Find Research Outputs

Search in all content

Filters for Research Outputs

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Ewan Pearson
2019

Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes

Patel, K. A., Weedon, M. N., Shields, B. M., Pearson, E. R., Hattersley, A. T. & McDonald, T. J., Feb 2019, In : Diabetes Care. 42, 2, p. e1-e2 2 p.

Research output: Contribution to journalLetter

9 Citations (Scopus)
2017

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., Colhoun, H., Morris, A. D., George, J., Doney, A., Pirmohamed, M., Alfirevic, A., Wadelius, M., Maitland-van der Zee, A. H., Ridker, P. M., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, Aug 2017, In : Circulation: Cardiovascular Genetics. 10, 4, e001737 .

Research output: Contribution to journalArticle

3 Citations (Scopus)
Open Access
File
1 Citation (Scopus)
152 Downloads (Pure)
2016

Effect of Serotonin Transporter 5HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study

Dujic, T., Zhou, K., Tavendale, R., Palmer, C. & Pearson, E., 1 Nov 2016, In : Diabetes Care. 39, 11, p. 1896-1901 6 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
162 Downloads (Pure)
2020

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E. & 43 others, Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M-G., Elders, P. J. M., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R. S., Sharma, S., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., 't Hart, L. M., Adamski, J., Musholt, P. B., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A. T., Walker, M., Beulens, J. W. J., Mari, A., Schwenk, J. M., Gupta, R., McCarthy, M. I., Pearson, E. R., Bell, J. D., Pavo, I. & Franks, P. W., 19 Jun 2020, In : PLoS Medicine. 17, 6, p. 1-27 27 p., e1003149.

Research output: Contribution to journalArticle

Open Access
File
8 Downloads (Pure)
2019

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H. & 30 others, Rauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. & Franks, P. W., 1 Sep 2019, In : Diabetologia. 62, 9, p. 1601-1615 15 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
12 Downloads (Pure)
2016

Statistical power considerations in genotype-based recall randomized controlled trials

Atabaki-Pasdar, N., Ohlsson, M., Shungin, D., Kurbasic, A., Ingelsson, E., Pearson, E. R., Ali, A. & Franks, P. W., 25 Nov 2016, In : Scientific Reports. 6, p. 1-11 11 p., 37307.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
141 Downloads (Pure)
2017

Clarifying the relationship between metformin, acute kidney injury and lactic acidosis

Bell, S., Soto-Pedre, E., Connelly, P., Livingstone, S. & Pearson, E., 13 Dec 2017, In : Nature Reviews Nephrology. 14, 1 p., 70.

Research output: Contribution to journalLetter

Open Access
File
1 Citation (Scopus)
118 Downloads (Pure)
2019

Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: a retrospective analysis of primary care data, 2010-2017

Dennis, J. M., Henley, W. E., McGovern, A. P., Farmer, A. J., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Shields, B. M., Jones, A. G. & MASTERMIND consortium, Jul 2019, In : Diabetes, Obesity & Metabolism. 21, 7, p. 1576-1584 9 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
106 Downloads (Pure)
2016

Pharmacogenetics in type 2 diabetes: Influence on response to oral hypoglycemic agents

Dawed, A. Y., Zhou, K. & Pearson, E. R., 6 Apr 2016, In : Pharmacogenomics and Personalized Medicine. 9, p. 17-29 13 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
176 Downloads (Pure)
2017

Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients

Shields, B. M., Shepherd, M. H., Hudson, M. M., McDonald, T. J., Colclough, K., Peters, J., Knight, B., Hyde, C., Ellard, S., Pearson, E. R., Hattersley, A. T. & on behalf of the UNITED study team, Aug 2017, In : Diabetes Care. 40, 8, p. 1017-1025 9 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
140 Downloads (Pure)
2018

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

Shepherd, M. H., Shields, B. M., Hudson, M., Pearson, E. R., Hyde, C., Ellard, S., Hattersley, A. T. & Patel, K. A., Dec 2018, In : Diabetologia. 61, 12, p. 2520-2527 8 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
92 Downloads (Pure)
2019

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease

Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P. K., Relan, D., Harris, S., Vaidya, S. S. ., Dhillon, B., Zhou, K., Pearson, E., Hayward, C., Polašek, O., Deary, I. J., MacGillivray, T. J., Wilson, J. F., Trucco, M., Palmer, C. & 1 others, Doney, A., Dec 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552 11 p.

