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Author

  • Colin Palmer
2014

A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility

Damotte, V., Guillot-Noel, L., Patsopoulos, N. A., Madireddy, L., El Behi, M., International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, De Jager, P. L., Baranzini, S. E., Cournu-Rebeix, I. & Fontaine, B., Mar 2014, In : Genes and Immunity. 15, 2, p. 126-132 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2012

A genome-wide association search for type 2 diabetes genes in African Americans

Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., Rotimi, C. N. & 6 others, Ng, M. C. Y., Langefeld, C. D., Freedman, B. I., Bowden, D. W., DIAGRAM Consortium & MAGIC Investigators, 2012, In : PLoS ONE. 7, 1, p. e29202

Research output: Contribution to journalArticle

120 Citations (Scopus)
2018

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

Dicker, A. J., Crichton, M. L., Pumphrey, E. G., Cassidy, A. J., Suarez-Cuartin, G., Sibila, O., Furrie, E., Fong, C. J., Ibrahim, W., Brady, G., Einarsson, G. G., Elborn, J. S., Schembri, S., Marshall, S. E., Palmer, C. N. A. & Chalmers, J. D., Jan 2018, In : Journal of Allergy and Clinical Immunology. 141, 1, p. 117-127 11 p.

Research output: Contribution to journalArticle

Open Access
File
63 Citations (Scopus)
136 Downloads (Pure)
2012

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

Hack, K., Reilly, L., Palmer, C., Read, K., Norval, S., Kime, R., Booth, K. & Foerster, J., May 2012, In : PLoS ONE. 7, 5

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
379 Downloads (Pure)
2013

Metformin pharmacogenetics and SLC2A2: genome-wide association study and 2-stage replication in GoDARTS and UKPDS

Zhou, K., Bennett, A., Coleman, R., Groves, R., Holman, R., McCarthy, M., Palmer, C. & Pearson, E., 2013.

Research output: Contribution to conferencePoster

2016

Opt-in method is vital for data sharing

Sullivan, F., McKinstry, B. & Palmer, C., 5 Aug 2016, In : BMJ. 354, 1 p., i4293.

Research output: Contribution to journalLetter

2011

PPAR alpha and PPAR delta nuclear receptor regulation of body weight and hepatic steatosis

Garbacz, W., Higgins, L. & Palmer, C., 18 Dec 2011, In : Toxicology. 290, 2-3, p. 135-135 1 p.

Research output: Contribution to journalBook/Film/Article review

FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype

Martin, A. J., Grant, A., Ashfield, A. M., Palmer, C. N., Baker, L., Quinlan, P. R., Purdie, C. A., Thompson, A. M., Jordan, L. B. & Berg, J. N., 1 Jan 2011, In : BMC Research Notes. 4

Research output: Contribution to journalArticle

18 Citations (Scopus)
2015

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

Yaghootkar, H., Stancáková, A., Freathy, R. M., Vangipurapu, J., Weedon, M. N., Xie, W., Wood, A. R., Ferrannini, E., Mari, A., Ring, S. M., Lawlor, D. A., Davey Smith, G., Jørgensen, T., Hansen, T., Pedersen, O., Steinthorsdottir, V., Guðbjartsson, D. F., Thorleifsson, G., Thorsteinsdottir, U., Stefansson, K. & 7 others, Hattersley, A. T., Walker, M., Morris, A. D., McCarthy, M. I., Palmer, C. N. A., Laakso, M. & Frayling, T. M., Jun 2015, In : Diabetes. 64, 6, p. 2279-2285 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2011

β-Agonist safety and the elephant in the room?

