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• Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

  Torrie, L. S., Robinson, D. A., Thomas, M. G., Hobrath, J. V., Shepherd, S. M., Post, J. M., Ko, E. J., Ferreira, R. A., Mackenzie, C. J., Wrobel, K., Edwards, D. P., Gilbert, I. H., Gray, D. W., Fairlamb, A. H. & De Rycker, M., 8 May 2020, In: ACS Infectious Diseases. 6, 5, p. 1044-1057 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Methionine-tRNA Ligase 100%
  • Allosteric Site 80%
  • Binding Sites 43%
  • Trypanosoma cruzi 34%
  • Enzymes 25%
  1 Citation (Scopus)

  18 Downloads (Pure)

• Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

  Cukier, C. D., Hope, A. G., Elamin, A. A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J. H., Lindqvist, Y., Gray, D. W. & Schneider, G., 2013, In: ACS Chemical Biology. n/a, cb4005063.

  Research output: Contribution to journal › Article › peer-review

  • Acyl Carrier Protein 100%
  • Pseudomonas aeruginosa 59%
  • Oxidoreductases 58%
  • Fatty Acids 54%
  • Fatty Acid 51%
  22 Citations (Scopus)

• Discovery of a new sialic acid binding region that regulates Siglec-7

  Yamakawa, N., Yasuda, Y., Yoshimura, A., Goshima, A., Crocker, P. R., Vergoten, G., Nishiura, Y., Takahashi, T., Hanashima, S., Matsumoto, K., Yamaguchi, Y., Tanaka, H., Kitajima, K. & Sato, C., 26 May 2020, In: Scientific Reports. 10, 14 p., 8647.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • N-Acetylneuraminic Acid 72%
  • Binding Sites 24%
  • Ligands 22%
  • 1,1,1,2-tetrafluoro-2-chloroethane 21%
  2 Citations (Scopus)

  15 Downloads (Pure)

• Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

  Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • glycylpeptide N-tetradecanoyltransferase 100%
  • Trypanocidal 82%
  • African Trypanosomiasis 81%
  • Trypanosoma brucei brucei 74%
  • Drug Target 65%
  83 Citations (Scopus)

  424 Downloads (Pure)

• Discovery of an RmlC/D fusion protein in the microalga Prymnesium parvum and its implications for NDP-β-L-rhamnose biosynthesis in microalgae

  Wagstaff, B., Rejzek, M., Kuhaudomlarp, S., Hill, L., Mascia, I., Nepogodiev, S. A., Dorfmueller, H. & Field, R. A., 7 Jun 2019, In: Journal of Biological Chemistry. 294, 23, p. 9172-9185 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Haptophyta 100%
  • Microalgae 88%
  • Rhamnose 81%
  • Nucleotide-Sugar 61%
  • Biosynthesis 47%
  3 Citations (Scopus)

  105 Downloads (Pure)

• Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres

  Kobayashi, N., Suzuki, Y., Schoenfeld, L., Müller, C., Nieduszynski, C., Wolfe, K. & Tanaka, T., 3 Aug 2015, In: Current Biology. 25, 15, p. 2026-2033 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Saccharomycetales 100%
  • Centromere 99%
  • centromeres 90%
  • DNA Sequence 85%
  • yeasts 54%
  25 Citations (Scopus)

  171 Downloads (Pure)

• Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221.

  Cohen, P. T. & Cohen, P., 15 Jun 1989, In: The Biochemical journal. 260, 3, p. 931-934 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacteriophage lambda 100%
  • Phosphoprotein Phosphatases 80%
  • Open Reading Frames 66%
  • Genome 46%
  • Caseins 32%
  91 Citations (Scopus)

• Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor

  Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R. & Gray, N. S., 14 May 2015, In: ACS Medicinal Chemistry Letters. 6, 5, p. 584-589 6 p.

