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  • Michael Ferguson

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat

Pinger, J., Nešić, D., Ali, L., Aresta-Branco, F., Lilic, M., Chowdhury, S., Kim, H. S., Verdi, J., Raper, J., Ferguson, M. A. J., Papavasiliou, F. N. & Stebbins, C. E., Aug 2018, In : Nature Microbiology. 3, 8, p. 932-938 7 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
242 Downloads (Pure)

A gene of the β3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei

Damerow, M., Graalfs, F., Guther, M. L. S., Mehlert, A., Izquierdo, L. & Ferguson, M. A. J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13834-13845 12 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
149 Downloads (Pure)

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

Raimi, O., Hurtado-Guerrero, R., Borodkin, V., Ferenbach, A., Urbaniak, M., Ferguson, M. & van Aalten, D., 1 Apr 2020, In : RSC Chemical Biology. 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sep 2013, In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
Open Access
File
137 Citations (Scopus)
297 Downloads (Pure)

Application of novel method to quantify akt phosphorylation in breast cancer

Thompson, A., Atrih, A., Quinlan, P. R., Bray, S., Ferguson, M. & Huang, J., May 2011, In : Annals of Oncology. 22, S2, p. ii38-iii38 1 p., 65P.

Research output: Contribution to journalMeeting abstract

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures

Galloway, A., Atrih, A., Grzela, R., Darzynkiewicz, E., Ferguson, M. A. J. & Cowling, V. H., 26 Feb 2020, In : Open Biology. 10, 2, p. 1-13 13 p., 190306.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
40 Downloads (Pure)

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei

Marino, K., Guther, M. L. S., Wernimont, A. K., Qiu, W., Hui, R. & Ferguson, M. A. J., Jul 2011, In : Eukaryotic Cell. 10, 7, p. 985-997 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G., 2012, In : ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction

Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J., 25 Nov 2011, In : Journal of Biological Chemistry. 286, 47, p. 40494-40508 15 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J., 2012, In : PLoS ONE. 7, 5, p. - 8 p., e36619.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Creation and characterization of glycosyltransferase mutants of trypanosoma brucei

Izquierdo, L., Güther, M. L. S. & Ferguson, M. A. J., 2013, Glycosyltransferases. Brockhausen, I. (ed.). Humana Press, p. 249-275 27 p. (Methods in Molecular Biology; vol. 1022).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

6 Citations (Scopus)

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In : Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journalArticle

Open Access
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34 Citations (Scopus)
447 Downloads (Pure)

Deep evolutionary conservation of an intramolecular protein kinase activation mechanism

Han, J., Luebbering, N., Cleghon, V., Miranda-Saavedra, D., Singh, A., Sibbet, G. & Ferguson, M. A. J., 3 Jan 2012, In : PLoS ONE. 7, 1, e29702.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. R., Lüder, C. G. K., Ferguson, M. A. J. & Routier, F. H., 3 Nov 2015, In : PLoS Neglected Tropical Diseases. 9, 11, e0004205.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
120 Downloads (Pure)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

Research output: Contribution to journalArticle

Open Access
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76 Citations (Scopus)
442 Downloads (Pure)

Drug discovery initiative at the University of Dundee: hit-to-lead development for hat and generation of chemical tools

Grimaldi, R., Urich, R., Sienkiewicz, N., Woodland, A., Urbaniak, M. D., Mathieson, T., Eberhard, D., Bantscheff, M., Drewes, G., Ferguson, M. A. J., Gilbert, I. H., Frearson, J. A., Wyatt, P. G. & Fairlamb, A. H., 2011, In : Tropical Medicine & International Health. 16, S.1, p. 212 1 p., 1.3-148.

Research output: Contribution to journalMeeting abstract

Evaluation of antigens for development of a serological test for Human African Trypanosomiasis

Biéler, S., Waltenberger, H., Barrett, M. P., McCulloch, R., Mottram, J. C., Carrington, M., Schwaeble, W., McKerrow, J., Phillips, M. A., Michels, P. A., Büscher, P., Sanchez, J-C., Bishop, R., Robinson, D. R., Bangs, J., Ferguson, M., Nerima, B., Albertini, A., Michel, G., Radwandska, M. & 1 others, Ndung'u, J. M., 9 Dec 2016, In : PLoS ONE. 11, 12, p. 1-23 23 p., e0168074.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
309 Downloads (Pure)

Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis

Sternberg, J. M., Gierlinski, M., Biéler, S., Ferguson, M. A. J. & Ndung'u, J. M., Dec 2014, In : PLoS Neglected Tropical Diseases. 8, 12, p. e3373 8 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
156 Downloads (Pure)

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Pizarro, J. C., Hills, T., Senisterra, G., Wernimont, A. K., Mackenzie, C., Norcross, N. R., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. & Hui, R., 17 Oct 2013, In : PLoS Neglected Tropical Diseases. 7, 10, e2492.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
131 Downloads (Pure)

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

Ivanova, I. M., Nepogodiev, S. A., Saalbach, G., O'Neill, E. C., Urbaniak, M. D., Ferguson, M. A. J., Gurcha, S. S., Besra, G. S. & Field, R. A., 13 Jan 2017, In : Carbohydrate Research. 438, p. 26-38 13 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
130 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
148 Downloads (Pure)

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. & Van Aalten, D. M. F., 11 Jul 2013, In : Bioscience Reports. 33, 5, 11 p., e00063.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. & van Aalten, D. M. F., Aug 2013, In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Genetic Metabolic Complementation establishes a requirement for GDP-fucose in Leishmania