Williamson, P. A., Short, P. M., McKinlay, L., Palmer, C. N. A. & Lipworth, B. J., Jun 2011, In : Thorax. 66, 6, p. 542 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults

Cunningham, J., Basu, K., Tavendale, R., Palmer, C. N. A., Smith, H. & Mukhopadhyay, S., May 2011, In : Annals of Allergy, Asthma & Immunology. 106, 5, p. 381-386 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2017

Genome-Wide Association Study of Asthma Exacerbations in European Children Treated with Inhaled Corticosteroids

Vijverberg, S. J. H., Hernandez-Pacheco, N., Farzan, N., Francis, B., Flores, C., Schieck, M., Soares, P., Karimi, L., Tavendale, R., Berce, V., Repnik, K., Verhamme, K. M. C., Potocnik, U., Mukhopadhyay, S., Pirmohamed, M., Palmer, C. N., Turner, S. W., Hawcutt, D. B., Kabesch, M., Pino-Yanes, M. & 1 others, Maitland-van der Zee, A-H., Aug 2017, In : Pharmacoepidemiology and Drug Safety. 26, p. 25-26

Research output: Contribution to journalMeeting abstract

2018

Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD

Dicker, A. J., Crichton, M. L., Cassidy, A. J., Brady, G., Hapca, A., Tavendale, R., Einarsson, G. G., Furrie, E., Elborn, J. S., Schembri, S., Marshall, S. E., Palmer, C. N. A. & Chalmers, J. D., Jun 2018, In : Thorax. 73, 6, p. 510-518 9 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
157 Downloads (Pure)

Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Pharmacogenomics in Childhood Asthma Consortium, Turner, S., Francis, B., Wani, N., Vijverberg, S., Pino-Yanes, M., Mukhopadhyay, S., Tavendale, R., Palmer, C., Burchard, E. G., Merid, S. K., Melén, E. & Maitland-van der Zee, A. H., Jun 2018, In : Pharmacogenomics. 19, 8, p. 707-713 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2020

Filaggrin gene defects are associated with eczema, wheeze, and nasal disease during infancy: Prospective study

Basu, K., Inglis, S. K., Bremner, S. A., Ramsay, R., Abd, A., Rabe, H., Strange, E., Phillips, V., Seddon, P., Tavendale, R., Memon, A., Palmer, C. N. A., Fidler, K. & Mukhopadhyay, S., 27 Apr 2020, In : Journal of Allergy and Clinical Immunology. 2 p.

Research output: Contribution to journalLetter

2014

The correlation between reading and mathematics ability at age twelve has a substantial genetic component

Davis, O. S. P., Band, G., Pirinen, M., Haworth, C. M. A., Meaburn, E. L., Kovas, Y., Harlaar, N., Docherty, S. J., Hanscombe, K. B., Trzaskowski, M., Curtis, C. J. C., Strange, A., Freeman, C., Bellenguez, C., Su, Z., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S. & 31 others, Gray, E., Dronov, S., Potter, S. C., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, S. J., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J. A. Z., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Barroso, I., Peltonen, L., Dale, P. S., Petrill, S. A., Schalkwyk, L. S., Craig, I. W., Lewis, C. M., Price, T. S., Donnelly, P. & Wellcome Trust Case Control Consortium, 8 Jul 2014, In : Nature Communications. 5, 6 p., 4204.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
124 Downloads (Pure)
2017

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., Colhoun, H., Morris, A. D., George, J., Doney, A., Pirmohamed, M., Alfirevic, A., Wadelius, M., Maitland-van der Zee, A. H., Ridker, P. M., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, Aug 2017, In : Circulation: Cardiovascular Genetics. 10, 4, e001737 .

Research output: Contribution to journalArticle

3 Citations (Scopus)
Open Access
File
1 Citation (Scopus)
152 Downloads (Pure)
2011

A multigenic model to predict risk of ischemic stroke in subjects with type 2 diabetes

Pola, R., Kimber, C. H., Giarretta, I., Doney, A., Morris, A. M., Gaetani, E. & Palmer, C. N., Jun 2011, In : Atherosclerosis. Supplements. 12, 1, p. 127-127 1 p.

