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  Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

  23andMe Research Team, Karlsson Linnér, R., Biroli, P., Kong, E., Meddens, S. F. W., Wedow, R., Fontana, M. A., Lebreton, M., Tino, S. P., Abdellaoui, A., Hammerschlag, A. R., Nivard, M. G., Okbay, A., Rietveld, C. A., Timshel, P. N., Trzaskowski, M., Vlaming, R. D., Zünd, C. L., Bao, Y., Buzdugan, L., & 22 othersCaplin, A. H., Chen, C. Y., Eibich, P., Fontanillas, P., Gonzalez, J. R., Joshi, P. K., Karhunen, V., Kleinman, A., Levin, R. Z., Lill, C. M., Meddens, G. A., Muntané, G., Sanchez-Roige, S., Rooij, F. J. V., Taskesen, E., Wu, Y., Zhang, F., Auton, A., Boardman, J. D., Clark, D. W., Conlin, A. & Beauchamp, J. P., 2019, In: Nature Genetics. 51, 2, p. 245-257 13 p.

  Research output: Contribution to journal › Article › peer-review
  249 Citations (Scopus)

• Genome-wide association analysis identifies 13 new risk loci for schizophrenia

  Ripke, S., O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., Bergen, S. E., Collins, A. L., Crowley, J. J., Fromer, M., Kim, Y., Lee, S. H., Magnusson, P. K. E., Sanchez, N., Stahl, E. A., Williams, S., Wray, N. R., Xia, K., Bettella, F., Borglum, A. D., & 31 othersBulik-Sullivan, B. K., Cormican, P., Craddock, N., de Leeuw, C., Durmishi, N., Gill, M., Golimbet, V., Hamshere, M. L., Holmans, P., Hougaard, D. M., Kendler, K. S., Lin, K., Morris, D. W., Mors, O., Mortensen, P. B., Neale, B. M., O'Neill, F. A., Owen, M. J., Milovancevic, M. P., Posthuma, D., Powell, J., Richards, A. L., Riley, B. P., Ruderfer, D., Rujescu, D., Sigurdsson, E., Silagadze, T., Smit, A. B., Stefansson, H., Palmer, C. N. A. & Multicenter Genetic Studies of Schizophrenia Consortium, 2013, In: Nature Genetics. 45, 10, p. 1150-1159 10 p.

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  1133 Citations (Scopus)

• Genome-wide association analysis identifies 20 loci that influence adult height

  Weedon, M. N., Lango, H., Lindgren, C. M., Wallace, C., Evans, D. M., Mangino, M., Freathy, R. M., Perry, J. R. B., Stevens, S., Hall, A. S., Samani, N. J., Shields, B., Prokopenko, I., Farrall, M., Dominiczak, A., Johnson, T., Bergmann, S., Beckmann, J. S., Vollenweider, P., Waterworth, D. M., & 10 othersMooser, V., Palmer, C. N. A., Morris, A. D., Ouwehand, W. H., Caulfield, M., Munroe, P. B., Hattersley, A. T., McCarthy, M. I., Frayling, T. M. & Wellcome Trust Case Control Consor, Cambridge GEM Consortium, Diabet Genetics Initiat, May 2008, In: Nature Genetics. 40, 5, p. 575-583 9 p.

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  636 Citations (Scopus)

• Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

  Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Lepe, M. P. S., O'Reilly, P. F., Knight, J., Snieder, H., & 37 othersKato, N., He, J., Tai, E. S., Said, M. A., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., The International Consortium of Blood Pressure (ICBP) 1000G Analyses, The CHD Exome+ Consortium, The ExomeBP Consortium, The T2D-GENES Consortium, The GoT2DGenes Consortium, The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, The International Genomics of Blood Pressure (iGEN-BP) Consortium, The UK Biobank CardioMetabolic Consortium BP working group, Caulfield, M. J. & Elliott, P., Jan 2017, In: Nature Genetics. 49, 3, p. 403-415 16 p.

