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  • Roland Wolf
2018

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5 /P450 reductase null (HBRN) mice

Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., Apr 2018, In : Archives of Toxicology. 92, 4, p. 1625-1638 14 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
146 Downloads (Pure)
2011

Enzyme and protein engineering: engineering a self-sufficient human cytochrome P450 monooxygenase system

Deeni, Y. & Wolf, R., Sep 2011, In : Current Opinion in Biotechnology. 22, p. S18-S18 1 p.

Research output: Contribution to journalBook/Film/Article review

Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R., 1 Jan 2012, In : Molecular Neurobiology. p. 1-12 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2017

Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver

Pouché, L., Vitobello, A., Römer, M., Glogovac, M., MacLeod, A. K., Ellinger-Ziegelbauer, H., Westphal, M., Dubost, V., Stiehl, D. P., Dumotier, B., Fekete, A., Moulin, P., Zell, A., Schwarz, M., Moreno, R., Huang, J. T. J., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moggs, J. G. & 1 others, Terranova, R., Aug 2017, In : Toxicological Sciences. 158, 2, p. 367-378 11 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
168 Downloads (Pure)
2013

The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells

Plitzko, B., Ott, G., Reichmann, D., Henderson, C. J., Wolf, C. R., Mendel, R., Bittner, F., Clement, B. & Havemeyer, A., 2013, In : Journal of Biological Chemistry. 288, 28, p. 20228-20237 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2016

Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs

Wolf, C. R., Kapelyukh, Y., Scheer, N. & Henderson, C. J., 20 Nov 2016, New Horizons in Predictive drug Metabolism and Pharmocokentics. 49 ed. Royal Society of Chemistry, Vol. 2016-January. p. 152-176 25 p. (RSC Drug Discovery Series; vol. 2016-January, no. 49).

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Model systems for understanding mechanisms of non-genotoxic carcinogenesis: response

Braeuning, A., Henderson, C. J., Wolf, C. R. & Schwarz, M., Oct 2015, In : Toxicological Sciences. 147, 2, p. 299-300 2 p.

Research output: Contribution to journalLetter

5 Citations (Scopus)
2017
Open Access
File
13 Citations (Scopus)
118 Downloads (Pure)
2011

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H., Dec 2011, In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2012

Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

Scheer, N., Balimane, P., Hayward, M. D., Buechel, S., Kauselmann, G. & Wolf, C. R., 2012, In : Drug Metabolism and Disposition. 40, 11, p. 2212-2218 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J., 2012, In : Molecular Neurobiology. 46, 2, p. 475-486 12 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2017

Genetically Humanized Animal Models

Samuelsson, K., Scheer, N., Wilson, I., Wolf, C. & Henderson, C. J., 13 Jun 2017, Comprehensive Medicinal Chemistry III. Chackalamannil, S., Rotella, D. P. & Ward, S. E. (eds.). Elsevier, p. 130-149 20 p. (Reference Module in Chemistry, Molecular Sciences and Chemical Engineering).

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane X receptors

Luisier, R., Lempiäinen, H., Scherbichler, N., Braeuning, A., Geissler, M., Dubost, V., Müller, A., Scheer, N., Chibout, S-D., Hara, H., Picard, F., Theil, D., Couttet, P., Vitobello, A., Grenet, O., Grasl-Kraupp, B., Ellinger-Ziegelbauer, H., Thomson, J. P., Meehan, R. R., Elcombe, C. R. & 6 others, Henderson, C. J., Wolf, C. R., Schwarz, M., Moulin, P., Terranova, R. & Moggs, J. G., 2014, In : Toxicological Sciences. 139, 2, p. 501-511 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2017

Feedback control of AHR signalling regulates intestinal immunity

Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W. & Stockinger, B., 9 Feb 2017, In : Nature. 542, 7640, p. 242-245 4 p.

