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Author

  • John Hayes

3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention

Nagle, A. A., Reddy, S. A., Bertrand, H., Tajima, H., Dang, T-M., Wong, S-C., Hayes, J. D., Wells, G. & Chew, E-H., 2014, In : ChemMedChem. 9, 8, p. 1763-1774 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics

Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., Hayes, J. & Park, B. K., 2012, In : Pharmacological Reports. 64, 3, p. 680-697 18 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

Gan, F-F., Leng, H., Ang, X., Reddy, S. A., Lee, S. S-H., Yang, H., Tan, S-H., Hayes, J. D., Chui, W-K. & Chew, E-H., 1 Nov 2013, In : Toxicology and Applied Pharmacology. 272, 3, p. 852-862 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

A partnership with the proteasome: the destructive nature of GSK3

Robertson, H., Hayes, J. D. & Sutherland, C., Jan 2018, In : Biochemical Pharmacology. 147, p. 77-92 16 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
187 Downloads (Pure)

Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice

Crawford, D. R., Ilic, Z., Guest, I., Milne, G. L., Hayes, J. D. & Sell, S., Jul 2017, In : Carcinogenesis. 38, 7, p. 717-727 11 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
138 Downloads (Pure)

Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In : British Journal of Cancer. 117, 1 p., e1.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In : Oncogene. 36, 44, p. 6204-6212 9 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
215 Downloads (Pure)
55 Citations (Scopus)
Open Access
File
6 Citations (Scopus)
276 Downloads (Pure)
Open Access
File
42 Citations (Scopus)
145 Downloads (Pure)

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

Gupta, K., Patani, R., Baxter, P., Serio, A., Story, D., Tsujita, T., Hayes, J. D., Pedersen, R. A., Hardingham, G. E. & Chandran, S., May 2012, In : Cell Death & Differentiation. 19, 5, p. 779-787 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2 Citations (Scopus)

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

Research output: Contribution to journalArticle

305 Citations (Scopus)

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

Higgins, L. G. & Hayes, J. D., May 2011, In : Drug Metabolism Reviews. 43, 2, p. 92-137 46 p.

Research output: Contribution to journalReview article

127 Citations (Scopus)

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., Hayes, J. D. & Hardingham, G. E., 4 Jan 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 1, p. E1-E2 2 p.

Research output: Contribution to journalLetter

92 Citations (Scopus)

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M. A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., Bilican, B., Chowdhry, S., Meakin, P. J., Ashford, M. L. J., Wyllie, D. J. A., Scannevin, R. H., Chandran, S., Hayes, J. D. & Hardingham, G. E., 13 May 2015, In : Nature Communications. 6, 15 p., 7066.

Research output: Contribution to journalArticle

75 Citations (Scopus)

New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology

Pi, J., Hayes, J. D. & Yamamoto, M., 15 Mar 2019, In : Toxicology and Applied Pharmacology. 367, p. 33-35 3 p.

Research output: Contribution to journalEditorial

Open Access
File
2 Citations (Scopus)
87 Downloads (Pure)

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A. & Hayes, J. D., 2012, In : Oncogene. 32, p. 3765-3781 17 p.

Research output: Contribution to journalArticle

263 Citations (Scopus)

Nrf2-mediated induction of antioxidant response element-driven gene expression by flavonoids is dependent on their chemical structure

Xiao, H., Hourihan, J. M., Brown, L., McMahon, M., Stewart, D. & Hayes, J. D., 18 Dec 2011, In : Toxicology. 290, 2-3, p. 126-127 2 p.

Research output: Contribution to journalBook/Film/Article review

Open Access
File
15 Citations (Scopus)
137 Downloads (Pure)

Nrf2 orchestrates fuel partitioning for cell proliferation

Hayes, J. D. & Ashford, M. L. J., 2012, In : Cell Metabolism. 16, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 in astrocytes

Deighton, R. F., Márkus, N. M., Al-Mubarak, B., Bell, K. F. S., Papadia, S., Meakin, P. J., Chowdhry, S., Hayes, J. & Hardingham, G. E., 2014, In : Proceedings of the National Academy of Sciences USA. 111, 18, p. E1818-1820 3 p., 24753562.

