-integrin function remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation

Meakin, P. J., Morrison, V. L., Sneddon, C. C., Savinko, T., Uotila, L., Jalicy, S. M., Gabriel, J. L., Kang, L., Ashford, M. L. J. & Fagerholm, S. C., 25 Sep 2015, In : PLoS ONE. 10, 9, 15 p., e0138872.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
149 Downloads (Pure)
2018

Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

Smith, M. A., Katsouri, L., Virtue, S., Choudhury, A. I., Vidal-Puig, A., Ashford, M. L. J. & Withers, D. J., 9 Oct 2018, In : Cell Reports. 25, 2, p. 278-287.e4 15 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
126 Downloads (Pure)
2015
18 Citations (Scopus)

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Rzepecka, J., Pineda, M. A., Al-Riyami, L., Rodgers, D. T., Huggan, J. K., Lumb, F. E., Khalaf, A. I., Meakin, P. J., Corbet, M., Ashford, M. L., Suckling, C. J., Harnett, M. M. & Harnett, W., Jun 2015, In : Journal of Autoimmunity. 60, p. 59-73 15 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2016
Open Access
File
15 Citations (Scopus)
137 Downloads (Pure)
2017
Open Access
File
9 Citations (Scopus)
271 Downloads (Pure)
2018

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Aug 2018, In : Metabolism. 85, p. 59-75 17 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
121 Downloads (Pure)

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
178 Downloads (Pure)
2014

AMPK: regulating energy balance at the cellular and whole body levels

Hardie, D. G. & Ashford, M. L. J., Mar 2014, In : Physiology. 29, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

Open Access
File
153 Citations (Scopus)
137 Downloads (Pure)
2020

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation. 15 p.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)
2014

Regulation of the Cardiac Sodium/Calcium Exchanger by Protein Palmitoylation

Reilly, L., Hilgemann, D. W., Ashford, M. & Fuller, W., 28 Jan 2014, In : Biophysical Journal. 106, 2, Supplement 1, p. 581a 1 p., 2935-Pos B627.

Research output: Contribution to journalArticle

2019

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75]

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Jul 2019, In : Metabolism: Clinical and Experimental. 96, p. 101-102 2 p.

Research output: Contribution to journalArticle

2014

Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle

Hamilton, D. L., Beall, C., Jeromson, S., Chevtzoff, C., Cuthbertson, D. J. & Ashford, M. L. J., Jan 2014, In : Journal of Physiological Sciences. 64, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013

Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression

Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. & Ashford, M. L. J., Feb 2013, In : NeuroSignals. 21, 1-2, p. 28-41 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2015

Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. & Fuller, W., 2015, In : FASEB Journal. 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2013

Beta-secretase 1 (BACE1) inhibition improves obese and diabetic phenotypes in a leptin dependent manner

Meakin, P. J., Jalicy, S. M., Irvine, S. W. & Ashford, M. L. J., Mar 2013, In : Diabetic Medicine. 30, Suppl. 1, p. 41-41 1 p., P43.

Research output: Contribution to journalMeeting abstract

2012

Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour

Beall, C., Hamilton, D. L., Gallagher, J., Logie, L., Wright, K., Soutar, M. P., Dadak, S., Ashford, F. B., Haythorne, E., Du, Q., Jovanovic, A., McCrimmon, R. J. & Ashford, M. L. J., Sep 2012, In : Diabetologia. 55, 9, p. 2432-2444 13 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2013

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J., Jun 2013, In : Journal of Bioenergetics and Biomembranes. 45, 3, p. 229-241 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012

Hypoglycaemia: exercise for the brain?

Ashford, M., Beall, C. & McCrimmon, R., Oct 2012, In : Journal of Neuroendocrinology. 24, 10, p. 1365-1366 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Oleate induces KATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge

Dadak, S., Beall, C., Vlachaki Walker, J. M., Soutar, M. P. M., McCrimmon, R. J. & Ashford, M. L. J., 27 Mar 2017, In : Neuroscience. 346, p. 29-42 14 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
110 Downloads (Pure)
2012
34 Citations (Scopus)
2014
93 Citations (Scopus)
243 Downloads (Pure)
2019

CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high fat-fed C57BL/6 mice

Hasib, A., Hennayake, C., Bracy, D. P., Bugler-Lamb, A-R., Lantier, L., Khan, F., Ashford, M., McCrimmon, R., Wasserman, D. H. & Kang, L., Dec 2019, In : American Journal of Physiology, Endocrinology and Metabolism. 317, 6, p. E973-E983 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid

Findlay, J. A., Hamilton, D. L. & Ashford, M. L., 1 Oct 2015, In : Frontiers in Cellular Neuroscience. 9, 14 p., 382.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
160 Downloads (Pure)
2013

Beta-secretase 1 (BACE1) inhibition improves obese and diabetic phenotypes in a leptin dependent manner

Meakin, P. J., Jalicy, S. M., Irvine, S. W. & Ashford, M. L. J., 2013.

Research output: Contribution to conferencePoster

2015

BACE1 activity as a determining factor in atherosclerosis development?

Meakin, P., Hamilton, A., Jalicy, S., Khan, F. & Ashford, M., Jul 2015, In : Atherosclerosis. 241, 1, p. e13 1 p., EAS-0263.

Research output: Contribution to journalArticle

2012

Nrf2 orchestrates fuel partitioning for cell proliferation

Hayes, J. D. & Ashford, M. L. J., 2012, In : Cell Metabolism. 16, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2015

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M. A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., Bilican, B., Chowdhry, S., Meakin, P. J., Ashford, M. L. J., Wyllie, D. J. A., Scannevin, R. H., Chandran, S., Hayes, J. D. & Hardingham, G. E., 13 May 2015, In : Nature Communications. 6, 15 p., 7066.

Research output: Contribution to journalArticle

74 Citations (Scopus)
2014

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes

Hamilton, D. L., Findlay, J. A., Montagut, G., Meakin, P. J., Bestow, D., Jalicy, S. M. & Ashford, M. L. J., Aug 2014, In : Diabetologia. 57, 8, p. 1684-1692 9 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
139 Downloads (Pure)
2011

Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

Claret, M., Smith, M. A., Knauf, C., Al-Qassab, H., Woods, A., Heslegrave, A., Piipari, K., Emmanuel, J. J., Colom, A., Valet, P., Cani, P. D., Begum, G., White, A., Mucket, P., Peters, M., Mizuno, K., Batterham, R. L., Giese, K. P., Ashworth, A., Burcelin, R. & 3 others, Ashford, M. L., Carling, D. & Withers, D. J., Mar 2011, In : Diabetes. 60, 3, p. 735-745 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2014

Substrate recognition by the cell surface palmitoyl transferase DHHC5

Howie, J., Reilly, L., Fraser, N. J., Vlachaki Walker, J., Wypijewski, K. J., Ashford, M. L. J., Calaghan, S., McClafferty, H., Tian, L., Shipston, M. J., Boguslavskyi, A., Shattock, M. J. & Fuller, W., 9 Dec 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17534-17539 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2017

AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner

Vlachaki Walker, J. M., Robb, J. L., Cruz, A. M., Malhi, A., Weightman Potter, P. G., Ashford, M. L. J., McCrimmon, R. J., Ellacott, K. L. J. & Beall, C., 21 Apr 2017, In : Diabetes, Obesity & Metabolism. 19, 7, p. 997-1005 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
252 Downloads (Pure)
2013

Continuous hypothalamic KATP channel activation blunts glucose counter-regulation in vivo in rats and supresses KATP conductance in vitro

Beall, C., Haythorne, E., Fan, X., Du, Q., Jovanovic, S., Sherwin, R., Ashford, M. L. J. & McCrimmon, R., Sep 2013, In : Diabetologia. 56, 9, p. 2088-2092 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30 Apr 2018, In : Clinical Science. 132, 8, p. 851-868 18 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
112 Downloads (Pure)
Open Access
File
42 Citations (Scopus)
145 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journalArticle

Open Access
File
243 Citations (Scopus)
643 Downloads (Pure)
2016

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C., 8 Aug 2016, In : Scientific Reports. 6, p. 1-17 17 p., 31159.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
278 Downloads (Pure)

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons

Hathorne, E., Hamilton, D. L., Findlay, J. A., Beall, C., McCrimmon, R. J. & Ashford, M. L. J., Dec 2016, In : Neuropharmacology. 111, p. 212-222 11 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
175 Downloads (Pure)