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• 2014

  Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

  Kim, H. J., Raphael, A. R., Ladow, E. S., Mcgurk, L., Weber, R. A., Trojanowski, J. Q., Lee, V. M. Y., Finkbeiner, S., Gitler, A. D. & Bonini, N. M., Feb 2014, In: Nature Genetics. 46, 2, p. 152-160 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic Lateral Sclerosis
  • Phosphorylation
  • Diptera
  • Ataxin-2
  • Carrier Proteins
  207 Citations (Scopus)
• 2018

  Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

  McGurk, L., Mojsilovic-Petrovic, J., Van Deerlin, V. M., Shorter, J., Kalb, R. G., Lee, V. M., Trojanowski, J. Q., Lee, E. B. & Bonini, N. M., 29 Aug 2018, In: Acta Neuropathologica Communications. 6, 1, p. 1-15 15 p., 84.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Poly Adenosine Diphosphate Ribose
  • Amyotrophic Lateral Sclerosis
  • veliparib
  • Spinal Cord
  • Nuclear RNA
  26 Citations (Scopus)

  71 Downloads (Pure)

• Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

  McGurk, L., Gomes, E., Guo, L., Mojsilovic-Petrovic, J., Tran, V., Kalb, R. G., Shorter, J. & Bonini, N. M., 6 Sep 2018, In: Molecular Cell. 71, 5, p. 703-717.e9 24 p.

  Research output: Contribution to journal › Article › peer-review

  • Tankyrases
  • Poly Adenosine Diphosphate Ribose
  • Amyotrophic Lateral Sclerosis
  • Phosphorylation
  • Poly(ADP-ribose) Polymerases
  95 Citations (Scopus)

• Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

  McGurk, L., Gomes, E., Guo, L., Shorter, J. & Bonini, N. M., 26 Dec 2018, In: Biochemistry. 57, 51, p. 6923-6926 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Poly Adenosine Diphosphate Ribose
  • Agglomeration
  • Prions
  • Biopolymers
  • DNA-Binding Proteins
  9 Citations (Scopus)
• 2014

  Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72

  McGurk, L., Lee, V. M., Trojanowksi, J. Q., Van Deerlin, V. M., Lee, E. B. & Bonini, N. M., 1 Sep 2014, In: Journal of Neuropathology and Experimental Neurology. 73, 9, p. 837-845 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Poly(A)-Binding Proteins
  • Amyotrophic Lateral Sclerosis
  • Inclusion Bodies
  • Motor Neurons
  • Sarcoma
  30 Citations (Scopus)
• 2019

  Poly(ADP-Ribosylation) in Age-Related Neurological Disease

  McGurk, L., Rifai, O. M. & Bonini, N. M., Aug 2019, In: Trends in Genetics. 35, 8, p. 601-613 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Poly ADP Ribosylation
  • Neurodegenerative Diseases
  • Proteins
  • Poly Adenosine Diphosphate Ribose
  • Amyotrophic Lateral Sclerosis
  3 Citations (Scopus)