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  • James Chalmers

10 years since TORCH: shining a new light on the risks of inhaled corticosteroids in COPD

Chalmers, J. D. & Keir, H. R., 1 Sep 2017, In : European Respiratory Journal. 50, 3, 5 p., 1701582.

Research output: Contribution to journalEditorial

3 Citations (Scopus)

A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial

Bradley, J. M., Anand, R., O'Neill, B., Ferguson, K., Clarke, M., Carroll, M., Chalmers, J., De Soyza, A., Duckers, J., Hill, A. T., Loebinger, M. R., Copeland, F., Gardner, E., Campbell, C., Agus, A., McGuire, A., Boyle, R., McKinney, F., Dickson, N., McAuley, D. F. & 1 others, Elborn, S., 19 Dec 2019, In : Trials. 20, 1, p. 1-10 10 p., 747.

Research output: Contribution to journalArticle

Open Access
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37 Downloads (Pure)

ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial

Wilkinson, T., Dixon, R., Page, C., Carroll, M., Griffiths, G., Ho, L-P., De Soyza, A., Felton, T., Lewis, K. E., Phekoo, K., Chalmers, J. D., Gordon, A., McGarvey, L., Doherty, J., Read, R. C., Shankar-Hari, M., Martinez-Alier, N., O'Kelly, M., Duncan, G., Walles, R. & 3 others, Sykes, J., Summers, C. & Singh, D., 31 Jul 2020, In : Trials. 21, 1, 3 p., 691.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)

A comprehensive analysis of the impact of Pseudomonas aeruginosa colonization on prognosis in adult bronchiectasis

Finch, S., McDonnell, M. J., Abo-Leyah, H., Aliberti, S. & Chalmers, J. D., Nov 2015, In : Annals of the American Thoracic Society. 12, 11, p. 1602-1611 10 p.

Research output: Contribution to journalArticle

Open Access
File
153 Citations (Scopus)
121 Downloads (Pure)

A comprehensive approach to lung function in bronchiectasis

Radovanovic, D., Santus, P., Blasi, F., Sotgiu, G., D'Arcangelo, F., Simonetta, E., Contarini, M., Franceschi, E., Goeminne, P. C., Chalmers, J. D. & Aliberti, S., Dec 2018, In : Respiratory Medicine. 145, p. 120-129 10 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
121 Downloads (Pure)

Additional important research priorities for bronchiectasis in China

Aliberti, S., Dhar, R., Aksamit, T. R., Morgan, L. & Chalmers, J. D., 1 Jan 2017, In : European Respiratory Journal. 49, 1, 1602317.

Research output: Contribution to journalLetter

Open Access
File
156 Downloads (Pure)

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity

Flume, P. A., Chalmers, J. D. & Olivier, K. N., 8 Sep 2018, In : The Lancet. 392, 10150, p. 880-890 11 p.

Research output: Contribution to journalReview article

Open Access
File
44 Citations (Scopus)
236 Downloads (Pure)

Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis

Sibila, O., Laserna, E., Shoemark, A., Keir, H. R., Finch, S., Rodrigo-Troyano, A., Perea, L., Lonergan, M., Goeminne, P. C. & Chalmers, J. D., 1 Jul 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
15 Downloads (Pure)

Airway Mucin 2 is decreased in patients with severe chronic obstructive pulmonary disease with bacterial colonization

Sibila, O., Garcia-Bellmunt, L., Giner, J., Rodrigo-Troyano, A., Suarez-Cuartin, G., Torrego, A., Castillo, D., Solanes, I., Mateus, E. F., Vidal, S., Sanchez-Reus, F., Sala, E., Cosio, B. G., Restrepo, M. I., Anzueto, A., Chalmers, J. D. & Plaza, V., 1 May 2016, In : Annals of the American Thoracic Society. 13, 5, p. 636-642 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A multidisciplinary intervention to reduce antibiotic duration in lower respiratory tract infections

Murray, C., Shaw, A., Lloyd, M., Smith, R. P., Fardon, T. C., Schembri, S. & Chalmers, J. D., Feb 2014, In : Journal of Antimicrobial Chemotherapy. 69, 2, p. 515-518 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A new free-cost e-service supporting clinicians to manage their difficult-to-treat tuberculosis cases: The European Respiratory Society-World Health Organization tuberculosis Consilium

D'Ambrosio, L., Tadolini, M., Centis, R., Chalmers, J. D. & Migliori, G. B., 27 Jul 2017, In : Indian Journal of Medical Research. 145, 3, p. 261-263 3 p.