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• Genome-wide association analysis identifies six new loci associated with forced vital capacity

  Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., Pottinger, T. D., Smith, A. V., Duan, Q., Oldmeadow, C., Lee, M. K., Strachan, D. P., James, A. L., Huffman, J. E., Vitart, V., Ramasamy, A., Wareham, N. J., Kaprio, J., Wang, X-Q., Trochet, H., & 33 othersKähönen, M., Flexeder, C., Albrecht, E., Lopez, L. M., de Jong, K., Thyagarajan, B., Alves, A. C., Enroth, S., Omenaas, E., Joshi, P. K., Fall, T., Viñuela, A., Launer, L. J., Loehr, L. R., Fornage, M., Li, G., Wilk, J. B., Tang, W., Manichaikul, A., Lahousse, L., Harris, T. B., North, K. E., Rudnicka, A. R., Hui, J., Gu, X., Lumley, T., Wright, A. F., Hastie, N. D., Campbell, S., Generation Scotland, Smith, B. H., Tobin, M. D. & London, S. J., Jul 2014, In: Nature Genetics. 46, 7, p. 669-677 9 p.

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  104 Citations (Scopus)

• Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

  ANZRAG Consortium, EPIC-Norfolk Eye Study & Brown, A. A., Feb 2016, In: Nature Genetics. 48, 2, p. 189-194 6 p.

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  161 Citations (Scopus)

• Genome-wide association analysis of grain yield-associated traits in a pan-European barley cultivar collection

  Xu, X., Sharma, R., Tondelli, A., Russell, J., Comadran, J., Pillen, K., Schnaithmann, F., Kilian, B., Cattivelli, L., Thomas, W. T. B. & Flavell, A. J., 25 Jan 2018, In: Plant Genome. 11, 1, p. 1-11 11 p., 170073.

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• Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

  Deshmukh, H. A., Madsen, A. L., Viñuela, A., Have, C. T., Grarup, N., Tura, A., Mahajan, A., Heggie, A. J., Koivula, R. W., De Masi, F., Tsirigos, K. K., Linneberg, A., Drivsholm, T., Pedersen, O., Sørensen, T. I. A., Astrup, A., Gjesing, A. A. P., Pavo, I., Wood, A. R., Ruetten, H., & 14 othersJones, A. G., Koopman, A. D. M., Cederberg, H., Rutters, F., Ridderstrale, M., Laakso, M., McCarthy, M. I., Frayling, T. M., Ferrannini, E., Franks, P. W., Pearson, E. R., Mari, A., Hansen, T. & Walker, M., Jan 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. 80-90 11 p.

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• Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis

  METASTROKE Consortium, INVENT Consortium, Hinds, D. A., Buil, A., Ziemek, D., Martinez-Perez, A., Malik, R., Folkersen, L., Germain, M., Mälarstig, A., Brown, A., Soria, J. M., Dichgans, M., Bing, N., Franco-Cereceda, A., Souto, J. C., Dermitzakis, E. T., Hamsten, A., Worrall, B. B., Tung, J. Y., & 1 othersSabater-Lleal, M., 1 May 2016, In: Human Molecular Genetics. 25, 9, p. 1867-1874 8 p.

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• Genome-wide association and functional follow-up reveals new loci for kidney function

  Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Boeger, C. A., Fuchsberger, C., Olden, M., Chen, M-H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A., Liu, C-T., & 31 othersSmith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Johnson, A. D., Gierman, H. J., Feitosa, M., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, A., Toenjes, A., Dehghan, A., Chouraki, V., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimaeki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Colhoun, H., Doney, A., Palmer, C. & WTCCC2, CARDIoGRAM Consortium, CARe Consortium, ICBP Consortium, 2012, In: PLoS Genetics. 8, 3, p. - 15 p., e1002584.

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• Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

  Artigas, M. S., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, M., Tang, W., Zhai, G., Zhao, J. H., Smith, A. V., Huffman, J. E., Albrecht, E., Jackson, C. M., Evans, D. M., Cadby, G., Fornage, M., Manichaikul, A., Lopez, L. M., Johnson, T., Aldrich, M. C., Aspelund, T., & 31 othersBarroso, I., Campbell, H., Cassano, P. A., Couper, D. J., Eiriksdottir, G., Franceschini, N., Garcia, M., Gieger, C., Gislason, G. K., Grkovic, I., Hammond, C. J., Hancock, D. B., Harris, T. B., Ramasamy, A., Heckbert, S. R., Heliovaara, M., Homuth, G., Hysi, P. G., James, A. L., Jankovic, S., Joubert, B. R., Karrasch, S., Klopp, N., Koch, B., Kritchevsky, S. B., Launer, L. J., Liu, Y., Loehr, L. R., Morris, A. D., Smith, G. D. & GIANT Consortium, Int Lung Canc Consortium, Nov 2011, In: Nature Genetics. 43, 11, p. 1082-U70 11 p.