Research output: Contribution to journalArticle

Open Access
File
103 Downloads (Pure)
2016
Open Access
File
32 Citations (Scopus)
265 Downloads (Pure)
2017

The sustained influence of metformin therapy on circulating GLP-1 levels in individuals with and without type 2 diabetes

Preiss, D., Dawed, A., Welsh, P., Heggie, A., Jones, A. G., Dekker, J., Koivula, R., Hansen, T. H., The DIRECT consortium, Stewart, C., Holman, R. R., Franks, P. W., Walker, M., Pearson, E. R. & Sattar, N., Mar 2017, In : Diabetes, Obesity & Metabolism. 19, 3, p. 356-363 8 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
146 Downloads (Pure)
2016

Adherence to oral glucose-lowering therapies and associations with 1-year HbA1c: A retrospective cohort analysis in a large primary care database

Farmer, A. J., Rodgers, L. R., Lonergan, M., Shields, B., Weedon, M. N., Donnelly, L., Holman, R. R., Pearson, E. R. & Hattersley, A. T., 1 Feb 2016, In : Diabetes Care. 39, 2, p. 258-263 6 p.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
143 Downloads (Pure)
2017

A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Wood, A. R., Jonsson, A., Jackson, A. U., Wang, N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., Stančáková, A., Boomsma, D. I., de Geus, E. J. C., Eekhoff, E. M. W., Fritsche, A., Kramer, M. H. H., Nijpels, G., Simonis-Bik, A. M. C., van Haeften, T. W., Mahajan, A. & 31 others, Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, K., Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, N., Eiberg, H., Pedersen, O., Chen, Y-D., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, T., Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M., 21 Jul 2017, In : Diabetes. 66, 8, p. 2296-2309 14 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
204 Downloads (Pure)
2018

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

Gudmundsdottir, V., Pedersen, H. K., Allebrandt, K. V., Brorsson, C., van Leeuwen, N., Banasik, K., Mahajan, A., Groves, C. J., van de Bunt, M., Dawed, A. Y., Fritsche, A., Staiger, H., Simonis-Bik, A. M. C., Deelen, J., Kramer, M. H. H., Dietrich, A., Hübschle, T., Willemsen, G., Häring, H-U., de Geus, E. J. C. & 8 others, Boomsma, D. I., Eekhoff, E. M. W., Ferrer, J., McCarthy, M. I., Pearson, E. R., Gupta, R., Brunak, S. & 't Hart, L. M., 2 Jan 2018, In : PLoS ONE. 13, 1, p. 1-19 19 p., e0189886.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
159 Downloads (Pure)
2020

The impact of phenotype, ethnicity and genotype on progression of Type 2 diabetes mellitus

Thakarakkattil Narayanan Nair, A., Donnelly, L. A., Dawed, A. Y., Gan, S., Anjana, R. M., Mohan, V., Palmer, C. & Pearson, E., 20 Apr 2020, In : Endocrinology, Diabetes & Metabolism. 3, 2, p. 1-11 11 p., e00108.

Research output: Contribution to journalReview article

Open Access
File
46 Downloads (Pure)
2018

Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study

Siddiqui, M. K., Kennedy, G., Carr, F., Doney, A., Pearson, E., Morris, A., Johnson, T., McLaughlin, M. M., Williams, R. E. & Palmer, C., Jun 2018, In : Diabetologia. 61, 6, p. 1344-1353 10 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
185 Downloads (Pure)

Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-Term Glycemic Response to DPP-4 Inhibitor Therapy

Dennis, J. M., Shields, B. M., Hill, A. V., Knight, B. A., McDonald, T. J., Rodgers, L. R., Weedon, M. N., Henley, W. E., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Jones, A. G. & MASTERMIND consortium, Apr 2018, In : Diabetes Care. 41, 4, p. 705-712 8 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
254 Downloads (Pure)

C-peptide decline in type 1 diabetes has two phases: An initial exponential fall and a subsequent stable phase

Shields, B. M., McDonald, T. J., Oram, R., Hill, A., Hudson, M., Leete, P., Pearson, E. R., Richardson, S. J., Morgan, N. G. & Hattersley, A. T., 1 Jul 2018, In : Diabetes Care. 41, 7, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
280 Downloads (Pure)
2016

Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes

Dujic, T., Causevic, A., Bego, T., Malenica, M., Velija-Asimi, Z., Pearson, E. R. & Semiz, S., Apr 2016, In : Diabetic Medicine. 33, 4, p. 511-514 4 p., 13040.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
140 Downloads (Pure)

Should studies of diabetes treatment stratification correct for baseline HbA1c?

