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  • Colin Palmer
2019

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 208-214 7 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
380 Downloads (Pure)

Serum kidney injury molecule 1 and β2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes

Colombo, M., Looker, H. C., Farran, B., Hess, S., Groop, L., Palmer, C. N. A., Brosnan, M. J., Dalton, R. N., Wong, M., Turner, C., Ahlqvist, E., Dunger, D., Agakov, F., Durrington, P., Livingstone, S., Betteridge, D. J., McKeigue, P. M. & Colhoun, H. M., 1 Jan 2019, In : Diabetologia. 62, 1, p. 156-168 13 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
146 Downloads (Pure)
2020

PheGWAS: A new dimension to visualize GWAS across multiple phenotypes

George, G., Gan, S., Huang, Y., Appleby, P., Nar, A. S., Venkatesan, R., Mohan, V., Palmer, C. N. A. & Doney, A. S. F., 15 Apr 2020, In : Bioinformatics. 36, 8, p. 2500-2505 6 p.

Research output: Contribution to journalArticle

Open Access
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62 Downloads (Pure)
2013
24 Citations (Scopus)
2012

Genome-wide association and functional follow-up reveals new loci for kidney function

Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Boeger, C. A., Fuchsberger, C., Olden, M., Chen, M-H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A., Liu, C-T. & 31 others, Smith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Johnson, A. D., Gierman, H. J., Feitosa, M., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, A., Toenjes, A., Dehghan, A., Chouraki, V., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimaeki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Colhoun, H., Doney, A., Palmer, C. & WTCCC2, CARDIoGRAM Consortium, CARe Consortium, ICBP Consortium, 2012, In : PLoS Genetics. 8, 3, p. - 15 p., e1002584.

Research output: Contribution to journalArticle

Open Access
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124 Citations (Scopus)
122 Downloads (Pure)
2011

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

Brown, S. J., Asai, Y., Cordell, H. J., Campbell, L. E., Zhao, Y., Liao, H., Northstone, K., Henderson, J., Alizadehfar, R., Ben-Shoshan, M., Morgan, K., Roberts, G., Masthoff, L. J. N., Pasmans, S. G. M. A., van den Akker, P. C., Wijmenga, C., Hourihane, J. OB., Palmer, C. N. A., Lack, G., Clarke, A. & 3 others, Hull, P. R., Irvine, A. D. & McLean, W. H. I., Mar 2011, In : Journal of Allergy and Clinical Immunology. 127, 3, p. 661-667 7 p.

Research output: Contribution to journalArticle

Open Access
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265 Citations (Scopus)
163 Downloads (Pure)
2013

Genetic variants predicting left ventricular hypertrophy in a diabetic population

Parry, H., Donnelly, L., Van Zuydam, N., Doney, A., Elder, D., Morris, A., Struthers, A. D., Palmer, C. & Lang, C., 2013, In : Journal of the American College of Cardiology. 61, 10 Supplement, p. E598 1 p.

Research output: Contribution to journalMeeting abstract

Characterization and validation of an isotope-dilution LC-MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum

Albarbarawi, O., Barton, A., Miller, D., McSharry, C., Chaudhuri, R., Thomson, N. C., Palmer, C. N. A., Devereux, G. & Huang, J. T-J., Aug 2013, In : Bioanalysis. 5, 16, p. 1991-2001 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis

Parry, H. M., Donnelly, L. A., Van Zuydam, N., Doney, A. S. F., Elder, D. H. J., Morris, A. D., Struthers, A. D., Palmer, C. N. A., Lang, C. C. & Wellcome Trust Case Control Consortium 2, 23 Jul 2013, In : Cardiovascular Diabetology. 12, 109.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
2018

Individuals with filaggrin-related eczema and asthma have increased long-term medication and hospital admission costs

Soares, P., Fidler, K., Felton, J., Tavendale, R., Hövels, A., Bremner, S. A., Palmer, C. N. A. & Mukhopadhyay, S., 17 Sep 2018, In : British Journal of Dermatology. 179, 3, p. 717-723 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
150 Downloads (Pure)
2017