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  319 Citations (Scopus)

• Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

  Regeneron Genetics Center, Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L., & 32 othersBloom, H. L., Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Dunn, M. E., Engström, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Mordi, I. R., Morris, A. D., Morris, A. P., Palmer, C. N. A., Parry, H. M., Smith, N. L., Veluchamy, A., McMurray, J. J. V., Lang, C. C. & Lumbers, R. T., 9 Jan 2020, In: Nature Communications. 11, 12 p., 163.

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• Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry

  Scott, L. J., Muglia, P., Kong, X. Q., Guan, W., Flickinger, M., Upmanyu, R., Tozzi, F., Li, J. Z., Burmeister, M., Absher, D., Thompson, R. C., Francks, C., Meng, F., Antoniades, A., Southwick, A. M., Schatzberg, A. F., Bunney, W. E., Barchask, J. D., Jones, E. G., Day, R., & 13 othersMatthews, K., McGuffin, P., Strauss, J. S., Kennedy, J. L., Middleton, L., Roses, A. D., Watson, S. J., Vincent, J. B., Myers, R. M., Farmer, A. E., Akil, H., Burns, D. K. & Boehnke, M., 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7501-7506 6 p.

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  228 Citations (Scopus)

• Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

  Power, R. A., Tansey, K. E., Buttenschøn, H. N., Cohen-Woods, S., Bigdeli, T., Hall, L. S., Kutalik, Z., Lee, S. H., Ripke, S., Steinberg, S., Teumer, A., Viktorin, A., Wray, N. R., Arolt, V., Baune, B. T., Boomsma, D. I., Børglum, A. D., Byrne, E. M., Castelao, E., Craddock, N., & 33 othersCraig, I. W., Dannlowski, U., Deary, I. J., Degenhardt, F., Forstner, A. J., Gordon, S. D., Grabe, H. J., Grove, J., Hamilton, S. P., Hayward, C., Heath, A. C., Hocking, L. J., Homuth, G., Hottenga, J. J., Kloiber, S., Krogh, J., Landén, M., Lang, M., Levinson, D. F., Lichtenstein, P., Lucae, S., MacIntyre, D. J., Madden, P., Magnusson, P. K. E., Martin, N. G., McIntosh, A. M., Middeldorp, C. M., Milaneschi, Y., Montgomery, G. W., Smith, B. H., CONVERGE Consortium, CARDIoGRAM Consortium & GERAD1 Consortium, 15 Feb 2017, In: Biological Psychiatry. 81, 4, p. 325-335 11 p.

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  131 Citations (Scopus)

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• Genome wide association mapping for arabinoxylan content in a collection of tetraploid wheats

  Marcotuli, I., Houston, K., Waugh, R., Fincher, G. B., Burton, R. A., Blanco, A. & Gadaleta, A., 15 Jul 2015, In: PLoS ONE. 10, 7, p. 1-14 14 p., e0132787.

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• Genome-wide association mapping in a diverse spring barley collection reveals the presence of QTL hotspots and candidate genes for root and shoot architecture traits at seedling stage

  Abdel-Ghani, A. H., Sharma, R., Wabila, C., Dhanagond, S., Owais, S. J., Duwayri, M. A., Al-Dalain, S. A., Klukas, C., Chen, D., Lübberstedt, T., von Wirén, N., Graner, A., Kilian, B. & Neumann, K., 23 May 2019, In: BMC Plant Biology. 19, p. 1-19 19 p., 216.

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• Genome-wide association mapping in winter barley for grain yield and culm cell wall polymer content using the high-throughput CoMPP technique

  Bellucci, A., Tondelli, A., Fangel, J. U., Torp, A. M., Xu, X., Willats, W. G. T., Flavell, A., Cattivelli, L. & Rasmussen, S. K., 16 Mar 2017, In: PLoS ONE. 12, 3, p. 1-21 21 p., e0173313.

