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  • Angus Lamond

Advancing cell biology through proteomics in space and time (PROSPECTS)

Lamond, A. I., Uhlen, M., Horning, S., Makarov, A., Robinson, C. V., Serrano, L., Hartl, F. U., Baumeister, W., Werenskiold, A. K., Andersen, J. S., Vorm, O., Linial, M., Aebersold, R. & Mann, M., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

50 Citations (Scopus)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
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40 Citations (Scopus)
147 Downloads (Pure)

Analysis of human protein replacement stable cell lines established using snoMEN-PR vector

Ono, M., Yamada, K., Endo, A., Avolio, F. & Lamond, A. I., 25 Apr 2013, In : PLoS ONE. 8, 4, 12 p., e62305.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
114 Downloads (Pure)

Analysis of mass spectrometry data for nucleolar proteomics experiments

Nicolas, A., Bensaddek, D. & Lamond, A. I., 2016, The nucleolus: methods and protocols. Németh, A. (ed.). New York: Springer , p. 263-276 14 p. (Methods in molecular biology; vol. 1455).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Liakath-Ali, K., Mills, E. W., Sequeira, I., Lichtenberger, B. M., Pisco, A. O., Sipilä, K. H., Mishra, A., Yoshikawa, H., Wu, C. C-C., Ly, T., Lamond, A. I., Adham, I. M., Green, R. & Watt, F. M., 11 Apr 2018, In : Nature. 556, p. 376-380 5 p.

Research output: Contribution to journalLetter

Open Access
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16 Citations (Scopus)
255 Downloads (Pure)

An intranucleolar body associated with rDNA

Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. & Lamond, A. I., Oct 2011, In : Chromosoma. 120, 5, p. 481-499 19 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
112 Downloads (Pure)

A perspective on proteomics in cell biology

Ahmad, Y. & Lamond, A. I., Apr 2014, In : Trends in Cell Biology. 24, 4, p. 257-264 8 p.

Research output: Contribution to journalReview article

Open Access
25 Citations (Scopus)

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

Mishra, A., Oulès, B., Pisco, A. O., Ly, T., Liakath-Ali, K., Walko, G., Viswanathan, P., Tihy, M., Nijjhar, J., Dunn, S-J., Lamond, A. I. & Watt, F. M., 18 Oct 2017, In : eLife. 6, p. 1-20 20 p., e27356.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
223 Downloads (Pure)

A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells

Ly, T., Ahmad, Y., Shlien, A., Soroka, D., Mills, A., Emanuele, M. J., Stratton, M. R. & Lamond, A. I., 4 Mar 2014, In : eLife. 2014, 3, e01630.

Research output: Contribution to journalArticle

Open Access
File
72 Citations (Scopus)
114 Downloads (Pure)

A quantitative spatial proteomics analysis of proteome turnover in human cells

Boisvert, F-M., Ahmad, Y., Gierlinski, M., Charrière, F., Lamont, D., Scott, M., Barton, G. & Lamond, A. I., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3, M111.011429.

Research output: Contribution to journalArticle

214 Citations (Scopus)

A role for SUMOylation in snoRNP biogenesis revealed by quantitative proteomics

Westman, B. J. & Lamond, A. I., 1 Jan 2011, In : Nucleus. 2, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II

Hutten, S., Chachami, G., Winter, U., Melchior, F. & Lamond, A. I., 1 Mar 2014, In : Journal of Cell Science. 127, 5, p. 1065-1078 14 p.

Research output: Contribution to journalArticle

Open Access
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28 Citations (Scopus)
209 Downloads (Pure)
Open Access
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6 Citations (Scopus)
178 Downloads (Pure)

Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes

McCarthy, D. J., Rostom, R., Huang, Y., Kunz, D. J., Danecek, P., Bonder, M. J., Hagai, T., Lyu, R., Wang, W., Gaffney, D. J., Simons, B. D., Stegle, O. & Teichmann, S. A., 16 Mar 2020, In : Nature Methods. 17, 4, p. 414-421 8 p.

