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  • Ewan Pearson

4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation

Sipeky, C., Llerena, A., Manolopoulos, V. G., Pearson, E., Mlakar, V., Gozzo, L., Simmaco, M., Marchetti, P., Re, M. D., Stankovic, S., Meyer, U., Cascorbi, I., Ingelman-Sundberg, M., Suarez-Kurtz, G., Marc, J., Katsila, T., Paulmichl, M., Nofziger, C., Ansari, M., Drago, F. & 1 others, van Schaik, R. H., Oct 2019, In : Pharmacogenomics. 20, 15, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

A common missense variant of LILRB5 is associated with statin intolerance: A GoDARTS study

Siddiqui, M. K., Veluchamy, A., Tavendale, R., Carr, F., Maroteau, C., Pearson, E. R., Looker, H. M., Morris, A. D., Dow, E., George, J., Doney, A. & Palmer, C. N. A., 6 Oct 2015.

Research output: Contribution to conferencePoster

A common missense variant of LILRB5 is associated with statin intolerance and myalgia

Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., Abelega, N-U., Carr, D., Bloch, K., Hallberg, P., Yue, Q-Y., Pearson, E. R., Colhoun, H., Morris, A. D., Dow, E., George, J., Pirmohamed, M., Ridker, P. M., Doney, A. S. F., Alfirevic, A. & 5 others, Wadelius, M., Maitland-van der Zee, A. H., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, 21 Dec 2017, In : European Heart Journal. 38, 48, p. 3569-3575 7 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
146 Downloads (Pure)

Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study

Connelly, P. J., Lonergan, M., Soto-Pedre, E., Donnelly, L., Zhou, K. & Pearson, E. R., 5 Jul 2017, In : Diabetes, Obesity & Metabolism. 19, 11, p. 1579-1586 7 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
164 Downloads (Pure)

Adherence to oral glucose-lowering therapies and associations with 1-year HbA1c: A retrospective cohort analysis in a large primary care database

Farmer, A. J., Rodgers, L. R., Lonergan, M., Shields, B., Weedon, M. N., Donnelly, L., Holman, R. R., Pearson, E. R. & Hattersley, A. T., 1 Feb 2016, In : Diabetes Care. 39, 2, p. 258-263 6 p.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
143 Downloads (Pure)

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts

van Leeuwen, N., Nijpels, G., Becker, M. L., Deshmukh, H., Zhou, K., Stricker, B. H. C., Uitterlinden, A. G., Hofman, A., van 't Riet, E., Palmer, C. N. A., Guigas, B., Slagboom, P. E., Durrington, P., Calle, R. A., Neil, A., Hitman, G., Livingstone, S. J., Colhoun, H., Holman, R. R., McCarthy, M. I. & 3 others, Dekker, J. M., 't Hart, L. M. & Pearson, E., 2012, In : Diabetologia. 55, 7, p. 1971-1977 7 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Wood, A. R., Jonsson, A., Jackson, A. U., Wang, N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., Stančáková, A., Boomsma, D. I., de Geus, E. J. C., Eekhoff, E. M. W., Fritsche, A., Kramer, M. H. H., Nijpels, G., Simonis-Bik, A. M. C., van Haeften, T. W., Mahajan, A. & 31 others, Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, K., Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, N., Eiberg, H., Pedersen, O., Chen, Y-D., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, T., Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M., 21 Jul 2017, In : Diabetes. 66, 8, p. 2296-2309 14 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
204 Downloads (Pure)

An interesting case of new-onset ketosis-prone diabetes in a Scottish teaching hospital

Gardiner, A., George, P. S., Pearson, E. & McCrimmon, R. J., 1 Oct 2013, In : British Journal of Diabetes and Vascular Disease. 13, 5-6, p. 265-268 4 p.

Research output: Contribution to journalArticle

Association of organic cation transporter 1 with intolerance to metformin in Type 2 diabetes: a GoDARTS study

Dujic, T., Zhou, K., Donnelly, L. A., Tavendale, R., Palmer, C. N. A. & Pearson, E. R., May 2015, In : Diabetes. 64, 5, p. 1786-1793 8 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 208-214 7 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
374 Downloads (Pure)

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

Shepherd, M. H., Shields, B. M., Hudson, M., Pearson, E. R., Hyde, C., Ellard, S., Hattersley, A. T. & Patel, K. A., Dec 2018, In : Diabetologia. 61, 12, p. 2520-2527 8 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
92 Downloads (Pure)

Casting the net wider: a comprehensive candidate gene study

Zhou, K. & Pearson, E. R., May 2011, In : Pharmacogenomics Journal. 12, 5, p. 710-711 2 p.