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• Genome-wide association mapping of agronomic and morphologic traits in highly structured populations of barley cultivars

  Wang, M., Jiang, N., Jia, T., Leach, L., Cockram, J., Waugh, R., Ramsay, L., Thomas, B. & Luo, Z., 1 Jan 2012, In: Theoretical and Applied Genetics. 124, 2, p. 233-246 14 p.

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  101 Citations (Scopus)

• Genome-wide association mapping of frost tolerance in barley (Hordeum vulgare L.)

  Visioni, A., Tondelli, A., Francia, E., Pswarayi, A., Malosetti, M., Russell, J., Thomas, W., Waugh, R., Pecchioni, N., Romagosa, I. & Comadran, J., 2013, In: BMC Genomics. 14, 13 p., 424.

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  73 Citations (Scopus)

• Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome

  Cockram, J., White, J., Zuluaga, D. L., Smith, D., Comadran, J., Macaulay, M., Luo, Z., Kearsey, M. J., Werner, P., Harrap, D., Tapsell, C., Liu, H., Hedley, P. E., Stein, N., Schulte, D., Steuernagel, B., Marshall, D. F., Thomas, W. T. B., Ramsay, L., MacKay, I., & 3 othersBalding, D. J., Waugh, R. & O'Sullivan, D. M., 14 Dec 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21611-21616 6 p.

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  215 Citations (Scopus)

• Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

  GenoMEL Consortium, Q-MEGA and QTWIN Investigators, ATHENS Melanoma Study Group, 23andMe, The SDH Study Group, IBD Investigators, Essen-Heidelberg Investigators, AMFS Investigators, MelaNostrum Consortium, Landi, M. T., Bishop, D. T., MacGregor, S., Machiela, M. J., Stratigos, A. J., Ghiorzo, P., Brossard, M., Calista, D., Choi, J., Fargnoli, M. C., Zhang, T., & 45 othersRodolfo, M., Trower, A. J., Menin, C., Martinez, J., Hadjisavvas, A., Song, L., Stefanaki, I., Scolyer, R., Yang, R., Goldstein, A. M., Potrony, M., Kypreou, K. P., Pastorino, L., Queirolo, P., Pellegrini, C., Cattaneo, L., Zawistowski, M., Gimenez-Xavier, P., Rodriguez, A., Elefanti, L., Manoukian, S., Rivoltini, L., Smith, B. H., Loizidou, M. A., Del Regno, L., Massi, D., Mandala, M., Khosrotehrani, K., Akslen, L. A., Amos, C. I., Andresen, P. A., Avril, M-F., Azizi, E., Soyer, H. P., Bataille, V., Dalmasso, B., Bowdler, L. M., Burdon, K. P., Chen, W. V., Codd, V., Craig, J. E., Harris, J., Shi, J., Iles, M. M. & Law, M. H., May 2020, In: Nature Genetics. 52, 5, p. 494-504 11 p.

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• Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

  CREAM, 23andMe Research Team, UK Biobank Eye and Vision Consortium & Klaver, C. C. W., 1 Jun 2018, In: Nature Genetics. 50, 6, p. 834-848 15 p.

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  152 Citations (Scopus)

• Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error

  Fan, Q., Pozarickij, A., Tan, N. Y. Q., Guo, X., Verhoeven, V. J. M., Vitart, V., Guggenheim, J. A., Miyake, M., Tideman, J. W. L., Khawaja, A. P., Zhang, L., MacGregor, S., Höhn, R., Chen, P., Biino, G., Wedenoja, J., Saffari, S. E., Tedja, M. S., Xie, J., Lanca, C., & 39 othersWang, Y. X., Sahebjada, S., Mazur, J., Mirshahi, A., Martin, N. G., Yazar, S., Pennell, C. E., Yap, M., Haarman, A. E. G., Enthoven, C. A., Polling, J. R., UK Biobank Eye and Vision Consortium, Hewitt, A. W., Jaddoe, V. W. V., van Duijn, C. M., Hayward, C., Polašek, O., Tai, E. S., Yoshikatsu, H., Hysi, P. G., Young, T. L., Tsujikawa, A., Wang, J. J., Mitchell, P., Pfeiffer, N., Pärssinen, O., Foster, P. J., Fossarello, M., Yip, S. P., Williams, C., Hammond, C. J., Jonas, J. B., He, M., Mackey, D. A., Wong, T-Y., Klaver, C. C. W., Saw, S-M., Baird, P. N. & Cheng, C-Y., Dec 2020, In: Communications Biology. 3, 1, p. 1-14 14 p., 133.

