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  Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase

  Kremer, A. N., Bausenwein, J., Lurvink, E., Kremer, A. E., Rutten, C. E., van Bergen, C. A. M., Kretschmann, S., van der Meijden, E., Honders, M. W., Mazzeo, D., Watts, C., Mackensen, A., Falkenburg, J. H. F. & Griffioen, M., 11 Mar 2020, In: Frontiers in Immunology. 11, 11 p., 381.

  Research output: Contribution to journal › Article › peer-review

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  4 Citations (Scopus)

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• Discovery and observations of ASASSN-13db, an EX lupi-type accretion event on a low-mass T tauri star

  Holoien, T. W. S., Prieto, J. L., Stanek, K. Z., Kochanek, C. S., Shappee, B. J., Zhu, Z., Sicilia-Aguilar, A., Grupe, D., Croxall, K., Adams, D. J., Simon, J. D., Morrell, N. W., McGraw, S. M., Wagner, R. M., Basu, U., Beacom, J. F., Bersier, D., Brimacombe, J., Jencson, J., Pojmanski, G., & 3 othersStarrfield, S. G., Szczygie, D. M. & Woodward, C. E., 20 Apr 2014, In: Astrophysical Journal Letters. 785, 2, 6 p., L35.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Discovery and Optimisation of a Compound Series active against Trypanosoma cruzi, the causative agent of Chagas’ Disease

  Harrison, J. R., Sarkar, S., Hampton, S., Riley, J., Stojanovski, L., Sahlberg, C., Appelqvist, P., Erath, J., Mathan, V., Rodriguez, A., Kaiser, M., Pacanowska, D. G., Read, K. D., Johansson, N. G. & Gilbert, I. H., 26 Mar 2020, In: Journal of Medicinal Chemistry. 63, 6, p. 3066-3089 24 p.

  Research output: Contribution to journal › Article › peer-review

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  4 Citations (Scopus)

  53 Downloads (Pure)

• Discovery and optimisation studies of antimalarial phenotypic hits

  Mital, A., Murugesan, D., Kaiser, M., Yeates, C. & Gilbert, I. H., 20 Oct 2015, In: European Journal of Medicinal Chemistry. 103, p. 530-538 9 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

  Brand, S., Ko, E. J., Viayna, E., Thompson, S., Spinks, D., Thomas, M., Sandberg, L., Francisco, A. F., Jayawardhana, S., Smith, V. C., Jansen, C., De Rycker, M., Thomas, J., MacLean, L., Osuna-Cabello, M., Riley, J., Scullion, P., Stojanovski, L., Simeons, F. R. C., Epemolu, O., & 16 othersShishikura, Y., Crouch, S. D., Bakshi, T. S., Nixon, C. J., Reid, I. H., Hill, A. P., Underwood, T. Z., Hindley, S. J., Robinson, S. A., Kelly, J. M., Fiandor, J. M., Wyatt, P. G., Marco, M., Miles, T. J., Read, K. D. & Gilbert, I. H., 14 Sep 2017, In: Journal of Medicinal Chemistry. 60, 17, p. 7284-7299 16 p.

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  32 Citations (Scopus)

  251 Downloads (Pure)

• Discovery and profiling of small RNAs responsive to stress conditions in the plant pathogen Pectobacterium atrosepticum

  Kwenda, S., Gorshkov, V., Ramesh, A. M., Naidoo, S., Rubagotti, E., Birch, P. R. J. & Moleleki, L. N., 12 Jan 2016, In: BMC Genomics. 17, 15 p., 47.

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  16 Citations (Scopus)

  156 Downloads (Pure)

• Discovery and refinement of loci associated with lipid levels

  Global Lipids Genetics Consortium, 2013, In: Nature Genetics. 45, 11, p. 1274-1283 10 p.

  Research output: Contribution to journal › Article › peer-review
  1872 Citations (Scopus)

• Discovery and structure-activity relationships of pyrrolone antimalarials

  Murugesan, D., Mital, A., Kaiser, M., Shackleford, D. M., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H., 2013, In: Journal of Medicinal Chemistry. 56, 7, p. 2975-2990 16 p.

