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  • Philip Cohen

ABIN1 dysfunction as a genetic basis for lupus nephritis

Caster, D. J., Korte, E. A., Nanda, S. K., McLeish, K. R., Oliver, R. K., G'Sell, R. T., Sheehan, R. M., Freeman, D. W., Coventry, S. C., Kelly, J. A., Guthridge, J. M., James, J. A., Sivils, K. L., Alarcon-Riquelme, M. E., Scofield, R. H., Adrianto, I., Gaffney, P. M., Stevens, A. M., Freedman, B. I., Langefeld, C. D. & 25 others, Tsao, B. P., Pons-Estel, B. A., Jacob, C. O., Kamen, D. L., Gilkeson, G. S., Brown, E. E., Alarcon, G. S., Edberg, J. C., Kimberly, R. P., Martin, J., Merrill, J. T., Harley, J. B., Kaufman, K. M., Reveille, J. D., Anaya, J. M., Criswell, L. A., Vila, L. M., Petri, M., Ramsey-Goldman, R., Bae, S. C., Boackle, S. A., Vyse, T. J., Niewold, T. B., Cohen, P. & Powell, D. W., 1 Nov 2013, In : Journal of the American Society of Nephrology. 24, 11, p. 1743-1754 12 p.

Research output: Contribution to journalArticle

Open Access
49 Citations (Scopus)

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. & Cohen, P., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3373-3382 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P., 17 Sep 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

Research output: Contribution to journalArticle

Open Access
File
219 Citations (Scopus)
138 Downloads (Pure)
Open Access
File
6 Citations (Scopus)
347 Downloads (Pure)

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P., 1 Aug 2014, In : Biochemical Journal. 461, 3, p. 531-537 7 p.

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
174 Downloads (Pure)

Bill Whelan's impact on my life and career

Cohen, P., Dec 2015, In : Molecular Aspects of Medicine. 46, p. 11-13 3 p.

Research output: Contribution to journalReview article

DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P., 23 Aug 2013, In : Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
137 Downloads (Pure)

Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

Tan, L., Nomanbhoy, T., Gurbani, D., Patricelli, M., Hunter, J., Geng, J., Herhaus, L., Zhang, J., Pauls, E., Ham, Y., Choi, H. G., Xie, T., Deng, X., Buhrlage, S. J., Sim, T., Cohen, P., Sapkota, G., Westover, K. D. & Gray, N. S., 8 Jan 2015, In : Journal of Medicinal Chemistry. 58, 1, p. 183-196 14 p.

Research output: Contribution to journalArticle

Open Access
36 Citations (Scopus)

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

Nanda, S. K., Petrova, T., Marchesi, F., Gierlinski, M., Razsolkov, M., Lee, K. L., Wright, S. W., Rao, V. R., Cohen, P. & Arthur, J. S. C., 1 Dec 2019, In : Life Science Alliance. 2, 6, 19 p., e201900533.

Research output: Contribution to journalArticle

Open Access
File
21 Downloads (Pure)

Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P., 1 Jun 2012, In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist, L., Jevnikar, Z., Riise, R., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S., Mattsson, J., Nanda, S., Cohen, P., Knebel, A., Arthur, S., Thörn, K., Svenungsson, E., Jönsen, A., Gunnarsson, I., Tandre, K., Alexsson, A., Kastbom, A. & 10 others, Rantapää-Dahlqvist, S., Eloranta, M-L., Syvänen, A-C., Bengtsson, A., Johansson, P., Sandling, J. K., Sjöwall, C., Rönnblom, L., Collins, B. & Vaarala, O., 1 Oct 2019, In : Annals of the Rheumatic Diseases. 78, 10, p. 1363-1370 8 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
284 Downloads (Pure)

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

Yang, G., Buhrlage, S., Tan, L., Liu, X., Chen, J., Xu, L., Tsakmaklis, N., Chen, J. G., Patterson, C. J., Brown, J. R., Castillo, J. J., Zhang, W., Zhang, X., Liu, S., Cohen, P., Hunter, Z. R., Gray, N. S. & Treon, S. P., 23 Jun 2016, In : Blood. 127, 25, p. 3237-3252 16 p.

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
149 Downloads (Pure)
Open Access
1 Citation (Scopus)

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β

Bakshi, S., Taylor, J., Strickson, S., Macartney, T. & Cohen, P., 15 Mar 2017, In : Biochemical Journal. 474, 7, p. 1163-1174 12 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
293 Downloads (Pure)

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P., 1 Jan 2012, In : Biochemical Journal. 441, p. 339-346 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Immune diseases caused by mutations in kinases and components of the ubiquitin system

Cohen, P., Jun 2014, In : Nature Immunology. 15, 6, p. 521-529 9 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3

Zhang, J., Macartney, T., Peggie, M. & Cohen, P., 26 Jul 2017, In : Biochemical Journal. 474, 13, p. 2235-2248 16 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
152 Downloads (Pure)

IRAK-1 bypasses priming and directly links TLRs torapid NLRP3 inflammasome activation

Lin, K. M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A. & Pasare, C., 14 Jan 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. 775-780 6 p.

Research output: Contribution to journalArticle

Open Access
109 Citations (Scopus)

Kinase drug discovery: What's next in the field?

Cohen, P. & Alessi, D. R., 2013, In : ACS Chemical Biology. 8, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

252 Citations (Scopus)

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling.