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

Wheeler, E., Leong, A., Liu, C-T., Hivert, M-F., Strawbridge, R. J., Podmore, C., Li, M., Yao, J., Sim, X., Hong, J., Chu, A. Y., Zhang, W., Wang, X., Chen, Y., Maruthur, N. M., Porneala, B. C., Sharp, S. J., Jia, Y., Kabagambe, E. K., Chang, L-C. & 31 others, Chen, W-M., Elks, C. E., Evans, D. S., Fan, Q., Giulianini, F., Go, M. J., Hottenga, J. J., Hu, Y., Jackson, A. U., Kanoni, S., Kim, Y. J., Kleber, M. E., Ladenvall, C., Lecoeur, C., Lim, S-H., Lu, Y., Mahajan, A., Marzi, C., Nalls, M. A., Navarro, P., Nolte, I. M., Rose, L. M., Rybin, D. V., Sanna, S., Shi, Y., Stram, D. O., Takeuchi, F., Tan, S. P., van der Most, P. J., Palmer, C. N. A. & EPIC-CVD Consortium, EPIC-InterAct Consortium, Lifelines Cohort Study , 12 Sep 2017, In : PLoS Medicine. 14, 9, 30 p., e1002383.

Research output: Contribution to journalArticle

Open Access
File
103 Citations (Scopus)
178 Downloads (Pure)

Exome-wide association study of plasma lipids in >300,000 individuals

Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X-Y., Mahajan, A., Saleheen, D., Emdin, C., Alam, D. S., Alves, A. C., Amouyel, P., Di Angelantonio, E., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 31 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M. J., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y-D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A. F., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Palmer, C. N. A., Smith, B. H. & Charge Diabetes Working Group, The EPIC-InterAct Consortium, EPIC-CVD Consortium, GOLD Consortium, VA Million Veteran Program, 30 Oct 2017, In : Nature Genetics. 49, 12, p. 1758-1766 9 p.

Research output: Contribution to journalLetter

Open Access
File
157 Citations (Scopus)
140 Downloads (Pure)

Association analyses based on false discovery rate implicate new loci for coronary artery disease

Nelson, C. P., Goel, A., Butterworth, A. S., Kanoni, S., Webb, T. R., Marouli, E., Zeng, L., Ntalla, I., Lai, F. Y., Hopewell, J. C., Giannakopoulou, O., Jiang, T., Hamby, S. E., Di Angelantonio, E., Assimes, T. L., Bottinger, E. P., Chambers, J. C., Clarke, R., Palmer, C. N. A., Cubbon, R. M. & 31 others, Ellinor, P. T., Ermel, R., Evangelou, E., Franks, P. W., Grace, C., Gu, D., Hingorani, A. D., Howson, J. M. M., Ingelsson, E., Kastrati, A., Kessler, T., Kyriakou, T., Lehtimäki, T., Lu, X., Lu, Y., März, W., McPherson, R., Metspalu, A., Pujades-Rodriguez, M., Ruusalepp, A., Schadt, E. E., Schmidt, A. F., Sweeting, M. J., Zalloua, P. A., AlGhalayini, K., Keavney, B. D., Kooner, J. S., Loos, R. J. F., Patel, R. S., Rutter, M. K. & EPIC-CVD Consortium, CARDIoGRAMplusC4D, The UK Biobank CardioMetabolic Consortium CHD working group , Sep 2017, In : Nature Genetics. 49, 9, p. 1385-1391 6 p.

Research output: Contribution to journalLetter

172 Citations (Scopus)
2016

Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children

Rautanen, A., Pirinen, M., Mills, T. C., Rockett, K. A., Strange, A., Ndungu, A. W., Naranbhai, V., Gilchrist, J. J., Bellenguez, C., Freeman, C., Band, G., Bumpstead, S. J., Edkins, S., Giannoulatou, E., Gray, E., Dronov, S., Hunt, S. E., Langford, C., Pearson, R. D., Su, Z. & 31 others, Vukcevic, D., Macharia, A. W., Uyoga, S., Ndila, C., Mturi, N., Njuguna, P., Mohammed, S., Berkley, J. A., Mwangi, I., Mwarumba, S., Kitsao, B. S., Lowe, B. S., Morpeth, S. C., Khandwalla, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Deloukas, P. & Kenyan Bacteraemia Study Group, 2 Jun 2016, In : American Journal of Human Genetics. 98, 6, p. 1092-1100 9 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
221 Downloads (Pure)
2015