  Research output: Contribution to journal › Article › peer-review

  • pyrrolopyrimidine 100%
  • Pyrrolopyrimidine 88%
  • Leucine 55%
  • Phosphotransferases 41%
  • compound 18 29%
  28 Citations (Scopus)

• Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

  Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A. & 7 others, Gray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 10 Nov 2016, In: Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DDD107498 100%
  • quinoline-4-carboxamide 98%
  • Peptide Elongation Factor 2 64%
  • Antiplasmodic 58%
  • Antimalarials 46%
  32 Citations (Scopus)

  174 Downloads (Pure)

• Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

  Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H. & 30 others, Rauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. & Franks, P. W., 1 Sep 2019, In: Diabetologia. 62, 9, p. 1601-1615 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epidemiologic Studies 100%
  • Type 2 Diabetes Mellitus 90%
  • Biomarkers 78%
  • Glucose 75%
  • Fasting 42%
  9 Citations (Scopus)

  10 Downloads (Pure)

• Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

  Koivula, R. W., Heggie, A., Barnett, A., Cederberg, H., Hansen, T. H., Koopman, A. D., Ridderstråle, M., Rutters, F., Vestergaard, H., Gupta, R., Herrgård, S., Heymans, M. W., Perry, M. H., Rauh, S., Siloaho, M., Teare, H. J. A., Thorand, B., Bell, J., Brunak, S., Frost, G. & 14 others, Jablonka, B., Mari, A., McDonald, T. J., Dekker, J. M., Hansen, T., Hattersley, A., Laakso, M., Pedersen, O., Koivisto, V., Ruetten, H., Walker, M., Pearson, E., Franks, P. W. & DIRECT Consortium, Jun 2014, In: Diabetologia. 57, 6, p. 1132-1142 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epidemiologic Studies 100%
  • Type 2 Diabetes Mellitus 90%
  • Biomarkers 78%
  • Feeding Behavior 46%
  • Sample Size 42%
  32 Citations (Scopus)

  166 Downloads (Pure)

• Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations

  Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K., 1 Nov 2011, In: Open Biology. 1, NOVEMBER, 110012.

  Research output: Contribution to journal › Article › peer-review

  • Substrate Specificity 100%
  • Mutation 75%
  • Parkinson Disease 75%
  • Phosphotransferases 69%
  • Threonine 50%
  64 Citations (Scopus)