Research output: Contribution to journalEditorial

Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes

Noyes, J. D., Soto-Pedre, E., Donnelly, L. A. & Pearson, E., 14 Jan 2018, In : Diabetic Medicine. 35, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
147 Downloads (Pure)

Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes

Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. & Li, S., 3 Jan 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.

Research output: Contribution to journalArticle

Open Access
File
40 Downloads (Pure)

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., Colhoun, H., Morris, A. D., George, J., Doney, A., Pirmohamed, M., Alfirevic, A., Wadelius, M., Maitland-van der Zee, A. H., Ridker, P. M., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, Aug 2017, In : Circulation: Cardiovascular Genetics. 10, 4, e001737 .

Research output: Contribution to journalArticle

3 Citations (Scopus)

Clarifying the relationship between metformin, acute kidney injury and lactic acidosis

Bell, S., Soto-Pedre, E., Connelly, P., Livingstone, S. & Pearson, E., 13 Dec 2017, In : Nature Reviews Nephrology. 14, 1 p., 70.

Research output: Contribution to journalLetter

Open Access
File
1 Citation (Scopus)
118 Downloads (Pure)

Clinical and genetic determinants of progression of type 2 diabetes: A DIRECT Study

Zhou, K., Donnelly, L. A., Morris, A. D., Franks, P. W., Jennison, C., Palmer, C. N. A. & Pearson, E. R., 1 Mar 2014, In : Diabetes Care. 37, 3, p. 718-724

Research output: Contribution to journalArticle

23 Citations (Scopus)

Clinical predictors of rate of progression of type 2 diabetes: an extreme case-control study

Donnelly, L. A., Zhou, K., Palmer, C. N. A., Doney, A. S. F., Morris, A. D. & Pearson, E. R., Mar 2013, In : Diabetic Medicine. 30, Suppl. 1, p. 94-94 1 p., P213.

Research output: Contribution to journalMeeting abstract

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

Hébert, H. L., Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
213 Downloads (Pure)
127 Citations (Scopus)

Common variants at 12q15 and 12q24 are associated with infant head circumference

Taal, H. R., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D. O., Warrington, N. M., Kaakinen, M., Kreiner-Moller, E., Bradfield, J. P., Freathy, R. M., Geller, F., Guxens, M., Cousminer, D. L., Kerkhof, M., Timpson, N. J., Ikram, M. A., Beilin, L. J., Bonnelykke, K., Buxton, J. L., Charoen, P. & 31 others, Chawes, B. L. K., Eriksson, J., Evans, D. M., Hofman, A., Kemp, J. P., Kim, C. E., Klopp, N., Lahti, J., Lye, S. J., McMahon, G., Mentch, F. D., Mueller-Nurasyid, M., O'Reilly, P. F., Prokopenko, I., Rivadeneira, F., Steegers, E. A. P., Sunyer, J., Tiesler, C., Yaghootkar, H., Breteler, M. M. B., Debette, S., Fornage, M., Gudnason, V., Launer, L. J., van der Lugt, A., Mosley, T. H., Seshadri, S., Smith, A. V., Vernooij, M. W., Pearson, E. R. & Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genetic Ep, May 2012, In : Nature Genetics. 44, 5, p. 532-538 9 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Common variants at 6q22 and 17q21 are associated with intracranial volume

Ikram, M. A., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, W. T., Niessen, W. J., DeStefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., Rivadeneira, F. & 109 others, Uitterlinden, A. G., Knopman, D. S., Hartikainen, A-L., Pennell, C. E., Thiering, E., Steegers, E. A. P., Hakonarson, H., Heinrich, J., Palmer, L. J., Jarvelin, M-R., McCarthy, M. I., Grant, S. F. A., St Pourcain, B., Timpson, N. J., Smith, G. D., Sovio, U., Nalls, M. A., Au, R., Hofman, A., Gudnason, H., van der Lugt, A., Harris, T. B., Meeks, W. M., Vernooij, M. W., van Buchem, M. A., Catellier, D., Jaddoe, V. W. V., Gudnason, V., Windham, B. G., Wolf, P. A., van Duijn, C. M., Mosley, T. H., Schmidt, H., Launer, L. J., Breteler, M. M. B., DeCarli, C., Adair, L. S., Ang, W., Atalay, M., vanBeijsterveldt, T., Bergen, N., Benke, K., Berry, D., Coin, L., Davis, O. S. P., Elliott, P., Flexeder, C., Frayling, T., Gaillard, R., Groen-Blokhuis, M., Goh, L-K., Haworth, C. M. A., Hadley, D., Hedebrand, J., Hinney, A., Hirschhorn, J. N., Holloway, J. W., Holst, C., Hottenga, J. J., Horikoshi, M., Huikari, V., Hypponen, E., Kilpelainen, T. O., Kirin, M., Kowgier, M., Lakka, H-M., Lange, L. A., Lawlor, D. A., Lehtimaki, T., Lewin, A., Lindgren, C., Lindi, V., Maggi, R., Marsh, J., Middeldorp, C., Millwood, I., Murray, J. C., Nivard, M., Nohr, E. A., Ntalla, I., Oken, E., Panoutsopoulou, K., Pararajasingham, J., Rodriguez, A., Salem, R. M., Sebert, S., Siitonen, N., Strachan, D. P., Teo, Y-Y., Valcarcel, B., Willemsen, G., Zeggini, E., Boomsma, D. I., Cooper, C., Gillman, M., Hocher, B., Lakka, T. A., Mohlke, K. L., Dedoussis, G. V., Ong, K. K., Pearson, E. R., Price, T. S., Power, C., Raitakari, O. T., Saw, S-M., Scherag, A., Simell, O., Sorensen, T. I. A. & Wilson, J. F., May 2012, In : Nature Genetics. 44, 5, p. 539-544 7 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N. & 31 others, Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Morris, A. D., Sutherland, C., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators, Feb 2011, In : Nature Genetics. 43, 2, p. 117-120 4 p.