Research output: Contribution to journalArticle

2017

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Farzan, N., Vijverberg, S. J. H., Andiappan, A. K., Arianto, L., Berce, V., Blanca-López, N., Bisgaard, H., Bønnelykke, K., Burchard, E. G., Campo, P., Canino, G., Carleton, B., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Daley, D., Den Dekker, H. T., Dijk, N. F., Duijts, L. & 26 others, Flores, C., Forno, E., Hawcutt, D. B., Hernandez-Pacheco, N., de Jongste, J. C., Kabesch, M., Koppelman, G. H., Manolopoulos, V. G., Melén, E., Mukhopadhyay, S., Nilsson, S., Palmer, C. N., Pino-Yanes, M., Pirmohamed, M., Potočnki, U., Raaijmakers, J. A. M., Repnik, K., Schieck, M., Sio, Y. Y., Smyth, R. L., Szalai, C., Tantisira, K. G., Turner, S., van der Schee, M. P., Verhamme, K. M. & Maitland-van der Zee, A. H., 1 Jul 2017, In : Pharmacogenomics. 18, 10

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

Common Polymorphisms in the CYP11B1 and CYP11B2 Genes: Evidence for a Digenic Influence on Hypertension

Alvarez-Madrazo, S., MacKenzie, S. M., Davies, E., Fraser, R., Lee, W-K., Brown, M., Caulfield, M. J., Dominiczak, A. F., Farrall, M., Lathrop, M., Hedner, T., Melander, O., Munroe, P. B., Samani, N., Stewart, P. M., Wahlstrand, B., Webster, J., Palmer, C. N. A., Padmanabhan, S. & Connell, J. M., 2013, In : Hypertension. 61, 1, p. 232-239 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2015
9 Citations (Scopus)
2017

Cohort Profile: Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO)

Akbar, T., McGurnaghan, S., Palmer, C. N. A., Livingstone, S. J., Petrie, J. R., Chalmers, J., Lindsay, R. S., McKnight, J. A., Pearson, D. W. M., Patrick, A. W., Walker, J., Looker, H. C. & Colhoun, H. M., Jun 2017, In : International Journal of Epidemiology. 46, 3, p. 796-796i 10 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
156 Downloads (Pure)
2016

Effect of Serotonin Transporter 5HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study

Dujic, T., Zhou, K., Tavendale, R., Palmer, C. & Pearson, E., 1 Nov 2016, In : Diabetes Care. 39, 11, p. 1896-1901 6 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
162 Downloads (Pure)
2011

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21

Spencer, C. C. A., Plagnol, V., Strange, A., Gardner, M., Paisan-Ruiz, C., Band, G., Barker, R. A., Bellenguez, C., Bhatia, K., Blackburn, H., Blackwell, J. M., Bramon, E., Brown, M. A., Brown, M. A., Burn, D., Casas, J-P., Chinnery, P. F., Clarke, C. E., Corvin, A., Craddock, N. & 31 others, Deloukas, P., Edkins, S., Evans, J., Freeman, C., Gray, E., Hardy, J., Hudson, G., Hunt, S., Jankowski, J., Langford, C., Lees, A. J., Markus, H. S., Mathew, C. G., McCarthy, M. I., Morrison, K. E., Palmer, C. N. A., Pearson, J. P., Peltonen, L., Pirinen, M., Plomin, R., Potter, S., Rautanen, A., Sawcer, S. J., Su, Z., Trembath, R. C., Viswanathan, A. C., Williams, N. W., Morris, H. R., Donnelly, P., Wood, N. W. & UK Parkinson's Disease Consortium, 2011, In : Human Molecular Genetics. 20, 2, p. 345-53 9 p.

Research output: Contribution to journalArticle

Open Access
File
160 Citations (Scopus)
136 Downloads (Pure)
2020

The effect of LRRK2 loss-of-function variants in humans

Whiffin, N., Armean, I. M., Kleinman, A., Marshall, J. L., Minikel, E. V., Goodrich, J. K., Quaife, N. M., Cole, J. B., Wang, Q., Karczewski, K. J., Cummings, B. B., Francioli, L., Laricchia, K., Guan, A., Alipanahi, B., Morrison, P., Baptista, M. A. S., Merchant, K. M., Ware, J. S., Havulinna, A. S. & 18 others, Iliadou, B., Lee, J-J., Nadkarni, G. N., Whiteman, C., 23andMe Research Team, Daly, M., Esko, T., Hultman, C., Loos, R. J. F., Milani, L., Palotie, A., Pato, C., Pato, M., Saleheen, D., Sullivan, P. F., Alföldi, J., Cannon, P. & MacArthur, D. G., 27 May 2020, In : Nature Medicine. 21 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
12 Downloads (Pure)
2013