• Discovery of common and rare genetic risk variants for colorectal cancer

  Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., Conti, D. V., Qu, C., Jeon, J., Edlund, C. K., Greenside, P., Wainberg, M., Schumacher, F. R., Smith, J. D., Levine, D. M., Nelson, S. C., Sinnott-Armstrong, N. A., Albanes, D., Alonso, M. H., Anderson, K. & 179 others, Arnau-Collell, C., Arndt, V., Bamia, C., Banbury, B. L., Baron, J. A., Berndt, S. I., Bézieau, S., Bishop, D. T., Boehm, J., Boeing, H., Brenner, H., Brezina, S., Buch, S., Buchanan, D. D., Burnett-Hartman, A., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chirlaque, M-D., Cho, S. H., Connolly, C. M., Cross, A. J., Cuk, K., Curtis, K. R., de la Chapelle, A., Doheny, K. F., Duggan, D., Easton, D. F., Elias, S. G., Elliott, F., English, D. R., Feskens, E. J. M., Figueiredo, J. C., Fischer, R., FitzGerald, L. M., Forman, D., Gala, M., Gallinger, S., Gauderman, W. J., Giles, G. G., Gillanders, E., Gong, J., Goodman, P. J., Grady, W. M., Grove, J. S., Gsur, A., Gunter, M. J., Haile, R. W., Hampe, J., Hampel, H., Harlid, S., Hayes, R. B., Hofer, P., Hoffmeister, M., Hopper, J. L., Hsu, W-L., Huang, W-Y., Hudson, T. J., Hunter, D. J., Ibañez-Sanz, G., Idos, G. E., Ingersoll, R., Jackson, R. D., Jacobs, E. J., Jenkins, M. A., Joshi, A. D., Joshu, C. E., Keku, T. O., Key, T. J., Kim, H. R., Kobayashi, E., Kolonel, L. N., Kooperberg, C., Kühn, T., Küry, S., Kweon, S-S., Larsson, S. C., Laurie, C. A., Le Marchand, L., Leal, S. M., Lee, S. C., Lejbkowicz, F., Lemire, M., Li, C. I., Li, L., Lieb, W., Lin, Y., Lindblom, A., Lindor, N. M., Ling, H., Louie, T. L., Männistö, S., Markowitz, S. D., Martín, V., Masala, G., McNeil, C. E., Melas, M., Milne, R. L., Moreno, L., Murphy, N., Myte, R., Naccarati, A., Newcomb, P. A., Offit, K., Ogino, S., Onland-Moret, N. C., Pardini, B., Parfrey, P. S., Pearlman, R., Perduca, V., Pharoah, P. D. P., Pinchev, M., Platz, E. A., Prentice, R. L., Pugh, E., Raskin, L., Rennert, G., Rennert, H. S., Riboli, E., Rodríguez-Barranco, M., Romm, J., Sakoda, L. C., Schafmayer, C., Schoen, R. E., Seminara, D., Shah, M., Shelford, T., Shin, M-H., Shulman, K., Sieri, S., Slattery, M. L., Southey, M. C., Stadler, Z. K., Stegmaier, C., Su, Y-R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Thomas, S. S., Toland, A. E., Trichopoulou, A., Ulrich, C. M., Van Den Berg, D. J., van Duijnhoven, F. J. B., Van Guelpen, B., van Kranen, H., Vijai, J., Visvanathan, K., Vodicka, P., Vodickova, L., Vymetalkova, V., Weigl, K., Weinstein, S. J., White, E., Win, A. K., Wolf, C. R., Wolk, A., Woods, M. O., Wu, A. H., Zaidi, S. H., Zanke, B. W., Zhang, Q., Zheng, W., Scacheri, P. C., Potter, J. D., Bassik, M. C., Kundaje, A., Casey, G., Moreno, V., Abecasis, G. R., Nickerson, D. A., Gruber, S. B., Hsu, L. & Peters, U., 1 Jan 2019, In: Nature Genetics. 51, 1, p. 76-87 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Colorectal Neoplasms 100%
  • Whole Genome Sequencing 48%
  • Long Noncoding RNA 45%
  • Genome-Wide Association Study 43%
  • Drug Development 39%
  114 Citations (Scopus)

  235 Downloads (Pure)

• Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

  Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H., 8 Oct 2015, In: Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

  Research output: Contribution to journal › Article › peer-review

  • indoline 100%
  • African Trypanosomiasis 77%
  • Trypanosoma brucei brucei 71%
  • Antiproliferative 54%
  • Pharmacokinetics 41%
  22 Citations (Scopus)

• Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

  Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In: ChemMedChem. 10, 11, p. 1809-1820 12 p.

  Research output: Contribution to journal › Article › peer-review

  • 1H-pyrazolo(3,4-b)pyridine 100%
  • Trypanosoma brucei brucei 84%
  • Protein Kinases 59%
  • Pyridine 45%
  • Growth 32%
  10 Citations (Scopus)

• Discovery of invariants through automated theory formation

  Llano, M. T., Ireland, A. & Pease, A., Oct 2012, In: Formal Aspects of Computing. n/a, p. 1-47 47 p.

  Research output: Contribution to journal › Article › peer-review

  • Formal Modeling 100%
  • Event-B 98%
  • Failure analysis 51%
  • Refinement 34%
  • Invariant 33%
  5 Citations (Scopus)

• Discovery of invariants through automated theory formation

  Llano, M. T., Ireland, A. & Pease, A., 17 Jun 2011, In: Electronic Proceedings in Theoretical Computer Science, EPTCS. 55, p. 1-19 19 p.