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• Genome-wide association of yield traits in a nested association mapping population of barley reveals new gene diversity for future breeding

  Sharma, R., Draicchio, F., Bull, H., Herzig, P., Maurer, A., Pillen, K., Thomas, W. T. B. & Flavell, A. J., 20 Jul 2018, In: Journal of Experimental Botany. 69, 16, p. 3811-3822 12 p.

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• Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

  Tenesa, A., Farrington, S. M., Prendergast, J. G. D., Porteous, M. E., Walker, M., Haq, N., Barnetson, R. A., Theodoratou, E., Cetnarskyj, R., Cartwright, N., Semple, C., Clark, A. J., Reid, F. J. L., Smith, L. A., Kavoussanakis, K., Koessler, T., Pharoah, P. D. P., Buch, S., Schafmayer, C., Tepel, J., & 37 othersSchreiber, S., Völzke, H., Schmidt, C. O., Hampe, J., Chang-Claude, J., Hoffmeister, M., Brenner, H., Wilkening, S., Canzian, F., Capella, G., Moreno, V., Deary, I. J., Starr, J. M., Tomlinson, I. P. M., Kemp, Z., Howarth, K., Carvajal-Carmona, L., Webb, E., Broderick, P., Vijayakrishnan, J., Houlston, R. S., Rennert, G., Ballinger, D., Rozek, L., Gruber, S. B., Matsuda, K., Kidokoro, T., Nakamura, Y., Zanke, B. W., Greenwood, C. M. T., Rangrej, J., Kustra, R., Montpetit, A., Hudson, T. J., Gallinger, S., Campbell, H. & Dunlop, M. G., May 2008, In: Nature Genetics. 40, 5, p. 631-637 7 p.

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  489 Citations (Scopus)

• Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution

  Lindgren, C. M., Heid, I. M., Randall, J. C., Lamina, C., Steinthorsdottir, V., Qi, L., Speliotes, E. K., Thorleifsson, G., Willer, C. J., Herrera, B. M., Jackson, A. U., Lim, N., Scheet, P., Soranzo, N., Amin, N., Aulchenko, Y. S., Chambers, J. C., Drong, A., Luan, J., Lyon, H. N., & 31 othersRivadeneira, F., Sanna, S., Timpson, N. J., Zillikens, M. C., Zhao, J. H., Almgren, P., Bandinelli, S., Bennett, A. J., Bergman, R. N., Bonnycastle, L. L., Bumpstead, S. J., Chanock, S. J., Cherkas, L., Chines, P., Coin, L., Cooper, C., Crawford, G., Doering, A., Dominiczak, A., Doney, A. S. F., Ebrahim, S., Elliott, P., Erdos, M. R., Estrada, K., Ferrucci, L., Fischer, G., Forouhi, N. G., Palmer, C. N. A., Smith, G. D., Morris, A. D. & Wellcome Trust Case Control Cons, GIANT Consortium, Hugh Watkins PROCARDIS Consortia, Jun 2009, In: PLoS Genetics. 5, 6, p. - 13 p., e1000508.

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  425 Citations (Scopus)

• Genome-wide association studies of exacerbations in children using long-acting beta2-agonists

  Slob, E. M. A., Richards, L. B., Vijverberg, S. J. H., Longo, C., Koppelman, G. H., Pijnenburg, M. W. H., Bel, E. H. D., Neerincx, A. H., Herrera Luis, E., Perez-Garcia, J., Chew, F. T., Sio, Y. Y., Andiappan, A. K., Turner, S. W., Mukhopadhyay, S., Palmer, C. N. A., Hawcutt, D., Jorgensen, A. L., Burchard, E. G., Hernandez-Pacheco, N., & 2 othersPino-Yanes, M. & Maitland-van der Zee, A. H., Aug 2021, In: Pediatric Allergy and Immunology. 32, 6, p. 1197-1207 11 p.