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

't Hart, L. M., Fritsche, A., Nijpels, G., van Leeuwen, N., Donnelly, L. A., Dekker, J. M., Alssema, M., Fadista, J., Carlotti, F., Gjesing, A. P., Palmer, C. N. A., van Haeften, T. W., Herzberg-Schäfer, S. A., Simonis-Bik, A. M. C., Houwing-Duistermaat, J. J., Helmer, Q., Deelen, J., Guigas, B., Hansen, T., Machicao, F. & 14 others, Willemsen, G., Heine, R. J., Kramer, M. H. H., Holst, J. J., de Koning, E. J. P., Häring, H-U., Pedersen, O., Groop, L., de Geus, E. J. C., Slagboom, P. E., Boomsma, D. I., Eekhoff, E. M. W., Pearson, E. R. & Diamant, M., 2013, In : Diabetes.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2011

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Evans, D. M., Spencer, C. C. A., Pointon, J. J., Su, Z., Harvey, D., Kochan, G., Opperman, U., Dilthey, A., Pirinen, M., Stone, M. A., Appleton, L., Moutsianas, L., Leslie, S., Wordsworth, T., Kenna, T. J., Karaderi, T., Thomas, G. P., Ward, M. M., Weisman, M. H., Farrar, C. & 31 others, Bradbury, L. A., Danoy, P., Inman, R. D., Maksymowych, W., Gladman, D., Rahman, P., Morgan, A., Marzo-Ortega, H., Bowness, P., Gaffney, K., Gaston, J. S. H., Smith, M., Bruges-Armas, J., Couto, A-R., Sorrentino, R., Paladini, F., Ferreira, M. A., Xu, H., Liu, Y., Jiang, L., Lopez-Larrea, C., Diaz-Pena, R., Lopez-Vazquez, A., Zayats, T., Band, G., Bellenguez, C., Blackburn, H., Blackwell, J. M., Bramon, E., Palmer, C. N. A. & Wellcome Trust Case Control Consor, Australo-Anglo-Amer Spondyloarthri, Spondyloarthrit Res Consortium Can, Aug 2011, In : Nature Genetics. 43, 8, p. 761-767 7 p.

Research output: Contribution to journalArticle

514 Citations (Scopus)
2013

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

Fakiola, M., Strange, A., Cordell, H. J., Miller, E. N., Pirinen, M., Su, Z., Mishra, A., Mehrotra, S., Monteiro, G. R., Band, G., Bellenguez, C., Dronov, S., Edkins, S., Freeman, C., Giannoulatou, E., Gray, E., Hunt, S. E., Lacerda, H. G., Langford, C., Pearson, R. & 32 others, Pontes, N. N., Rai, M., Singh, S. P., Smith, L., Sousa, O., Vukcevic, D., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Wilson, M. E., Deloukas, P., Peltonen, L., Christiansen, F., Witt, C., Jeronimo, S. M. B., Sundar, S., Spencer, C. C. A., Blackwell, J. M., LeishGEN Consortium & Wellcome Trust Case Control, 2013, In : Nature Genetics. 45, 2, p. 208-213 6 p.

Research output: Contribution to journalLetter

68 Citations (Scopus)
2018

MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer

Rose, A. M., Krishan, A., Chakarova, C. F., Moya, L., Chambers, S., Hollands, M., Illingworth, J. C., Williams, S. M. G., James, H. E., Shah, A. Z., Palmer, C. N. A., Chakravarti, A., Berg, J. N., Batra, J. & Bhattacharya, S. S., May 2018, In : Annals of Oncology. 29, 5, p. 1292-1303 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
105 Downloads (Pure)
2013