Research output: Contribution to journalLetter

299 Citations (Scopus)

Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study

Eibich, P., Green, A., Hattersley, A. T., Jennison, C., Lonergan, M., Pearson, E. R. & Gray, A. M., Oct 2017, In : Diabetes Therapy. 8, 5, p. 1031-1045 15 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
128 Downloads (Pure)

C-peptide decline in type 1 diabetes has two phases: An initial exponential fall and a subsequent stable phase

Shields, B. M., McDonald, T. J., Oram, R., Hill, A., Hudson, M., Leete, P., Pearson, E. R., Richardson, S. J., Morgan, N. G. & Hattersley, A. T., 1 Jul 2018, In : Diabetes Care. 41, 7, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
280 Downloads (Pure)

Crossover studies can help the individualisation of care in type 2 diabetes: the MASTERMIND approach

Angwin, C., Pearson, E. & Hattersley, A., 23 May 2016, In : Practical Diabetes. 33, 4, p. 115-117 3 p.

Research output: Contribution to journalEditorial

Open Access
File
125 Downloads (Pure)

CYP2C8 and SLCO1B1 variants and therapeutic response to thiazolidinediones in patients with type 2 diabetes.

Dawed, A. Y., Donnelly, L., Tavendale, R., Carr, F., Leese, G., Palmer, C. N. A., Pearson, E. & Zhou, K., Nov 2016, In : Diabetes Care. 39, 11, p. 1902-1908 7 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
199 Downloads (Pure)

Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial

Singh, J. S. S., Mordi, I. R., Vickneson, K., Fathi, A., Donnan, P. T., Mohan, M., Choy, A. M. J., Gandy, S., George, J., Khan, F., Pearson, E. R., Houston, J. G., Struthers, A. D. & Lang, C. C., 1 Jun 2020, In : Diabetes Care. 43, 6, p. 1356-1359 4 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
62 Downloads (Pure)

Defining drug response for stratified medicine

Lonergan, M., Senn, S. J., McNamee, C., Daly, A. K., Sutton, R., Hattersley, A., Pearson, E. & Pirmohamed, M., Jan 2017, In : Drug Discovery Today. 22, 1, p. 173-179 7 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Determinants of glycemic response to metformin: do the organic cation transporters hold the key?

Zhou, K. & Pearson, E. R., May 2011, In : Pharmacogenomics Journal. 12, 5, p. 707-708 2 p.

Research output: Contribution to journalEditorial

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

Lynam, A., McDonald, T., Hill, A., Dennis, J., Oram, R., Pearson, E., Weedon, M., Hattersley, A., Owen, K., Shields, B. & Jones, A., 26 Sep 2019, In : BMJ Open. 9, 9, p. 1-10 10 p., e031586.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
70 Downloads (Pure)

Diabetes: Is there a future for Pharmacogenomics guided treatment?

Pearson, E., 12 Jul 2019, In : Clinical Pharmacology & Therapeutics. 106, 2, p. 329-337 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
86 Downloads (Pure)

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

Eriksen, R., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Prehn, C., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J. & 18 others, Kokkola, T., Rutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G., Aug 2020, In : EBioMedicine. 58, 9 p., 102932.