Research output: Contribution to journalLetter

15 Citations (Scopus)
Open Access
File
8 Citations (Scopus)
200 Downloads (Pure)

Oxidative Stress in Cancer

Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 9 Jul 2020, In : Cancer Cell. 38, 31 p.

Research output: Contribution to journalReview article

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction

Hancock, R., Bertrand, H. C., Tsujita, T., Naz, S., El-Bakry, A., Laoruchupong, J., Hayes, J. D. & Wells, G., 15 Jan 2012, In : Free Radical Biology and Medicine. 52, 2, p. 444-451 8 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Phosphoinositide 3-kinases upregulate system xc- via eukaryotic initiation factor 2α and activating transcription factor 4-A pathway active in glioblastomas and epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M-A., Halatsch, M-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., Aronica, E., Smolders, I., Ludolph, A. C., Methner, A., Conrad, M., Massie, A., Hardingham, G. E. & Maher, P., 28 May 2014, In : Antioxidants & Redox Signaling. 20, 18, p. 2907-2922 16 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In : Current Opinion in Toxicology. 1, p. 92-103 12 p.

Research output: Contribution to journalReview article

Open Access
File
9 Citations (Scopus)
314 Downloads (Pure)

RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

Wang, H., Liu, K., Geng, M., Gao, P., Wu, X., Hai, Y., Li, Y., Li, Y., Luo, L., Hayes, J. D., Wang, X. J. & Tang, X., 2013, In : Cancer Research. 73, 10, p. 3097-3108 12 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D. & Cuadrado, A., Mar 2011, In : Molecular and Cellular Biology. 31, 6, p. 1121-1133 13 p.

Research output: Contribution to journalArticle

355 Citations (Scopus)

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP Axis

Rada, P., Rojo, A. I., Evrard-Todeschi, N., Innamorato, N. G., Cotte, A., Jaworski, T., Tobón-Velasco, J. C., Devijver, H., García-Mayoral, M. F., Van Leuven, F., Hayes, J. D., Bertho, G. & Cuadrado, A., 2012, In : Molecular and Cellular Biology. 32, 17, p. 3486-99 14 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)
93 Citations (Scopus)
248 Downloads (Pure)

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Agathanggelou, A., Weston, V. J., Perry, T., Davies, N. J., Skowronska, A., Payne, D. T., Fossey, J. S., Oldreive, C. E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, S. J., Hole, P. S., Darley, R. L., McMahon, M., Hayes, J. D., Moss, P., Stewart, G., Taylor, A. M. R. & 1 others, Stankovic, T., Aug 2015, In : Haematologica. 100, 8, p. 1076-1085 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
95 Citations (Scopus)

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

O'Connell, M. A. & Hayes, J. D., Aug 2015, In : Biochemical Society Transactions. 43, 4, p. 687-689 3 p.

Research output: Contribution to journalArticle

Open Access
File
93 Citations (Scopus)
265 Downloads (Pure)
24 Citations (Scopus)
759 Citations (Scopus)

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
File
134 Citations (Scopus)
204 Downloads (Pure)

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

Zhang, Y., Li, S., Xiang, Y., Qiu, L., Zhao, H. & Hayes, J. D., 13 Aug 2015, In : Scientific Reports. 5, 30 p., 12983.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
273 Downloads (Pure)

Transcription factor Nrf1 Is topologically repartitioned across membranes to enable target gene transactivation through Its acidic glucose-responsive domains

Zhang, Y., Ren, Y., Li, S. & Hayes, J. D., Apr 2014, In : PLoS ONE. 9, 4, 17 p., e93458.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
76 Downloads (Pure)

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

Tsujita, T., Peirce, V., Baird, L., Matsuyama, Y., Takaku, M., Walsh, S. V., Griffin, J. L., Uruno, A., Yamamoto, M. & Hayes, J. D., Oct 2014, In : Molecular and Cellular Biology. 34, 20, p. 3800-3816 17 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
Open Access
File
7 Citations (Scopus)
147 Downloads (Pure)