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  • Alan Prescott
2020

Cold climate adaptation is a plausible cause for evolution of multicellular sporulation in Dictyostelia

Lawal, H. M., Schilde, C., Kin, K., Brown, M. W., James, J., Prescott, A. R. & Schaap, P., 29 May 2020, In : Scientific Reports. 10, 1, p. 1-9 9 p., 8797.

Research output: Contribution to journalArticle

Open Access
File
19 Downloads (Pure)
2018

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 others, Smith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, p. 1-18 18 p., 181108.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
131 Downloads (Pure)

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Martinez-Fabregas, J., Prescott, A., van Kasteren, S., Leslie Pedrioli, D., McLean, W., Moles, A., Reinheckel, T., Poli, V. & Watts, C., 17 Dec 2018, In : Nature Communications. 9, 1, p. 1-16 16 p., 5343.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
136 Downloads (Pure)
2019

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
10 Downloads (Pure)
2018

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks

Malik, N., Macartney, T., Hornberger, A., Anderson, K., Tovell, H., Prescott, A. R. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 117-135 19 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
249 Downloads (Pure)
2019

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 1 Sep 2019, In : EMBO Reports. 20, 9, p. 1-19 19 p., e47495.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
95 Downloads (Pure)
2016

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 22 Apr 2016, In : eLife. 5, p. 1-18 18 p., e12278.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
141 Downloads (Pure)
2019
Open Access
File
1 Citation (Scopus)
71 Downloads (Pure)
2020

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation. 15 p.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)
2018

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
160 Downloads (Pure)
2017

Bifunctionality of a biofilm matrix protein controlled by redox state

Arnaouteli, S., Ferreira, A. S., Schor, M., Morris, R. J., Bromley, K. M., Jo, J., Cortez, K. L., Sukhodub, T., Prescott, A. R., Dietrich, L. E. P., MacPhee, C. E. & Stanley-Wall, N. R., 25 Jul 2017, In : Proceedings of the National Academy of Sciences. 114, 30, p. E6184-E6191 8 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
509 Downloads (Pure)
2020

A conserved ATG2-GABARAP family interaction is critical for phagophore formation

Bozic, M., van den Bekerom, L., Milne, B. A., Goodman, N., Roberston, L., Prescott, A., Macartney, T., Dawe, N. & McEwan, D., 4 Mar 2020, In : EMBO Reports. 21, 3, p. 1-17 17 p., e48412.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
66 Downloads (Pure)
2019

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
187 Downloads (Pure)
2017

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)

Logie, L., Van Aalten, L., Knebel, A., Force, T., Hastie, C. J., MacLauchlan, H., Campbell, D. G., Gourlay, R., Prescott, A., Davidson, J., Fuller, W. & Sutherland, C., 15 Dec 2017, In : Scientific Reports. 7, p. 1-14 14 p., 17682.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
178 Downloads (Pure)
2019

Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages

Guo, M., Härtlova, A., Gierlinski, M., Prescott, A., Castellvi, J., Hernandez Losa, J., Petersen, S. K., Wenzel, U. A., Dill, B. D., Emmerich, C. H., Ramon Y Cajal, S., Russell, D. G. & Trost, M., 3 Jun 2019, In : EMBO Journal. 38, 11, p. 1-15 15 p., e100299.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
187 Downloads (Pure)

Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 17 May 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
162 Downloads (Pure)

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.

Research output: Contribution to journalArticle

Open Access
File
60 Downloads (Pure)

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 9 Sep 2019, In : Wellcome Open Research. 4, p. 134 28 p.

Research output: Contribution to journalArticle

Open Access
File
61 Downloads (Pure)
2018

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P. & Ganley, I. G., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 439-449.e5 17 p.

Research output: Contribution to journalArticle

Open Access
File
126 Citations (Scopus)
184 Downloads (Pure)
2020

Antibody RING-Mediated Destruction of Endogenous Proteins

Ibrahim, A. F. M., Shen, L., Tatham, M. H., Dickerson, D., Prescott, A. R., Abidi, N., Xirodimas, D. P. & Hay, R. T., 2 Jul 2020, In : Molecular Cell. 12 p.

Research output: Contribution to journalArticle

Open Access
File
25 Downloads (Pure)
2016

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

McWilliams, T., Prescott, A., Allen, G., Tamjar, J., Munson, M., Thomson, C., Muqit, M. & Ganley, I., 25 Jul 2016, In : Journal of Cell Biology. 214, 3, p. 333-345 13 p.

Research output: Contribution to journalArticle

Open Access
File
122 Citations (Scopus)
281 Downloads (Pure)
2017
Open Access
File
6 Citations (Scopus)
178 Downloads (Pure)
2016

Deep intronic sequence variants in COL2A1 affect the alternative splicing efficiency of Exon 2, and may confer a risk for rhegmatogenous retinal detachment

Spickett, C., Hysi, P., Hammond, C. J., Prescott, A., Fincham, G. S., Poulson, A. V., McNinch, A. M., Richards, A. J. & Snead, M. P., 21 Aug 2016, In : Human Mutation. 37, 10, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
144 Downloads (Pure)