Find Research Outputs

Search in all content

Filters for Research Outputs

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Leeanne McGurk
2018

Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

McGurk, L., Gomes, E., Guo, L., Shorter, J. & Bonini, N. M., 26 Dec 2018, In : Biochemistry. 57, 51, p. 6923-6926 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2020

TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2

McGurk, L., Rifai, O. & Bonini, N. M., 14 May 2020, In : Journal of Cell Science.

Research output: Contribution to journalArticle

Open Access
File
8 Downloads (Pure)
2018

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

McGurk, L., Mojsilovic-Petrovic, J., Van Deerlin, V. M., Shorter, J., Kalb, R. G., Lee, V. M., Trojanowski, J. Q., Lee, E. B. & Bonini, N. M., 29 Aug 2018, In : Acta Neuropathologica Communications. 6, 1, p. 1-15 15 p., 84.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
50 Downloads (Pure)

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

McGurk, L., Gomes, E., Guo, L., Mojsilovic-Petrovic, J., Tran, V., Kalb, R. G., Shorter, J. & Bonini, N. M., 6 Sep 2018, In : Molecular Cell. 71, 5, p. 703-717.e9 24 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
2014

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Kim, H. J., Raphael, A. R., Ladow, E. S., Mcgurk, L., Weber, R. A., Trojanowski, J. Q., Lee, V. M. Y., Finkbeiner, S., Gitler, A. D. & Bonini, N. M., 2014, In : Nature Genetics. 46, 2, p. 152-160 9 p.

Research output: Contribution to journalArticle

190 Citations (Scopus)

Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72

McGurk, L., Lee, V. M., Trojanowksi, J. Q., Van Deerlin, V. M., Lee, E. B. & Bonini, N. M., 1 Sep 2014, In : Journal of Neuropathology and Experimental Neurology. 73, 9, p. 837-845 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012
Open Access
File
15 Citations (Scopus)
49 Downloads (Pure)
2020

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

Deng, P., Khan, A., Jacobson, D., Sambrani, N., McGurk, L., Li, X., Jayasree, A., Hejatko, J., Shohat-Ophir, G., O'Connell, M. A., Li, J. B. & Keegan, L. P., 27 Mar 2020, In : Nature Communications. 11, 1, p. 1580 1580.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
16 Downloads (Pure)
2019

Poly(ADP-Ribosylation) in Age-Related Neurological Disease

McGurk, L., Rifai, O. M. & Bonini, N. M., Aug 2019, In : Trends in Genetics. 35, 8, p. 601-613 13 p.

Research output: Contribution to journalReview article

2011

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: Loss of ADAR1 in insects

Keegan, L. P., McGurk, L., Palavicini, J. P., Brindle, J., Paro, S., Li, X., Rosenthal, J. J. C. & O'Connell, M. A., 1 Sep 2011, In : Nucleic Acids Research. 39, 16, p. 7249-7262 14 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
50 Downloads (Pure)
2020

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

Khan, A., Paro, S., McGurk, L., Sambrani, N., Hogg, M. C., Brindle, J., Pennetta, G., Keegan, L. P. & O'Connell, M. A., 14 Feb 2020, In : BMC Biology. 18, 1, 16 p., 15.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
30 Downloads (Pure)
2011

Yeast informs Alzheimer's disease

McGurk, L. & Bonini, N. M., 2 Dec 2011, In : Science. 334, 6060, p. 1212-1213 2 p.

Research output: Contribution to journalShort survey

7 Citations (Scopus)
2015

Drosophila as an in vivo model for human neurodegenerative disease

McGurk, L., Berson, A. & Bonini, N. M., Oct 2015, In : Genetics. 201, 2, p. 377-402 26 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)