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

Persson, J., Strawbridge, R. J., McLeod, O., Gertow, K., Silveira, A., Baldassarre, D., Van Zuydam, N., Shah, S., Fava, C., Gustafsson, S., Veglia, F., Sennblad, B., Larsson, M., Sabater-Lleal, M., Leander, K., Gigante, B., Tabak, A., Kivimaki, M., Kauhanen, J., Rauramaa, R. & 19 others, Smit, A. J., Mannarino, E., Giral, P., Humphries, S. E., Tremoli, E., de Faire, U., Lind, L., Ingelsson, E., Hedblad, B., Melander, O., Kumari, M., Hingorani, A., Morris, A. D., Palmer, C. N. A., Lundman, P., Öhrvik, J., Söderberg, S., Hamsten, A. & IMPROVE Study Group, 14 Aug 2015, In : Journal of the American Heart Association. 4, 8, e001853.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
129 Downloads (Pure)
2019

Association of Chromosome 9p21 with Subsequent Coronary Heart Disease events: A GENIUS-CHD study of individual participant data

CARDIoGRAMplusC4D Consortium, Patel, R. S., Schmidt, A. F., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., Direk, K., Åkerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehlschlegel, J. D., Dubé, M. P., Allayee, H., Almgren, P., Alver, M., Baranova, E. V., Behlouli, H., Boeckx, B. & 31 others, Braund, P. S., Breitling, L. P., Delgado, G., Duarte, N. E., Dufresne, L., Eriksson, N., Foco, L., Gijsberts, C. M., Gong, Y., Hartiala, J., Heydarpour, M., Hubacek, J. A., Kleber, M., Kofink, D., Kuukasjärvi, P., Lee, V. V., Leiherer, A., Lenzini, P. A., Levin, D., Lyytikäinen, L. P., Martinelli, N., Mons, U., Nelson, C. P., Nikus, K., Pilbrow, A. P., Ploski, R., Sun, Y. V., Tanck, M. W. T., Mordi, I. R., Palmer, C. N. & Lang, C. C., Apr 2019, In : Circulation: Genomic and Precision Medicine. 12, 4, p. 161-172 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
10 Downloads (Pure)
2013

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Kilpeläinen, T. O., Esko, T., Mägi, R., Li, S., Workalemahu, T., Feitosa, M. F., Croteau-Chonka, D. C., Day, F. R., Fall, T., Ferreira, T., Gustafsson, S., Locke, A. E., Mathieson, I., Scherag, A. & 32 others, Vedantam, S., Wood, A. R., Liang, L., Steinthorsdottir, V., Thorleifsson, G., Dermitzakis, E. T., Dimas, A. S., Karpe, F., Min, J. L., Nicholson, G., Clegg, D. J., Person, T., Krohn, J. P., Bauer, S., Buechler, C., Eisinger, K., DIAGRAM Consortium, Bonnefond, A., Froguel, P., MAGIC Investigators, Hottenga, J-J., Prokopenko, I., Waite, L. L., Harris, T. B., Smith, A. V., Shuldiner, A. R., McArdle, W. L., Caulfield, M. J., Munroe, P. B., Grönberg, H., Morris, A. D. & Palmer, C. N. A., Jun 2013, In : PLoS Genetics. 9, 6, p. e1003500

Research output: Contribution to journalArticle

204 Citations (Scopus)
2014

Inactivating mutations in NPC1L1 and protection from coronary heart disease

Stitziel, N. O., Won, H-H., Morrison, A. C., Peloso, G. M., Do, R., Lange, L. A., Fontanillas, P., Gupta, N., Duga, S., Goel, A., Farrall, M., Saleheen, D., Ferrario, P., König, I., Asselta, R., Merlini, P. A., Marziliano, N., Notarangelo, M. F., Schick, U., Auer, P. & 57 others, Assimes, T. L., Reilly, M., Wilensky, R., Rader, D. J., Hovingh, G. K., Meitinger, T., Kessler, T., Kastrati, A., Laugwitz, K-L., Siscovick, D., Rotter, J. I., Hazen, S. L., Tracy, R., Cresci, S., Spertus, J., Jackson, R., Schwartz, S. M., Natarajan, P., Crosby, J., Muzny, D., Ballantyne, C., Rich, S. S., O'Donnell, C. J., Abecasis, G., Sunyaev, S., Nickerson, D. A., Buring, J. E., Ridker, P. M., Chasman, D. I., Austin, E., Ye, Z., Kullo, I. J., Weeke, P. E., Shaffer, C. M., Bastarache, L. A., Denny, J. C., Roden, D. M., Palmer, C., Deloukas, P., Lin, D-Y., Tang, Z., Erdmann, J., Schunkert, H., Danesh, J., Marrugat, J., Elosua, R., Ardissino, D., McPherson, R., Watkins, H., Reiner, A. P., Wilson, J. G., Altshuler, D., Gibbs, R. A., Lander, E. S., Boerwinkle, E., Gabriel, S. & Kathiresan, S., 27 Nov 2014, In : New England Journal of Medicine. 371, 22, p. 2072-2082 11 p.