Jones, A. G., Lonergan, M., Henley, W. E., Pearson, E. R., Hattersley, A. T. & Shields, B. M., 6 Apr 2016, In : PLoS ONE. 11, 4, 14 p., e0152428.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
139 Downloads (Pure)
2018

Performance of Cardiovascular Disease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register

Scottish Diabetes Research Network Epidemiology Group, Read, S. H., van Diepen, M., Colhoun, H. M., Halbesma, N., Lindsay, R. S., McKnight, J. A., McAllister, D. A., Pearson, E. R., Petrie, J. R., Philip, S., Sattar, N., Woodward, M. & Wild, S. H., 1 Sep 2018, In : Diabetes Care. 41, 9, p. 2010-2018 9 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
177 Downloads (Pure)

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J-L., Demine, S., Schiavo, A. A., Pachera, N., Deglasse, J-P., Jonas, J-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M., 2 Nov 2018, In : Nucleic Acids Research. 46, 19, p. 10302-10318 17 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
105 Downloads (Pure)
2017

Quantifying the extent to which index event biases influence large genetic association studies

Yaghootkar, H., Bancks, M. P., Jones, S. E., McDaid, A., Beaumont, R., Donnelly, L., Wood, A. R., Campbell, A., Tyrrell, J., Hocking, L. J., Tuke, M. A., Ruth, K. S., Pearson, E. R., Murray, A., Freathy, R. M., Munroe, P. B., Hayward, C., Palmer, C., Weedon, M. N., Pankow, J. S. & 2 others, Frayling, T. M. & Kutalik, Z., 1 Jun 2017, In : Human Molecular Genetics. 26, 5, p. 1018-1030 13 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
129 Downloads (Pure)
2016

Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease

Yaghootkar, H., Lotta, L. A., Tyrrell, J., Smit, R. A. J., Jones, S. E., Donnelly, L., Beaumont, R., Campbell, A., Tuke, M. A., Hayward, C., Ruth, K. S., Padmanabhan, S., Jukema, J. W., Palmer, C. C., Hattersley, A., Freathy, R. M., Langenberg, C., Wareham, N. J., Wood, A. R., Murray, A. & 5 others, Weedon, M. N., Sattar, N., Pearson, E., Scott, R. A. & Frayling, T. M., Aug 2016, In : Diabetes. 65, 8, p. 2448-2460 13 p.

Research output: Contribution to journalArticle

Open Access
File
44 Citations (Scopus)
178 Downloads (Pure)
2018

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Neonatal Diabetes International Collaborative Group, Bowman, P., Sulen, Å., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M., Iafusco, D. & 2 others, Hattersley, A. T. & Njølstad, P. R., 1 Aug 2018, In : The Lancet Diabetes and Endocrinology. 6, 8, p. 637-646 10 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
196 Downloads (Pure)
2019

Motivations for data sharing-views of research participants from four European countries: A DIRECT study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 30 Jan 2019, In : European Journal of Human Genetics. 27, 5, p. 721-729 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
105 Downloads (Pure)
2017

Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study

Connelly, P. J., Lonergan, M., Soto-Pedre, E., Donnelly, L., Zhou, K. & Pearson, E. R., 5 Jul 2017, In : Diabetes, Obesity & Metabolism. 19, 11, p. 1579-1586 7 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
164 Downloads (Pure)
2018

First Genome Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Cousminer, D. L., Ahlqvist, E., Mishra, R., Andersen, M. K., Chesi, A., Hawa, M. I., Davis, A., Hodge, K. M., Bradfield, J. P., Zhou, K., Guy, V. C., Åkerlund, M., Wod, M., Fritsche, L. G., Vestergaard, H., Snyder, J., Højlund, K., Linneberg, A., Käräjämäki, A., Brandslund, I. & 33 others, Kim, C. E., Witte, D. R., Sørgjerd, E. P., Brillon, D. J., Pedersen, O., Beck-Nielsen, H., Grarup, N., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Melander, O., Harris, R. I., Varvel, S., Grill, V. E. R., Hakonarson, H. H., Froguel, P., Lonsdale, J. T., Mauricio, D., Schloot, N. C., Khunti, K., Greenbaum, C. J., Asvold, B. O., Yderstræde, K. B., Pearson, E., Schwartz, S., Voight, B. F., Hansen, T., Tuomi, T., Boehm, B. O., Groop, L. C., Leslie, R. D. & Grant, S. F. A., 1 Nov 2018, In : Diabetes Care. p. 2396-2403 7 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
162 Downloads (Pure)

Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers-validation of technique and implications for clinical studies

Marzetti, M., Brunton, T., McCreight, L., Pearson, E., Docherty, S. & Gandy, S. J., 17 May 2018, In : British Journal of Radiology. 91, 1087, 7 p., 20180025.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
187 Downloads (Pure)
2016

CYP2C8 and SLCO1B1 variants and therapeutic response to thiazolidinediones in patients with type 2 diabetes.