  Research output: Contribution to journal › Conference article › peer-review

  • Failure analysis 100%
  • Experiments 41%
  5 Citations (Scopus)

• Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

  Navratilova, I., Aristotelous, T., Picaud, S., Chaikuad, A., Knapp, S., Filappakopoulos, P. & Hopkins, A. L., 8 Dec 2016, In: ACS Medicinal Chemistry Letters. 7, 12, p. 1213-1218 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Biosensing Techniques 100%
  • Dimethyl Sulfoxide 91%
  • Surface Plasmon Resonance 51%
  • Lysine 39%
  • Crystal Structure 20%
  11 Citations (Scopus)

• Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)

  Brasca, M. G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Casale, E., Ceccarelli, W., Colombo, N., De Ponti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E. R., Ferguson, R. D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L. & 4 others, Sola, F., Visco, C., Zuccotto, F. & Fogliatto, G., 15 Nov 2013, In: Bioorganic & Medicinal Chemistry. 21, 22, p. 7047-7063 17 p.

  Research output: Contribution to journal › Article › peer-review

  • NMS-E973 100%
  • HSP90 Heat-Shock Proteins 55%
  • compound 18 34%
  • Heat 31%
  • Pharmaceutical Chemistry 28%
  18 Citations (Scopus)

• Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists

  Jones, D. G., Liang, X., Stewart, E. L., Noe, R. A., Kallander, L. S., Madauss, K. P., Williams, S. P., Thompson, S. K., Gray, D. W. & Hoekstra, W. J., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 13, p. 3203-6 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Mifepristone 100%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 63%
  • Progesterone Receptors 59%
  • Abortifacient 26%
  • Ketosteroids 23%
  28 Citations (Scopus)

• Discovery of novel heart rate-associated loci using the Exome Chip

  van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Müller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikäinen, L-P. & 101 others, Hall, L. M., van Setten, J., Trompet, S., Prins, B. P., Isaacs, A., Radmanesh, F., Marten, J., Entwistle, A., Kors, J. A., Silva, C. T., Alonso, A., Bis, J. C., de Boer, R. A., de Haan, H. G., de Mutsert, R., Dedoussis, G., Dominiczak, A. F., Doney, A. S. F., Ellinor, P. T., Eppinga, R. N., Felix, S. B., Guo, X., Hagemeijer, Y., Hansen, T., Harris, T. B., Heckbert, S. R., Huang, P. L., Hwang, S-J., Kähönen, M., Kanters, J. K., Kolcic, I., Launer, L. J., Li, M., Yao, J., Linneberg, A., Liu, S., Macfarlane, P. W., Mangino, M., Morris, A. D., Mulas, A., Murray, A. D., Nelson, C. P., Orrú, M., Padmanabhan, S., Peters, A., Porteous, D. J., Poulter, N. R., Psaty, B. M., Qi, L., Raitakari, O. T., Rivadeneira, F., Roselli, C., Rudan, I., Sattar, N., Sever, P., Sinner, M. F., Soliman, E. Z., Spector, T. D., Stanton, A. V., Stirrups, K. E., Taylor, K. D., Tobin, M. D., Uitterlinden, A. G., Vaartjes, I., Hoes, A. W., van der Meer, P., Völker, U., Waldenberger, M., Xie, Z., Zoledziewska, M., Tinker, A., Polasek, O., Rosand, J., Jamshidi, Y., van Duijn, C. M., Zeggini, E., Wouter Jukema, J., Asselbergs, F. W., Samani, N. J., Lehtimäki, T., Gudnason, V., Wilson, J., Lubitz, S. A., Kääb, S., Sotoodehnia, N., Caulfield, M. J., Palmer, C. N. A., Sanna, S., Mook-Kanamori, D. O., Deloukas, P., Pedersen, O., Rotter, J. I., Dörr, M., O'Donnell, C. J., Hayward, C., Arking, D. E., Kooperberg, C., van der Harst, P., Eijgelsheim, M., Stricker, B. H. C. & Munroe, P. B., 15 Jun 2017, In: Human Molecular Genetics. 26, 12, p. 2346-2363 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Exome 100%
  • Heart Rate 60%
  • Genes 14%
  • Fetal Heart 12%
  • Heart 12%
  13 Citations (Scopus)