  Research output: Contribution to journal › Article › peer-review
  54 Citations (Scopus)

• Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a H-1-NMR Method to Assess Deacetylase Activity

  Pirrie, L., McCarthy, A. R., Major, L. L., Morkunaite, V., Zubriene, A., Matulis, D., Lain, S., Lebl, T. & Westwood, N. J., 2012, In: Molecules. 17, 10, p. 12206-12224 19 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): a potent, orally available, and highly selective PARP-1 inhibitor for cancer therapy

  Papeo, G., Posteri, H., Borghi, D., Busel, A. A., Caprera, F., Casale, E., Ciomei, M., Cirla, A., Corti, E., D'Anello, M., Fasolini, M., Forte, B., Galvani, A., Isacchi, A., Khvat, A., Krasavin, M. Y., Lupi, R., Orsini, P., Perego, R., Pesenti, E., & 9 othersPezzetta, D., Rainoldi, S., Riccardi-Sirtori, F., Scolaro, A., Sola, F., Zuccotto, F., Felder, E. R., Donati, D. & Montagnoli, A., 10 Sep 2015, In: Journal of Medicinal Chemistry. 58, 17, p. 6875-6898 24 p.

  Research output: Contribution to journal › Article › peer-review
  79 Citations (Scopus)

• Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

  Holloway, G. A., Baell, J. B., Fairlamb, A. H., Novello, P. M., Parisot, J. P., Richardson, J., Watson, K. G. & Street, I. P., 1 Mar 2007, In: Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1422-1427 6 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)

• Discovery of A Ca2+-and calmodulin-dependent protein phosphatase

  Stewart, A. A., Ingebritsen, T. S., Manalan, A., Klee, C. B. & Cohen, P., 11 Jan 1982, In: FEBS Letters. 137, 1, p. 80-84 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  339 Citations (Scopus)

• Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

  Torrie, L. S., Robinson, D. A., Thomas, M. G., Hobrath, J. V., Shepherd, S. M., Post, J. M., Ko, E. J., Ferreira, R. A., Mackenzie, C. J., Wrobel, K., Edwards, D. P., Gilbert, I. H., Gray, D. W., Fairlamb, A. H. & De Rycker, M., 8 May 2020, In: ACS Infectious Diseases. 6, 5, p. 1044-1057 14 p.

  Research output: Contribution to journal › Article › peer-review

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  5 Citations (Scopus)

  80 Downloads (Pure)

• Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

  Cukier, C. D., Hope, A. G., Elamin, A. A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J. H., Lindqvist, Y., Gray, D. W. & Schneider, G., 2013, In: ACS Chemical Biology. n/a, cb4005063.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2

  Ridgway, H., Moore, G. J., Mavromoustakos, T., Tsiodras, S., Ligielli, I., Kelaidonis, K., Chasapis, C. T., Gadanec, L. K., Zulli, A., Apostolopoulos, V., Petty, R., Karakasiliotis, I., Gorgoulis, V. G. & Matsoukas, J. M., 2022, In: Computational and structural biotechnology journal. 20, p. 2091-2111 21 p.

  Research output: Contribution to journal › Article › peer-review

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  8 Citations (Scopus)

  25 Downloads (Pure)

• Discovery of a new sialic acid binding region that regulates Siglec-7

  Yamakawa, N., Yasuda, Y., Yoshimura, A., Goshima, A., Crocker, P. R., Vergoten, G., Nishiura, Y., Takahashi, T., Hanashima, S., Matsumoto, K., Yamaguchi, Y., Tanaka, H., Kitajima, K. & Sato, C., 26 May 2020, In: Scientific Reports. 10, 14 p., 8647.

  Research output: Contribution to journal › Article › peer-review

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  14 Citations (Scopus)

  50 Downloads (Pure)

• Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

  Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

  Research output: Contribution to journal › Article › peer-review

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  91 Citations (Scopus)

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• Discovery of an RmlC/D fusion protein in the microalga Prymnesium parvum and its implications for NDP-β-L-rhamnose biosynthesis in microalgae

  Wagstaff, B., Rejzek, M., Kuhaudomlarp, S., Hill, L., Mascia, I., Nepogodiev, S. A., Dorfmueller, H. & Field, R. A., 7 Jun 2019, In: Journal of Biological Chemistry. 294, 23, p. 9172-9185 14 p.