Dawed, A. Y., Donnelly, L., Tavendale, R., Carr, F., Leese, G., Palmer, C. N. A., Pearson, E. & Zhou, K., Nov 2016, In : Diabetes Care. 39, 11, p. 1902-1908 7 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
199 Downloads (Pure)
2017

Defining drug response for stratified medicine

Lonergan, M., Senn, S. J., McNamee, C., Daly, A. K., Sutton, R., Hattersley, A., Pearson, E. & Pirmohamed, M., Jan 2017, In : Drug Discovery Today. 22, 1, p. 173-179 7 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)
2018

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes

Rotroff, D. M., Yee, S. W., Zhou, K., Marvel, S. W., Shah, H. S., Jack, J. R., Havener, T. M., Hedderson, M. M., Kubo, M., Herman, M. A., Gao, H., Mychaleckyi, J. C., McLeod, H. L., Doria, A., Giacomini, K. M., Pearson, E. R., Wagner, M. J., Buse, J. B., Motsinger-Reif, A. A. & MetGen Investigators and the ACCORD/ACCORDion Investigators, Jul 2018, In : Diabetes. 67, 7, p. 1428-1440 13 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
88 Downloads (Pure)
2019

Type 2 diabetes: a multifaceted disease

Pearson, E., Jul 2019, In : Diabetologia. 62, 7, p. 1107-1112 6 p.

Research output: Contribution to journalReview article

Open Access
File
12 Citations (Scopus)
240 Downloads (Pure)
2018

The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project

Teare, H. J. A., de Masi, F., Banasik, K., Barnett, A., Herrgard, S., Jablonka, B., Postma, J. W. M., McDonald, T. J., Forgie, I., Chmura, P. J., Rydzka, E. K., Gupta, R., Brunak, S., Pearson, E. & Kaye, J., 4 Sep 2018, In : Life Sciences, Society and Policy. 14, 1, p. 1-17 17 p., 20.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
133 Downloads (Pure)
2020
Open Access
File
2 Citations (Scopus)
146 Downloads (Pure)
2017
Open Access
File
10 Citations (Scopus)
144 Downloads (Pure)
2018

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O’Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C., Pearson, E., Scott, R. A., van Heel, D. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 711.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
156 Downloads (Pure)

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

Molnos, S., Wahl, S., Haid, M., Eekhoff, E. M. W., Pool, R., Floegel, A., Deelen, J., Much, D., Prehn, C., Breier, M., Draisma, H. H. M., van Leeuwen, N., Simonis-Bik, A. M. C., Jonsson, A., Willemsen, G., Bernigau, W., Wang-Sattler, R., Suhre, K., Peters, A., Thorand, B. & 24 others, Herder, C., Rathmann, W., Roden, M., Gieger, C., Kramer, M. H. H., van Heemst, D., Pedersen, H. K., Gudmundsdottir, V., Schulze, M. B., Pischon, T., de Geus, E. J. C., Boeing, H., Boomsma, D. I., Ziegler, A. G., Slagboom, P. E., Hummel, S., Beekman, M., Grallert, H., Brunak, S., McCarthy, M. I., Gupta, R., Pearson, E. R., Adamski, J. & 't Hart, L. M., Jan 2018, In : Diabetologia. 61, 1, p. 117-129 13 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
147 Downloads (Pure)
2019

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Wilman, H. R., Parisinos, C. A., Atabaki-Pasdar, N., Kelly, M., Thomas, E. L., Neubauer, S., Mahajan, A., Hingorani, A. D., Patel, R. S., Hemingway, H., Franks, P. W., Bell, J. D., Banerjee, R. & Yaghootkar, H., Sep 2019, In : Journal of Hepatology. 71, 3, p. 594-602 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
74 Downloads (Pure)
2017

Rates of glycaemic deterioration in a real-world population with type 2 diabetes

Donnelly, L. A., Zhou, K., Doney, A. S. F., Jennison, C., Franks, P. W. & Pearson, E. R., 19 Dec 2017, In : Diabetologia. 61, p. 607-615 9 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
175 Downloads (Pure)
2016

Personalized medicine in diabetes: The role of 'omics' and biomarkers

Pearson, E. R., 1 Jun 2016, In : Diabetic Medicine. 33, 6, p. 712-717 6 p.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
186 Downloads (Pure)
2018

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

Hébert, H. L., Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
213 Downloads (Pure)
2019

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 208-214 7 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
374 Downloads (Pure)
2016

Crossover studies can help the individualisation of care in type 2 diabetes: the MASTERMIND approach

Angwin, C., Pearson, E. & Hattersley, A., 23 May 2016, In : Practical Diabetes. 33, 4, p. 115-117 3 p.

Research output: Contribution to journalEditorial

Open Access
File
125 Downloads (Pure)
2017

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes

Dawed, A. Y., Ali, A., Zhou, K., Pearson, E. R. & Franks, P. W., Nov 2017, In : Diabetologia. 60, 11, p. 2231-2239 8 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
149 Downloads (Pure)