Research output: Contribution to journalEditorial

Open Access
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20 Downloads (Pure)

Antibiotic prophylaxis is ineffective in preventing pneumonia post-stroke

Rae, N. & Chalmers, J. D., 2015, In : Journal of the Royal College of Physicians of Edinburgh. 45, 4, p. 276-277 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis

Sibila, O., Perea, L., Cantó, E., Shoemark, A., Cassidy, D., Smith, A. H., Suarez-cuartin, G., Rodrigo-troyano, A., Keir, H. R., Oriano, M., Ong, S., Vidal, S., Blasi, F., Aliberti, S. & Chalmers, J. D., Sep 2019, In : Thorax. 74, 9, p. 835-842 8 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
181 Downloads (Pure)

Anti-Pseudomonas aeruginosa IgG antibodies and chronic airway infection in bronchiectasis

Suarez-Cuartin, G., Smith, A., Abo-Leyah, H., Rodrigo-Troyano, A., Perea, L., Vidal, S., Plaza, V., Fardon, T. C., Sibila, O. & Chalmers, J. D., Jul 2017, In : Respiratory Medicine. 128, p. 1-6 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A point of care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

Shoemark, A., Cant, E., Carreto, L., Smith, A., Oriano, M., Keir, H. R., Perea, L., Canto, E., Terranova, L., Vidal, S., Moffitt, K., Aliberti, S., Sibila, O. & Chalmers, J. D., 1 Jun 2019, In : European Respiratory Journal. 53, 6, 1900303.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
12 Downloads (Pure)

A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk

McDonnell, M. J., O'Toole, D., Ward, C., Pearson, J. P., Lordan, J. L., De Soyza, A., Loebinger, M., Chalmers, J. D., Laffey, J. G. & Rutherford, R. M., Aug 2018, In : Respiratory Medicine. 141, p. 132-143 12 p.

Research output: Contribution to journalReview article

Open Access
File
6 Citations (Scopus)
142 Downloads (Pure)

A randomised control trial of atorvastatin in bronchiectasis patients infected with Pseudomonas aeruginosa- a proof of concept study

Bedi, P., Chalmers, J. D., Graham, C., Clarke, A., Donaldson, S., Doherty, C. J., Govan, J. R. W., Davidson, D. J., Rossi, A. G. & Hill, A. T., Aug 2017, In : Chest. 152, 2, p. 368-378 11 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
148 Downloads (Pure)

A Randomized Controlled Trial of Nebulized Gentamicin in Non-Cystic Fibrosis Bronchiectasis

Murray, M. P., Govan, J. R. W., Doherty, C. J., Simpson, A. J., Wilkinson, T. S., Chalmers, J. D., Greening, A. P., Haslett, C. & Hill, A. T., 15 Feb 2011, In : American Journal of Respiratory and Critical Care Medicine. 183, 4, p. 491-499 9 p.

Research output: Contribution to journalArticle

198 Citations (Scopus)
Open Access
File
6 Citations (Scopus)
171 Downloads (Pure)

A systematic review of clinical trial registration in major respiratory journals 2010-2018

Suntila, N. S. M., Smith, A., Al-Dabbagh, Y. & Chalmers, J. D., 6 Dec 2018, In : European Respiratory Journal. 52, 6, 1801491.

Research output: Contribution to journalLetter

Open Access
File
69 Downloads (Pure)

A systematic review of pharmacotherapeutic clinical trial end-points for bronchiectasis in adults

Crichton, M. L., Aliberti, S. & Chalmers, J. D., 31 Mar 2019, In : European Respiratory Review. 28, 151, p. 1-14 14 p., 180108.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
133 Downloads (Pure)

A systematic review of the burden of vaccine preventable pneumococcal disease in UK adults

Chalmers, J. D., Dicker, A., Woodhead, M. & Madhava, H., 11 May 2016, In : BMC Pulmonary Medicine. 16, 1, p. 1-11 11 p., 77.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
200 Downloads (Pure)

Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial

Mandal, P., Chalmers, J. D., Graham, C., Harley, C., Sidhu, M. K., Doherty, C., Govan, J. W., Sethi, T., Davidson, D. J., Rossi, A. G. & Hill, A. T., 2014, In : The Lancet Respiratory Medicine. 2, 6, p. 455-463 9 p.

