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  • Ewan Pearson
2018

Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers-validation of technique and implications for clinical studies

Marzetti, M., Brunton, T., McCreight, L., Pearson, E., Docherty, S. & Gandy, S. J., 17 May 2018, In : British Journal of Radiology. 91, 1087, 7 p., 20180025.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
187 Downloads (Pure)
2019

Motivations for data sharing-views of research participants from four European countries: A DIRECT study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 30 Jan 2019, In : European Journal of Human Genetics. 27, 5, p. 721-729 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
105 Downloads (Pure)
2011

More OCT1 variants in the Asian population

Zhou, K. & Pearson, E. R., May 2011, In : Pharmacogenomics Journal. 12, 5, p. 709-709 1 p.

Research output: Contribution to journalEditorial

2016

Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery

Zhou, K., Pedersen, H. K., Dawed, A. Y. & Pearson, E. R., Jun 2016, In : Nature Reviews Endocrinology. 12, 6, p. 337-346 10 p.

Research output: Contribution to journalReview article

Open Access
File
33 Citations (Scopus)
231 Downloads (Pure)
2019

Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals

McCreight, L., Mari, A., Coppin, L., Jackson, N., Umpleby, A. M. & Pearson, E., 22 Nov 2019, In : Diabetologia. 4 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
80 Downloads (Pure)
2018

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Neonatal Diabetes International Collaborative Group, Bowman, P., Sulen, Å., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M., Iafusco, D. & 2 others, Hattersley, A. T. & Njølstad, P. R., 1 Aug 2018, In : The Lancet Diabetes and Endocrinology. 6, 8, p. 637-646 10 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
196 Downloads (Pure)

The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project

Teare, H. J. A., de Masi, F., Banasik, K., Barnett, A., Herrgard, S., Jablonka, B., Postma, J. W. M., McDonald, T. J., Forgie, I., Chmura, P. J., Rydzka, E. K., Gupta, R., Brunak, S., Pearson, E. & Kaye, J., 4 Sep 2018, In : Life Sciences, Society and Policy. 14, 1, p. 1-17 17 p., 20.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
133 Downloads (Pure)
2011

Identifying a new role for OCT1 in pharmacogenetics

Zhou, K. & Pearson, E. R., May 2011, In : Pharmacogenomics Journal. 12, 5, p. 711-711 1 p.

Research output: Contribution to journalEditorial

2013

Measuring endogenous insulin secretion in type 1 diabetes is life changing

Connelly, P. J., Gellatly, E., Bell, L., Shepherd, M., Hattersley, A. T. & Pearson, E., Mar 2013, In : Diabetic Medicine. 30, Suppl. 1, p. 94-95 2 p., P215.

Research output: Contribution to journalMeeting abstract

Time to reconsider? Reassessment of diagnosis in long duration Type 1 diabetes with urinary C-peptide creatinine ratio and antibodies identifies people with alternate diagnoses

Sanders, T., Oram, R. A., Shepherd, M., Pearson, E., MacDonald, T. J., Ellard, S., Shields, B. M., Hattersley, A. T. & UNITED Res Team, 2013, In : Diabetic Medicine. 30, Supplement 1, p. 26-26 1 p., A72 (P110).

Research output: Contribution to journalMeeting abstract

23 Citations (Scopus)
2020

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W., 19 Jun 2020, In : Diabetologia. 23 p.

Research output: Contribution to journalArticle

2018

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

McCreight, L., Stage, T. B., Connelly, P., Lonergan, M., Nielsen, F., Prehn, C., Adamski, J., Brosen, K. & Pearson, E. R., 1 Jul 2018, In : Diabetes, Obesity & Metabolism. 20, 7, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
185 Downloads (Pure)
2013

The first prospective study of treatment change in transcription factor maturity onset diabetes of the young (MODY): impact on glycaemic control and quality of life

Shepherd, M., Shields, B. M., Pearson, E., Oram, R., Ellard, S., Hattersley, A. T. & UNITED Res Team, 2013, In : Diabetic Medicine. 30, Supplement 1, p. 25 1 p., A69 (P434).

Research output: Contribution to journalMeeting abstract

2019

Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: a retrospective analysis of primary care data, 2010-2017

Dennis, J. M., Henley, W. E., McGovern, A. P., Farmer, A. J., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Shields, B. M., Jones, A. G. & MASTERMIND consortium, Jul 2019, In : Diabetes, Obesity & Metabolism. 21, 7, p. 1576-1584 9 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
106 Downloads (Pure)
2017

A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Wood, A. R., Jonsson, A., Jackson, A. U., Wang, N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., Stančáková, A., Boomsma, D. I., de Geus, E. J. C., Eekhoff, E. M. W., Fritsche, A., Kramer, M. H. H., Nijpels, G., Simonis-Bik, A. M. C., van Haeften, T. W., Mahajan, A. & 31 others, Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, K., Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, N., Eiberg, H., Pedersen, O., Chen, Y-D., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, T., Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M., 21 Jul 2017, In : Diabetes. 66, 8, p. 2296-2309 14 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
204 Downloads (Pure)
2013

An interesting case of new-onset ketosis-prone diabetes in a Scottish teaching hospital

Gardiner, A., George, P. S., Pearson, E. & McCrimmon, R. J., 1 Oct 2013, In : British Journal of Diabetes and Vascular Disease. 13, 5-6, p. 265-268 4 p.