  116 Downloads (Pure)

• Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

  Wang, S., Midgley, C. A., Scaërou, F., Grabarek, J. B., Griffiths, G., Jackson, W., Kontopidis, G., McClue, S. J., McInnes, C., Meades, C., Mezna, M., Plater, A., Stuart, I., Thomas, M. P., Wood, G., Clarke, R. G., Blake, D. G., Zheleva, D. I., Lane, D. P., Jackson, R. C. & 2 others, Glover, D. M. & Fischer, P. M., 10 Jun 2010, In: Journal of Medicinal Chemistry. 53, 11, p. 4367-4378 12 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine 100%
  • Aurora Kinase Inhibitor 78%
  • Pyrimidin-2-Amine 74%
  • compound 18 71%
  • Aurora 67%
  77 Citations (Scopus)

• Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1

  Osborne, J., Birchall, K., Tsagris, D. J., Lewis, S. J., Smiljanic-Hurley, E., Taylor, D. L., Levy, A., Alessi, D. & McIver, E. G., 15 Feb 2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 4, p. 668-673 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • High Throughput Screening 100%
  • Leucine 95%
  • Communication 84%
  • Disorder 79%
  • Mutation 78%
  3 Citations (Scopus)

  41 Downloads (Pure)

• Discovery of potent and selective covalent inhibitors of JNK

  Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. & Gray, N. S., 27 Jan 2012, In: Chemistry & Biology. 19, 1, p. 140-154 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cysteine Residue 100%
  • Cysteine 90%
  • Mitogen-Activated Protein Kinase 8 72%
  • Signal Transduction 51%
  • Mitogens 48%
  200 Citations (Scopus)

• Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

  Cavazzuti, A., Paglietti, G., Hunter, W. N., Gamarro, F., Piras, S., Loriga, M., Alleca, S., Corona, P., McLuskey, K., Tulloch, L., Gibellini, F., Ferrari, S. & Costin, M. P., 5 Feb 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1448-1453 6 p.

  Research output: Contribution to journal › Article › peer-review

  • pteridine reductase 100%
  • Folic Acid Antagonists 69%
  • Drug Development 47%
  • Leishmania major 34%
  • Trypanosoma cruzi 30%
  102 Citations (Scopus)

• Discovery of powerful millisecond flares from Cygnus X-1

  Gierliński, M. & Zdziarski, A. A., 11 Aug 2003, In: Monthly Notices of the Royal Astronomical Society. 343, 3, p. L84-L88 5 p.

  Research output: Contribution to journal › Article › peer-review

  • flares 100%
  • folding 63%
  • energy flux 36%
  • accretion 31%
  • hardness 30%
  31 Citations (Scopus)

• Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

  LifeLines Cohort Study, EPIC-CVD Consortium, EPIC-InterAct Consortium, Understanding Society Scientific Group, Million Veteran Program, Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G. & 37 others, Liu, D. J., Prins, B. P., Stewart, I. D., Cabrera, C. P., Eales, J. M., Akbarov, A., Auer, P. L., Bielak, L. F., Bis, J. C., Braithwaite, V. S., Brody, J. A., Daw, E. W., Warren, H. R., Drenos, F., Nielsen, S. F., Faul, J. D., Fauman, E. B., Fava, C., Ferreira, T., Foley, C. N., Franceschini, N., Gao, H., Giannakopoulou, O., Giulianini, F., Gudbjartsson, D. F., Guo, X., Harris, S. E., Havulinna, A. S., Helgadottir, A., Huffman, J. E., Hwang, S-J., Kanoni, S., Smith, J. A., Palmer, C. N. A., Smith, B. H., Munroe, P. B. & Howson, J. M. M., Dec 2020, In: Nature Genetics. 52, 12, p. 1314-1332 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Meta-Analysis 100%
  • Blood Pressure 85%
  • Gene Frequency 26%
  • Genetic Association Studies 14%
  • Fetal Development 13%
  6 Citations (Scopus)