Genetic Loci for retinal arteriolar microcirculation

Sim, X., Jensen, R. A., Ikram, M. K., Cotch, M. F., Li, X., MacGregor, S., Xie, J., Smith, A. V., Boerwinkle, E., Mitchell, P., Klein, R., Klein, B. E. K., Glazer, N. L., Lumley, T., McKnight, B., Psaty, B. M., de Jong, P. T. V. M., Hofman, A., Rivadeneira, F., Uitterlinden, A. G. & 32 others, van Duijn, C. M., Aspelund, T., Eiriksdottir, G., Harris, T. B., Jonasson, F., Launer, L. J., Wellcome Trust Case Control Consortium 2, Attia, J., Baird, P. N., Harrap, S., Holliday, E. G., Inouye, M., Rochtchina, E., Scott, R. J., Viswanathan, A., Global BPgen Consortium, Li, G., Smith, N. L., Wiggins, K. L., Kuo, J. Z., Taylor, K. D., Hewitt, A. W., Martin, N. G., Montgomery, G. W., Sun, C., Young, T. L., Mackey, D. A., van Zuydam, N. R., Doney, A. S. F., Palmer, C. N. A., Morris, A. D. & Rotter, J. I., Jun 2013, In : PLoS ONE. 8, 6, e65804.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2014

Clinical and genetic determinants of progression of type 2 diabetes: A DIRECT Study

Zhou, K., Donnelly, L. A., Morris, A. D., Franks, P. W., Jennison, C., Palmer, C. N. A. & Pearson, E. R., 1 Mar 2014, In : Diabetes Care. 37, 3, p. 718-724

Research output: Contribution to journalArticle

23 Citations (Scopus)
2015

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

Mahajan, A., Sim, X., Ng, H. J., Manning, A., Rivas, M. A., Highland, H. M., Locke, A. E., Grarup, N., Im, H. K., Cingolani, P., Flannick, J., Fontanillas, P., Fuchsberger, C., Gaulton, K. J., Teslovich, T. M., Rayner, N. W., Robertson, N. R., Beer, N. L., Rundle, J. K., Bork-Jensen, J. & 31 others, Ladenvall, C., Blancher, C., Buck, D., Buck, G., Burtt, N. P., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Syvänen, A-C., Trakalo, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Hanis, C. L., Doney, A. S. F., Morris, A. D., Palmer, C. N. A. & On Behalf of the T2D-GENES consortium and GoT2D consortium, 27 Jan 2015, In : PLoS Genetics. 11, 1, 25 p., e1004876.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2019

A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity

Meng, W., Chan, B., Ezeonwumelu, C., Hebert, H., Campbell, A., Soler, V. & Palmer, C., 2 Jul 2019, In : Ophthalmic Genetics. 40, 3, p. 252-258 7 p.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)
2018

Individuals with filaggrin-related eczema and asthma have increased long-term medication and hospital admission costs

Soares, P., Fidler, K., Felton, J., Tavendale, R., Hövels, A., Bremner, S. A., Palmer, C. N. A. & Mukhopadhyay, S., 17 Sep 2018, In : British Journal of Dermatology. 179, 3, p. 717-723 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
144 Downloads (Pure)
2012

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Genetic Anal Psoriasis Consortium, Wellcome Trust Case Control, 1 Dec 2012, In : Nature Genetics. 44, 12, p. 1341-1348 8 p.

Research output: Contribution to journalArticle

544 Citations (Scopus)
2015

Biological interpretation of genome-wide association studies using predicted gene functions

Pers, T. H., Karjalainen, J. M., Chan, Y., Westra, H-J., Wood, A. R., Yang, J., Lui, J. C., Vedantam, S., Gustafsson, S., Esko, T., Frayling, T., Speliotes, E. K., Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Boehnke, M., Raychaudhuri, S., Fehrmann, R. S. N., Hirschhorn, J. N. & Franke, L., 19 Jan 2015, In : Nature Communications. 6, p. 1-9 9 p., 5890.