Research output: Contribution to journalArticle

268 Citations (Scopus)
2011

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N. & 31 others, Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Morris, A. D., Sutherland, C., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators, Feb 2011, In : Nature Genetics. 43, 2, p. 117-120 4 p.

Research output: Contribution to journalLetter

302 Citations (Scopus)
2015

PPARα is required for PPARδ action in regulation of body weight and hepatic steatosis in mice

Garbacz, W. G., Huang, J. T. J., Higgins, L. G., Wahli, W. & Palmer, C. N. A., 2015, In : PPAR Research. 2015, 15 p., 927057.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2019

Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes

McKeigue, P. M., Spiliopoulou, A., McGurnaghan, S., Colombo, M., Blackbourn, L., McDonald, T. J., Onengut-Gomuscu, S., Rich, S. S., Palmer, C. N. A., McKnight, J. A., Strachan, M. W. J., Patrick, A. W., Chalmers, J., Lindsay, R. S., Petrie, J. R., Thekkepat, S., Collier, A., MacRury, S. & Colhoun, H. M., 23 Aug 2019, In : BMC Medicine. 17, 1, p. 1-11 11 p., 165.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
70 Downloads (Pure)
2012

Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia

Wellcome Trust Case Control Consortium 2, 15 Oct 2012, In : Biological Psychiatry. 72, 8, p. 620-628 9 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)
2019

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

Hernandez-Pacheco, N., Farzan, N., Francis, B., Karimi, L., Repnik, K., Vijverberg, S. J., Soares, P., Schieck, M., Gorenjak, M., Forno, E., Eng, C., Oh, S. S., Pérez-Méndez, L., Berce, V., Tavendale, R., Samedy, L. A., Hunstman, S., Hu, D., Meade, K., Farber, H. J. & 21 others, Avila, P. C., Serebrisky, D., Thyne, S. M., Brigino-Buenaventura, E., Rodriguez-Cintron, W., Sen, S., Kumar, R., Lenoir, M., Rodriguez-Santana, J. R., Celedón, J. C., Mukhopadhyay, S., Potočnik, U., Pirmohamed, M., Verhamme, K. M., Kabesch, M., Palmer, C. N. A., Hawcutt, D. B., Flores, C., van der Zee, A. H. M., Burchard, E. G. & Pino-Yanes, M., 3 Jun 2019, In : Clinical and Experimental Allergy. 49, 6, p. 789-798 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
79 Downloads (Pure)
2011

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Evans, D. M., Spencer, C. C. A., Pointon, J. J., Su, Z., Harvey, D., Kochan, G., Opperman, U., Dilthey, A., Pirinen, M., Stone, M. A., Appleton, L., Moutsianas, L., Leslie, S., Wordsworth, T., Kenna, T. J., Karaderi, T., Thomas, G. P., Ward, M. M., Weisman, M. H., Farrar, C. & 31 others, Bradbury, L. A., Danoy, P., Inman, R. D., Maksymowych, W., Gladman, D., Rahman, P., Morgan, A., Marzo-Ortega, H., Bowness, P., Gaffney, K., Gaston, J. S. H., Smith, M., Bruges-Armas, J., Couto, A-R., Sorrentino, R., Paladini, F., Ferreira, M. A., Xu, H., Liu, Y., Jiang, L., Lopez-Larrea, C., Diaz-Pena, R., Lopez-Vazquez, A., Zayats, T., Band, G., Bellenguez, C., Blackburn, H., Blackwell, J. M., Bramon, E., Palmer, C. N. A. & Wellcome Trust Case Control Consor, Australo-Anglo-Amer Spondyloarthri, Spondyloarthrit Res Consortium Can, Aug 2011, In : Nature Genetics. 43, 8, p. 761-767 7 p.