  2 Downloads (Pure)

• Discovery of sarolaner: A novel, Orally administered, broad-spectrum, Isoxazoline ectoparasiticide for dogs

  McTier, T. L., Chubb, N., Curtis, M. P., Hedges, L., Inskeep, G. A., Knauer, C. S., Menon, S., Mills, B., Pullins, A., Zinser, E., Woods, D. J. & Meeus, P., 30 May 2016, In: Veterinary Parasitology. 222, p. 3-11 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sarolaner 100%
  • ectoparasiticides 83%
  • Ctenocephalides felis 58%
  • Siphonaptera 57%
  • Ctenocephalides 37%
  80 Citations (Scopus)

  35 Downloads (Pure)

• Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

  Bell, M., Foley, D., Naylor, C., Wood, G., Robinson, C., Riley, J., Epemolu, R., Ellis, L., Scullion, S., Shishikura, Y., Osuna-Cabello, M., Ferguson, L., Pinto, E., Fletcher, D., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 341–347 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sphingosine 1 Phosphate Receptor Modulators 100%
  • Sphingosine 1-Phosphate 90%
  • Drug Discovery 59%
  • Drug 30%
  • ponesimod 28%
  2 Citations (Scopus)

  112 Downloads (Pure)

• Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

  Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 15 Oct 2018, In: Bioorganic & Medicinal Chemistry Letters. 28, 19, p. 3255-3259 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ponesimod 100%
  • Sphingosine 1 Phosphate Receptor Modulators 86%
  • Sphingosine 1-Phosphate 78%
  • Esters 50%
  • Agonist 47%
  10 Citations (Scopus)

  184 Downloads (Pure)

• Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies

  Lucas, X., Simon, S., Schubert, R. & Günther, S., 9 Apr 2013, In: PLoS ONE. 8, 4, 8 p., e60679.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 100%
  • Phosphatidylinositols 96%
  • In Vitro Techniques 39%
  • Nutritional Sciences 35%
  • Cell Line 26%
  7 Citations (Scopus)

  141 Downloads (Pure)

• Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

  Tan, L., Nomanbhoy, T., Gurbani, D., Patricelli, M., Hunter, J., Geng, J., Herhaus, L., Zhang, J., Pauls, E., Ham, Y., Choi, H. G., Xie, T., Deng, X., Buhrlage, S. J., Sim, T., Cohen, P., Sapkota, G., Westover, K. D. & Gray, N. S., 8 Jan 2015, In: Journal of Medicinal Chemistry. 58, 1, p. 183-196 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hematopoietic progenitor kinase 1 100%
  • Phosphotransferase Inhibitor 65%
  • Structure-Activity Relationship 44%
  • Phosphotransferases 40%
  • Pharmacokinetics 39%
  46 Citations (Scopus)

• Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

  Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I., 2013, In: ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Adrenergic 100%
  • Biosensing Techniques 92%
  • G-Protein-Coupled Receptors 76%
  • Adrenergic Receptors 72%
  • Ligands 53%
  44 Citations (Scopus)

• Discrete cell modelling

  Macklin, P., Edgerton, M. E., Lowengrub, J. S. & Cristini, V., 2010, Multiscale modeling of cancer: an integrated experimental and mathematical modeling approach. Cristini, V. & Lowengrub, J. (eds.). Cambridge University Press, p. 88-122 35 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Discrete Element Modeling of Compound Rockfall Fence Nets

