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Author

  • Michael Ferguson
2017

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

Ivanova, I. M., Nepogodiev, S. A., Saalbach, G., O'Neill, E. C., Urbaniak, M. D., Ferguson, M. A. J., Gurcha, S. S., Besra, G. S. & Field, R. A., 13 Jan 2017, In : Carbohydrate Research. 438, p. 26-38 13 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
130 Downloads (Pure)
2016

Proteomic identification of immunodiagnostic antigens for Trypanosoma vivax infections in cattle and generation of a proof-of-concept lateral flow test diagnostic device

Fleming, J. R., Sastry, L., Wall, S. J., Sullivan, L. & Ferguson, M. A. J., 8 Sep 2016, In : PLoS Neglected Tropical Diseases. 10, 9, 11 p., e0004977.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
165 Downloads (Pure)
2011

On the hunt for new diagnostic antigens for human African trypanosomiasis

Sullivan, L., Carrington, M. & Ferguson, M. A. J., Oct 2011, In : Tropical Medicine & International Health. 16, p. 201-201 1 p.

Research output: Contribution to journalMeeting abstract

2013

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. & Van Aalten, D. M. F., 11 Jul 2013, In : Bioscience Reports. 33, 5, 11 p., e00063.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei

Damerow, M., Rodrigues, J. A., Wu, D., Güther, M. L. S., Mehlert, A. & Ferguson, M. A. J., 28 Mar 2014, In : Journal of Biological Chemistry. 289, 13, p. 9328-9339 12 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
124 Downloads (Pure)
2011

Systematic review of performance of non-invasive biomarkers in the evaluation of non-alcoholic fatty liver disease

Miller, M. H., Ferguson, M. A. J. & Dillon, J. F., Apr 2011, In : Liver International. 31, 4, p. 461-473 13 p.

Research output: Contribution to journalReview article

37 Citations (Scopus)
2013

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. & van Aalten, D. M. F., Aug 2013, In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma brucei

Izquierdo, L., Acosta-Serrano, A., Mehlert, A. & Ferguson, M. A. J., 2015, In : Glycobiology. 25, 4, p. 438-447 50 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M. D., Mar 2012, In : Chemical Biology & Drug Design. 79, 3, p. 270-278 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2013

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sep 2013, In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2015

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J. & 21 others, Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., 28 Jan 2015, In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. R., Lüder, C. G. K., Ferguson, M. A. J. & Routier, F. H., 3 Nov 2015, In : PLoS Neglected Tropical Diseases. 9, 11, e0004205.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
120 Downloads (Pure)
2011

Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

Capes, A. S., Crossman, A. T., Webster, L. A., Ferguson, M. A. J. & Gilbert, I. H., 28 Dec 2011, In : Tetrahedron Letters. 52, 52, p. 7091-7094 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
13 Downloads (Pure)
2015

Molecular control of irreversible bistability during trypanosome developmental commitment

Domingo-Sananes, M. R., Szöor, B., Ferguson, M. A. J., Urbaniak, M. D. & Matthews, K. R., 19 Oct 2015, In : Journal of Cell Biology. 211, 2, p. 455-468 14 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
146 Downloads (Pure)
2013
101 Citations (Scopus)
2019

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
134 Downloads (Pure)
2018

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat

Pinger, J., Nešić, D., Ali, L., Aresta-Branco, F., Lilic, M., Chowdhury, S., Kim, H. S., Verdi, J., Raper, J., Ferguson, M. A. J., Papavasiliou, F. N. & Stebbins, C. E., Aug 2018, In : Nature Microbiology. 3, 8, p. 932-938 7 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
243 Downloads (Pure)
2017
Open Access
File
4 Citations (Scopus)
183 Downloads (Pure)
2012

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

Research output: Contribution to journalArticle

Open Access
File
76 Citations (Scopus)
443 Downloads (Pure)
2020

Setting our sights on infectious diseases

De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In : ACS Infectious Diseases. 6, p. 3-13 11 p.

Research output: Contribution to journalArticle

Open Access
File
60 Downloads (Pure)
2018

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In : Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
456 Downloads (Pure)
2019

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

2014

Proteomic Selection of Immunodiagnostic Antigens for Trypanosoma congolense

Fleming, J. R., Sastry, L., Crozier, T. W. M., Napier, G. B., Sullivan, L. & Ferguson, M. A. J., 2014, In : PLoS Neglected Tropical Diseases. 8, 6, e2936.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
367 Downloads (Pure)
2019

Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix

Mattos, E. C., Canuto, G., Varón, N. C. M., Magalhães, R. D. M., Crozier, T. W. M., Lamont, D. J., Tavares, M. F. M., Colli, W., Ferguson, M. A. J. & Alves, M. J. M., 6 Feb 2019, In : PLoS Neglected Tropical Diseases. 13, 2, p. 1-27 27 p., e0007103.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
118 Downloads (Pure)
2014
21 Citations (Scopus)
2011

Novel non-invasive scoring system for the detection of NASH from a NAFLD population

Miller, M., Jafferbhoy, H., Crowther, D., Walsh, S., Ferguson, M. A. & Dillon, J. F., Oct 2011, In : Hepatology. 54, p. 1113A-1113A 1 p.

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)
2015

Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. F. R., Ferguson, M. A. J. & Routier, F. H., Oct 2015, In : International Journal for Parasitology. 45, 12, p. 783-790 8 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
165 Downloads (Pure)
2012

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J., 2012, In : PLoS ONE. 7, 5, p. - 8 p., e36619.