Research output: Contribution to journalArticle

299 Citations (Scopus)
2014

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., Cho, K., Gaziano, J. M. & 32 others, Wilson, P. W. F., Tsao, P. S., Kovesdy, C. P., Esko, T., Mägi, R., Milani, L., Almgren, P., Boutin, T., Debette, S., Ding, J., Giulianini, F., Holliday, E. G., Jackson, A. U., Li-Gao, R., Lin, W-Y., Luan, J., Mangino, M., Oldmeadow, C., Prins, B. P., Qian, Y., Sargurupremraj, M., Shah, N., Surendran, P., Thériault, S., Verweij, N., Willems, S. M., Connell, J., Morris, A. D., Morris, A. P., Palmer, C. N. A., Elliott, P. & Caulfield, M. J., 14 Nov 2014, In : Nature Genetics. 50, p. 1755 1 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment

Turner, S., Francis, B., Vijverberg, S., Pino-Yanes, M., Maitland-van der Zee, A. H., Basu, K., Bignell, L., Mukhopadhyay, S., Tavendale, R., Palmer, C., Hawcutt, D., Pirmohamed, M., Burchard, E. G. & Lipworth, B., Jul 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 107-113 7 p.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
143 Downloads (Pure)
2019

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease

Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P. K., Relan, D., Harris, S., Vaidya, S. S. ., Dhillon, B., Zhou, K., Pearson, E., Hayward, C., Polašek, O., Deary, I. J., MacGillivray, T. J., Wilson, J. F., Trucco, M., Palmer, C. & 1 others, Doney, A., Dec 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552 11 p.

Research output: Contribution to journalArticle

Open Access
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103 Downloads (Pure)

Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine

Cowan, K., MacLuskie, G., Finch, M., Palmer, C. N. A., Hair, J., Bylesjo, M., Lynagh, S., Brankin, P., McNeil, M., Low, C., Mallinson, D., Gourlay, E. M., Child, H., Cheyne, L. & Bunton, D. C., 20 Dec 2019, In : PLoS ONE. 14, 12, p. 1-15 15 p., e0226564.

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2017

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Scott, R. A., Scott, L. J., Maegi, R., Marullo, L., Gaulton, K. J., Kaakinen, M., Pervjakova, N., Pers, T. H., Johnson, A. D., Eicher, J. D., Jackson, A. U., Ferreira, T., Lee, Y., Ma, C., Steinthorsdottir, V., Thorleifsson, G., Qi, L., Van Zuydam, N. R., Mahajan, A., Chen, H. & 31 others, Almgren, P., Voight, B. F., Grallert, H., Mueller-Nurasyid, M., Ried, J. S., Rayner, N. W., Robertson, N., Karssen, L. C., Van Leeuwen, E. M., Willems, S. M., Fuchsberger, C., Kwan, P., Teslovich, T. M., Chanda, P., Li, M., Lu, Y., Dina, C., Thuillier, D., Yengo, L., Jiang, L., Sparso, T., Kestler, H. A., Chheda, H., Eisele, L., Gustafsson, S., Franberg, M., Strawbridge, R. J., Benediktsson, R., Morris, A. D., Palmer, C. N. A. & for the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Nov 2017, In : Diabetes. 66, 11, p. 2888-2902 15 p.

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2016

Analysis with the exome array identifies multiple new independent variants in lipid loci

Kanoni, S., Masca, N. G. D., Stirrups, K. E., Varga, T. V., Warren, H. R., Scott, R. A., Southam, L., Zhang, W., Yaghootkar, H., Müller-Nurasyid, M., Couto Alves, A., Strawbridge, R. J., Lataniotis, L., Hashim, N. A., Besse, C., Boland, A., Braund, P. S., Connell, J. M., Dominiczak, A., Farmaki, A-E. & 31 others, Franks, S., Grallert, H., Jansson, J-H., Karaleftheri, M., Keinänen-Kiukaanniemi, S., Matchan, A., Pasko, D., Peters, A., Poulter, N., Rayner, N. W., Renström, F., Rolandsson, O., Sabater-Lleal, M., Sennblad, B., Sever, P., Shields, D., Silveira, A., Stanton, A. V., Strauch, K., Tomaszewski, M., Tsafantakis, E., Waldenberger, M., Blakemore, A. I. F., Dedoussis, G., Escher, S. A., Kooner, J. S., McCarthy, M. I., Palmer, C. N. A., Wellcome Trust Case Control Consortium, Hamsten, A. & Caulfield, M. J., 27 Jul 2016, In : Human Molecular Genetics. 25, 18, p. 4094-4106 13 p.