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• Genome-wide Association Study for Alcohol-related Cirrhosis Identifies Risk Loci in MARC1 and HNRNPUL1

  Innes, H., Buch, S., Hutchinson, S., Guha, I. N., Morling, J. R., Barnes, E., Irving, W., Forrest, E., Pedergnan, V., Goldberg, D., Aspinall, E., Barclay, S., Hayes, P., Dillon, J., Nischalke, H. D., Lutz, P., Spengler, U., Fischer, J., Berg, T., Brosch, M., & 11 othersEyer, F., Datz, C., Mueller, S., Peccerella, T., Deltenre, P., Marot, A., Soyka, M., McQuillin, A., Morgan, M. Y., Hampe, J. & Stickel, F., Oct 2020, In: Gastroenterology. 159, 4, p. 1276-1298.e7 21 p.

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• Genome-wide association study for resistance to rhynchosporium in a diverse collection of spring barley germplasm

  Thauvin, J. N., Russell, J., Vequaud, D., Looseley, M., Bayer, M., Le Roux, P. M., Pin, P., Waugh, R. & Avrova, A., 24 Mar 2022, In: Agronomy. 12, 4, 14 p., 782.

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• Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

  Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, C. C. A., Burgess, A. I., Pirinen, M., Jackson, C. A., Traylor, M., Strange, A., Su, Z., Band, G., Syme, P. D., Malik, R., Pera, J., Norrving, B., Lemmens, R., Freeman, C., Schanz, R., James, T., Poole, D., & 31 othersMurphy, L., Segal, H., Cortellini, L., Cheng, Y-C., Woo, D., Nalls, M. A., Müller-Myhsok, B., Meisinger, C., Seedorf, U., Ross-Adams, H., Boonen, S., Wloch-Kopec, D., Valant, V., Slark, J., Furie, K., Delavaran, H., Langford, C., Deloukas, P., Edkins, S., Hunt, S., Gray, E., Dronov, S., Peltonen, L., Gretarsdottir, S., Thorleifsson, G., Thorsteinsdottir, U., Stefansson, K., Boncoraglio, G. B., Parati, E. A., Palmer, C. N. A. & WTCCC2, ISGC, Mar 2012, In: Nature Genetics. 44, 3, p. 328-U141 8 p.

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  332 Citations (Scopus)

• Genome-wide association study identifies eight loci associated with blood pressure

  Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., Najjar, S. S., Zhao, J. H., Heath, S. C., Eyheramendy, S., Papadakis, K., Voight, B. F., Scott, L. J., Zhang, F., Farrall, M., Tanaka, T., Wallace, C., Chambers, J. C., Khaw, K-T., Nilsson, P., & 31 othersvan der Harst, P., Polidoro, S., Grobbee, D. E., Onland-Moret, N. C., Bots, M. L., Wain, L. V., Elliott, K. S., Teumer, A., Luan, J., Lucas, G., Kuusisto, J., Burton, P. R., Hadley, D., McArdle, W. L., Brown, M., Dominiczak, A., Newhouse, S. J., Samani, N. J., Webster, J., Zeggini, E., Beckmann, J. S., Bergmann, S., Lim, N., Song, K., Vollenweider, P., Waeber, G., Waterworth, D. M., Yuan, X., Groop, L., Connell, J. M. & Wellcome Trust Case Control Consor, 2009, In: Nature Genetics. 41, 6, p. 666-676 11 p.

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  986 Citations (Scopus)

• Genome-wide association study identifies five loci associated with lung function

  Repapi, E., Sayers, I., Wain, L. V., Burton, P. R., Johnson, T., Obeidat, M., Zhao, J. H., Ramasamy, A., Zhai, G., Vitart, V., Huffman, J. E., Igl, W., Albrecht, E., Deloukas, P., Henderson, J., Granell, R., McArdle, W. L., Rudnicka, A. R., Barroso, I., Loos, R. J. F., & 31 othersWareham, N. J., Mustelin, L., Rantanen, T., Surakka, I., Imboden, M., Wichmann, H. E., Grkovic, I., Jankovic, S., Zgaga, L., Hartikainen, A-L., Peltonen, L., Gyllensten, U., Johansson, A., Zaboli, G., Campbell, H., Wild, S. H., Wilson, J. F., Glaeser, S., Homuth, G., Voelzke, H., Mangino, M., Soranzo, N., Spector, T. D., Polasek, O., Rudan, I., Wright, A. F., Heliovaara, M., Ripatti, S., Pouta, A., Morris, A. D. & Wellcome Trust Case Control Consor, NSHD Resp Study Team, Jan 2010, In: Nature Genetics. 42, 1, p. 36-U51 10 p.