Guo, H., Novozhilova, N. M., Bandini, G., Turco, S. J., Ferguson, M. A. J. & Beverley, S. M., 23 Jun 2017, In : Journal of Biological Chemistry. 292, 25, p. 10696-10708 13 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
122 Downloads (Pure)

Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling

Larance, M., Kirkwood, K. J., Tinti, M., Brenes Murillo, A., Ferguson, M. & Lamond, A., 1 Jul 2016, In : Molecular & Cellular Proteomics. 15, 7, p. 2476-2490 15 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
122 Downloads (Pure)
101 Citations (Scopus)

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

Kovarova, J., Nagar, R., Correia Faria, J., Ferguson, M., Barrett, M. P. & Horn, D., 27 Dec 2018, In : PLoS Pathogens. 14, 12, p. 1-22 22 p., e1007475.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
108 Downloads (Pure)
Open Access
File
53 Citations (Scopus)
132 Downloads (Pure)

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei

Damerow, M., Rodrigues, J. A., Wu, D., Güther, M. L. S., Mehlert, A. & Ferguson, M. A. J., 28 Mar 2014, In : Journal of Biological Chemistry. 289, 13, p. 9328-9339 12 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
124 Downloads (Pure)

Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma brucei

Izquierdo, L., Acosta-Serrano, A., Mehlert, A. & Ferguson, M. A. J., 2015, In : Glycobiology. 25, 4, p. 438-447 50 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

Sullivan, L., Fleming, J., Sastry, L., Mehlert, A., Wall, S. J. & Ferguson, M. A. J., 17 Jul 2014, In : PLoS Neglected Tropical Diseases. 8, 7, p. e2976

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
166 Downloads (Pure)

Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M. D., Mar 2012, In : Chemical Biology & Drug Design. 79, 3, p. 270-278 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

Capes, A. S., Crossman, A. T., Webster, L. A., Ferguson, M. A. J. & Gilbert, I. H., 28 Dec 2011, In : Tetrahedron Letters. 52, 52, p. 7091-7094 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
13 Downloads (Pure)
Open Access
File
32 Citations (Scopus)
91 Downloads (Pure)

Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. F. R., Ferguson, M. A. J. & Routier, F. H., Oct 2015, In : International Journal for Parasitology. 45, 12, p. 783-790 8 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
165 Downloads (Pure)

Modeling of the N-Glycosylated Transferrin Receptor Suggests How Transferrin Binding Can Occur within the Surface Coat of Trypanosoma brucei

Mehlert, A., Wormald, M. R. & Ferguson, M. A. J., Apr 2012, In : PLoS Pathogens. 8, 4, p. - 11 p., e1002618.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Molecular control of irreversible bistability during trypanosome developmental commitment

Domingo-Sananes, M. R., Szöor, B., Ferguson, M. A. J., Urbaniak, M. D. & Matthews, K. R., 19 Oct 2015, In : Journal of Cell Biology. 211, 2, p. 455-468 14 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
145 Downloads (Pure)

N-glycan microheterogeneity regulates interactions of plasma proteins

Wu, D., Struwe, W. B., Harvey, D. J., Ferguson, M. A. J. & Robinson, C. V., 28 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 35, p. 8763-8768 6 p., 201807439.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
127 Downloads (Pure)

Novel non-invasive scoring system for the detection of NASH from a NAFLD population

Miller, M., Jafferbhoy, H., Crowther, D., Walsh, S., Ferguson, M. A. & Dillon, J. F., Oct 2011, In : Hepatology. 54, p. 1113A-1113A 1 p.

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)

On the hunt for new diagnostic antigens for human African trypanosomiasis

Sullivan, L., Carrington, M. & Ferguson, M. A. J., Oct 2011, In : Tropical Medicine & International Health. 16, p. 201-201 1 p.

Research output: Contribution to journalMeeting abstract

Organizational innovation for developing new medicines that target aging and age-related conditions

Ford, G. A., Lord, J. M., Ferguson, M. A. J., Bountra, C. & Le Couteur, D. G., 6 Mar 2019, In : The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 75, 1, p. 87-88 2 p., glz062.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
141 Downloads (Pure)

Parasite Glycobiology: A Bittersweet Symphony

Rodrigues, J. A., Acosta-Serrano, A., Aebi, M., Ferguson, M. A. J., Routier, F. H., Schiller, I., Soares, S., Spencer, D., Titz, A., Wilson, I. B. H. & Izquierdo, L., 12 Nov 2015, In : PLoS Pathogens. 11, 11, e1005169.

Research output: Contribution to journalReview article

Open Access
File
19 Citations (Scopus)
119 Downloads (Pure)

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

Open Access
File
8 Citations (Scopus)
174 Downloads (Pure)

Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

Bandini, G., Marino, K., Güther, M. L. S., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. & Ferguson, M. A. J., 2012, In : Molecular Microbiology. 85, 3, p. 513-534 22 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
131 Downloads (Pure)

Prediction of protein complexes in Trypanosoma brucei by protein correlation profiling mass spectrometry and machine learning

Crozier, T. W. M., Tinti, M., Larance, M., Lamond, A. I. & Ferguson, M. A. J., 1 Dec 2017, In : Molecular & Cellular Proteomics. 16, 12, p. 2254-2267 14 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
170 Downloads (Pure)