Search concepts
|
Selected filters
|
- 9,300 - 9,350 out of 51,890 results
Search results
-
Article
Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase
Kremer, A. N., Bausenwein, J., Lurvink, E., Kremer, A. E., Rutten, C. E., van Bergen, C. A. M., Kretschmann, S., van der Meijden, E., Honders, M. W., Mazzeo, D., Watts, C., Mackensen, A., Falkenburg, J. H. F. & Griffioen, M., 11 Mar 2020, In: Frontiers in Immunology. 11, 11 p., 381.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)40 Downloads (Pure) -
Discovery and observations of ASASSN-13db, an EX lupi-type accretion event on a low-mass T tauri star
Holoien, T. W. S., Prieto, J. L., Stanek, K. Z., Kochanek, C. S., Shappee, B. J., Zhu, Z., Sicilia-Aguilar, A., Grupe, D., Croxall, K., Adams, D. J., Simon, J. D., Morrell, N. W., McGraw, S. M., Wagner, R. M., Basu, U., Beacom, J. F., Bersier, D., Brimacombe, J., Jencson, J., Pojmanski, G., & 3 others , 20 Apr 2014, In: Astrophysical Journal Letters. 785, 2, 6 p., L35.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Discovery and Optimisation of a Compound Series active against Trypanosoma cruzi, the causative agent of Chagas’ Disease
Harrison, J. R., Sarkar, S., Hampton, S., Riley, J., Stojanovski, L., Sahlberg, C., Appelqvist, P., Erath, J., Mathan, V., Rodriguez, A., Kaiser, M., Pacanowska, D. G., Read, K. D., Johansson, N. G. & Gilbert, I. H., 26 Mar 2020, In: Journal of Medicinal Chemistry. 63, 6, p. 3066-3089 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)53 Downloads (Pure) -
Discovery and optimisation studies of antimalarial phenotypic hits
Mital, A., Murugesan, D., Kaiser, M., Yeates, C. & Gilbert, I. H., 20 Oct 2015, In: European Journal of Medicinal Chemistry. 103, p. 530-538 9 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi
Brand, S., Ko, E. J., Viayna, E., Thompson, S., Spinks, D., Thomas, M., Sandberg, L., Francisco, A. F., Jayawardhana, S., Smith, V. C., Jansen, C., De Rycker, M., Thomas, J., MacLean, L., Osuna-Cabello, M., Riley, J., Scullion, P., Stojanovski, L., Simeons, F. R. C., Epemolu, O., & 16 others , 14 Sep 2017, In: Journal of Medicinal Chemistry. 60, 17, p. 7284-7299 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)251 Downloads (Pure) -
Discovery and profiling of small RNAs responsive to stress conditions in the plant pathogen Pectobacterium atrosepticum
Kwenda, S., Gorshkov, V., Ramesh, A. M., Naidoo, S., Rubagotti, E., Birch, P. R. J. & Moleleki, L. N., 12 Jan 2016, In: BMC Genomics. 17, 15 p., 47.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)156 Downloads (Pure) -
Discovery and refinement of loci associated with lipid levels
Global Lipids Genetics Consortium, 2013, In: Nature Genetics. 45, 11, p. 1274-1283 10 p.Research output: Contribution to journal › Article › peer-review
1872 Citations (Scopus) -
Discovery and structure-activity relationships of pyrrolone antimalarials
Murugesan, D., Mital, A., Kaiser, M., Shackleford, D. M., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H., 2013, In: Journal of Medicinal Chemistry. 56, 7, p. 2975-2990 16 p.Research output: Contribution to journal › Article › peer-review
54 Citations (Scopus) -
Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a H-1-NMR Method to Assess Deacetylase Activity
Pirrie, L., McCarthy, A. R., Major, L. L., Morkunaite, V., Zubriene, A., Matulis, D., Lain, S., Lebl, T. & Westwood, N. J., 2012, In: Molecules. 17, 10, p. 12206-12224 19 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): a potent, orally available, and highly selective PARP-1 inhibitor for cancer therapy
