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  • Iva Hopkins Navratilova
2011

Screening for GPCR Ligands Using Surface Plasmon Resonance

Hopkins Navratilova, I., Besnard, J. & Hopkins, A. L., Jul 2011, In : ACS Medicinal Chemistry Letters. 2, 7, p. 549-554 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Emerging role of surface plasmon resonance in fragment-based drug discovery

Navratilova, I. & Hopkins, A. L., Oct 2011, In : Future Medicinal Chemistry. 3, 14, p. 1809-1820 12 p.

Research output: Contribution to journalReview article

46 Citations (Scopus)

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R., 4 May 2011, In : EMBO Journal. 30, 9, p. 1730-1741 12 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Substrate and product analogues as human O-GlcNAc transferase inhibitors

Dorfmueller, H. C., Borodkin, V. S., Blair, D. E., Pathak, S., Navratilova, I. & van Aalten, D. M. F., Mar 2011, In : Amino Acids. 40, 3, p. 781-792 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2019

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates

Cahill, S. T., Tyrrell, J. M., Navratilova, I. H., Calvopiña, K., Robinson, S. W., Lohans, C. T., McDonough, M. A., Cain, R., Fishwick, C. W. G., Avison, M. B., Walsh, T. R., Schofield, C. J. & Brem, J., 1 Apr 2019, In : Biochimica et Biophysica Acta: General Subjects. 1863, 4, p. 742-748 7 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
58 Downloads (Pure)
2018

Inhibitors against Fungal Cell Wall Remodeling Enzymes

Delso, I., Valero-Gonzalez, J., Gomollón-Bel, F., Castro-López, J., Fang, W., Navratilova, I., van Aalten, D. M. F., Tejero, T., Merino, P. & Hurtado-Guerrero, R., 22 Jan 2018, In : ChemMedChem. 13, 2, p. 128-132 5 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
160 Downloads (Pure)

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry

Borodkin, V. S., Rafie, K., Selvan, N., Aristotelous, T., Navratilova, I., Ferenbach, A. T. & Van Aalten, D. M. F., 18 May 2018, In : ACS Chemical Biology. 13, 5, p. 1353-1360 8 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
149 Downloads (Pure)

Surveying GPCR solubilisation conditions using surface plasmon resonance

Navratilova, I. H., Aristotelous, T., Bird, L. E. & Hopkins, A. L., 1 Sep 2018, In : Analytical Biochemistry. 556, p. 23-34 12 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
23 Downloads (Pure)
2013

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F., 2 Oct 2013, In : Open Biology. 3, 130021.

Research output: Contribution to journalArticle

25 Citations (Scopus)

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sep 2013, In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I., 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2018

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Mousnier, A., Bell, A. S., Swieboda, D. P., Morales-Sanfrutos, J., Pérez-Dorado, I., Brannigan, J. A., Newman, J., Ritzefeld, M., Hutton, J. A., Guedán, A., Asfor, A. S., Robinson, S. W., Hopkins-Navratilova, I., Wilkinson, A. J., Johnston, S. L., Leatherbarrow, R. J., Tuthill, T. J., Solari, R. & Tate, E. W., Jun 2018, In : Nature Chemistry. 10, 6, p. 599-606 8 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
137 Downloads (Pure)
2016

Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

Navratilova, I., Aristotelous, T., Picaud, S., Chaikuad, A., Knapp, S., Filappakopoulos, P. & Hopkins, A. L., 8 Dec 2016, In : ACS Medicinal Chemistry Letters. 7, 12, p. 1213-1218 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Fragment screening by SPR and advanced application to GPCRs

Shepherd, C. A., Hopkins, A. L. & Navratilova, I., Nov 2014, In : Progress in Biophysics and Molecular Biology. 116, 2-3, p. 113-123 11 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2020

Mining Public Domain Data to Develop Selective DYRK1A Inhibitors

Henderson, S. H., Sorrell, F., Bennett, J., Hanley, M. T., Robinson, S., Hopkins Navratilova, I., Elkins, J. M. & Ward, S. E., 13 Aug 2020, In : ACS Medicinal Chemistry Letters. 11, 8, p. 1620-1626 7 p.

Research output: Contribution to journalArticle

Open Access
File
6 Downloads (Pure)
2011

Mechanism of ubiquitylation by dimeric RING ligase RNF4

Plechanovova, A., Jaffray, E. G., McMahon, S. A., Johnson, K. A., Navratilova, I., Naismith, J. H. & Hay, R. T., Sep 2011, In : Nature Structural & Molecular Biology. 18, 9, p. 1052-1059 8 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)