Research output: Contribution to journalArticle

Open Access
File
53 Citations (Scopus)
126 Downloads (Pure)

Author response-vitamin D deficiency and systemic inflammation in bronchiectasis

Chalmers, J. D., 2013, In : Thorax. 68, 7, p. 679 1 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD

Lonergan, M., Dicker, A. J., Crichton, M. L., Keir, H. R., Van Dyke, M. K., Mullerova, H., Miller, B. E., Tal-Singer, R. & Chalmers, J. D., 1 Jul 2020, In : Respiratory Research. 21, p. 1-10 10 p., 166.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)

British Thoracic Society guideline for bronchiectasis in adults

Hill, A. T., Sullivan, A. L., Chalmers, J. D., De Soyza, A., Elborn, J. S., Floto, R. A., Grillo, L., Gruffydd-Jones, K., Harvey, A., Haworth, C. S., Hiscocks, E., Hurst, J. R., Johnson, C., Kelleher, W. P., Bedi, P., Payne, K., Saleh, H., Screaton, N. J., Smith, M., Tunney, M. & 3 others, Whitters, D., Wilson, R. & Loebinger, M. R., 1 Dec 2018, In : BMJ Open Respiratory Research. 5, 1, 16 p., e000348.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
126 Downloads (Pure)

British Thoracic Society Guideline for bronchiectasis in adults

Hill, A. T., Sullivan, A. L., Chalmers, J. D., De Soyza, A., Elborn, J. S., Floto, R. A., Grillo, L., Gruffydd-Jones, K., Harvey, A., Haworth, C. S., Hiscocks, E., Hurst, J. R., Johnson, C., Kelleher, W. P., Bedi, P., Payne, K., Saleh, H., Screaton, N. J., Smith, M., Tunney, M. & 3 others, Whitters, D., Wilson, R. & Loebinger, M. R., Jan 2019, In : Thorax. 74, Suppl 1, p. 1-69 69 p., 74.

Research output: Contribution to journalArticle

Open Access
File
41 Citations (Scopus)
100 Downloads (Pure)

Bronchiectasis

Chalmers, J. D., Chang, A. B., Chotirmall, S. H., Dhar, R. & McShane, P. J., 15 Nov 2018, In : Nature reviews. Disease primers. 4, 1, 1 p., 45.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Bronchiectasis: new therapies and new perspectives

Chalmers, J. D. & Chotirmall, S. H., Sep 2018, In : The Lancet Respiratory Medicine. 6, 9, p. 715-726 12 p.

Research output: Contribution to journalReview article

Open Access
File
54 Citations (Scopus)
396 Downloads (Pure)

Bronchiectasis: a case-based approach to investigation and management

Contarini, M., Finch, S. & Chalmers, J. D., 30 Sep 2018, In : European Respiratory Review. 27, 149, p. 1-13 13 p., 180016.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
137 Downloads (Pure)

Bronchiectasis: working together for better evidence

Chalmers, J. D., Dec 2015, In : The Lancet Respiratory Medicine. 3, 12, p. 915-917 3 p.

Research output: Contribution to journalArticle

Bronchiectasis: an emerging global epidemic

Chotirmall, S. H. & Chalmers, J. D., 22 May 2018, In : BMC Pulmonary Medicine. 18, 1, p. 1-3 3 p., 76.

Research output: Contribution to journalEditorial

Open Access
File
6 Citations (Scopus)
125 Downloads (Pure)

Bronchiectasis: Phenotyping a Complex Disease

Chalmers, J. D., 17 Mar 2017, In : COPD. 14, Suppl.1, p. S12-S18 7 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
154 Downloads (Pure)

Bronchiectasis and COPD Overlap: A Case of Mistaken Identity?

Chalmers, J. D., Jun 2017, In : Chest. 151, 6, p. 1204-1206 3 p.

Research output: Contribution to journalEditorial

11 Citations (Scopus)

Bronchiectasis Exacerbations Are Heart-Breaking

Chalmers, J. D., 1 Mar 2018, In : Annals of the American Thoracic Society. 15, 3, p. 301-303 3 p.

Research output: Contribution to journalEditorial

Open Access
2 Citations (Scopus)

Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry

Dhar, R., Singh, S., Talwar, D., Mohan, M., Tripathi, S. K., Swarnakar, R., Trivedi, S., Rajagopala, S., D'Souza, G., Padmanabhan, A., Baburao, A., Mahesh, P. A., Ghewade, B., Nair, G., Jindal, A., Jayadevappa, G. D. H., Sawhney, H., Sarmah, K. R., Saha, K., Anantharaj, S. & 44 others, Khanna, A., Gami, S., Shah, A., Shah, A., Dutt, N., Garg, H., Vyas, S., Venugopal, K., Prasad, R., Aleemuddin, N. M., Karmakar, S., Singh, V., Jindal, S. K., Sharma, S., Prajapat, D., Chandrashekaria, S., McDonnell, M. J., Mishra, A., Rutherford, R., Ramanathan, R. P., Goeminne, P. C., Vasudev, P., Dimakou, K., Crichton, M. L., Jayaraj, B. S., Kungwani, R., Das, A., Sawhney, M., Polverino, E., Torres, A., Gulecha, N. S., Shteinberg, M., De Soyza, A., Mangala, A., Shah, P., Chauhan, N. K., Jajodia, N., Singhal, A., Batra, S., Hasan, A., Limaye, S., Salvi, S., Aliberti, S. & Chalmers, J. D., 1 Sep 2019, In : The Lancet Global Health. 7, 9, p. e1269-e1279 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
76 Downloads (Pure)

Bronchiectasis insanity: Doing the same thing over and over again and expecting different results?

Metersky, M. & Chalmers, J., 15 Mar 2019, In : F1000Research. 8, p. 1-7 7 p., 293.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
102 Downloads (Pure)

Bronchiectasis Management: The State of the Union

Chalmers, J. D. & Restrepo, M. I., Dec 2017, In : Chest. 152, 6, p. 1097-1099 3 p.

Research output: Contribution to journalEditorial

2 Citations (Scopus)

Bronchiectasis Rheumatoid Overlap Syndrome Is an Independent Risk Factor for Mortality in Patients With Bronchiectasis: A Multicenter Cohort Study

De Soyza, A., McDonnell, M. J., Goeminne, P. C., Aliberti, S., Lonni, S., Davison, J., Dupont, L. J., Fardon, T. C., Rutherford, R. M., Hill, A. T. & Chalmers, J. D., Jun 2017, In : Chest. 151, 6, p. 1247-1254 8 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
178 Downloads (Pure)

Bronchiectasis trials: losing the battle but winning the war?

Chalmers, J. D., Sep 2014, In : The Lancet Respiratory Medicine. 2, 9, p. 679-681 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a Multinational Point Prevalence Study of Hospitalised Patients

Restrepo, M. I., Babu, B. L., Reyes, L. F., Chalmers, J. D., Soni, N. J., Sibila, O., Faverio, P., Cilloniz, C., Rodriguez-Cintron, W. & Aliberti, S., 9 Aug 2018, In : European Respiratory Journal. 52, 2, 1701190.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
53 Downloads (Pure)

Burden of pneumococcal community-acquired pneumonia in adults across Europe: A literature review

Torres, A., Cillóniz, C., Blasi, F., Chalmers, J. D., Gaillat, J., Dartois, N., Schmitt, H-J. & Welte, T., Apr 2018, In : Respiratory Medicine. 137, p. 6-13 8 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

Cardiovascular disease as a complication of community-acquired pneumonia

Rae, N., Finch, S. & Chalmers, J. D., May 2016, In : Current Opinion in Pulmonary Medicine. 22, 3, p. 212-218 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies

Schembri, S., Williamson, P. A., Short, P. M., Singanayagam, A., Akram, A., Taylor, J., Singanayagam, A., Hill, A. T. & Chalmers, J. D., 22 Mar 2013, In : BMJ (Clinical Research Ed.). 346, 11 p., f1235.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Challenges in severe community-acquired pneumonia: a point-of-view review

Torres, A., Chalmers, J. D., Dela Cruz, C. S., Dominedò, C., Kollef, M., Martin-Loeches, I., Niederman, M. & Wunderink, R. G., Feb 2019, In : Intensive Care Medicine. 45, 2, p. 159-171 13 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Challenges in the development of new therapies for bronchiectasis

Chalmers, J. D., Loebinger, M. & Aliberti, S., Apr 2015, In : Expert Opinion on Pharmacotherapy. 16, 6, p. 833-850 18 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Changes in respiratory symptoms during 48 weeks treatment with ARD-3150 (inhaled liposomal ciprofloxacin) in bronchiectasis: results from the ORBIT-3 and -4 studies

Chalmers, J. D., Cipolla, D., Thompson, B., Davis, A. M., O'Donnell, A., Tino, G., Gonda, I., Haworth, C. & Froehlich, J., 18 Jun 2020, In : European Respiratory Journal. 55, 6

Research output: Contribution to journalArticle

Characterization of bronchiectasis in the elderly

Bellelli, G., Chalmers, J. D., Sotgiu, G., Dore, S., McDonnell, M. J., Goeminne, P. C., Dimakou, K., Skrbic, D., Lombi, A., Pane, F., Obradovic, D., Fardon, T. C., Rutherford, R. M., Pesci, A. & Aliberti, S., Oct 2016, In : Respiratory Medicine. 119, p. 13-19 7 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
281 Downloads (Pure)

Characterization of the “frequent exacerbator phenotype” in bronchiectasis

Chalmers, J. D., Aliberti, S., Filonenko, A., Shteinberg, M., Goeminne, P. C., Hill, A. T., Fardon, T. C., Obradovic, D., Gerlinger, C., Sotgiu, G., Operschall, E., Rutherford, R. M., Dimakou, K., Polverino, E., De Soyza, A. & McDonnell, M. J., 1 Jun 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 11, p. 1410-1420 11 p.

Research output: Contribution to journalArticle

Open Access
File
67 Citations (Scopus)
162 Downloads (Pure)