Papeo, G., Posteri, H., Borghi, D., Busel, A. A., Caprera, F., Casale, E., Ciomei, M., Cirla, A., Corti, E., D'Anello, M., Fasolini, M., Forte, B., Galvani, A., Isacchi, A., Khvat, A., Krasavin, M. Y., Lupi, R., Orsini, P., Perego, R., Pesenti, E., & 9 others , 10 Sep 2015, In: Journal of Medicinal Chemistry. 58, 17, p. 6875-6898 24 p.Research output: Contribution to journal › Article › peer-review
79 Citations (Scopus) -
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening
Holloway, G. A., Baell, J. B., Fairlamb, A. H., Novello, P. M., Parisot, J. P., Richardson, J., Watson, K. G. & Street, I. P., 1 Mar 2007, In: Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1422-1427 6 p.Research output: Contribution to journal › Article › peer-review
52 Citations (Scopus) -
Discovery of A Ca2+-and calmodulin-dependent protein phosphatase
Stewart, A. A., Ingebritsen, T. S., Manalan, A., Klee, C. B. & Cohen, P., 11 Jan 1982, In: FEBS Letters. 137, 1, p. 80-84 5 p.Research output: Contribution to journal › Article › peer-review
Open Access339 Citations (Scopus) -
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
Torrie, L. S., Robinson, D. A., Thomas, M. G., Hobrath, J. V., Shepherd, S. M., Post, J. M., Ko, E. J., Ferreira, R. A., Mackenzie, C. J., Wrobel, K., Edwards, D. P., Gilbert, I. H., Gray, D. W., Fairlamb, A. H. & De Rycker, M., 8 May 2020, In: ACS Infectious Diseases. 6, 5, p. 1044-1057 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)80 Downloads (Pure) -
Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa
Cukier, C. D., Hope, A. G., Elamin, A. A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J. H., Lindqvist, Y., Gray, D. W. & Schneider, G., 2013, In: ACS Chemical Biology. n/a, cb4005063.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2
Ridgway, H., Moore, G. J., Mavromoustakos, T., Tsiodras, S., Ligielli, I., Kelaidonis, K., Chasapis, C. T., Gadanec, L. K., Zulli, A., Apostolopoulos, V., Petty, R., Karakasiliotis, I., Gorgoulis, V. G. & Matsoukas, J. M., 2022, In: Computational and structural biotechnology journal. 20, p. 2091-2111 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)25 Downloads (Pure) -
Discovery of a new sialic acid binding region that regulates Siglec-7
Yamakawa, N., Yasuda, Y., Yoshimura, A., Goshima, A., Crocker, P. R., Vergoten, G., Nishiura, Y., Takahashi, T., Hanashima, S., Matsumoto, K., Yamaguchi, Y., Tanaka, H., Kitajima, K. & Sato, C., 26 May 2020, In: Scientific Reports. 10, 14 p., 8647.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)50 Downloads (Pure) -
Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile91 Citations (Scopus)461 Downloads (Pure) -
Discovery of an RmlC/D fusion protein in the microalga Prymnesium parvum and its implications for NDP-β-L-rhamnose biosynthesis in microalgae
Wagstaff, B., Rejzek, M., Kuhaudomlarp, S., Hill, L., Mascia, I., Nepogodiev, S. A., Dorfmueller, H. & Field, R. A., 7 Jun 2019, In: Journal of Biological Chemistry. 294, 23, p. 9172-9185 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)162 Downloads (Pure) -
Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres
Kobayashi, N., Suzuki, Y., Schoenfeld, L., Müller, C., Nieduszynski, C., Wolfe, K. & Tanaka, T., 3 Aug 2015, In: Current Biology. 25, 15, p. 2026-2033 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)225 Downloads (Pure) -
Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221.