Research output: Contribution to journalArticle

CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

Ortmann, B., Bensaddek, D., Carvalhal, S., Moser, S. C., Mudie, S., Griffis, E. R., Swedlow, J. R., Lamond, A. I. & Rocha, S., Jan 2016, In : Journal of Cell Science. 129, 1, p. 191-205 15 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
198 Downloads (Pure)

Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP

Pawellek, A., Ryder, U., Tammsalu, T., King, L. J., Kreinin, H., Ly, T., Hay, R. T., Hartley, R. & Lamond, A., 8 Sep 2017, In : eLife. 6, e27402.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
152 Downloads (Pure)

Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway

Larance, M., Kirkwood, K. J., Xirodimas, D. P., Lundberg, E., Uhlen, M. & Lamond, A. I., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

17 Citations (Scopus)

Characterization of Native Protein Complexes and Protein Isoform Variation Using Size-fractionation-based Quantitative Proteomics

Kirkwood, K. J., Ahmad, Y., Larance, M. & Lamond, A. I., 1 Dec 2013, In : Molecular & Cellular Proteomics. 12, 12, p. 3851-3873 23 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Cleaning up the masses: Exclusion lists to reduce contamination with HPLC-MS/MS

Hodge, K., Ten Have, S., Hutton, L. & Lamond, A. I., 2 Aug 2013, In : Journal of Proteomics. 88, p. 92-103 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Common genetic variation drives molecular heterogeneity in human iPSCs

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., Danecek, P., Faulconbridge, A., Harrison, P. W., Kathuria, A., McCarthy, D. J., McCarthy, S. A., Meleckyte, R., Memari, Y., Moens, N., Soares, F. & 23 others, Mann, A., Streeter, I., Agu, C. A., Alderton, A., Nelson, R., Harper, S., Patel, M., White, A., Patel, S. R., Clarke, L., Halai, R., Kirton, C. M., Kolb-Kokocinski, A., Beales, P. L., Birney, E., Danovi, D., Lamond, A. I., Ouwehand, W. H., Vallier, L., Watt, F. M., Durbin, R., Stegle, O. & Gaffney, D. J., 15 Jun 2017, In : Nature. 546, 7658, p. 370-375 6 p.

Research output: Contribution to journalArticle

Open Access
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137 Citations (Scopus)
151 Downloads (Pure)
Open Access
File
5 Citations (Scopus)
169 Downloads (Pure)

Composition of the Survival Motor Neuron (SMN) complex in Drosophila melanogaster

Matera, A. G., Raimer, A. C., Schmidt, C. A., Kelly, J. A., Droby, G. N., Baillat, D., Ten Have, S., Lamond, A. I., Wagner, E. J. & Gray, K. M., 1 Feb 2019, In : G3 : Genes, Genomes, Genetics. 9, 2, p. 491-503 13 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
130 Downloads (Pure)

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs (Nature (2017) 546 (370-375) DOI: 10.1038/nature22403)

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., Danecek, P., Faulconbridge, A., Harrison, P. W., Kathuria, A., McCarthy, D. J., McCarthy, S. A., Meleckyte, R., Memari, Y., Moens, N., Soares, F. & 23 others, Mann, A., Streeter, I., Agu, C. A., Alderton, A., Nelson, R., Harper, S., Patel, M., White, A., Patel, S. R., Clarke, L., Halai, R., Kirton, C. M., Kolb-Kokocinski, A., Beales, P. L., Birney, E., Danovi, D., Lamond, A., Ouwehand, W. H., Vallier, L., Watt, F. M., Durbin, R., Stegle, O. & Gaffney, D. J., 29 Jun 2017, In : Nature. 546, 7660, p. 686 1 p.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

Hegarat, N., Crncec, A., Suarez Peredoa Rodriguez, M. F., Iturra, F. E., Gu, Y., Busby, O., Lang, P. F., Barr, A. R., Bakal, C., Kanemaki, M. T., Lamond, A. I., Novak, B., Ly, T. & Hochegger, H., 2 Jun 2020, In : EMBO Journal. 39, 11, p. 1-23 23 p., e104419.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
35 Downloads (Pure)

Deep Proteome Analysis Identifies Age-Related Processes in C. elegans

Narayan, V., Ly, T., Pourkarimi, E., Brenes Murillo, A., Gartner, A., Lamond, A. & Kenyon, C., 24 Aug 2016, In : Cell Systems. 3, 2, p. 144-159 15 p.