Research output: Contribution to journalArticle

521 Citations (Scopus)
2012

Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients

Corvol, H., Beucher, J., Boelle, P-Y., Busson, P-F., Muselet-Charlier, C., Clement, A., Ratjen, F., Grasemann, H., Laki, J., Palmer, C. N. A., Elborn, J. S. & Mehta, A., Jan 2012, In : Journal of Cystic Fibrosis. 11, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A. & 43 others, Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T., Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Campbell, P. T., Evangelou, E., Li, J., Mitchell, P., Morris, A. D., Morris, A. D., Palmer, C. N. A., Roberts, D. J., Scott, R. A., Wood, A. R., Hirschhorn, J. N. & Loos, R. J. F., 3 Jun 2019, In : Nature Genetics. 51, p. 1191-1192 2 p.

Research output: Contribution to journalArticle

2017

Early health technology assessments in pharmacogenomics: a case example in cardiovascular drugs

Geenen, J. W., Baranova, E. V., Asselbergs, F. W., de Boer, A., Vreman, R. A., Palmer, C. N. A., Maitland-van der Zee, A. H., Hövels, A. M. & PREDICTION-ADR Consortium, Aug 2017, In : Pharmacogenomics. 18, 12

Research output: Contribution to journalArticle

6 Citations (Scopus)
2011

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility

Jafar-Mohammadi, B., Groves, C. J., Gjesing, A. P., Herrera, B. M., Winckler, W., Stringham, H. M., Morris, A. P., Lauritzen, T., Doney, A. S. F., Morris, A. D., Weedon, M. N., Swift, A. J., Kuusisto, J., Laakso, M., Altshuler, D., Hattersley, A. T., Collins, F. S., Boehnke, M., Hansen, T., Pedersen, O. & 5 others, Palmer, C. N. A., Frayling, T. M., Gloyn, A. L., McCarthy, M. I. & DIAGRAM Consortium, Jan 2011, In : Diabetologia. 54, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2017

Homozygous status for the Arg16 variant is associated with increased prescribing of controller asthma medication and increased asthma-related prescribing cost

Soares, P., Fidler, K., Tavendale, R., Turner, S., Lipworth, B., Bremner, S., Palmer, C. N. A. & Mukhopadhyay, S., Dec 2017, In : Clinical and Experimental Allergy. 47, 12, p. 1681-1682 2 p., O.010.

Research output: Contribution to journalMeeting abstract

Genetic variation in Kruppel like factor 15 is associated with left ventricular hypertrophy in patients with type 2 diabetes: discovery and replication cohorts

Patel, S. K., Wai, B., Lang, C. C., Levin, D., Palmer, C. N. A., Parry, H. M., Velkoska, E., Harrap, S. B., Srivastava, P. M. & Burrell, L. M., Apr 2017, In : EBioMedicine. 18, p. 171-178 8 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
71 Downloads (Pure)
2020

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

Meng, W., Chan, B. W., Harris, C., Freidin, M. B., Hebert, H., Adams, M. J., Campbell, A., Hayward, C., Zheng, H., Zhang, X., Colvin, L., Hales, T., Palmer, C., Williams, F. M. K., McIntosh, A. M. & Smith, B. H., 15 Apr 2020, In : Human Molecular Genetics. 29, 8, p. 1396-1404 9 p.

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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Regeneron Genetics Center, Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L. & 32 others, Bloom, H. L., Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Dunn, M. E., Engström, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Mordi, I. R., Morris, A. D., Morris, A. P., Palmer, C. N. A., Parry, H. M., Smith, N. L., Veluchamy, A., McMurray, J. J. V., Lang, C. C. & Lumbers, R. T., 9 Jan 2020, In : Nature Communications. 11, 12 p., 163.

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2017

Rare and low-frequency coding variants alter human adult height

CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium, ReproGen Consortium, MAGIC Investigators, Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E. & 41 others, Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T., Karaderi, T., Locke, A. E., Masca, N. G. D., Ng, M. C. Y., Mudgal, P., Rivas, M. A., Vedantam, S., Mahajan, A., Guo, X., Abecasis, G., Aben, K. K., Adair, L. S., Alam, D. S., Albrecht, E., Allin, K. H., Allison, M., Amouyel, P., Appel, E. V., Arveiler, D., Asselbergs, F. W., Auer, P. L., Balkau, B., Banas, B., Bang, L. E., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boeing, H., Morris, A. D., Palmer, C. N. A., Hirschhorn, J. N., Deloukas, P., Lettre, G. & EPIC-InterAct Consortium, 9 Feb 2017, In : Nature. 542, 7640, p. 186-190 5 p.