Cohen, P. T. & Cohen, P., 15 Jun 1989, In: The Biochemical journal. 260, 3, p. 931-934 4 p.Research output: Contribution to journal › Article › peer-review
95 Citations (Scopus) -
Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor
Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R. & Gray, N. S., 14 May 2015, In: ACS Medicinal Chemistry Letters. 6, 5, p. 584-589 6 p.Research output: Contribution to journal › Article › peer-review
36 Citations (Scopus) -
Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy
Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A., & 7 others , 10 Nov 2016, In: Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus)227 Downloads (Pure) -
Discovery of benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain
Cipriano, A., Milite, C., Feoli, A., Viviano, M., Pepe, G., Campiglia, P., Sarno, G., Picaud, S., Imaide, S., Makukhin, N., Filippakopoulos, P., Ciulli, A., Castellano, S. & Sbardella, G., 19 Oct 2022, In: ChemMedChem. 17, 20, 14 p., e202200343.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium
Koivula, R. W., Heggie, A., Barnett, A., Cederberg, H., Hansen, T. H., Koopman, A. D., Ridderstråle, M., Rutters, F., Vestergaard, H., Gupta, R., Herrgård, S., Heymans, M. W., Perry, M. H., Rauh, S., Siloaho, M., Teare, H. J. A., Thorand, B., Bell, J., Brunak, S., Frost, G., & 14 others , Jun 2014, In: Diabetologia. 57, 6, p. 1132-1142 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)210 Downloads (Pure) -
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H., & 30 others , 1 Sep 2019, In: Diabetologia. 62, 9, p. 1601-1615 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)27 Downloads (Pure) -
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations
Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K., 1 Nov 2011, In: Open Biology. 1, NOVEMBER, 110012.Research output: Contribution to journal › Article › peer-review
73 Citations (Scopus) -
Discovery of common and rare genetic risk variants for colorectal cancer
Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., Conti, D. V., Qu, C., Jeon, J., Edlund, C. K., Greenside, P., Wainberg, M., Schumacher, F. R., Smith, J. D., Levine, D. M., Nelson, S. C., Sinnott-Armstrong, N. A., Albanes, D., Alonso, M. H., Anderson, K., & 179 others , 1 Jan 2019, In: Nature Genetics. 51, 1, p. 76-87 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile225 Citations (Scopus)268 Downloads (Pure) -
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models
IMI DIRECT Consortium, Rasmussen, S. & Brunak, S., 2 Jan 2023, (E-pub ahead of print) In: Nature Biotechnology. 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei
Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H., 8 Oct 2015, In: Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library
Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In: ChemMedChem. 10, 11, p. 1809-1820 12 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
Discovery of invariants through automated theory formation
Llano, M. T., Ireland, A. & Pease, A., Oct 2012, In: Formal Aspects of Computing. n/a, p. 1-47 47 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening
Navratilova, I., Aristotelous, T., Picaud, S., Chaikuad, A., Knapp, S., Filappakopoulos, P. & Hopkins, A. L., 8 Dec 2016, In: ACS Medicinal Chemistry Letters. 7, 12, p. 1213-1218 6 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)
Brasca, M. G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Casale, E., Ceccarelli, W., Colombo, N., De Ponti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E. R., Ferguson, R. D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L., & 4 others , 15 Nov 2013, In: Bioorganic & Medicinal Chemistry. 21, 22, p. 7047-7063 17 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists
Jones, D. G., Liang, X., Stewart, E. L., Noe, R. A., Kallander, L. S., Madauss, K. P., Williams, S. P., Thompson, S. K., Gray, D. W. & Hoekstra, W. J., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 13, p. 3203-6 4 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Discovery of novel heart rate-associated loci using the Exome Chip
van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Müller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikäinen, L-P., & 101 others , 15 Jun 2017, In: Human Molecular Genetics. 26, 12, p. 2346-2363 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)163 Downloads (Pure) -
Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors
Wang, S., Midgley, C. A., Scaërou, F., Grabarek, J. B., Griffiths, G., Jackson, W., Kontopidis, G., McClue, S. J., McInnes, C., Meades, C., Mezna, M., Plater, A., Stuart, I., Thomas, M. P., Wood, G., Clarke, R. G., Blake, D. G., Zheleva, D. I., Lane, D. P., Jackson, R. C., & 2 others , 10 Jun 2010, In: Journal of Medicinal Chemistry. 53, 11, p. 4367-4378 12 p.Research output: Contribution to journal › Article › peer-review