Research output: Contribution to journalArticle

Open Access
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34 Citations (Scopus)
286 Downloads (Pure)

Efficient Analysis of Mammalian Polysomes in cells and tissues using Ribo Mega-SEC

Yoshikawa, H., Larance, M., Harney, D. J., Sundaramoorthy, R., Ly, T., Owen-Hughes, T. & Lamond, A. I., 10 Aug 2018, In : eLife. 7, 7, p. 1-26 26 p., e36530.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
133 Downloads (Pure)

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
9 Downloads (Pure)

Enhanced snoMEN Vectors Facilitate Establishment of GFP–HIF-1α Protein Replacement Human Cell Lines

Ono, M., Ono, K., Bensaddek, D., Afzal, V., Biddlestone, J., Ortmann, B., Mudie, S., Boivin, V., S. Scott, M., Rocha, S. & Lamond, A. I., 29 Apr 2016, In : PLoS ONE. 11, 4, 28 p., e0154759.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
179 Downloads (Pure)

Evaluating the use of HILIC in large-scale, multi dimensional proteomics: horses for courses?

Bensaddek, D., Nicolas, A. & Lamond, A. I., 30 Nov 2015, In : International Journal of Mass Spectrometry. 391, p. 105-114 10 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
154 Downloads (Pure)

Exo70, a subunit of the exocyst complex, interacts with SNEVhPrp19/hPso4 and is involved in pre-mRNA splicing

Dellago, H., Löscher, M., Ajuh, P., Ryder, U., Kaisermayer, C., Grillari-Voglauer, R., Fortschegger, K., Gross, S., Gstraunthaler, A., Borth, N., Eisenhaber, F., Lamond, A. I. & Grillari, J., 15 Aug 2011, In : Biochemical Journal. 438, p. 81-91 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

FMDV replicons encoding green fluorescent protein are replication competent

Tulloch, F., Pathania, U., Luke, G. A., Nicholson, J., Stonehouse, N. J., Rowlands, D. J., Jackson, T., Tuthill, T., Haas, J., Lamond, A. I. & Ryan, M. D., 1 Dec 2014, In : Journal of Virological Methods. 209, p. 35-40 6 p.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
125 Downloads (Pure)

FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21

Yamada, K., Ono, M., Bensaddek, D., Lamond, A. I. & Rocha, S., 1 Aug 2013, In : Cell cycle (Georgetown, Tex.). 12, 15, p. 2348-2354 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 9 Sep 2019, In : Wellcome Open Research. 4, p. 134 28 p.

Research output: Contribution to journalArticle

Open Access
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61 Downloads (Pure)

Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling

Larance, M., Kirkwood, K. J., Tinti, M., Brenes Murillo, A., Ferguson, M. & Lamond, A., 1 Jul 2016, In : Molecular & Cellular Proteomics. 15, 7, p. 2476-2490 15 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
123 Downloads (Pure)

Global proteomics analysis of the response to starvation in C. elegans

Larance, M., Pourkarimi, E., Wang, B., Brenes Murillo, A., Kent, R., Lamond, A. I. & Gartner, A., 1 Jul 2015, In : Molecular & Cellular Proteomics. 14, 7, p. 1989-2001 13 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
169 Downloads (Pure)

Global subcellular characterization of protein degradation using quantitative proteomics

Larance, M., Ahmad, Y., Kirkwood, K. J., Ly, T. & Lamond, A. I., Mar 2013, In : Molecular & Cellular Proteomics. 12, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies

Drakou, C. E., Malekkou, A., Hayes, J. M., Lederer, C. W., Leonidas, D. D., Oikonomakos, N. G., Lamond, A. I., Santama, N. & Zographos, S. E., Jan 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 1, p. 206-220 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Human box C/D snoRNA processing conservation across multiple cell types

Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I., Apr 2012, In : Nucleic Acids Research. 40, 8, p. 3676-3688 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation

Hiraga, S., Ly, T., Garzón, J., Hořejší, Z., Ohkubo, Y., Endo, A., Obuse, C., Boulton, S. J., Lamond, A. & Donaldson, A. D., 1 Mar 2017, In : EMBO Reports. 18, 3, p. 403-419 17 p.

Research output: Contribution to journalArticle

Open Access
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44 Citations (Scopus)
130 Downloads (Pure)

Identification and functional characterization of FMN2: a regulator of the cyclin-dependent kinase Inhibitor p21

Yamada, K., Ono, M., Perkins, N. D., Rocha, S. & Lamond, A. I., Mar 2013, In : Molecular Cell. 49, 5, p. 922-933 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Identification of human miRNA precursors that resemble box C/D snoRNAs

Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. & Lamond, A. I., May 2011, In : Nucleic Acids Research. 39, 9, p. 3879-3891 13 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Identification of small molecule inhibitors of pre-mRNA splicing

Pawallek, A., McElroy, S., Samatov, T., Mitchell, L., Woodland, A., Ryder, U., Gray, D., Lührmann, R. & Lamond, A. I., 6 Mar 2015, In : Journal of Biological Chemistry. 290, 10, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2 Citations (Scopus)

Identification of small molecule inhibitors of pre-mRNA splicing

Pawellek, A., McElroy, S., Samatov, T., Mitchell, L., Woodland, A., Ryder, U., Gray, D., Lührmann, R. & Lamond, A. I., 12 Dec 2014, In : Journal of Biological Chemistry. 289, 50, p. 34683-34698 16 p.

Research output: Contribution to journalArticle

Open Access
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38 Citations (Scopus)
254 Downloads (Pure)

Inhibition of Pre-mRNA Splicing by a Synthetic Blom7α-Interacting Small RNA

Löscher, M., Schosserer, M., Dausse, E., Lee, K., Ajuh, P. M., Grillari-Voglauer, R., Lamond, A. I., Toulmé, J. J. & Grillari, J., 29 Oct 2012, In : PLoS ONE. 7, 10, 9 p., e47497.

Research output: Contribution to journalArticle

Open Access

Mass spectrometry-based immuno-precipitation proteomics - The user's guide

ten Have, S., Boulon, S., Ahmad, Y. & Lamond, A. I., Mar 2011, In : Proteomics. 11, 6, p. 1153-1159 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Micro-proteomics with iterative data analysis: proteome analysis in C.elegans at the single worm level

Bensaddek, D., Narayan, V., Nicolas, A., Brenes Murillo, A., Gartner, A., Kenyon, C. & Lamond, A., 10 Feb 2016, In : Proteomics. 16, 3, p. 381-392

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
133 Downloads (Pure)

Modulation of higher order chromatin conformation in mammalian cell nuclei can be mediated by polyamines and divalent cations

Visvanathan, A., Ahmed, K., Even-Faitelson, L., Lleres, D., Bazett-Jones, D. P. & Lamond, A. I., 2013, In : PLoS ONE. 8, 6, 16 p., e67689.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Multi-batch TMT reveals false positives, batch effects and missing values

Brenes Murillo, A., Hukelmann, J., Bensaddek, D. & Lamond, A., 1 Oct 2019, In : Molecular and Cellular Proteomics. 18, 10, p. 1967-1980 14 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
10 Downloads (Pure)

Multidimentional proteomics for cell biology

Larance, M. & Lamond, A. I., May 2015, In : Nature Reviews Molecular Cell Biology. 16, 5, p. 269-280 12 p.

Research output: Contribution to journalArticle

Open Access
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206 Citations (Scopus)
282 Downloads (Pure)