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  443 Citations (Scopus)

• Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia

  Wallace, C., Newhouse, S. J., Braund, P., Zhang, F., Tobin, M., Falchi, M., Ahmadi, K., Dobson, R. J., Maracano, A. C. B., Hajat, C., Burton, P., Deloukas, P., Brown, M., Connell, J. M., Dominiczak, A., Lathrop, G. M., Webster, J., Farrall, M., Spector, T., Samani, N. J., & 3 othersCaulfield, M. J., Munroe, P. B. & Wellcome Trust Case Control, Jan 2008, In: American Journal of Human Genetics. 82, 1, p. 139-149 11 p.

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  366 Citations (Scopus)

• Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

  Navarini, A. A., Simpson, M. A., Weale, M., Knight, J., Carlavan, I., Reiniche, P., Burden, D. A., Layton, A., Bataille, V., Allen, M., Pleass, R., Pink, A., Creamer, D., English, J., Munn, S., Walton, S., The Acne Genetic Study Group, Willis, C., Déret, S., Voegel, J. J., & 4 othersSmith, C. H., Trembath, R. C., Barker, J. N. & Ferguson, A., 13 Jun 2014, In: Nature Communications. 5, 6 p., 4020.

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  49 Citations (Scopus)

• Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

  Mangold, E., Ludwig, K. U., Birnbaum, S., Baluardo, C., Ferrian, M., Herms, S., Reutter, H., de Assis, N. A., Al Chawa, T., Mattheisen, M., Steffens, M., Barth, S., Kluck, N., Paul, A., Becker, J., Lauster, C., Schmidt, G., Braumann, B., Scheer, M., Reich, R. H., & 18 othersHemprich, A., Poetzsch, S., Blaumeiser, B., Moebus, S., Krawczak, M., Schreiber, S., Meitinger, T., Wichmann, H-E., Steegers-Theunissen, R. P., Kramer, F-J., Cichon, S., Propping, P., Wienker, T. F., Knapp, M., Rubini, M., Mossey, P. A., Hoffmann, P. & Noethen, M. M., Jan 2010, In: Nature Genetics. 42, 1, p. 24-26 3 p.

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  311 Citations (Scopus)

• Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia

  Wellcome Trust Case Control Consortium 2, 15 Oct 2012, In: Biological Psychiatry. 72, 8, p. 620-628 9 p.

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  128 Citations (Scopus)

• Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

  Tziotzios, C., Petridis, C., Dand, N., Ainali, C., Saklatvala, J. R., Pullabhatla, V., Onoufriadis, A., Pramanik, R., Baudry, D., Lee, S. H., Wood, K., Liu, L., Seegobin, S., Michelotti, G. A., Lwin, S. M., Christou, E. A. A., Curtis, C. J., de Rinaldis, E., Saxena, A., Holmes, S., & 54 othersHarries, M., Palamaras, I., Cunningham, F., Parkins, G., Kaur, M., Farrant, P., McDonagh, A., Messenger, A., Jones, J., Jolliffe, V., Ali, I., Ardern-Jones, M., Mitchell, C., Burrows, N., Atkar, R., Banfield, C., Alexandroff, A., Champagne, C., Cooper, H. L., Vañó-Galván, S., Molina-Ruiz, A. M., Perez, N. O., Patel, G. K., Macbeth, A., Page, M., Bryden, A., Mowbray, M., Wahie, S., Armstrong, K., Cooke, N., Goodfield, M., Man, I., de Berker, D., Dunnill, G., Takwale, A., Rao, A., Siah, T-W., Sinclair, R., Wade, M. S., Dlova, N. C., Setterfield, J., Lewis, F., Bhargava, K., Kirkpatrick, N., Estivill, X., Stefanato, C. M., Flohr, C., Spector, T., Watt, F. M., Smith, C. H., Barker, J. N., Fenton, D. A., Simpson, M. A. & McGrath, J. A., 8 Mar 2019, In: Nature Communications. 10, 1, p. 1-9 9 p., 1150.