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2017

Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype

Tragante, V., Gho, J. M. I. H., Felix, J. F., Vasan, R. S., Smith, N. L., Voight, B. F., Palmer, C., van der Harst, P., Moore, J. H., Asselbergs, F. W. & CHARGE Heart Failure Working Group, 26 May 2017, In : BioData Mining. 10, p. 1-11 11 p., 18.

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2016

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12

Jackson, V. E., Ntalla, I., Sayers, I., Morris, R., Whincup, P., Casas, J-P., Amuzu, A., Choi, M., Dale, C., Kumari, M., Engmann, J., Kalsheker, N., Chappell, S., Guetta-Baranes, T., McKeever, T. M., Palmer, C. N. A., Tavendale, R., Holloway, J. W., Sayer, A. A., Dennison, E. M. & 20 others, Cooper, C., Bafadhel, M., Barker, B., Brightling, C., Bolton, C. E., John, M. E., Parker, S. G., Moffat, M. F., Wardlaw, A. J., Connolly, M. J., Porteous, D. J., Smith, B. H., Padmanabhan, S., Hocking, L., Stirrups, K. E., Deloukas, P., Strachan, D. P., Hall, I. P., Tobin, M. D. & Wain, L. V., Jun 2016, In : Thorax. 71, 6, p. 501-509 9 p.

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Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children

Rautanen, A., Pirinen, M., Mills, T. C., Rockett, K. A., Strange, A., Ndungu, A. W., Naranbhai, V., Gilchrist, J. J., Bellenguez, C., Freeman, C., Band, G., Bumpstead, S. J., Edkins, S., Giannoulatou, E., Gray, E., Dronov, S., Hunt, S. E., Langford, C., Pearson, R. D., Su, Z. & 31 others, Vukcevic, D., Macharia, A. W., Uyoga, S., Ndila, C., Mturi, N., Njuguna, P., Mohammed, S., Berkley, J. A., Mwangi, I., Mwarumba, S., Kitsao, B. S., Lowe, B. S., Morpeth, S. C., Khandwalla, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Deloukas, P. & Kenyan Bacteraemia Study Group, 2 Jun 2016, In : American Journal of Human Genetics. 98, 6, p. 1092-1100 9 p.

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2019

Associations of autozygosity with a broad range of human phenotypes

Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M. & 416 others, Baumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J-F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M-L., Chen, G., Chen, Y-D. I., Chen, Z., Chiu, Y-F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y-J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K-T., Khor, C. C., de Kleijn, D. P. V., Koh, W-P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I-T., Lee, W-J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P-E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H-H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y-C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J-M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C-Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C-K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O'connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E-S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D-A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T-Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 31 Oct 2019, In : Nature Communications. 10, 1, p. 1-17 17 p., 4957.

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2013

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W. & 14 others, Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

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78 Citations (Scopus)
2020

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

Meng, W., Chan, B. W., Harris, C., Freidin, M. B., Hebert, H., Adams, M. J., Campbell, A., Hayward, C., Zheng, H., Zhang, X., Colvin, L., Hales, T., Palmer, C., Williams, F. M. K., McIntosh, A. M. & Smith, B. H., 15 Apr 2020, In : Human Molecular Genetics. 29, 8, p. 1396-1404 9 p.

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2017

Variants in pharmacokinetic transporters and glycemic response to metformin: A metgen meta-analysis

Dujic, T., Zhou, K., Yee, S. W., van Leeuwen, N., de Keyser, C. E., Javorský, M., Goswami, S., Zaharenko, L., Christiansen, M. M. H., Out, M., Tavendale, R., Kubo, M., Hedderson, M. M., van der Heijden, A. A., Klimčáková, L., Pirags, V., Kooy, A., Brøsen, K., Klovins, J., Semiz, S. & 6 others, Tkáč, I., Stricker, B. H., Palmer, C. N. A., 't Hart, L. M., Giacomini, K. M. & Pearson, E. R., Jun 2017, In : Clinical Pharmacology & Therapeutics. 101, 6, p. 763-772 10 p.

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