Research output: Contribution to journalLetter

Open Access
File
122 Citations (Scopus)
198 Downloads (Pure)
2014

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

Sawers, L., Ferguson, M. J., Ihrig, B. R., Young, H. C., Chakravarty, P., Wolf, C. R. & Smith, G., 9 Sep 2014, In : British Journal of Cancer. 111, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
186 Downloads (Pure)
2019

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
122 Downloads (Pure)
2016

The role of protein-protein and protein-membrane Interactions on P450 function

Scott, E. E., Wolf, C. R., Otyepka, M., Humphreys, S. C., Reed, J. R., Henderson, C. J., McLaughlin, L. A., Paloncyova, M., Navratilova, V., Berka, K., Anzenbacher, P., Dahal, U. P., Barnaba, C., Brozik, J. A., Jones, J. P., Estrada, F., Laurence, J. S., Park, J. W. & Backes, W. L., Apr 2016, In : Drug Metabolism and Disposition. 44, 4, p. 576-590 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2011

Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R., Jun 2011, In : Transgenic Research. 20, 3, p. 491-502 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

McGarry, D. J., Wolf, C. R. & Henderson, C. J., 18 Dec 2011, In : Toxicology. 290, 2-3, p. 130-130 1 p.

Research output: Contribution to journalBook/Film/Article review

Role of CAR and PXR in xenobiotic toxicity

Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C., 28 Aug 2011, In : Toxicology Letters. 205, p. S13 1 p.

Research output: Contribution to journalBook/Film/Article review

1 Citation (Scopus)
2016

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

Takahashi, S., Fukami, T., Masuo, Y., Brocker, C. N., Xie, C., Krausz, K. W., Wolf, C. R., Henderson, C. J. & Gonzalez, F. J., Dec 2016, In : Journal of Lipid Research. 57, p. 2130-2037 8 p.

Research output: Contribution to journalArticle

Open Access
File
67 Citations (Scopus)
198 Downloads (Pure)
2012

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Simultaneous Non-Negative Matrix Factorization for Multiple Large Scale Gene Expression Datasets in Toxicology

Lee, C. M., Mudaliar, M. A. V., Haggart, D. R., Wolf, C. R., Miele, G., Vass, J. K., Higham, D. J. & Crowther, D., 14 Dec 2012, In : PLoS ONE. 7, 12, p. 1-21 21 p., e48238.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
94 Downloads (Pure)
2013

Generation and utility of genetically humanized mouse models

Scheer, N., Snaith, M., Wolf, C. R. & Seibler, J., Dec 2013, In : Drug Discovery Today. 18, 23-24, p. 1200-1211 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2017
Open Access
File
5 Citations (Scopus)
126 Downloads (Pure)
2014

Epigenetic profiles as defined signatures of xenobiotic exposure

Thomson, J. P., Moggs, J. G., Wolf, C. R. & Meehan, R. R., Apr 2014, In : Mutation Research: Genetic Toxicology and Environmental Mutagenesis. 764-765, p. 3-9 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2013
38 Citations (Scopus)
2018

Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In : Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
148 Downloads (Pure)
2011

Decision-making in the pharmaceutical industry: Analysis of entrepreneurial risk and attitude using uncertain information

Cowlrick, I., Hedner, T., Wolf, R., Olausson, M. & Klofsten, M., 14 Sep 2011, In : R and D Management. 41, 4, p. 321-336 16 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2019

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
82 Downloads (Pure)
2015

Recurrent Coding Sequence Variation Explains only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Timofeeva, M. N., Kinnersley, B., Farrington, S. M., Whiffin, N., Palles, C., Svinti, V., Lloyd, A., Gorman, M., Ooi, L. Y., Hosking, F., Barclay, E., Zgaga, L., Dobbins, S., Martin, L., Theodoratou, E., Broderick, P., Tenesa, A., Smillie, C., Grimes, G., Hayward, C. & 41 others, Campbell, A., Porteous, D., Deary, I. J., Harris, S. E., Northwood, E. L., Barrett, J. H., Smith, G., Wolf, R., Forman, D., Morreau, H., Ruano, D., Tops, C., Wijnen, J., Schrumpf, M., Boot, A., Vasen, H. F. A., Hes, F. J., Van Wezel, T., Franke, A., Lieb, W., Schafmayer, C., Hampe, J., Buch, S., Propping, P., Hemminki, K., Försti, A., Westers, H., Hofstra, R., Pinheiro, M., Pinto, C., Teixeira, M., Ruiz-Ponte, C., Fernández-Rozadilla, C., Carracedo, A., Castells, A., Castellví-Bel, S., Campbell, H., Bishop, D. T., Tomlinson, I. P. M., Dunlop, M. G. & Houlston, R. S., 10 Nov 2015, In : Scientific Reports. 5, 10 p., 16286.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
150 Downloads (Pure)
2017

Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In : British Journal of Cancer. 117, 1 p., e1.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2011

Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R., 15 Nov 2011, In : Cancer Research. 71, 22, p. 7048-7060 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

Stiborová, M., Moserová, M., Černá, V., Indra, R., Dračínský, M., Šulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M., 6 Apr 2014, In : Toxicology. 318, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

Macleod, A. K., Zang, T., Riches, Z., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., 7 Feb 2014, In : Journal of Proteome Research. 13, 2, p. 866-874 9 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
95 Downloads (Pure)

A role for cytochrome b5 in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice

Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y. & Wolf, C. R., Jan 2014, In : Drug Metabolism and Disposition. 42, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2015

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo

Henderson, C. J., McLaughlin, L. A., Scheer, N., Stanley, L. A. & Wolf, C. R., Apr 2015, In : Molecular Pharmacology. 87, 4, p. 733-739 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2011

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

Hasegawa, M., Kapelyukh, Y., Tahara, H., Seibler, J., Rode, A., Krueger, S., Lee, D. N., Wolf, C. R. & Scheer, N., Sep 2011, In : Molecular Pharmacology. 80, 3, p. 518-528 11 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2013

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

Riddick, D. S., Ding, X., Wolf, C. R., Porter, T. D., Pandey, A. V., Zhang, Q-Y., Gu, J., Finn, R. D., Ronseaux, S., McLaughlin, L. A., Henderson, C. J., Zou, L. & Flück, C. E., Jan 2013, In : Drug Metabolism and Disposition. 41, 1, p. 12-23 12 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
2014

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

Braeuning, A., Gavrilov, A., Brown, S., Wolf, C. R., Henderson, C. J. & Schwarz, M., 1 Aug 2014, In : Toxicological Sciences. 140, 2, p. 259-70 12 p.

Research output: Contribution to journalArticle

Open Access
File
41 Citations (Scopus)
160 Downloads (Pure)
2012

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

Smith, G., Ng, M. T. H., Shepherd, L., Herrington, C. S., Gourley, C., Ferguson, M. & Wolf, C. R., 9 Oct 2012, In : British Journal of Cancer. 107, 8, p. 1327-1336 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2013

Xenobiotic receptor humanized mice and their utility

Scheer, N. & Roland Wolf, C., 1 Feb 2013, In : Drug Metabolism Reviews. 45, 1, p. 110-121 12 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)
2011

The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z., Aug 2011, In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2012

Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

Scheer, N., Kapelyukh, Y., McEwan, J., Beuger, V., Stanley, L. A., Rode, A. & Wolf, C. R., Jan 2012, In : Molecular Pharmacology. 81, 1, p. 63-72 10 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2013

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet (PUVA) sensitivity

Deeni, Y. Y., Ibbotson, S. H., Woods, J. A., Wolf, C. R. & Smith, G., 2013, In : PLoS ONE. 8, 9, e75494.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice

Carvalho, A. N., Marques, C., Rodrigues, E., Henderson, C. J., Wolf, C. R., Pereira, P. & Gama, M. J., Apr 2013, In : Molecular Neurobiology. 47, 2, p. 662-72 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2012

Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H., 2012, In : Toxicology Letters. 213, 2, p. 160-166 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2016

Loss of Tet1-associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer

Thomson, J. P., Ottaviano, R., Unterberger, E. B., Lempiäinen, H., Muller, A., Terranova, R., Illingworth, R. S., Webb, S., Kerr, A. R. W., Lyall, M. J., Drake, A. J., Wolf, C. R., Moggs, J. G., Schwarz, M. & Meehan, R. R., 15 May 2016, In : Cancer Research. 76, 10, p. 3097-3108 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2015

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and-independent mechanisms

Amankwatia, E. B., Chakravarty, P., Carey, F. A., Weidlich, S., Steele, R. J. C., Munro, A. J., Wolf, C. R. & Smith, G., 28 Apr 2015, In : British Journal of Cancer. 112, 9, p. 1480-1490 11 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)