Research output: Contribution to journalArticle

Open Access
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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H. & 30 others, Rauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. & Franks, P. W., 1 Sep 2019, In : Diabetologia. 62, 9, p. 1601-1615 15 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
12 Downloads (Pure)

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

Koivula, R. W., Heggie, A., Barnett, A., Cederberg, H., Hansen, T. H., Koopman, A. D., Ridderstråle, M., Rutters, F., Vestergaard, H., Gupta, R., Herrgård, S., Heymans, M. W., Perry, M. H., Rauh, S., Siloaho, M., Teare, H. J. A., Thorand, B., Bell, J., Brunak, S., Frost, G. & 14 others, Jablonka, B., Mari, A., McDonald, T. J., Dekker, J. M., Hansen, T., Hattersley, A., Laakso, M., Pedersen, O., Koivisto, V., Ruetten, H., Walker, M., Pearson, E., Franks, P. W. & DIRECT Consortium, Jun 2014, In : Diabetologia. 57, 6, p. 1132-1142 11 p.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
185 Downloads (Pure)

Dissecting the etiology of type 2 diabetes in the Pima Indian population

Pearson, E. R., Dec 2015, In : Diabetes. 64, 12, p. 3993-3995 3 p.

Research output: Contribution to journalComment/debate

Open Access
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9 Citations (Scopus)
203 Downloads (Pure)

Drug-drug-gene interactions and adverse drug reactions

Malki, M. A. & Pearson, E. R., 3 Dec 2019, In : Pharmacogenomics Journal. 12 p.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
49 Downloads (Pure)

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Neonatal Diabetes International Collaborative Group, Bowman, P., Sulen, Å., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M., Iafusco, D. & 2 others, Hattersley, A. T. & Njølstad, P. R., 1 Aug 2018, In : The Lancet Diabetes and Endocrinology. 6, 8, p. 637-646 10 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
196 Downloads (Pure)

Effect of Serotonin Transporter 5HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study

Dujic, T., Zhou, K., Tavendale, R., Palmer, C. & Pearson, E., 1 Nov 2016, In : Diabetes Care. 39, 11, p. 1896-1901 6 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
162 Downloads (Pure)
223 Citations (Scopus)

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: A joint modelling approach

MASTERMIND consortium, Dennis, J. M., Shields, B. M., Jones, A. G., Pearson, E., Hattersley, A. T. & Henley, W. E., 14 Dec 2018, In : Clinical Epidemiology. 10, p. 1869-1877 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
76 Downloads (Pure)

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes

Dawed, A. Y., Ali, A., Zhou, K., Pearson, E. R. & Franks, P. W., Nov 2017, In : Diabetologia. 60, 11, p. 2231-2239 8 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
149 Downloads (Pure)

First Genome Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Cousminer, D. L., Ahlqvist, E., Mishra, R., Andersen, M. K., Chesi, A., Hawa, M. I., Davis, A., Hodge, K. M., Bradfield, J. P., Zhou, K., Guy, V. C., Åkerlund, M., Wod, M., Fritsche, L. G., Vestergaard, H., Snyder, J., Højlund, K., Linneberg, A., Käräjämäki, A., Brandslund, I. & 33 others, Kim, C. E., Witte, D. R., Sørgjerd, E. P., Brillon, D. J., Pedersen, O., Beck-Nielsen, H., Grarup, N., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Melander, O., Harris, R. I., Varvel, S., Grill, V. E. R., Hakonarson, H. H., Froguel, P., Lonsdale, J. T., Mauricio, D., Schloot, N. C., Khunti, K., Greenbaum, C. J., Asvold, B. O., Yderstræde, K. B., Pearson, E., Schwartz, S., Voight, B. F., Hansen, T., Tuomi, T., Boehm, B. O., Groop, L. C., Leslie, R. D. & Grant, S. F. A., 1 Nov 2018, In : Diabetes Care. p. 2396-2403 7 p.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
162 Downloads (Pure)

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O’Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C., Pearson, E., Scott, R. A., van Heel, D. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 711.

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Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

Franks, P. W., Pearson, E. & Florez, J. C., May 2013, In : Diabetes Care. 36, 5, p. 1413-1421 9 p.

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79 Citations (Scopus)

Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease

Yaghootkar, H., Lotta, L. A., Tyrrell, J., Smit, R. A. J., Jones, S. E., Donnelly, L., Beaumont, R., Campbell, A., Tuke, M. A., Hayward, C., Ruth, K. S., Padmanabhan, S., Jukema, J. W., Palmer, C. C., Hattersley, A., Freathy, R. M., Langenberg, C., Wareham, N. J., Wood, A. R., Murray, A. & 5 others, Weedon, M. N., Sattar, N., Pearson, E., Scott, R. A. & Frayling, T. M., Aug 2016, In : Diabetes. 65, 8, p. 2448-2460 13 p.

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Genetics of Drug Response in Diabetes

Pearson, E. R. & Florez, J. C., 2014, In : Frontiers in Diabetes. 23, p. 158-172 15 p.

Research output: Contribution to journalArticle