Research output: Contribution to journalArticle

105 Citations (Scopus)
2018

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

Kovarova, J., Nagar, R., Correia Faria, J., Ferguson, M., Barrett, M. P. & Horn, D., 27 Dec 2018, In : PLoS Pathogens. 14, 12, p. 1-22 22 p., e1007475.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
109 Downloads (Pure)
2012

Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

Bandini, G., Marino, K., Güther, M. L. S., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. & Ferguson, M. A. J., 2012, In : Molecular Microbiology. 85, 3, p. 513-534 22 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2011

Drug discovery initiative at the University of Dundee: hit-to-lead development for hat and generation of chemical tools

Grimaldi, R., Urich, R., Sienkiewicz, N., Woodland, A., Urbaniak, M. D., Mathieson, T., Eberhard, D., Bantscheff, M., Drewes, G., Ferguson, M. A. J., Gilbert, I. H., Frearson, J. A., Wyatt, P. G. & Fairlamb, A. H., 2011, In : Tropical Medicine & International Health. 16, S.1, p. 212 1 p., 1.3-148.

Research output: Contribution to journalMeeting abstract

2013

Creation and characterization of glycosyltransferase mutants of trypanosoma brucei

Izquierdo, L., Güther, M. L. S. & Ferguson, M. A. J., 2013, Glycosyltransferases. Brockhausen, I. (ed.). Humana Press, p. 249-275 27 p. (Methods in Molecular Biology; vol. 1022).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

6 Citations (Scopus)
2014

TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei

Nakanishi, M., Karasudani, M., Shiraishi, T., Hashida, K., Hino, M., Ferguson, M. A. J. & Nomoto, H., Jun 2014, In : Parasitology International. 63, 3, p. 513-518 6 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
162 Downloads (Pure)
2018

N-glycan microheterogeneity regulates interactions of plasma proteins

Wu, D., Struwe, W. B., Harvey, D. J., Ferguson, M. A. J. & Robinson, C. V., 28 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 35, p. 8763-8768 6 p., 201807439.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
127 Downloads (Pure)
2013

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Pizarro, J. C., Hills, T., Senisterra, G., Wernimont, A. K., Mackenzie, C., Norcross, N. R., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. & Hui, R., 17 Oct 2013, In : PLoS Neglected Tropical Diseases. 7, 10, e2492.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
132 Downloads (Pure)

The Scales of Life

Shemilt, E. & Ferguson, M., Sep 2013

Research output: Non-textual formArtefact

4 Citations (Scopus)
2 Downloads (Pure)
2014

Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

Sullivan, L., Fleming, J., Sastry, L., Mehlert, A., Wall, S. J. & Ferguson, M. A. J., 17 Jul 2014, In : PLoS Neglected Tropical Diseases. 8, 7, p. e2976

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
168 Downloads (Pure)
2019
Open Access
File
9 Citations (Scopus)
174 Downloads (Pure)
2017
Open Access
File
138 Citations (Scopus)
298 Downloads (Pure)
2020

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures

Galloway, A., Atrih, A., Grzela, R., Darzynkiewicz, E., Ferguson, M. A. J. & Cowling, V. H., 26 Feb 2020, In : Open Biology. 10, 2, p. 1-13 13 p., 190306.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
40 Downloads (Pure)

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

Raimi, O., Hurtado-Guerrero, R., Borodkin, V., Ferenbach, A., Urbaniak, M., Ferguson, M. & van Aalten, D., 1 Apr 2020, In : RSC Chemical Biology. 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

2011

Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction

Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J., 25 Nov 2011, In : Journal of Biological Chemistry. 286, 47, p. 40494-40508 15 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Application of novel method to quantify akt phosphorylation in breast cancer

Thompson, A., Atrih, A., Quinlan, P. R., Bray, S., Ferguson, M. & Huang, J., May 2011, In : Annals of Oncology. 22, S2, p. ii38-iii38 1 p., 65P.

Research output: Contribution to journalMeeting abstract

2014

Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H., Mar 2014, In : Organic and Biomolecular Chemistry. 12, 12, p. 1919-1934 16 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
162 Downloads (Pure)
2013

Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J., 19 Apr 2013, In : Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2019

Organizational innovation for developing new medicines that target aging and age-related conditions

Ford, G. A., Lord, J. M., Ferguson, M. A. J., Bountra, C. & Le Couteur, D. G., 6 Mar 2019, In : The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 75, 1, p. 87-88 2 p., glz062.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
142 Downloads (Pure)
2016

Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling

Larance, M., Kirkwood, K. J., Tinti, M., Brenes Murillo, A., Ferguson, M. & Lamond, A., 1 Jul 2016, In : Molecular & Cellular Proteomics. 15, 7, p. 2476-2490 15 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
125 Downloads (Pure)
2013

Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device

Sullivan, L., Wall, S. J., Carrington, M. & Ferguson, M. A. J., 28 Feb 2013, In : PLoS Neglected Tropical Diseases. 7, 2, 14 p., e2087.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2012

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G., 2012, In : ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2014

Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis

Sternberg, J. M., Gierlinski, M., Biéler, S., Ferguson, M. A. J. & Ndung'u, J. M., Dec 2014, In : PLoS Neglected Tropical Diseases. 8, 12, p. e3373 8 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
156 Downloads (Pure)