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  • Jeremy Lambert

5-chloroindole: a potent allosteric modulator of the 5-HT3 receptor

Newman, A. . S., Batis, N., Grafton, G., Caputo, F., Brady, C. A., Lambert, J. J., Peters, J. A., Gordon, J., Barnes, N. M., Brain, K. L., Powell, A. D. & Barnes, N. M., 2013, In : British Journal of Pharmacology. 169, 6, p. 1228-1238 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

5-HT3 receptors

Peters, J., Cooper, M., Livesey, M., Carland, J. & Lambert, J., 22 Mar 2012, Ion Channels: From Structure to Function. Kew, J. & Davies, C. (eds.). Oxford: Oxford University Press, p. 232-251 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

An isotope dilution based-targeted and non-targeted carbonyl neurosteroid/steroid profiling

Sharp, S., Mitchell, S., Vallée, M., Kuzmanova, E., Cooper, M., Belelli, D., Lambert, J. & Huang, J., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5247-5255 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
197 Downloads (Pure)

A novel GABAA alpha 5 receptor inhibitor with therapeutic potential

Ling, I., Mihalik, B., Etherington, L-A., Kapus, G., Pálvölgyi, A., Gigler, G., Kertész, S., Gaál, A., Pallagi, K., Kiricsi, P., Szabó, É., Szénási, G., Papp, L., Hársing, L. G., Lévay, G., Spedding, M., Lambert, J. J., Belelli, D., Barkóczy, J., Volk, B. & 3 others, Simig, G., Gacsályi, I. & Antoni, F. A., 5 Oct 2015, In : European Journal of Pharmacology. 764, p. 497-507 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors

Jensen, M. L., Wafford, K. A., Brown, A. R., Belelli, D., Lambert, J. J. & Mirza, N. R., 2013, In : British Journal of Pharmacology. 168, 5, p. 1118-1132 15 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Behavioural pharmacology of the α5-GABAA receptor antagonist S44819: Enhancement and remediation of cognitive performance in preclinical models

Gacsályi, I., Móricz, K., Gigler, G., Wellmann, J., Nagy, K., Ling, I., Barkóczy, J., Haller, J., Lambert, J. J., Szénási, G., Spedding, M. & Antoni, F. A., Oct 2017, In : Neuropharmacology. 125, p. 30-38 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
159 Downloads (Pure)

Control of inhibition by the direct action of cannabinoids on GABAA receptors

Golovko, T., Min, R., Lozovaya, N., Falconer, C., Yatsenko, N., Tsintsadze, T., Tsintsadze, V., Ledent, C., Harvey, R. J., Belelli, D., Lambert, J. J., Rozov, A. & Burnashev, N., 1 Sep 2015, In : Cerebral Cortex. 25, 9, p. 2440-2455 16 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones

Brown, A. R., Herd, M. B., Belelli, D. & Lambert, J. J., 1 Jan 2015, In : Journal of Physiology. 593, 1, p. 267-284 37 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Distinct mechanisms regulate GABA(A) receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells

Panzanelli, P., Gunn, B. G., Schlatter, M. C., Benke, D., Tyagarajan, S. K., Scheiffele, P., Belelli, D., Lambert, J. J., Rudolph, U. & Fritschy, J-M., 15 Oct 2011, In : Journal of Physiology. 589, 20, p. 4959-4980 22 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons

Brown, A. R., Mitchell, S., Peden, D. R., Herd, M. B., Seifi, M., Swinny, J. D., Belelli, D. & Lambert, J., Apr 2016, In : Neuropharmacology. 103, p. 163-173 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
134 Downloads (Pure)

Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress-response.