Research output: Contribution to journalArticle

2016
Open Access
File
32 Citations (Scopus)
265 Downloads (Pure)
2012
223 Citations (Scopus)
2018

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

Shepherd, M. H., Shields, B. M., Hudson, M., Pearson, E. R., Hyde, C., Ellard, S., Hattersley, A. T. & Patel, K. A., Dec 2018, In : Diabetologia. 61, 12, p. 2520-2527 8 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
92 Downloads (Pure)
2019

Sharing data for future research-engaging participants' views about data governance beyond the original project: a DIRECT Study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., May 2019, In : Genetics in Medicine. 21, p. 1131-1138 8 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
384 Downloads (Pure)
2018

Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes

Noyes, J. D., Soto-Pedre, E., Donnelly, L. A. & Pearson, E., 14 Jan 2018, In : Diabetic Medicine. 35, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
147 Downloads (Pure)
2020

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E. & 43 others, Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M-G., Elders, P. J. M., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R. S., Sharma, S., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., 't Hart, L. M., Adamski, J., Musholt, P. B., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A. T., Walker, M., Beulens, J. W. J., Mari, A., Schwenk, J. M., Gupta, R., McCarthy, M. I., Pearson, E. R., Bell, J. D., Pavo, I. & Franks, P. W., 19 Jun 2020, In : PLoS Medicine. 17, 6, p. 1-27 27 p., e1003149.

Research output: Contribution to journalArticle

Open Access
File
8 Downloads (Pure)
2019

The effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study

Scottish Diabetes Research Network Epidemiology Group, McGurnaghan, S. J., Brierley, L., Caparrotta, T. M., McKeigue, P. M., Blackbourn, L. A. K., Wild, S. H., Leese, G., McCrimmon, R., McKnight, J. A., Pearson, E., Petrie, J. R., Sattar, N. & Colhoun, H. M., Apr 2019, In : Diabetologia. 62, 4, p. 621-632 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
120 Downloads (Pure)
2016

Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes

Dujic, T., Causevic, A., Bego, T., Malenica, M., Velija-Asimi, Z., Pearson, E. R. & Semiz, S., Apr 2016, In : Diabetic Medicine. 33, 4, p. 511-514 4 p., 13040.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
140 Downloads (Pure)
2019

Type 2 diabetes: a multifaceted disease

Pearson, E., Jul 2019, In : Diabetologia. 62, 7, p. 1107-1112 6 p.

Research output: Contribution to journalReview article

Open Access
File
12 Citations (Scopus)
240 Downloads (Pure)
2012

Treating type 2 diabetes in youth: a depressing picture

Pearson, E. R., 2012, In : Journal of the Royal College of Physicians of Edinburgh. 42, 3, p. 228 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Common variants at 6q22 and 17q21 are associated with intracranial volume

Ikram, M. A., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, W. T., Niessen, W. J., DeStefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., Rivadeneira, F. & 109 others, Uitterlinden, A. G., Knopman, D. S., Hartikainen, A-L., Pennell, C. E., Thiering, E., Steegers, E. A. P., Hakonarson, H., Heinrich, J., Palmer, L. J., Jarvelin, M-R., McCarthy, M. I., Grant, S. F. A., St Pourcain, B., Timpson, N. J., Smith, G. D., Sovio, U., Nalls, M. A., Au, R., Hofman, A., Gudnason, H., van der Lugt, A., Harris, T. B., Meeks, W. M., Vernooij, M. W., van Buchem, M. A., Catellier, D., Jaddoe, V. W. V., Gudnason, V., Windham, B. G., Wolf, P. A., van Duijn, C. M., Mosley, T. H., Schmidt, H., Launer, L. J., Breteler, M. M. B., DeCarli, C., Adair, L. S., Ang, W., Atalay, M., vanBeijsterveldt, T., Bergen, N., Benke, K., Berry, D., Coin, L., Davis, O. S. P., Elliott, P., Flexeder, C., Frayling, T., Gaillard, R., Groen-Blokhuis, M., Goh, L-K., Haworth, C. M. A., Hadley, D., Hedebrand, J., Hinney, A., Hirschhorn, J. N., Holloway, J. W., Holst, C., Hottenga, J. J., Horikoshi, M., Huikari, V., Hypponen, E., Kilpelainen, T. O., Kirin, M., Kowgier, M., Lakka, H-M., Lange, L. A., Lawlor, D. A., Lehtimaki, T., Lewin, A., Lindgren, C., Lindi, V., Maggi, R., Marsh, J., Middeldorp, C., Millwood, I., Murray, J. C., Nivard, M., Nohr, E. A., Ntalla, I., Oken, E., Panoutsopoulou, K., Pararajasingham, J., Rodriguez, A., Salem, R. M., Sebert, S., Siitonen, N., Strachan, D. P., Teo, Y-Y., Valcarcel, B., Willemsen, G., Zeggini, E., Boomsma, D. I., Cooper, C., Gillman, M., Hocher, B., Lakka, T. A., Mohlke, K. L., Dedoussis, G. V., Ong, K. K., Pearson, E. R., Price, T. S., Power, C., Raitakari, O. T., Saw, S-M., Scherag, A., Simell, O., Sorensen, T. I. A. & Wilson, J. F., May 2012, In : Nature Genetics. 44, 5, p. 539-544 7 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2019

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

MASTERMIND consortium, McGovern, A. P., Dennis, J. M., Shields, B. M., Hattersley, A. T., Pearson, E. R. & Jones, A. G., 12 Apr 2019, In : BMC Medicine. 17, 1, p. 1-17 17 p., 79.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
117 Downloads (Pure)
2011

Casting the net wider: a comprehensive candidate gene study

Zhou, K. & Pearson, E. R., May 2011, In : Pharmacogenomics Journal. 12, 5, p. 710-711 2 p.

Research output: Contribution to journalEditorial

2018

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J-L., Demine, S., Schiavo, A. A., Pachera, N., Deglasse, J-P., Jonas, J-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M., 2 Nov 2018, In : Nucleic Acids Research. 46, 19, p. 10302-10318 17 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
105 Downloads (Pure)
2013

Molecular mechanism of action of metformin: old or new insights?

Rena, G., Pearson, E. R. & Sakamoto, K., Sep 2013, In : Diabetologia. 56, 9, p. 1898-1906 9 p.

Research output: Contribution to journalArticle

268 Citations (Scopus)
2018

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: A joint modelling approach

MASTERMIND consortium, Dennis, J. M., Shields, B. M., Jones, A. G., Pearson, E., Hattersley, A. T. & Henley, W. E., 14 Dec 2018, In : Clinical Epidemiology. 10, p. 1869-1877 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
76 Downloads (Pure)
2020

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W., Jul 2020, In : Diabetes Care. 43, 7, p. 1617-1635 19 p.

Research output: Contribution to journalArticle

Open Access
File
7 Downloads (Pure)
2019

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

Lynam, A., McDonald, T., Hill, A., Dennis, J., Oram, R., Pearson, E., Weedon, M., Hattersley, A., Owen, K., Shields, B. & Jones, A., 26 Sep 2019, In : BMJ Open. 9, 9, p. 1-10 10 p., e031586.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
70 Downloads (Pure)
2016

Systematic population screening, using biomarkers and genetic testing, identifies 2.5% of the U.K. pediatric diabetes population with monogenic diabetes

Shepherd, M., Shields, B., Hammersley, S., Hudson, M., McDonald, T. J., Colclough, K., Oram, R. A., Knight, B., Hyde, C., Cox, J., Mallam, K., Moudiotis, C., Smith, R., Fraser, B., Robertson, S., Greene, S., Ellard, S., Pearson, E. R., Hattersley, A. T. & on behalf of the UNITED Team, Nov 2016, In : Diabetes Care. 39, 11, p. 1879-1888 10 p.

Research output: Contribution to journalArticle

Open Access
File
60 Citations (Scopus)
404 Downloads (Pure)
2012

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts

van Leeuwen, N., Nijpels, G., Becker, M. L., Deshmukh, H., Zhou, K., Stricker, B. H. C., Uitterlinden, A. G., Hofman, A., van 't Riet, E., Palmer, C. N. A., Guigas, B., Slagboom, P. E., Durrington, P., Calle, R. A., Neil, A., Hitman, G., Livingstone, S. J., Colhoun, H., Holman, R. R., McCarthy, M. I. & 3 others, Dekker, J. M., 't Hart, L. M. & Pearson, E., 2012, In : Diabetologia. 55, 7, p. 1971-1977 7 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
2017
Open Access
File
1 Citation (Scopus)
152 Downloads (Pure)
2013

Clinical predictors of rate of progression of type 2 diabetes: an extreme case-control study

Donnelly, L. A., Zhou, K., Palmer, C. N. A., Doney, A. S. F., Morris, A. D. & Pearson, E. R., Mar 2013, In : Diabetic Medicine. 30, Suppl. 1, p. 94-94 1 p., P213.