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• Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

  DIAGRAM, Kooner, J. S., Saleheen, D., Sim, X., Sehmi, J., Zhang, W., Frossard, P., Been, L. F., Chia, K-S., Dimas, A. S., Hassanali, N., Jafar, T., Jowett, J. B. M., Li, X., Radha, V., Rees, S. D., Takeuchi, F., Young, R., Aung, T., Basit, A., & 48 othersChidambaram, M., Das, D., Grundberg, E., Hedman, A. K., Hydrie, Z. I., Islam, M., Khor, C-C., Kowlessur, S., Kristensen, M. M., Liju, S., Lim, W-Y., Matthews, D. R., Liu, J., Morris, A. P., Nica, A. C., Pinidiyapathirage, J. M., Prokopenko, I., Rasheed, A., Samuel, M., Shah, N., Shera, A. S., Small, K. S., Suo, C., Wickremasinghe, A. R., Wong, T. Y., Yang, M., Zhang, F., Abecasis, G. R., Barnett, A. H., Caulfield, M., Deloukas, P., Frayling, T. M., Froguel, P., Kato, N., Katulanda, P., Kelly, A. M., Liang, J., Mohan, V., Sanghera, D. K., Scott, J., Seielstad, M., Zimmet, P. Z., Elliott, P., Teo, Y-Y., McCarthy, M. I., Danesh, J., Tai, E. S. & Chambers, J. C., 28 Aug 2011, In: Nature Genetics. 43, 10, p. 984-989 6 p.

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  405 Citations (Scopus)

• Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

  Peters, M. J., Broer, L., Willemen, H. L. D. M., Eiriksdottir, G., Hocking, L. J., Holliday, K. L., Horan, M. A., Meulenbelt, I., Neogi, T., Popham, M., Schmidt, C. O., Soni, A., Valdes, A. M., Amin, N., Dennison, E. M., Eijkelkamp, N., Harris, T. B., Hart, D. J., Hofman, A., Huygen, F. J. P. M., & 32 othersJameson, K. A., Jones, G. T., Launer, L. J., Kerkhof, H. J. M., De Kruijf, M., McBeth, J., Kloppenburg, M., Ollier, W. E., Oostra, B., Payton, A., Rivadeneira, F., Smith, B. H., Smith, A. V., Stolk, L., Teumer, A., Thomson, W., Uitterlinden, A. G., Wang, K., Van Wingerden, S. H., Arden, N. K., Cooper, C., Felson, D., Gudnason, V., Macfarlane, G. J., Pendleton, N., Slagboom, P. E., Spector, T. D., Völzke, H., Kavelaars, A., Van Duijn, C. M., Williams, F. M. K. & Van Meurs, J. B. J., Mar 2013, In: Annals of the Rheumatic Diseases. 72, 3, p. 427-436 10 p.

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  89 Citations (Scopus)

• Genome­-wide association study of alcohol consumption and genetic overlap with other health-­related traits in UK Biobank (N =112,117)

  Clarke, T. K., Adams, M. J., Davies, G., Howard, D. M., Hall, L. S., Padmanabhan, S., Smith, B. H., Hayward, C., Porteous, D. J., Deary, I. J. & McIntosh, A. M., Oct 2017, In: Molecular Psychiatry. 22, 10, p. 1376-1384 9 p.

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• Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment

  Rasmussen, E. R., Hallberg, P., Baranova, E. V., Eriksson, N., Karawajczyk, M., Johansson, C., Cavalli, M., Maroteau, C., Veluchamy, A., Islander, G., Hugosson, S., Terreehorst, I., Asselbergs, F. W., Norling, P., Johansson, H-E., Kohnke, H., Syvänen, A-C., Siddiqui, M. K., Lang, C., Magnusson, P. K. E., & 8 othersYue, Q-Y., Wadelius, C., von Buchwald, C., Bygum, A., Alfirevic, A., Maitland-van der Zee, A. H., Palmer, C. N. A. & Wadelius, M., Dec 2020, In: Pharmacogenomics Journal. 20, p. 770-783 14 p.

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• Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP

  Wigmore, E. M., Hafferty, J. D., Hall, L. S., Howard, D. M., Clarke, T-K., Fabbri, C., Lewis, C. M., Uher, R., Navrady, L., Adams, M. J., Zeng, Y., Campbell, A., