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  Cutting Edge: Building bridges between cellular and molecular structural biology

  Patwardhan, A., Brandt, R., Butcher, S. J., Collinson, L., Gault, D., Grünewald, K., Hecksel, C., Huiskonen, J. T., Iudin, A., Jones, M. L., Korir, P. K., Koster, A. J., Lagerstedt, I., Lawson, C. L., Mastronarde, D., McCormick, M., Parkinson, H. E., Rosenthal, P. B., Saalfeld, S., Saibil, H. R. & 7 others, Sarntivijai, S., Solanes Valero, I., Subramaniam, S., Swedlow, J. R., Tudose, I., Winn, M. & Kleywegt, G. J., 24 Jul 2017, In: eLife. 6, p. 1-11 11 p., e25835.

  Research output: Contribution to journal › Article › peer-review

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  8 Citations (Scopus)

  144 Downloads (Pure)

• CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

  Rousseau, S., Dolado, I., Beardmore, V., Shpiro, N., Marquez, R., Nebreda, A. R., Arthur, J. S. C., Case, L. M., Tessier-Lavigne, M., Gaestel, M., Cuenda, A. & Cohen, P., 1 Nov 2006, In: Cellular Signalling. 18, 11, p. 1897-1905 9 p.

  Research output: Contribution to journal › Article › peer-review
  106 Citations (Scopus)

• CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

  Keir, H. R., Richardson, H., Fillmore, C., Shoemark, A., Lazaar, A. L., Miller, B. E., Tal-Singer, R., Chalmers, J. D. & Mohan, D., 10 Nov 2020, In: ERJ Open Research. 6, 4, 4 p., 00583-2020.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  24 Downloads (Pure)

• Cyanobacterial effects in Lake Ludoš, Serbia - Is preservation of a degraded aquatic ecosystem justified?

  Tokodi, N., Drobac, D., Meriluoto, J., Lujić, J., Marinović, Z., Važić, T., Nybom, S., Simeunović, J., Dulić, T., Lazić, G., Petrović, T., Vuković-Gačić, B., Sunjog, K., Kolarević, S., Kračun-Kolarević, M., Subakov-Simić, G., Miljanović, B., Codd, G. A. & Svirčev, Z., 1 Sep 2018, In: Science of the Total Environment. 635, p. 1047-1062 16 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

  MacKintosh, C., Beattie, K. A., Klumpp, S., Cohen, P. & Codd, G. A., 1990, In: FEBS Letters. 264, 2, p. 187-192 6 p.

  Research output: Contribution to journal › Article › peer-review
  1365 Citations (Scopus)

• Cyanobacterial toxins: Occurrence, properties and biological significance

  Codd, G. A., 1995, In: Water Science and Technology. 32, 4, p. 149-156 8 p.

  Research output: Contribution to journal › Article › peer-review
  325 Citations (Scopus)

• Cyanobacterial toxins: risk management for health protection

  Codd, G. A., Morrison, L. F. & Metcalf, J. S., Mar 2005, In: Toxicology and Applied Pharmacology. 203, 3, p. 264-272 9 p.

  Research output: Contribution to journal › Article › peer-review
  858 Citations (Scopus)

• Cyanobacteria vs green algae: which group has the edge?

  Beardall, J. & Raven, J. A., 8 Sep 2017, In: Journal of Experimental Botany. 68, 14, p. 3697-3699 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  10 Citations (Scopus)

  144 Downloads (Pure)

• Cyanotoxins in desert environments may present a risk to human health

  Metcalf, J. S., Richer, R., Cox, P. A. & Codd, G. A., 1 Apr 2012, In: Science of the Total Environment. 421, p. 118-123 6 p.

  Research output: Contribution to journal › Article › peer-review
  86 Citations (Scopus)

• Cycles of Identity Formation in Interorganizational Collaborations

  Beech, N., 2003, In: International Studies of Management and Organization. p. 28-52 25 p.

  Research output: Contribution to journal › Article › peer-review

• Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

  Gould, M. K., Bachmaier, S., Ali, J. A. M., Alsford, S., Tagoe, D. N. A., Munday, J. C., Schnaufer, A. C., Horn, D., Boshart, M. & de Koning, H. P., Oct 2013, In: Antimicrobial Agents and Chemotherapy. 57, 10, p. 4882-4893 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  41 Citations (Scopus)

  20 Downloads (Pure)

• Cyclic AMP induction of Dictyostelium prespore gene expression requires autophagy

  Yamada, Y. & Schaap, P., 15 Aug 2019, In: Developmental Biology. 452, 2, p. 114-126 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  12 Citations (Scopus)

  99 Downloads (Pure)

• Cyclic AMP regulates a calcium-activated non-selective cation channel in a rat insulinoma cell line

  Reale, V., Hales, C. N. & Ashford, M. L. J., 30 Mar 1992, In: Journal of Physiology. 446

  Research output: Contribution to journal › Article › peer-review

  3 Citations (Scopus)

• Cyclic and Fatigue Behaviour of Rock Materials: Review, Interpretation and Research Perspectives

  Cerfontaine, B. & Collin, F., 1 Feb 2018, In: Rock Mechanics and Rock Engineering. 51, 2, p. 391-414 24 p.

