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Author

  • Alan Prescott
2015

High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M., Sep 2015, In : Proteomics. 15, 18, p. 3169-3174 6 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
127 Downloads (Pure)
2014
Open Access
38 Citations (Scopus)

A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C., 1 Oct 2014, In : Journal of Cell Science. 127, 19, p. 4213-4224 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2012

Evolution of the vertebrate beaded filament protein, Bfsp2: comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue

Qu, B., Landsbury, A., Schoenthaler, H. B., Dahm, R., Liu, Y., Clark, J. I., Prescott, A. R. & Quinlan, R. A., Jan 2012, In : Experimental Eye Research. 94, 1, p. 192-202 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions

Pechenick Jowers, T., Featherstone, R. J., Reynolds, D. K., Brown, H. K., James, J., Prescott, A., Haga, I. R. & Beard, P. M., 15 Jan 2015, In : Virology. 475, p. 66-73 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

Ozanne, J., Prescott, A. R. & Clark, K., 15 Jan 2015, In : Biochemical Journal. 465, 2, p. 271-279 9 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)
2011

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

MacPherson, M., Lek, H. S., Prescott, A. & Fagerholm, S. C., 13 May 2011, In : Journal of Biological Chemistry. 286, 19, p. 17303-17310 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2019

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 1 Sep 2019, In : EMBO Reports. 20, 9, p. 1-19 19 p., e47495.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
93 Downloads (Pure)
2018

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P. & Ganley, I. G., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 439-449.e5 17 p.

Research output: Contribution to journalArticle

Open Access
File
126 Citations (Scopus)
183 Downloads (Pure)
2019

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

2013

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling

McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R., 14 Mar 2013, In : Blood. 121, 11, p. 2084-2094 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2012

ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 1 Oct 2012, In : Journal of Cell Science. 125, 19, p. 4662-4675 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014
Open Access
File
10 Citations (Scopus)
146 Downloads (Pure)

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Banerjee, S., Buhrlage, S. J., Huang, H-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. & Gray, N. S., 1 Jan 2014, In : Biochemical Journal. 457, 1, p. 215-225 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2015

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling

Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G. & Hundal, H., 1 Sep 2015, In : Biochemical Journal. 470, 2, p. 207-221

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
163 Downloads (Pure)
2018

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks

Malik, N., Macartney, T., Hornberger, A., Anderson, K., Tovell, H., Prescott, A. R. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 117-135 19 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
249 Downloads (Pure)
2011

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R., 1 Mar 2011, In : Journal of Cell Science. 124, 5, p. 789-800 12 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)
2013

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W. & 14 others, Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2020

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation. 15 p.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)
2019

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 9 Sep 2019, In : Wellcome Open Research. 4, p. 134 28 p.

Research output: Contribution to journalArticle

Open Access
File
61 Downloads (Pure)
2020

A conserved ATG2-GABARAP family interaction is critical for phagophore formation

Bozic, M., van den Bekerom, L., Milne, B. A., Goodman, N., Roberston, L., Prescott, A., Macartney, T., Dawe, N. & McEwan, D., 4 Mar 2020, In : EMBO Reports. 21, 3, p. 1-17 17 p., e48412.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
66 Downloads (Pure)
2013

The β2 integrin–kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

Morrison, V. L., MacPherson, M., Savinko, T., San Lek, H., Prescott, A. & Fagerholm, S. C., 22 Aug 2013, In : Blood. 122, 8, p. 1428-1436 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
20 Citations (Scopus)
2014
5 Citations (Scopus)
2012

Cellular Responses to the Metal-Binding Properties of Metformin

Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G., Jun 2012, In : Diabetes. 61, 6, p. 1423-1433 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2013

Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. & Cohen, P. T. W., 1 Sep 2013, In : Cell Cycle. 12, 17, p. 2876-2887 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2012

A role for PP1/NIPP1 in steering migration of human cancer cells

Martin-Granados, C., Prescott, A. R., Van Dessel, N., Van Eynde, A., Arocena, M., Klaska, I. P., Görnemann, J., Beullens, M., Bollen, M., Forrester, J. V. & McCaig, C. D., 2012, In : PLoS ONE. 7, 7, e40769.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2013

The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

Elliott, J. L., Perng, M. D., Prescott, A. R., Jansen, K. A., Koenderink, G. H. & Quinlan, R. A., 2013, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 368, 1617, 15 p., 20120375.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2014
Open Access
File
53 Citations (Scopus)
132 Downloads (Pure)
2011

Homeostasis in the vertebrate lens: mechanisms of solute exchange

Dahm, R., van Marle, J., Quinlan, R. A., Prescott, A. R. & Vrensen, G. F. J. M., 27 Apr 2011, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1568, p. 1265-1277 13 p.