  Research output: Contribution to journal › Article › peer-review

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  8 Citations (Scopus)

  162 Downloads (Pure)

• Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres

  Kobayashi, N., Suzuki, Y., Schoenfeld, L., Müller, C., Nieduszynski, C., Wolfe, K. & Tanaka, T., 3 Aug 2015, In: Current Biology. 25, 15, p. 2026-2033 8 p.

  Research output: Contribution to journal › Article › peer-review

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  29 Citations (Scopus)

  225 Downloads (Pure)

• Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221.

  Cohen, P. T. & Cohen, P., 15 Jun 1989, In: The Biochemical journal. 260, 3, p. 931-934 4 p.

  Research output: Contribution to journal › Article › peer-review
  95 Citations (Scopus)

• Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor

  Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R. & Gray, N. S., 14 May 2015, In: ACS Medicinal Chemistry Letters. 6, 5, p. 584-589 6 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

  Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A., & 7 othersGray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 10 Nov 2016, In: Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.

  Research output: Contribution to journal › Article › peer-review

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  46 Citations (Scopus)

  227 Downloads (Pure)

• Discovery of benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain

  Cipriano, A., Milite, C., Feoli, A., Viviano, M., Pepe, G., Campiglia, P., Sarno, G., Picaud, S., Imaide, S., Makukhin, N., Filippakopoulos, P., Ciulli, A., Castellano, S. & Sbardella, G., 19 Oct 2022, In: ChemMedChem. 17, 20, 14 p., e202200343.

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• Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

  Koivula, R. W., Heggie, A., Barnett, A., Cederberg, H., Hansen, T. H., Koopman, A. D., Ridderstråle, M., Rutters, F., Vestergaard, H., Gupta, R., Herrgård, S., Heymans, M. W., Perry, M. H., Rauh, S., Siloaho, M., Teare, H. J. A., Thorand, B., Bell, J., Brunak, S., Frost, G., & 14 othersJablonka, B., Mari, A., McDonald, T. J., Dekker, J. M., Hansen, T., Hattersley, A., Laakso, M., Pedersen, O., Koivisto, V., Ruetten, H., Walker, M., Pearson, E., Franks, P. W. & DIRECT Consortium, Jun 2014, In: Diabetologia. 57, 6, p. 1132-1142 11 p.

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  38 Citations (Scopus)

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• Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

  Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H., & 30 othersRauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. & Franks, P. W., 1 Sep 2019, In: Diabetologia. 62, 9, p. 1601-1615 15 p.

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  15 Citations (Scopus)

  27 Downloads (Pure)

• Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations

  Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K., 1 Nov 2011, In: Open Biology. 1, NOVEMBER, 110012.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• Discovery of common and rare genetic risk variants for colorectal cancer

  Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., Conti, D. V., Qu, C., Jeon, J., Edlund, C. K., Greenside, P., Wainberg, M., Schumacher, F. R., Smith, J. D., Levine, D. M., Nelson, S. C., Sinnott-Armstrong, N. A., Albanes, D., Alonso, M. H., Anderson, K., & 179 othersArnau-Collell, C., Arndt, V., Bamia, C., Banbury, B. L., Baron, J. A., Berndt, S. I., Bézieau, S., Bishop, D. T., Boehm, J., Boeing, H., Brenner, H., Brezina, S., Buch, S., Buchanan, D. D., Burnett-Hartman, A., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chirlaque, M-D., Cho, S. H., Connolly, C. M., Cross, A. J., Cuk, K., Curtis, K. R., de la Chapelle, A., Doheny, K. F., Duggan, D., Easton, D. F., Elias, S. G., Elliott, F., English, D. R., Feskens, E. J. M., Figueiredo, J. C., Fischer, R., FitzGerald, L. M., Forman, D., Gala, M., Gallinger, S., Gauderman, W. J., Giles, G. G., Gillanders, E., Gong, J., Goodman, P. J., Grady, W. M., Grove, J. S., Gsur, A., Gunter, M. J., Haile, R. W., Hampe, J., Hampel, H., Harlid, S., Hayes, R. B., Hofer, P., Hoffmeister, M., Hopper, J. L., Hsu, W-L., Huang, W-Y., Hudson, T. J., Hunter, D. J., Ibañez-Sanz, G., Idos, G. E., Ingersoll, R., Jackson, R. D., Jacobs, E. J., Jenkins, M. A., Joshi, A. D., Joshu, C. E., Keku, T. O., Key, T. J., Kim, H. R., Kobayashi, E., Kolonel, L. N., Kooperberg, C., Kühn, T., Küry, S., Kweon, S-S., Larsson, S. C., Laurie, C. A., Le Marchand, L., Leal, S. M., Lee, S. C., Lejbkowicz, F., Lemire, M., Li, C. I., Li, L., Lieb, W., Lin, Y., Lindblom, A., Lindor, N. M., Ling, H., Louie, T. L., Männistö, S., Markowitz, S. D., Martín, V., Masala, G., McNeil, C. E., Melas, M., Milne, R. L., Moreno, L., Murphy, N., Myte, R., Naccarati, A., Newcomb, P. A., Offit, K., Ogino, S., Onland-Moret, N. C., Pardini, B., Parfrey, P. S., Pearlman, R., Perduca, V., Pharoah, P. D. P., Pinchev, M., Platz, E. A., Prentice, R. L., Pugh, E., Raskin, L., Rennert, G., Rennert, H. S., Riboli, E., Rodríguez-Barranco, M., Romm, J., Sakoda, L. C., Schafmayer, C., Schoen, R. E., Seminara, D., Shah, M., Shelford, T., Shin, M-H., Shulman, K., Sieri, S., Slattery, M. L., Southey, M. C., Stadler, Z. K., Stegmaier, C., Su, Y-R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Thomas, S. S., Toland, A. E., Trichopoulou, A., Ulrich, C. M., Van Den Berg, D. J., van Duijnhoven, F. J. B., Van Guelpen, B., van Kranen, H., Vijai, J., Visvanathan, K., Vodicka, P., Vodickova, L., Vymetalkova, V., Weigl, K., Weinstein, S. J., White, E., Win, A. K., Wolf, C. R., Wolk, A., Woods, M. O., Wu, A. H., Zaidi, S. H., Zanke, B. W., Zhang, Q., Zheng, W., Scacheri, P. C., Potter, J. D., Bassik, M. C., Kundaje, A., Casey, G., Moreno, V., Abecasis, G. R., Nickerson, D. A., Gruber, S. B., Hsu, L. & Peters, U., 1 Jan 2019, In: Nature Genetics. 51, 1, p. 76-87 12 p.

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  225 Citations (Scopus)

  268 Downloads (Pure)

• Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

  IMI DIRECT Consortium, Rasmussen, S. & Brunak, S., 2 Jan 2023, (E-pub ahead of print) In: Nature Biotechnology. 17 p.

  Research output: Contribution to journal › Article › peer-review

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• Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

  Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H., 8 Oct 2015, In: Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

  Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In: ChemMedChem. 10, 11, p. 1809-1820 12 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Discovery of invariants through automated theory formation

  Llano, M. T., Ireland, A. & Pease, A., Oct 2012, In: Formal Aspects of Computing. n/a, p. 1-47 47 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

  Navratilova, I., Aristotelous, T., Picaud, S., Chaikuad, A., Knapp, S., Filappakopoulos, P. & Hopkins, A. L., 8 Dec 2016, In: ACS Medicinal Chemistry Letters. 7, 12, p. 1213-1218 6 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)

  Brasca, M. G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Casale, E., Ceccarelli, W., Colombo, N., De Ponti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E. R., Ferguson, R. D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L., & 4 othersSola, F., Visco, C., Zuccotto, F. & Fogliatto, G., 15 Nov 2013, In: Bioorganic & Medicinal Chemistry. 21, 22, p. 7047-7063 17 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists

  Jones, D. G., Liang, X., Stewart, E. L., Noe, R. A., Kallander, L. S., Madauss, K. P., Williams, S. P., Thompson, S. K., Gray, D. W. & Hoekstra, W. J., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 13, p. 3203-6 4 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Discovery of novel heart rate-associated loci using the Exome Chip

  van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Müller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikäinen, L-P., & 101 othersHall, L. M., van Setten, J., Trompet, S., Prins, B. P., Isaacs, A., Radmanesh, F., Marten, J., Entwistle, A., Kors, J. A., Silva, C. T., Alonso, A., Bis, J. C., de Boer, R. A., de Haan, H. G., de Mutsert, R., Dedoussis, G., Dominiczak, A. F., Doney, A. S. F., Ellinor, P. T., Eppinga, R. N., Felix, S. B., Guo, X., Hagemeijer, Y., Hansen, T., Harris, T. B., Heckbert, S. R., Huang, P. L., Hwang, S-J., Kähönen, M., Kanters, J. K., Kolcic, I., Launer, L. J., Li, M., Yao, J., Linneberg, A., Liu, S., Macfarlane, P. W., Mangino, M., Morris, A. D., Mulas, A., Murray, A. D., Nelson, C. P., Orrú, M., Padmanabhan, S., Peters, A., Porteous, D. J., Poulter, N. R., Psaty, B. M., Qi, L., Raitakari, O. T., Rivadeneira, F., Roselli, C., Rudan, I., Sattar, N., Sever, P., Sinner, M. F., Soliman, E. Z., Spector, T. D., Stanton, A. V., Stirrups, K. E., Taylor, K. D., Tobin, M. D., Uitterlinden, A. G., Vaartjes, I., Hoes, A. W., van der Meer, P., Völker, U., Waldenberger, M., Xie, Z., Zoledziewska, M., Tinker, A., Polasek, O., Rosand, J., Jamshidi, Y., van Duijn, C. M., Zeggini, E., Wouter Jukema, J., Asselbergs, F. W., Samani, N. J., Lehtimäki, T., Gudnason, V., Wilson, J., Lubitz, S. A., Kääb, S., Sotoodehnia, N., Caulfield, M. J., Palmer, C. N. A., Sanna, S., Mook-Kanamori, D. O., Deloukas, P., Pedersen, O., Rotter, J. I., Dörr, M., O'Donnell, C. J., Hayward, C., Arking, D. E., Kooperberg, C., van der Harst, P., Eijgelsheim, M., Stricker, B. H. C. & Munroe, P. B., 15 Jun 2017, In: Human Molecular Genetics. 26, 12, p. 2346-2363 18 p.

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• Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

  Wang, S., Midgley, C. A., Scaërou, F., Grabarek, J. B., Griffiths, G., Jackson, W., Kontopidis, G., McClue, S. J., McInnes, C., Meades, C., Mezna, M., Plater, A., Stuart, I., Thomas, M. P., Wood, G., Clarke, R. G., Blake, D. G., Zheleva, D. I., Lane, D. P., Jackson, R. C., & 2 othersGlover, D. M. & Fischer, P. M., 10 Jun 2010, In: Journal of Medicinal Chemistry. 53, 11, p. 4367-4378 12 p.

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  86 Citations (Scopus)

• Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1

  Osborne, J., Birchall, K., Tsagris, D. J., Lewis, S. J., Smiljanic-Hurley, E., Taylor, D. L., Levy, A., Alessi, D. & McIver, E. G., 15 Feb 2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 4, p. 668-673 6 p.

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• Discovery of potent and selective covalent inhibitors of JNK

  Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. & Gray, N. S., 27 Jan 2012, In: Chemistry & Biology. 19, 1, p. 140-154 15 p.

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  239 Citations (Scopus)

• Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

  Cavazzuti, A., Paglietti, G., Hunter, W. N., Gamarro, F., Piras, S., Loriga, M., Alleca, S., Corona, P., McLuskey, K., Tulloch, L., Gibellini, F., Ferrari, S. & Costin, M. P., 5 Feb 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1448-1453 6 p.

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  120 Citations (Scopus)

• Discovery of powerful millisecond flares from Cygnus X-1

  Gierliński, M. & Zdziarski, A. A., 11 Aug 2003, In: Monthly Notices of the Royal Astronomical Society. 343, 3, p. L84-L88 5 p.