Research output: Contribution to journalMeeting abstract

2014

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

Zhou, K., Donnelly, L., Yang, J., Li, M., Deshmukh, H., Van Zuydam, N., Ahlqvist, E., Spencer, C. C., Groop, L., Morris, A. D., Colhoun, H. M., Sham, P. C., McCarthy, M. I., Palmer, C. N. A. & Pearson, E. R., Jun 2014, In : The Lancet: Diabetes and Endocrinology. 2, 6, p. 481-487 7 p.

Research output: Contribution to journalArticle

Open Access
File
62 Citations (Scopus)
146 Downloads (Pure)
2012

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

Palmer, C. N. A., Maglio, C., Pirazzi, C., Burza, M. A., Adiels, M., Burch, L., Donnelly, L. A., Colhoun, H., Doney, A. S., Dillon, J. F., Pearson, E. R., McCarthy, M., Hattersley, A. T., Frayling, T., Morris, A. D., Peltonen, M., Svensson, P-A., Jacobson, P., Borén, J., Sjöström, L. & 2 others, Carlsson, L. M. S. & Romeo, S., 2012, In : PLoS ONE. 7, 6, e39362.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2015

Association of organic cation transporter 1 with intolerance to metformin in Type 2 diabetes: a GoDARTS study

Dujic, T., Zhou, K., Donnelly, L. A., Tavendale, R., Palmer, C. N. A. & Pearson, E. R., May 2015, In : Diabetes. 64, 5, p. 1786-1793 8 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)
2013

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

't Hart, L. M., Fritsche, A., Nijpels, G., van Leeuwen, N., Donnelly, L. A., Dekker, J. M., Alssema, M., Fadista, J., Carlotti, F., Gjesing, A. P., Palmer, C. N. A., van Haeften, T. W., Herzberg-Schäfer, S. A., Simonis-Bik, A. M. C., Houwing-Duistermaat, J. J., Helmer, Q., Deelen, J., Guigas, B., Hansen, T., Machicao, F. & 14 others, Willemsen, G., Heine, R. J., Kramer, M. H. H., Holst, J. J., de Koning, E. J. P., Häring, H-U., Pedersen, O., Groop, L., de Geus, E. J. C., Slagboom, P. E., Boomsma, D. I., Eekhoff, E. M. W., Pearson, E. R. & Diamant, M., 2013, In : Diabetes.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Metformin pharmacogenetics and SLC2A2: genome-wide association study and 2-stage replication in GoDARTS and UKPDS

Zhou, K., Bennett, A., Coleman, R., Groves, R., Holman, R., McCarthy, M., Palmer, C. & Pearson, E., Mar 2013, In : Diabetic Medicine. 30, Suppl. 1, p. 52-52 1 p., P79.

Research output: Contribution to journalMeeting abstract

9 Citations (Scopus)
2011

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N. & 31 others, Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Morris, A. D., Sutherland, C., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators, Feb 2011, In : Nature Genetics. 43, 2, p. 117-120 4 p.

Research output: Contribution to journalLetter

299 Citations (Scopus)
2020

The impact of phenotype, ethnicity and genotype on progression of Type 2 diabetes mellitus

Thakarakkattil Narayanan Nair, A., Donnelly, L. A., Dawed, A. Y., Gan, S., Anjana, R. M., Mohan, V., Palmer, C. & Pearson, E., 20 Apr 2020, In : Endocrinology, Diabetes & Metabolism. 3, 2, p. 1-11 11 p., e00108.

Research output: Contribution to journalReview article

Open Access
File
46 Downloads (Pure)

Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes

Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. & Li, S., 3 Jan 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.

Research output: Contribution to journalArticle

Open Access
File
40 Downloads (Pure)
2016

Pharmacogenetics of sulfonylureas

Kovacs, P. & Pearson, E., 12 Apr 2016, The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Florez, J. C. (ed.). Springer International Publishing, p. 483-497 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance

Connelly, P. J., Smith, N., Chadwick, R., Exley, A. R., Shneerson, J. M. & Pearson, E. R., Mar 2016, In : Diabetic Medicine. 33, 3, p. 371-375 5 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
149 Downloads (Pure)
2017

The mechanisms of action of metformin

Rena, G., Hardie, D. G. & Pearson, E. R., Sep 2017, In : Diabetologia. 60, 9, p. 1577-1585 9 p.

Research output: Contribution to journalReview article

Open Access
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345 Citations (Scopus)
313 Downloads (Pure)
2013

Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

Franks, P. W., Pearson, E. & Florez, J. C., May 2013, In : Diabetes Care. 36, 5, p. 1413-1421 9 p.

Research output: Contribution to journalReview article

79 Citations (Scopus)