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Variants in pharmacokinetic transporters and glycemic response to metformin: A metgen meta-analysis

Dujic, T., Zhou, K., Yee, S. W., van Leeuwen, N., de Keyser, C. E., Javorský, M., Goswami, S., Zaharenko, L., Christiansen, M. M. H., Out, M., Tavendale, R., Kubo, M., Hedderson, M. M., van der Heijden, A. A., Klimčáková, L., Pirags, V., Kooy, A., Brøsen, K., Klovins, J., Semiz, S. & 6 others, Tkáč, I., Stricker, B. H., Palmer, C. N. A., 't Hart, L. M., Giacomini, K. M. & Pearson, E. R., Jun 2017, In : Clinical Pharmacology & Therapeutics. 101, 6, p. 763-772 10 p.

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40 Citations (Scopus)
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2020
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2017

Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors

Mahmoudpour, S. H., Veluchamy, A., Siddiqui, M. K., Asselbergs, F. W., Souverein, P. C., de Keyser, C. E., Hofman, A., Lang, C. C., Doney, A. S. F., Stricker, B. H., de Boer, A., Maitland-van der Zee, A-H., Palmer, C. N. A. & PREDICTION-ADR Consortium, Mar 2017, In : Pharmacogenetics and Genomics. 27, 3, p. 112-119 8 p.

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11 Citations (Scopus)
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1 Citation (Scopus)
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2016

Common Creatine Kinase gene mutation results in falsely reassuring CK levels in muscle disorders

Wallace, B., Siddiqui, M., Palmer, C. N. A. & George, J., 1 Jun 2016, In : QJM : an International Journal of Medicine. 109, 6, p. 413-414 3 p.

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3 Citations (Scopus)
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2017

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., Colhoun, H., Morris, A. D., George, J., Doney, A., Pirmohamed, M., Alfirevic, A., Wadelius, M., Maitland-van der Zee, A. H., Ridker, P. M., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, Aug 2017, In : Circulation: Cardiovascular Genetics. 10, 4, e001737 .

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3 Citations (Scopus)
2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 40 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Campbell, P. T., Davies, G., Evangelou, E., Li, J., Mitchell, P., Morris, A. P., Palmer, C. N. A., Roberts, D. J., Smith, A. V., Wood, A. R., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators & Understanding Society Scientific Group, May 2018, In : Nature Genetics. 50, 5, p. 765-766 2 p.

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2019

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing

PREDICTION-ADR Consortium, EUDRAGENE, Floyd, J. S., Bloch, K. M., Brody, J. A., Maroteau, C., Siddiqui, M. K., Gregory, R., Carr, D. F., Molokhia, M., Liu, X., Bis, J. C., Ahmed, A., Liu, X., Hallberg, P., Yue, Q., Magnusson, P. K. E., Brisson, D., Wiggins, K. L., Morrison, A. C. & 23 others, Khoury, E., McKeigue, P., Stricker, B. H., Lapeyre-Mestre, M., Heckbert, S. R., Gallagher, A. M., Chinoy, H., Gibbs, R. A., Bondon-Guitton, E., Tracy, R., Boerwinkle, E., Gaudet, D., Conforti, A., Van Staa, T., Sitlani, C. M., Rice, K. M., Maitland-van der Zee, A., Wadelius, M., Morris, A. P., Pirmohamed, M., Palmer, C. N. A., Psaty, B. M. & Alfirevic, A., 26 Jun 2019, In : PLoS ONE. 14, 6, p. 1-13 13 p., e0218115.

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Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker–Induced Angioedema

Maroteau, C., Siddiqui, M. K., Veluchamy, A., Carr, F., White, M., Cassidy, A. J., Rasmussen, E. R., Baranova, E. V., Eriksson, N., Bloch, K. M., Brown, N. J., Bygum, A., Hallberg, P., Karawajczyk, M., Magnusson, P. K. E., Yue, Q-Y., Syvänen, A-C., von Buchwald, C., Alfirevic, A., Maitland-van der Zee, A. H. & 3 others, Wadelius, M., Palmer, C. N. A. & PREDICTION-ADR Consortium, 4 Jun 2020, In : Clinical Pharmacology and Therapeutics. 8 p.