  Previtali, M., Ciantia, M., Spadea, S., Castellanza, R. & Crosta, G. B., 2021, Challenges and Innovations in Geomechanics: Proceedings of the 16th International Conference of IACMAG - Volume 2. Barla, M., Di Donna, A. & Sterpi, D. (eds.). Switzerland: Springer , Vol. 2. p. 560-567 8 p. (Lecture Notes in Civil Engineering; vol. 126).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Fences 100%
  • Sieves 48%
  • Bearing capacity 37%
  • Energy dissipation 32%
  • Calibration 28%
  1 Citation (Scopus)

• Discrete element modelling of soil erosion

  Muir Wood, D., Maeda, K. & Nukudani, E., 2008, 4th International Conference on Scour and Erosion. Japanese Geotechnical Society, p. 491-496 6 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

  File

  • soil erosion 100%
  • critical state 68%
  • particle 53%
  • modeling 45%
  • material 22%
  200 Downloads (Pure)

• Discrete Model for Dynamic Structure-Soil-Structure Interaction

  Aldaikh, H., Alexander, N. & Ibraim, E., 2012, Proceedings of the 15th World Conference of Earthquake Engineering (15WCEE): Proceedings of a meeting held 24-28 September 2012, Lisbon, Portugal.. Red Hook, NY: International Association for Earthquake Engineering , Vol. 24. p. 19433-19442 10 p. 3386

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

  • Soil structure interactions 100%
  • Soils 31%

• Discrete modelling of vertical track-soil coupling for vehicle-track dynamics

  Kouroussis, G., Gazetas, G., Anastasopoulos, I., Conti, C. & Verlinden, O., Dec 2011, In: Soil Dynamics and Earthquake Engineering. 31, 12, p. 1711-1723 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Soils 100%
  • vehicle 99%
  • soil 64%
  • modeling 53%
  • railroads 22%
  71 Citations (Scopus)

• Discretion not to quash permission despite breach of Habitats Directive

  Reid, C., Aug 2019, Scottish Planning and Environmental Law, 194, p. 93-93 1 p.

  Research output: Contribution to specialist publication › Article

  • habitats directive 100%
  • permission 92%
  • local government 71%
  • decision 44%
  • city 39%

• Discretised eigenvalue problems, LBB constants and stabilization

  Griffiths, D., Griffiths, D. (ed.) & Watson, A. (ed.), 1995

  Research output: Non-textual form › Digital or Visual Products

• Discretization provides a conceptually simple tool to build expression networks

  Vass, J. K., Higham, D. J., Mudaliar, M. A. V., Mao, X. & Crowther, D. J., 18 Apr 2011, In: PLoS ONE. 6, 4, p. 1-12 12 p., e18634.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biological Marker 100%
  • Microarrays 59%
  • White 46%
  • Genes 44%
  • Pharmacological Metabolism 42%
  4 Citations (Scopus)

  67 Downloads (Pure)

• Discriminant analysis of mandibular measurements for the estimation of sex in a modern Brazilian sample

  Lopez-Capp, T. T., Rynn, C., Wilkinson, C., de Paiva, L. A. S., Michel-Crosato, E. & Biazevic, M. G. H., May 2018, In: International Journal of Legal Medicine. 132, 3, p. 843-851 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Discriminant Analysis 100%
  • Mandible 87%
  • Sexism 20%
  • Sex Characteristics 13%
  • ROC Curve 12%
  9 Citations (Scopus)

• Discriminating between barley genotypes using microsatellite markers

  Russell, J., Fuller, J., Young, G., Thomas, B., Macaulay, M., Waugh, R., Powell, W. & Taramino, G., Aug 1997, In: Genome. 40, 4, p. 442-450 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hordeum 100%
  • Microsatellite Repeats 74%
  • Pedigree 58%
  • Genotype 50%
  • Breeding 20%
  138 Citations (Scopus)