Emmerich, C., Bakshi, S., Kelsall, I., Ortiz-Guerrero, J., Shpiro, N. & Cohen, P., 3 Jun 2016, In : Biochemical and Biophysical Research Communications. 474, 3, p. 452-461 10 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
186 Downloads (Pure)

Molecular control of the NEMO family of ubiquitin-binding proteins

Clark, K., Nanda, S. & Cohen, P., 2013, In : Nature Reviews Molecular Cell Biology. 14, p. 673-685 13 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Novel cross-talk within the IKK family controls innate immunity

Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P., 15 Feb 2011, In : Biochemical Journal. 434, p. 93-104 12 p.

Research output: Contribution to journalArticle

160 Citations (Scopus)
Open Access
44 Citations (Scopus)

Optineurin negatively regulates osteoclast differentiation by modulating NF-κB and interferon signaling: implications for Paget's disease

Obaid, R., Wani, S. E., Azfer, A., Hurd, T., Jones, R., Cohen, P., Ralston, S. H. & Albagha, O. M. E., 10 Nov 2015, In : Cell Reports. 13, 6, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
143 Downloads (Pure)

p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

Tiedje, C., Lubas, M., Tehrani, M., Menon, M. B., Ronkina, N., Rousseau, S., Cohen, P., Kotlyarov, A. & Gaestel, M., Feb 2015, In : RNA: a Publication of the RNA Society. 21, 2, p. 262-278 17 p.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P., 2012, In : Journal of Biological Chemistry. 287, 41, p. 34825-34835 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91 6 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

Nanda, S. K., Venigalla, R. K. C., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S. C. & Cohen, P., 6 Jun 2011, In : Journal of Experimental Medicine. 208, 6, p. 1215-1228 14 p.

Research output: Contribution to journalArticle

Open Access
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88 Citations (Scopus)
226 Downloads (Pure)

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon beta

Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C. & Cohen, P., 14 Oct 2011, In : Journal of Biological Chemistry. 286, 41, p. 35663-35674 12 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

Lopez Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S. & Cohen, P., 9 Dec 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17432-17437 6 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

Strickson, S., Emmerich, C. H., Goh, E. T. H., Zhang, J., Kelsall, I. R., Macartney, T., Hastie, C. J., Knebel, A., Peggie, M., Marchesi, F., Arthur, J. S. C. & Cohen, P., 25 Apr 2017, In : Proceedings of the National Academy of Sciences. 114, 7, p. E3481-E3489 9 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
162 Downloads (Pure)

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

Hutchinson, L. D., Darling, N. J., Nicolaou, S., Gori, L., Squair, D. R., Cohen, P., Hill, C. S. & Sapkota, G. P., 22 Jan 2020, In : Cell Death and Disease. 11, p. 1-17 17 p., 49.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
46 Downloads (Pure)

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P., 15 Jun 2015, In : Biochemical Journal. 468, 3, p. 363-372 10 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
Open Access
File
19 Citations (Scopus)
173 Downloads (Pure)

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P., Dec 2012, In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

TAK1 inhibition in the DFG-out conformation

Kilty, I., Green, M. P., Bell, A. S., Brown, D. G., Dodd, P. G., Hewson, C., Hughes, S. J., Phillips, C., Ryckmans, T., Smith, R. T., van Hoorn, W. P., Cohen, P. & Jones, L. H., 1 Nov 2013, In : Chemical Biology and Drug Design. 82, 5, p. 500-505 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

Krishnan, N., Bencze, G., Cohen, P. & Tonks, N. K., 2013, In : FEBS Journal. 280, 12, p. 2830-2841 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P., 1 May 2013, In : Biochemical Journal. 451, 3, p. 427-437 11 p.

Research output: Contribution to journalArticle

Open Access
File
97 Citations (Scopus)
140 Downloads (Pure)
Open Access
File
5 Citations (Scopus)
94 Downloads (Pure)

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P., 2012, In : PLoS ONE. 7, 6, e39132.

Research output: Contribution to journalArticle

119 Citations (Scopus)

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and TollLike receptor agonists

Vollmer, S., Strickson, S., Zhang, T., Gray, N., Lee, K., Rao, V. & Cohen, P., 6 Jun 2017, In : Biochemical Journal. 474, 12, p. 2027-2038 12 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
144 Downloads (Pure)

The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation

Thomas, Y., Scott, D. C., Kristariyanto, Y. A., Rinehart, J., Clark, K., Cohen, P. & Kurz, T., 29 Jun 2018, In : PLoS ONE. 13, 6, p. 1-19 19 p., e0199197.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
106 Downloads (Pure)

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., Buser-Doepner, C., Campbell, R. M., Carter, A. J., Cohen, P., Copeland, R. A., Cravatt, B., Dahlin, J. L., Dhanak, D., Edwards, A. M., Frederiksen, M. & 34 others, Frye, S. V., Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Roth, B., Ross, R., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N. & Zuercher, W. J., Aug 2015, In : Nature Chemical Biology. 11, 8, p. 536-541 6 p.

Research output: Contribution to journalComment/debate

Open Access
373 Citations (Scopus)

The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways

Cohen, P. & Strickson, S., May 2017, In : Cell Death & Differentiation. 24, p. 1153-1159 7 p.

Research output: Contribution to journalReview article

Open Access
File
22 Citations (Scopus)
157 Downloads (Pure)

The role of TBK1 and IKKε in the expression and activation of Pellino 1

Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F., 15 Mar 2011, In : Biochemical Journal. 434, p. 537-548 12 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

The TLR and IL-1 signalling network at a glance

Cohen, P., Jun 2014, In : Journal of Cell Science. 127, 11, p. 2383-2390 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
73 Citations (Scopus)
50 Citations (Scopus)

Ubiquitin chains as second messengers

Cohen, P., Apr 2018, In : Nature Reviews Molecular Cell Biology. 19, 4, 1 p., 212.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)