Research output: Contribution to journalReview article

31 Citations (Scopus)
2016

Deep intronic sequence variants in COL2A1 affect the alternative splicing efficiency of Exon 2, and may confer a risk for rhegmatogenous retinal detachment

Spickett, C., Hysi, P., Hammond, C. J., Prescott, A., Fincham, G. S., Poulson, A. V., McNinch, A. M., Richards, A. J. & Snead, M. P., 21 Aug 2016, In : Human Mutation. 37, 10, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
141 Downloads (Pure)
2015

The PDK1-Rsk signaling pathway controls Langerhans cell proliferation and patterning

Zaru, R., Matthews, S. P., Edgar, A. J., Prescott, A. R., Gomez-Nicola, D., Hanauer, A. & Watts, C., 1 Nov 2015, In : Journal of Immunology. 195, 9, p. 4264-4272 9 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
139 Downloads (Pure)
2016

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 22 Apr 2016, In : eLife. 5, p. 1-18 18 p., e12278.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
140 Downloads (Pure)
2017
Open Access
File
6 Citations (Scopus)
178 Downloads (Pure)
2013

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S., 2013, In : Scientific Reports. 3, 1275.

Research output: Contribution to journalArticle

25 Citations (Scopus)

PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C., 15 Jan 2013, In : Journal of Immunology. 190, 2, p. 565-577 13 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)
2020

Antibody RING-Mediated Destruction of Endogenous Proteins

Ibrahim, A. F. M., Shen, L., Tatham, M. H., Dickerson, D., Prescott, A. R., Abidi, N., Xirodimas, D. P. & Hay, R. T., 2 Jul 2020, In : Molecular Cell. 12 p.

Research output: Contribution to journalArticle

Open Access
File
25 Downloads (Pure)
2016

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

McWilliams, T., Prescott, A., Allen, G., Tamjar, J., Munson, M., Thomson, C., Muqit, M. & Ganley, I., 25 Jul 2016, In : Journal of Cell Biology. 214, 3, p. 333-345 13 p.

Research output: Contribution to journalArticle

Open Access
File
122 Citations (Scopus)
281 Downloads (Pure)
2013

A synthetic system for expression of components of a bacterial microcompartment

Sargent, F., Davidson, F. A., Kelly, C. L., Binny, R., Christodoulides, N., Gibson, D., Johansson, E., Kozyrska, K., Licandro Lado, L., MacCallum, J., Montague, R., Ortmann, B., Owen, R., Coulthurst, S. J., Dupuy, L., Prescott, A. R. & Palmer, T., Nov 2013, In : Microbiology. 159, 11, p. 2427-2436 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2011

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R., 2011, In : Biochemical Journal. 437, p. 157-167 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2017

Bifunctionality of a biofilm matrix protein controlled by redox state

Arnaouteli, S., Ferreira, A. S., Schor, M., Morris, R. J., Bromley, K. M., Jo, J., Cortez, K. L., Sukhodub, T., Prescott, A. R., Dietrich, L. E. P., MacPhee, C. E. & Stanley-Wall, N. R., 25 Jul 2017, In : Proceedings of the National Academy of Sciences. 114, 30, p. E6184-E6191 8 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
506 Downloads (Pure)
2018

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
160 Downloads (Pure)
2013

DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P., 23 Aug 2013, In : Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
137 Downloads (Pure)
2019

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
9 Downloads (Pure)
2011

YuaB Functions Synergistically with the Exopolysaccharide and TasA Amyloid Fibers To Allow Biofilm Formation by Bacillus subtilis

Ostrowski, A., Mehert, A., Prescott, A., Kiley, T. B. & Stanley-Wall, N. R., Sep 2011, In : Journal of Bacteriology. 193, 18, p. 4821-4831 11 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

An intranucleolar body associated with rDNA

Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. & Lamond, A. I., Oct 2011, In : Chromosoma. 120, 5, p. 481-499 19 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2015

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P., 15 Jun 2015, In : Biochemical Journal. 468, 3, p. 363-372 10 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2012

The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G., 1 Apr 2012, In : Biochemical Journal. 443, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking

Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E., 15 Feb 2014, In : Journal of Cell Science. 127, 4, p. 812-827 16 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

A key role for PTP1B in dendritic cell maturation, migration, and T cell activation

Martin-Granados, C., Prescott, A. R., Le Sommer, S., Klaska, I. P., Yu, T., Muckersie, E., Giuraniuc, C. V., Grant, L., Delibegovic, M. & Forrester, J. V., Dec 2015, In : Journal of Molecular Cell Biology. 7, 6, p. 517-528 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)