86 Citations (Scopus) -
Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1
Osborne, J., Birchall, K., Tsagris, D. J., Lewis, S. J., Smiljanic-Hurley, E., Taylor, D. L., Levy, A., Alessi, D. & McIver, E. G., 15 Feb 2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 4, p. 668-673 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)79 Downloads (Pure) -
Discovery of potent and selective covalent inhibitors of JNK
Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. & Gray, N. S., 27 Jan 2012, In: Chemistry & Biology. 19, 1, p. 140-154 15 p.Research output: Contribution to journal › Article › peer-review
239 Citations (Scopus) -
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Cavazzuti, A., Paglietti, G., Hunter, W. N., Gamarro, F., Piras, S., Loriga, M., Alleca, S., Corona, P., McLuskey, K., Tulloch, L., Gibellini, F., Ferrari, S. & Costin, M. P., 5 Feb 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1448-1453 6 p.Research output: Contribution to journal › Article › peer-review
120 Citations (Scopus) -
Discovery of powerful millisecond flares from Cygnus X-1
Gierliński, M. & Zdziarski, A. A., 11 Aug 2003, In: Monthly Notices of the Royal Astronomical Society. 343, 3, p. L84-L88 5 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
LifeLines Cohort Study, EPIC-CVD Consortium, EPIC-InterAct Consortium, Understanding Society Scientific Group, Million Veteran Program, Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G., & 37 others , Dec 2020, In: Nature Genetics. 52, 12, p. 1314-1332 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Citations (Scopus)31 Downloads (Pure) -
Discovery of sarolaner: A novel, Orally administered, broad-spectrum, Isoxazoline ectoparasiticide for dogs
McTier, T. L., Chubb, N., Curtis, M. P., Hedges, L., Inskeep, G. A., Knauer, C. S., Menon, S., Mills, B., Pullins, A., Zinser, E., Woods, D. J. & Meeus, P., 30 May 2016, In: Veterinary Parasitology. 222, p. 3-11 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile87 Citations (Scopus)322 Downloads (Pure) -
Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)
Bell, M., Foley, D., Naylor, C., Wood, G., Robinson, C., Riley, J., Epemolu, R., Ellis, L., Scullion, S., Shishikura, Y., Osuna-Cabello, M., Ferguson, L., Pinto, E., Fletcher, D., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 341–347 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)211 Downloads (Pure) -
Discovery of soticlestat, a potent and selective inhibitor for cholesterol 24-hydroxylase (CH24H)
Koike, T., Yoshikawa, M., Ando, H. K., Farnaby, W., Nishi, T., Watanabe, E., Yano, J., Miyamoto, M., Kondo, S., Ishii, T. & Kuroita, T., 26 Aug 2021, In: Journal of Medicinal Chemistry. 64, 16, p. 12228-12244 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)1 Downloads (Pure) -
Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1
Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 15 Oct 2018, In: Bioorganic & Medicinal Chemistry Letters. 28, 19, p. 3255-3259 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)243 Downloads (Pure) -
Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies
Lucas, X., Simon, S., Schubert, R. & Günther, S., 9 Apr 2013, In: PLoS ONE. 8, 4, 8 p., e60679.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)164 Downloads (Pure) -
Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)
Tan, L., Nomanbhoy, T., Gurbani, D., Patricelli, M., Hunter, J., Geng, J., Herhaus, L., Zhang, J., Pauls, E., Ham, Y., Choi, H. G., Xie, T., Deng, X., Buhrlage, S. J., Sim, T., Cohen, P., Sapkota, G., Westover, K. D. & Gray, N. S., 8 Jan 2015, In: Journal of Medicinal Chemistry. 58, 1, p. 183-196 14 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Citations (Scopus) -
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2
Liu, X., Kalogeropulou, A. F., Domingos, S., Makukhin, N., Nirujogi, R., Singh, F., Shpiro, N., Saalfrank, A., Sammler, E., Ganley, I. G., Moreira, R., Alessi, D. R. & Ciulli, A., 21 Sep 2022, In: Journal of the American Chemical Society. 144, 37, p. 16930-16952 23 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)73 Downloads (Pure) -
Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor
Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I., 2013, In: ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.Research output: Contribution to journal › Article › peer-review
50 Citations (Scopus) -
Discrete modelling of vertical track-soil coupling for vehicle-track dynamics
Kouroussis, G., Gazetas, G., Anastasopoulos, I., Conti, C. & Verlinden, O., Dec 2011, In: Soil Dynamics and Earthquake Engineering. 31, 12, p. 1711-1723 13 p.Research output: Contribution to journal › Article › peer-review
77 Citations (Scopus)