• Discriminating dysplasia: optical tomographic texture analysis of colorectal polyps

  Li, W., Coats, M., Zhang, J. & McKenna, S., Dec 2015, In: Medical Image Analysis. 26, 1, p. 57-69 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Polyps 100%
  • Textures 78%
  • Optical Tomography 74%
  • Three-Dimensional Imaging 58%
  • Calibration 50%
  8 Citations (Scopus)

  240 Downloads (Pure)

• Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry

  Nenutil, R., Smardova, J., Pavlova, S., Hanzelkova, Z., Muller, P., Fabian, P., Hrstka, R., Janotova, P., Radina, M., Lane, D. P., Coates, P. J. & Vojtesek, B., 2005, In: Journal of Pathology. 207, 3, p. 251-259 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunohistochemistry 100%
  • Staining and Labeling 77%
  • Mutation 67%
  • Neoplasms 46%
  • p53 Genes 26%
  116 Citations (Scopus)

• Discrimination of bladder cancer cells from normal urothelial cells with high specificity and sensitivity: combined application of AFM and modulated Raman spectroscopy

  Canetta, E., Riches, A., Borger, E., Herrington, S., Dholakia, K. & Adya, A. K., May 2014, In: Acta Biomaterialia. 10, 5, p. 2043-2055

  Research output: Contribution to journal › Article › peer-review

  • Raman spectroscopy 100%
  • Raman Spectrum Analysis 98%
  • Atomic force microscopy 95%
  • Atomic Force Microscopy 91%
  • Cells 73%
  36 Citations (Scopus)

• Discrimination of closely homologous HPV types by nonisotopic in situ hybridization: definition and derivation of tissue melting temperatures

  Herrington, C. S., Graham, A. K., Flannery, D. M. J., Burns, J. & McGee, J. OD., 1990, In: Histochemical Journal. 22, 10, p. 545-554 10 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Discrimination of closely homologous human genomic and viral sequences in cells and tissues: further characterization of Tmt

  Herrington, C. S. & McGee, J. OD., 1994, In: Histochemical Journal. 26, 7, p. 545-552 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Temperature 100%
  • In Situ Hybridization 42%
  • Paraffin Embedding 35%
  • Waxes 29%
  • Aldehydes 27%
  6 Citations (Scopus)

• Discrimination of healthy and cancer cells of the bladder by metabolic state, based on autofluorescence

  Palmer, S., Litvinova, K., Rafailov, E. U. & Nabi, G., 2015, Photonic Therapeutics and Diagnostics XI. Choi, B., Kollias, N., Zeng, H., Kang, H. W., Wong, B. J. F., Ilgner, J. F., Nuttal, A., Richter, C-P., Skala, M. C., Dewhirst, M. W., Tearney, G. J., Gregory, K. W., Marcu, L. & Mandelis, A. (eds.). Bellingham: SPIE-International Society for Optical Engineering, 93030T. (Proceedings of SPIE; vol. 9303)(Progress In Biomedical Optics And Imaging; vol. 16, no. 1).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • bladder 100%
  • Oxidation-Reduction 96%
  • Cells 71%
  • discrimination 70%
  • Urinary Bladder Neoplasms 70%
  2 Citations (Scopus)

• Discrimination of human papillomavirus types in low and high grade cervical squamous neoplasia by in situ hybridization

  Southern, S. A., Graham, D. A. & Herrington, C. S., Apr 1998, In: Diagnostic Molecular Pathology. 7, 2, p. 114-121 8 p.

  Research output: Contribution to journal › Article › peer-review

  • In Situ Hybridization 100%
  • Human papillomavirus 11 44%
  • Human papillomavirus 6 43%
  • Neoplasms 35%
  • Human papillomavirus 31 24%
  4 Citations (Scopus)