Gunn, B., Cunningham, L., Cooper, M. A., Corteen, N., Seifi, M., Swinny, J. D., Lambert, J. J. & Belelli, D., 11 Dec 2013, In : Journal of Neuroscience. 33, 50, p. 19534-19554 21 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine

Mitchell, S. J., Maguire, E. P., Cunningham, L., Gunn, B. G., Linke, M., Zechner, U., Dixon, C. I., King, S. L., Stephens, D. N., Swinny, J. D., Belelli, D. & Lambert, J. J., Oct 2018, In : Neuropharmacology. 141, p. 98-112 15 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
158 Downloads (Pure)

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression

Dixon, C. I., Walker, S. E., Swinny, J., Belelli, D., Lambert, J. J., King, S. L. & Stephens, D. N., Apr 2019, In : Behavioural Pharmacology. 30, 2-3, p. 272-281 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
51 Downloads (Pure)

Endogenous neurosteroids influence synaptic GABAA receptors during post-natal development

Belelli, D., Brown, A. R., Mitchell, S. J., Gunn, B. G., Herd, M. B., Phillips, G. D., Seifi, M., Swinny, J. D. & Lambert, J. J., 18 Feb 2018, In : Journal of Neuroendocrinology. 30, 2, p. 11-15 5 p., e12537.

Research output: Contribution to journalReview article

Open Access
File
6 Citations (Scopus)
172 Downloads (Pure)

Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus

Herd, M., Brown, A. R., Lambert, J. & Belelli, D., 11 Sep 2013, In : Journal of Neuroscience. 33, 37, p. 14850-14868

Research output: Contribution to journalArticle

46 Citations (Scopus)

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol

Maguire, E. P., Mitchell, E. A., Greig, S. J., Corteen, N., Balfour, D. J. K., Swinny, J. D., Lambert, J. J. & Belelli, D., Apr 2014, In : Neuropsychopharmacology. 39, 5, p. 1232-1244 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response

Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J. & Belelli, D., Jan 2015, In : Frontiers in Neuroendocrinology. 36, p. 28-48 21 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

GABAA receptor subtype involvement in addictive behaviour

Stephens, D. N., King, S. L., Lambert, J. J., Belelli, D. & Duka, T., Jan 2017, In : Genes, Brain and Behavior. 16, 1, p. 149-184 36 p.

Research output: Contribution to journalReview article

Open Access
File
29 Citations (Scopus)
161 Downloads (Pure)

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents

Wlodarczyk, A. I., Sylantyev, S., Herd, M. B., Kersanté, F., Lambert, J. J., Rusakov, D. A., Linthorst, A. C. E., Semyanov, A., Belelli, D., Pavlov, I. & Walker, M. C., 27 Feb 2013, In : Journal of Neuroscience. 33, 9, p. 3905-3914 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus

Corteen, N. L., Carter, J. A., Rudolph, U., Belelli, D., Lambert, J. J. & Swinny, J. D., Sep 2015, In : Brain Structure and Function. 220, 5, p. 2739-2763 25 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J. J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. & 1 others, Stroh, A., 4 Sep 2018, In : eLife. 7, p. 1-32 32 p., e38744.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
148 Downloads (Pure)

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon

Seifi, M., Brown, J. F., Mills, J., Bhandari, P., Belelli, D., Lambert, J. J., Rudolph, U. & Swinny, J. D., 2014, In : Journal of Neuroscience. 34, 31, p. 10361-10378 18 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src

Bull, F. A., Baptista-Hon, D. T., Lambert, J. J., Walwyn, W. & Hales, T. G., 1 Dec 2017, In : Scientific Reports. 7, 1, p. 1-11 11 p., 9969.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
156 Downloads (Pure)

Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor

Carland, J. E., Cooper, M. A., Livesey, M. R., Hales, T. G., Lambert, J. J. & Peters, J. A., 1 Nov 2013, In : Journal of Biological Chemistry. 288, 44, p. 31592-31601 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition

Anstee, Q., Knapp, S., Maguire, E. P., Hosie, A. M., Thomas, P., Mortensen, M., Bhome, R., Martinez, A., Walker, S. E., Dixon, C. I., Ruparelia, K., Montagnese, S., Kuo, Y-T., Herlihy, A., Bell, J. D., Robinson, I., Guerrini, I., McQuillin, A., Fisher, E. M. C., Ungless, M. A. & 8 others, Gurling, H. M. D., Morgan, M. Y., Brown, S. D. M., Stephens, D. N., Belelli, D., Lambert, J., Smart, T. G. & Thomas, H. C., 26 Nov 2013, In : Nature Communications. 4, 2816.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies

Kumar, N., Fagart, J., Liere, P., Mitchell, S. J., Knibb, A. R., Petit-Topin, I., Rame, M., El-Etr, M., Schumacher, M., Lambert, J. J., Rafestin-Oblin, M-E. & Sitruk-Ware, R., 1 Jan 2017, In : Endocrinology. 158, 1, p. 170-182 12 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
137 Downloads (Pure)

Neurosteroids and GABAA receptor interactions: A focus on stress

Gunn, B. G., Brown, A. R., Lambert, J. J. & Belelli, D., 5 Dec 2011, In : Frontiers in Neuroscience. 5, p. 1-20 20 p., 131.

Research output: Contribution to journalReview article

Open Access
File
78 Citations (Scopus)
125 Downloads (Pure)

Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures

Monteiro, O., Chen, C., Bingham, R., Argyrou, A., Buxton, R., Jönsson, C. P., Jones, E., Bridges, A., Gatfield, K., Krauß, S., Lambert, J., Langston, R., Schweiger, S. & Uings, I., 23 Apr 2018, In : Neuroscience Letters. 673, p. 44-50 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
224 Downloads (Pure)

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

Belelli, D., Hogenkamp, D., Gee, K. W. & Lambert, J. J., May 2020, In : Neurobiology of Stress. 12, p. 1-11 11 p., 100207.

Research output: Contribution to journalArticle

Open Access
File
64 Downloads (Pure)

Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule

Zhang, H., Etherington, L-A., Hafner, A-S., Belelli, D., Coussen, F., Delagrange, P., Chaouloff, F., Spedding, M., Lambert, J. J., Choquet, D. & Groc, L., 2012, In : Molecular Psychiatry. 18, p. 471-484 14 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Rings of Charge within the Extracellular Vestibule Influence Ion Permeation of the 5-HT(3)A Receptor

Livesey, M. R., Cooper, M. A., Lambert, J. J. & Peters, J. A., 6 May 2011, In : Journal of Biological Chemistry. 286, 18, p. 16008-16017 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

Weir, C. J., Mitchell, S. J. & Lambert, J. J., Dec 2017, In : British Journal of Anaesthesia. 119, Suppl. 1, p. i167-i175 9 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
97 Downloads (Pure)

Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent

Etherington, L-A., Mihalik, B., Pálvölgyi, A., Ling, I., Pallagi, K., Kertész, S., Varga, P., Gunn, B. G., Brown, A. R., Livesey, M. R., Monteiro, O., Belelli, D., Barkóczy, J., Spedding, M., Gacsályi, I., Antoni, F. A. & Lambert, J. J., Oct 2017, In : Neuropharmacology. 125, p. 353-364 12 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
144 Downloads (Pure)

The actions of neurosteroids at alpha 2-GABAA receptors in stress-sensitive neuronal targets

Belelli, D., Gunn, B. G., Maguire, E. P. & Lambert, J. J., May 2011, In : Alcohol. 45, 3, p. 287-287 1 p., S85.

Research output: Contribution to journalBook/Film/Article review

Open Access
File
13 Citations (Scopus)
139 Downloads (Pure)
21 Citations (Scopus)

Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants

Maguire, E. P., Macpherson, T., Swinny, J. D., Dixon, C. I., Herd, M. B., Belelli, D., Stephens, D. N., King, S. L. & Lambert, J. J., 15 Jan 2014, In : Journal of Neuroscience. 34, 3, p. 823-838 16 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)