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2016

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

Postmus, I., Warren, H. R., Trompet, S., Arsenault, B. J., Avery, C. L., Bis, J. C., Chasman, D. I., de Keyser, C. E., Deshmukh, H. A., Evans, D. S., Feng, Q., Li, X., Smit, R. A. J., Smith, A. V., Sun, F., Taylor, K. D., Arnold, A. M., Barnes, M. R., Barratt, B. J., Betteridge, J. & 68 others, Boekholdt, S. M., Boerwinkle, E., Buckley, B. M., Chen, Y-D. I., de Craen, A. J. M., Cummings, S. R., Denny, J. C., Dubé, M. P., Durrington, P. N., Eiriksdottir, G., Ford, I., Guo, X., Harris, T. B., Heckbert, S. R., Hofman, A., Hovingh, G. K., Kastelein, J. J. P., Launer, L. J., Liu, C-T., Liu, Y., Lumley, T., McKeigue, P. M., Munroe, P. B., Neil, A., Nickerson, D. A., Nyberg, F., O'Brien, E., O'Donnell, C. J., Post, W., Poulter, N., Vasan, R. S., Rice, K., Rich, S. S., Rivadeneira, F., Sattar, N., Sever, P., Shaw-Hawkins, S., Shields, D. C., Slagboom, P. E., Smith, N. L., Smith, J. D., Sotoodehnia, N., Stanton, A., Stott, D. J., Stricker, B. H., Stürmer, T., Uitterlinden, A. G., Wei, W-Q., Westendorp, R. G. J., Whitsel, E. A., Wiggins, K. L., Wilke, R. A., Ballantyne, C. M., Colhoun, H. M., Cupples, L. A., Franco, O. H., Gudnason, V., Hitman, G., Palmer, C. N. A., Psaty, B. M., Ridker, P. M., Stafford, J. M., Stein, C. M., Tardif, J-C., Caulfield, M. J., Jukema, J. W., Rotter, J. I. & Krauss, R. M., Dec 2016, In : Journal of Medical Genetics. 53, 12, p. 835-845 11 p.

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19 Citations (Scopus)
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Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment

Turner, S., Francis, B., Vijverberg, S., Pino-Yanes, M., Maitland-van der Zee, A. H., Basu, K., Bignell, L., Mukhopadhyay, S., Tavendale, R., Palmer, C., Hawcutt, D., Pirmohamed, M., Burchard, E. G. & Lipworth, B., Jul 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 107-113 7 p.

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38 Citations (Scopus)
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Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease

Yaghootkar, H., Lotta, L. A., Tyrrell, J., Smit, R. A. J., Jones, S. E., Donnelly, L., Beaumont, R., Campbell, A., Tuke, M. A., Hayward, C., Ruth, K. S., Padmanabhan, S., Jukema, J. W., Palmer, C. C., Hattersley, A., Freathy, R. M., Langenberg, C., Wareham, N. J., Wood, A. R., Murray, A. & 5 others, Weedon, M. N., Sattar, N., Pearson, E., Scott, R. A. & Frayling, T. M., Aug 2016, In : Diabetes. 65, 8, p. 2448-2460 13 p.

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44 Citations (Scopus)
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2019

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S., Boehnke, M. & 32 others, Bots, M. L., Brazel, D. M., Chambers, J. C., Chang-Claude, J., Chen, C., Corley, J., Chou, Y. L., David, S. P., de Boer, R. A., de Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Smith, J. A., Zhou, K., Palmer, C. N. A., Liu, D. J. & Howson, J. M. M., 7 Jan 2019, In : Molecular Psychiatry. p. 1-18 18 p.

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2018

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 380 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M. P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A. E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H. J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J. H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K. H., Lin, L. A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C. T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, JA., Lubitz, S. A., Lyytikäinen, L. P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. P., Morris, A. D., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J. C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., Van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 2018, In : Nature Genetics. 50, 1, p. 26-41 16 p.

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2020

Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: a data-driven cluster analysis: the INSPIRED study

Anjana, R. M., Baskar, V., Nair, A. T. N., Jebarani, S., Siddiqui, M. K., Pradeepa, R., Unnikrishnan, R., Palmer, C., Pearson, E. & Mohan, V., 17 Aug 2020, In : BMJ Open Diabetes Research and Care. 8, 1, 8 p., e001506.

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