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  31 Citations (Scopus)

• Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

  LifeLines Cohort Study, EPIC-CVD Consortium, EPIC-InterAct Consortium, Understanding Society Scientific Group, Million Veteran Program, Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G., & 37 othersLiu, D. J., Prins, B. P., Stewart, I. D., Cabrera, C. P., Eales, J. M., Akbarov, A., Auer, P. L., Bielak, L. F., Bis, J. C., Braithwaite, V. S., Brody, J. A., Daw, E. W., Warren, H. R., Drenos, F., Nielsen, S. F., Faul, J. D., Fauman, E. B., Fava, C., Ferreira, T., Foley, C. N., Franceschini, N., Gao, H., Giannakopoulou, O., Giulianini, F., Gudbjartsson, D. F., Guo, X., Harris, S. E., Havulinna, A. S., Helgadottir, A., Huffman, J. E., Hwang, S-J., Kanoni, S., Smith, J. A., Palmer, C. N. A., Smith, B. H., Munroe, P. B. & Howson, J. M. M., Dec 2020, In: Nature Genetics. 52, 12, p. 1314-1332 19 p.

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• Discovery of sarolaner: A novel, Orally administered, broad-spectrum, Isoxazoline ectoparasiticide for dogs

  McTier, T. L., Chubb, N., Curtis, M. P., Hedges, L., Inskeep, G. A., Knauer, C. S., Menon, S., Mills, B., Pullins, A., Zinser, E., Woods, D. J. & Meeus, P., 30 May 2016, In: Veterinary Parasitology. 222, p. 3-11 9 p.

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• Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

  Bell, M., Foley, D., Naylor, C., Wood, G., Robinson, C., Riley, J., Epemolu, R., Ellis, L., Scullion, S., Shishikura, Y., Osuna-Cabello, M., Ferguson, L., Pinto, E., Fletcher, D., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 341–347 7 p.

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• Discovery of soticlestat, a potent and selective inhibitor for cholesterol 24-hydroxylase (CH24H)

  Koike, T., Yoshikawa, M., Ando, H. K., Farnaby, W., Nishi, T., Watanabe, E., Yano, J., Miyamoto, M., Kondo, S., Ishii, T. & Kuroita, T., 26 Aug 2021, In: Journal of Medicinal Chemistry. 64, 16, p. 12228-12244 17 p.

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• Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

  Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 15 Oct 2018, In: Bioorganic & Medicinal Chemistry Letters. 28, 19, p. 3255-3259 5 p.

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• Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies

  Lucas, X., Simon, S., Schubert, R. & Günther, S., 9 Apr 2013, In: PLoS ONE. 8, 4, 8 p., e60679.

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• Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

  Tan, L., Nomanbhoy, T., Gurbani, D., Patricelli, M., Hunter, J., Geng, J., Herhaus, L., Zhang, J., Pauls, E., Ham, Y., Choi, H. G., Xie, T., Deng, X., Buhrlage, S. J., Sim, T., Cohen, P., Sapkota, G., Westover, K. D. & Gray, N. S., 8 Jan 2015, In: Journal of Medicinal Chemistry. 58, 1, p. 183-196 14 p.

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  53 Citations (Scopus)

• Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2

  Liu, X., Kalogeropulou, A. F., Domingos, S., Makukhin, N., Nirujogi, R., Singh, F., Shpiro, N., Saalfrank, A., Sammler, E., Ganley, I. G., Moreira, R., Alessi, D. R. & Ciulli, A., 21 Sep 2022, In: Journal of the American Chemical Society. 144, 37, p. 16930-16952 23 p.

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• Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

  Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I., 2013, In: ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

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  50 Citations (Scopus)

• Discrete modelling of vertical track-soil coupling for vehicle-track dynamics

  Kouroussis, G., Gazetas, G., Anastasopoulos, I., Conti, C. & Verlinden, O., Dec 2011, In: Soil Dynamics and Earthquake Engineering. 31, 12, p. 1711-1723 13 p.

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  77 Citations (Scopus)