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  • Jeremy Lambert
2017

Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent

Etherington, L-A., Mihalik, B., Pálvölgyi, A., Ling, I., Pallagi, K., Kertész, S., Varga, P., Gunn, B. G., Brown, A. R., Livesey, M. R., Monteiro, O., Belelli, D., Barkóczy, J., Spedding, M., Gacsályi, I., Antoni, F. A. & Lambert, J. J., Oct 2017, In : Neuropharmacology. 125, p. 353-364 12 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
144 Downloads (Pure)

GABAA receptor subtype involvement in addictive behaviour

Stephens, D. N., King, S. L., Lambert, J. J., Belelli, D. & Duka, T., Jan 2017, In : Genes, Brain and Behavior. 16, 1, p. 149-184 36 p.

Research output: Contribution to journalReview article

Open Access
File
29 Citations (Scopus)
158 Downloads (Pure)
2018

Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures

Monteiro, O., Chen, C., Bingham, R., Argyrou, A., Buxton, R., Jönsson, C. P., Jones, E., Bridges, A., Gatfield, K., Krauß, S., Lambert, J., Langston, R., Schweiger, S. & Uings, I., 23 Apr 2018, In : Neuroscience Letters. 673, p. 44-50 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
222 Downloads (Pure)
2020

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

Belelli, D., Hogenkamp, D., Gee, K. W. & Lambert, J. J., May 2020, In : Neurobiology of Stress. 12, p. 1-11 11 p., 100207.

Research output: Contribution to journalArticle

Open Access
File
62 Downloads (Pure)
2019

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression

Dixon, C. I., Walker, S. E., Swinny, J., Belelli, D., Lambert, J. J., King, S. L. & Stephens, D. N., Apr 2019, In : Behavioural Pharmacology. 30, 2-3, p. 272-281 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
50 Downloads (Pure)
2017

Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

Weir, C. J., Mitchell, S. J. & Lambert, J. J., Dec 2017, In : British Journal of Anaesthesia. 119, Suppl. 1, p. i167-i175 9 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
97 Downloads (Pure)

Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src

Bull, F. A., Baptista-Hon, D. T., Lambert, J. J., Walwyn, W. & Hales, T. G., 1 Dec 2017, In : Scientific Reports. 7, 1, p. 1-11 11 p., 9969.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
155 Downloads (Pure)

Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies

Kumar, N., Fagart, J., Liere, P., Mitchell, S. J., Knibb, A. R., Petit-Topin, I., Rame, M., El-Etr, M., Schumacher, M., Lambert, J. J., Rafestin-Oblin, M-E. & Sitruk-Ware, R., 1 Jan 2017, In : Endocrinology. 158, 1, p. 170-182 12 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
135 Downloads (Pure)
2018

Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine

Mitchell, S. J., Maguire, E. P., Cunningham, L., Gunn, B. G., Linke, M., Zechner, U., Dixon, C. I., King, S. L., Stephens, D. N., Swinny, J. D., Belelli, D. & Lambert, J. J., Oct 2018, In : Neuropharmacology. 141, p. 98-112 15 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
158 Downloads (Pure)

An isotope dilution based-targeted and non-targeted carbonyl neurosteroid/steroid profiling

Sharp, S., Mitchell, S., Vallée, M., Kuzmanova, E., Cooper, M., Belelli, D., Lambert, J. & Huang, J., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5247-5255 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
196 Downloads (Pure)

Endogenous neurosteroids influence synaptic GABAA receptors during post-natal development

Belelli, D., Brown, A. R., Mitchell, S. J., Gunn, B. G., Herd, M. B., Phillips, G. D., Seifi, M., Swinny, J. D. & Lambert, J. J., 18 Feb 2018, In : Journal of Neuroendocrinology. 30, 2, p. 11-15 5 p., e12537.

Research output: Contribution to journalReview article

Open Access
File
6 Citations (Scopus)
169 Downloads (Pure)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J. J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. & 1 others, Stroh, A., 4 Sep 2018, In : eLife. 7, p. 1-32 32 p., e38744.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
147 Downloads (Pure)
2016

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons

Brown, A. R., Mitchell, S., Peden, D. R., Herd, M. B., Seifi, M., Swinny, J. D., Belelli, D. & Lambert, J., Apr 2016, In : Neuropharmacology. 103, p. 163-173 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
134 Downloads (Pure)
2017

Behavioural pharmacology of the α5-GABAA receptor antagonist S44819: Enhancement and remediation of cognitive performance in preclinical models

Gacsályi, I., Móricz, K., Gigler, G., Wellmann, J., Nagy, K., Ling, I., Barkóczy, J., Haller, J., Lambert, J. J., Szénási, G., Spedding, M. & Antoni, F. A., Oct 2017, In : Neuropharmacology. 125, p. 30-38 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
156 Downloads (Pure)