  Research output: Contribution to journal › Article › peer-review
  142 Citations (Scopus)

• Cyclic and macrocyclic peptides as chemical tools to recognise protein surfaces and probe protein-protein interactions

  Cardote, T. A. F. & Ciulli, A., 19 Apr 2016, In: ChemMedChem. 11, 8, p. 787-794 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  108 Citations (Scopus)

  157 Downloads (Pure)

• Cyclic change of server's performance: Impacts and applications

  Huang, B., Xie, J. & He, Q. M., Mar 2014, In: IEEE Transactions on Automatic Control. 59, 3, p. 703-713 11 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Cyclic-di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions

  Zeden, M. S., Schuster, C. F., Bowman, L., Zhong, Q., Williams, H. D. & Gründling, A., 2 Mar 2018, In: Journal of Biological Chemistry. 293, 9, p. 3180-3200 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  49 Citations (Scopus)

  165 Downloads (Pure)

• Cyclic di-GMP signalling and the regulation of bacterial virulence

  Ryan, R. P., Jul 2013, In: Microbiology. 159, 7, p. 1286-1297 12 p.

  Research output: Contribution to journal › Article › peer-review
  64 Citations (Scopus)

• Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate

  Wright, D., Ferjentsik, Z., Chong, S-W., Qiu, X., Jiang, Y-J., Malapert, P., Pourquie, O., Van Hateren, N., Wilson, S. A., Franco, C., Gerhardt, H., Dale, J. K. & Maroto, M., Dec 2009, In: Developmental Dynamics. 238, 12, p. 3043-3055 13 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

  Hegarat, N., Crncec, A., Suarez Peredoa Rodriguez, M. F., Iturra, F. E., Gu, Y., Busby, O., Lang, P. F., Barr, A. R., Bakal, C., Kanemaki, M. T., Lamond, A. I., Novak, B., Ly, T. & Hochegger, H., 2 Jun 2020, In: EMBO Journal. 39, 11, 23 p., e104419.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  24 Citations (Scopus)

  82 Downloads (Pure)

• Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis

  Chen, Q., Zhang, X., Jiang, Q., Clarke, P. R. & Zhang, C., Feb 2008, In: Cell Research. 18, 2, p. 268-280 13 p.

  Research output: Contribution to journal › Article › peer-review
  55 Citations (Scopus)

• Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint

  Allan, L. A., Reis, M. C., Ciossani, G., Huigs in ‘t Veld, P. J., Wohlgemuth, S., Kops, G. J. P. L., Musacchio, A. & Saurin, A. T., 17 Jun 2020, In: EMBO Journal. 39, 12, 16 p., e103180.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  21 Citations (Scopus)

  157 Downloads (Pure)

• Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

  Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In: Nature. 560, 7717, p. 192-197 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  72 Citations (Scopus)

  546 Downloads (Pure)

• Cyclin-Dependent Kinases: CAK-handed kinase activation

  Clarke, P. R., 1 Jan 1995, In: Current Biology. 5, 1, p. 40-42 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Citations (Scopus)

• Cycling injuries requiring orthopaedic intervention during the first COVID-19 lockdown period: A multi-centre SCottish Orthopaedic Research collaborativE (SCORE) study

  Faulkner, A., MacDonald, D. R. W., Neilly, D. W., Davies, P. S. E., Ha, T. T., Stevenson, I. M., Jariwala, A. C., Donoghue, C. J., Lee, A., Bashyam, J., Greensmith, T. S., Macinnes, A., Pennington, R., Sinnerton, R., Supparamaniam, S., Crome, C. R., Guiot, L., Harte, C., Kennedy, M. J., Noteman, T. W. & 7 others, Scicluna, G., Wheelwright, B. R. F., Torkington, M. S., Jamal, B., Gill, S. L., Boddie, D. E. & Ashcroft, G. P., 26 Jun 2021, (E-pub ahead of print) In: Surgeon. 6 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

  Higgins, A. J., Flynn, A. J., Marconnet, A., Musgrove, L. J., Postis, V. L. G., Lippiat, J. D., Chung, C., Ceska, T., Zoonens, M., Sobott, F. & Muench, S. P., 25 Nov 2021, In: Communications Biology. 4, 9 p., 1337.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1 Citation (Scopus)

  22 Downloads (Pure)

• Cyclobutane pyrimidine dimers are photosensitised by carprofen plus UVA in human HaCaT cells

  Robinson, K. S., Traynor, N. J., Moseley, H., Ferguson, J. & Woods, J. A., Jun 2010, In: Toxicology in Vitro. 24, 4, p. 1126-1132 7 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Cyclooxygenase-1 is a marker for a subpopulation of putative nociceptive neurons in rat dorsal root ganglia

  Chopra, B., Giblett, S., Little, J. G., Donaldson, L. F., Tate, S., Evans, R. J. & Grubb, B. D., 24 Dec 2001, In: European Journal of Neuroscience. 12, 3, p. 911-920 10 p.

  Research output: Contribution to journal › Article › peer-review
  66 Citations (Scopus)

• Cyclosporin-induced hypertension precedes renal dysfunction and sodium retention in man

  Sturrock, N. D. C., Lang, C. C. & Struthers, A. D., 1993, In: Journal of Hypertension. 11, 11, p. 1209-1216 8 p.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• Cyclosporin-induced nephrotoxicity and hypertension

  Sturrock, N. D., Lang, C. C. & Struthers, A. D., 1992, In: British Journal of Hospital Medicine. 48, 8, p. 483-485, 488-489 5 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Cyclosporin-induced renal vasoconstriction is augmented by frusemide and by angiotensin II in humans

  Sturrock, N. D. C., Lang, C. C., Coutie, W. J. & Struthers, A. D., 1995, In: Journal of Hypertension. 13, 9, p. 987-991 5 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• CYP2B6 and OPRM1 gene variations predict methadone-related deaths

  Bunten, H., Liang, W-J., Pounder, D., Seneviratne, C. & Osselton, M. D., Jan 2011, In: Addiction Biology. 16, 1, p. 142-144 3 p.

  Research output: Contribution to journal › Article › peer-review
  54 Citations (Scopus)

• Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

  Takahashi, S., Fukami, T., Masuo, Y., Brocker, C. N., Xie, C., Krausz, K. W., Wolf, C. R., Henderson, C. J. & Gonzalez, F. J., Dec 2016, In: Journal of Lipid Research. 57, p. 2130-2037 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  137 Citations (Scopus)

  213 Downloads (Pure)

• CYP2C8 and SLCO1B1 variants and therapeutic response to thiazolidinediones in patients with type 2 diabetes.

  Dawed, A. Y., Donnelly, L., Tavendale, R., Carr, F., Leese, G., Palmer, C. N. A., Pearson, E. & Zhou, K., Nov 2016, In: Diabetes Care. 39, 11, p. 1902-1908 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  39 Citations (Scopus)

  221 Downloads (Pure)

• CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations

  Province, M. A., Goetz, M. P., Brauch, H., Flockhart, D. A., Hebert, J. M., Whaley, R., Suman, V. J., Schroth, W., Winter, S., Zembutsu, H., Mushiroda, T., Newman, W. G., Lee, M-T. M., Ambrosone, C. B., Beckmann, M. W., Choi, J-Y., Dieudonné, A-S., Fasching, P. A., Ferraldeschi, R., Gong, L. & 34 others, Haschke-Becher, E., Howell, A., Jordan, L. B., Hamann, U., Kiyotani, K., Krippl, P., Lambrechts, D., Latif, A., Langsenlehner, U., Lorizio, W., Neven, P., Nguyen, A. T., Park, B-W., Purdie, C. A., Quinlan, P., Renner, W., Schmidt, M., Schwab, M., Shin, J-G., Stingl, J. C., Wegman, P., Wingren, S., Wu, A. H. B., Ziv, E., Zirpoli, G., Thompson, A. M., Jordan, V. C., Nakamura, Y., Altman, R. B., Ames, M. M., Weinshilboum, R. M., Eichelbaum, M., Ingle, J. N. & Klein, T. E., Feb 2014, In: Clinical Pharmacology & Therapeutics. 95, 2, p. 216-227 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  139 Citations (Scopus)

  152 Downloads (Pure)

• CYP3A4 active site volume modification by mutagenesis of leucine 211

  Fowler, S. M., Taylor, J. M., Friedberg, T., Roland Wolf, C. & Riley, R. J., 10 Apr 2002, In: Drug Metabolism and Disposition. 30, 4, p. 452-456 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Citations (Scopus)

• Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis

  Matthews, S. P., McMillan, S. J., Colbert, J. D., Lawrence, R. A. & Watts, C., 19 Apr 2016, In: Immunity. 44, 4, p. 795-806 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  27 Citations (Scopus)

  165 Downloads (Pure)

• Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

  Hamilton, G., Colbert, J. D., Schuettelkopf, A. W. & Watts, C., 6 Feb 2008, In: EMBO Journal. 27, 3, p. 499-508 10 p.

  Research output: Contribution to journal › Article › peer-review
  81 Citations (Scopus)

• Cystatin F Regulates Proteinase Activity in IL-2-activated Natural Killer Cells

  Maher, K., Konjar, S., Watts, C., Turk, B. & Kopitar-Jerala, N., Sep 2014, In: Protein and Peptide Letters. 21, 9, p. 957-965 9 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Cysteine eliminates the feeder cell requirement for cultivation of Trypanosoma brucei bloodstream forms in vitro

  Duszenko, M., Ferguson, M. A. J., Lamont, G. S., Rifkin, M. R. & Cross, G. A., 1 Oct 1985, In: Journal of Experimental Medicine. 162, 4, p. 1256-1263 8 p.

  Research output: Contribution to journal › Article › peer-review
  78 Citations (Scopus)

• Cysteine residues 244 and 458-459 within the catalytic subunit of Na,K-ATPase control the enzyme's hydrolytic and signaling function under hypoxic conditions

  Petrushanko, I. Y., Mitkevich, V. A., Lakunina, V. A., Anashkina, A. A., Spirin, P. V., Rubtsov, P. M., Prassolov, V. S., Bogdanov, N. B., Hänggi, P., Fuller, W., Makarov, A. & Bogdanova, A., Oct 2017, In: Redox Biology. 13, p. 310-319 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  16 Citations (Scopus)

  140 Downloads (Pure)

• Cysteine-scanning mutagenesis and disulfide mapping studies of the conserved domain of the twin-arginine translocase TatB component

  Lee, P. A., Orriss, G. L., Buchanan, G., Greene, N. P., Bond, P. J., Punginelli, C., Jack, R. L., Sansom, M. S. P., Berks, B. C. & Palmer, T., 2006, In: Journal of Biological Chemistry. 281, 45, p. 34072-34085 14 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Cysteine scanning mutagenesis and disulfide mapping studies of the TatA component of the bacterial twin arginine translocase

  Greene, N. P., Porcelli, I., Buchanan, G., Hicks, M. G., Schermann, S. M., Palmer, T. & Berks, B. C., 2007, In: Journal of Biological Chemistry. 282, 33, p. 23937-23945 9 p.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Cysteine scanning mutagenesis and topological mapping of the Escherichia coli twin-arginine translocase TatC component

  Punginelli, C., Maldonado, B., Grahl, S., Jack, R., Alami, M., Schroeder, J., Berks, B. C. & Palmer, T., 2007, In: Journal of Bacteriology. 189, 15, p. 5482-5494 13 p.

  Research output: Contribution to journal › Article › peer-review
  37 Citations (Scopus)

• Cystic Fibrosis: A Pocket Guide

  Roughley, M., MacDougall, L. & Erolin, C., 2020, In: Journal of Visual Communication in Medicine. 43, 4, p. 198-210 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  20 Downloads (Pure)

• Cystic fibrosis across Europe: EuroCareCF analysis of demographic data from 35 countries

  Mehta, G., Macek, M., Mehta, A. & European Registry Working Grp, Dec 2010, In: Journal of Cystic Fibrosis. 9, S2, p. S5-S21 17 p.

  Research output: Contribution to journal › Article › peer-review
  76 Citations (Scopus)

• Cystic fibrosis as a bowel cancer syndrome and the potential role of CK2

  Mehta, A., Sep 2008, In: Molecular and Cellular Biochemistry. 316, 1-2, p. 169-175 7 p.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• Cystic fibrosis diagnosed after 2 months of age leads to worse outcomes and requires more therapy

  Sims, E. J., Clark, A., McCormick, J., Mehta, G., Connett, G. & Mehta, A., 2007, In: Pediatrics. 119, 1, p. 19-28 10 p.

  Research output: Contribution to journal › Article › peer-review
  105 Citations (Scopus)

• Cystic fibrosis in the mouse by targeted insertional mutagenesis

  Dorin, J. R., Dickinson, P., Alton, E. W., Smith, S. N., Geddes, D. M., Stevenson, B. J., Kimber, W. L., Fleming, S., Clarke, A. R. & Hooper, M. L., 1992, In: Nature. 359, 6392, p. 211-5 5 p.

  Research output: Contribution to journal › Article › peer-review
  236 Citations (Scopus)

• Cystic fibrosis transmembrane regulator fragments with the Phe(508) deletion exert a dual allosteric control over the master kinase CK2

  Pagano, M. A., Marin, O., Cozza, G., Sarno, S., Meggio, F., Treharne, K. J., Mehta, A. & Pinna, L. A., 15 Feb 2010, In: Biochemical Journal. 426, 1, p. 19-29 11 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)