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  • Doreen Cantrell

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., 2 Sep 2014, In : PLoS ONE. 9, 9, 7 p., e106710.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
158 Downloads (Pure)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
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40 Citations (Scopus)
148 Downloads (Pure)

AMPKα1: a glucose sensor that controls CD8 T-cell memory

Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In : European Journal of Immunology. 43, 4, p. 889-896 8 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
112 Downloads (Pure)

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A., May 2013, In : Nature Immunology. 14, 5, p. 500-508 9 p.

Research output: Contribution to journalArticle

353 Citations (Scopus)

Control of amino-acid transport coordinates metabolic reprogramming in T cell malignancy

Grzes, K. M., Swamy, M., Hukelmann, J. L., Emslie, E., Sinclair, L. V. & Cantrell, D. A., 26 May 2017, In : Leukemia. 31, p. 2771-2779 9 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
143 Downloads (Pure)
Open Access
2 Citations (Scopus)

Environmental and metabolic sensors that control T cell biology

Ramsay, G. & Cantrell, D., 2015, In : Frontiers in Immunology. 6, 8 p., 99.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A., Jun 2016, In : Nature Immunology. 17, 6, p. 712-720 9 p.

Research output: Contribution to journalArticle

Open Access
File
109 Citations (Scopus)
167 Downloads (Pure)

ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation

Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M., 17 Feb 2015, In : Immunity. 42, 2, p. 239-251 13 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs

Rollings, C., Sinclair, L., Brady, H. J. M., Cantrell, D. & Ross, S., 17 Apr 2018, In : Science Signaling. 11, 526, p. 1-16 16 p., eaap8112.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
219 Downloads (Pure)

LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

Zarrouk, M., Rolf, J. & Cantrell, D. A., 22 Mar 2013, In : PLoS ONE. 8, 3, 9 p., e60217.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Mathematical models for immunology: current state of the art and future research directions

Eftimie, R., Gillard, J. J. & Cantrell, D. A., Oct 2016, In : Bulletin of Mathematical Biology. 78, 10, p. 2091-2134 44 p.

Research output: Contribution to journalReview article

Open Access
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54 Citations (Scopus)
167 Downloads (Pure)

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. & Maini, M. K., 11 May 2015, In : Nature Medicine. 21, 6, p. 591-600 10 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

Metabolism, migration and memory in cytotoxic T cells

Finlay, D. & Cantrell, D. A., Feb 2011, In : Nature Reviews Immunology. 11, 2, p. 109-117 9 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Move to metabolism

Cantrell, D. A., 29 Mar 2019, In : Nature Reviews Immunology. 19, 1 p., 270.

Research output: Contribution to journalComment/debate

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A., 17 Dec 2012, In : Journal of Experimental Medicine. 209, 13, p. 2441-2453 13 p.

Research output: Contribution to journalArticle

Open Access
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289 Citations (Scopus)
345 Downloads (Pure)

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K., Atrih, A., Foretz, M., Viollet, B., Lamont, D. J., Cantrell, D. A. & Hardie, D. G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4 15 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
126 Downloads (Pure)

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8+ T Cells

Ross, S. H., Rollings, C., Anderson, K. E., Hawkins, P. T., Stephens, L. R. & Cantrell, D. A., 20 Sep 2016, In : Immunity. 45, 3, p. 685-700 16 p.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
271 Downloads (Pure)

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

Navarro, M. N., Goebel, J., Feijoo-Carnero, C., Morrice, N. & Cantrell, D. A., Apr 2011, In : Nature Immunology. 12, 4, p. 352-361 11 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Potent and selective chemical probe of hypoxic signaling downstream of HIF-α hydroxylation via VHL inhibition

Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4 Nov 2016, In : Nature Communications. 7, p. 1-12 12 p., 13312.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
144 Downloads (Pure)

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

Macintyre, A. N., Finlay, D., Preston, G., Sinclair, L. V., Waugh, C. M., Tamas, P., Feijoo, C., Okkenhaug, K. & Cantrell, D. A., 25 Feb 2011, In : Immunity. 34, 2, p. 224-236 13 p.

Research output: Contribution to journalArticle

File
169 Citations (Scopus)
244 Downloads (Pure)

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2

Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D. & Poole, A. W., 14 Jul 2011, In : Blood. 118, 2, p. 416-424 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A., 15 Mar 2012, In : Biochemical Journal. 442, 3, p. 649-659 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8+ T cells

Navarro, M. N., Feijoo-Carnero, C., Gonzalez Arandilla, A., Trost, M. & Cantrell, D. A., 21 Oct 2014, In : Science Signaling. 7, 348, 12 p., ra99.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

Matthews, S. A., Lek, H. S., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C., May 2012, In : European Journal of Immunology. 42, 5, p. 1316-1326 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Open Access
File
5 Citations (Scopus)
31 Downloads (Pure)
Open Access
File
13 Citations (Scopus)
16 Downloads (Pure)

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A., Dec 2014, In : Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
155 Downloads (Pure)

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, Liu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journalMeeting abstract

Serine-threonine kinases in TCR signaling

Navarro, M. N. & Cantrell, D. A., Sep 2014, In : Nature Immunology. 15, 9, p. 808-814 7 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Signaling and Function of Interleukin-2 in T Lymphocytes

Ross, S. H. & Cantrell, D. A., 26 Apr 2018, In : Annual Review of Immunology. 36, p. 411-433 23 p.

Research output: Contribution to journalArticle

Open Access
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53 Citations (Scopus)
180 Downloads (Pure)

Signaling in lymphocyte activation

Cantrell, D., Jun 2015, In : Cold spring harbor perspectives in biology. 7, 6, 14 p., a018788.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Single cell analysis of kynurenine and System L amino acid transport in T cells

Sinclair, L., Neyens, D., Ramsay, G., Taylor, P. & Cantrell, D., 17 May 2018, In : Nature Communications. 9, 1, 11 p., 1981 (2018).

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
133 Downloads (Pure)

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A., 4 Aug 2015, In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

Research output: Contribution to journalArticle

Open Access
58 Citations (Scopus)

System L amino acid transporter 1 (slc7a5) expression is crucial for T cell blastogenesis

Sinclair, L. V., Taylor, P. M. & Cantrell, D. A., Sep 2012, In : Immunology. 137, s1, p. 347-347 1 p.

Research output: Contribution to journalMeeting abstract

The active inner life of naïve T cells

Marchingo, J. M. & Cantrell, D. A., Aug 2020, In : Nature Immunology. 21, p. 827-828 2 p.

Research output: Contribution to journalArticle

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

Schweighoffer, E., Vanes, L., Nys, J., Cantrell, D., McCleary, S., Smithers, N. & Tybulewicz, V. L. J., 21 Mar 2013, In : Immunity. 38, 3, p. 475-488 14 p.

Research output: Contribution to journalArticle

Open Access
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113 Citations (Scopus)
91 Downloads (Pure)

The coordination of T-cell function by serine/threonine kinases

Finlay, D. & Cantrell, D., Jan 2011, In : Cold spring harbor perspectives in biology. 3, 1, p. - 10 p., a002261.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The cytotoxic T cell proteome and its shaping by the kinase mTOR

Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A., Jan 2016, In : Nature Immunology. 17, 1, p. 104-112 9 p.

Research output: Contribution to journalArticle

Open Access
File
85 Citations (Scopus)
220 Downloads (Pure)

The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A., 2013, In : PLoS ONE. 8, 10, 16 p., e77537.

Research output: Contribution to journalArticle

12 Citations (Scopus)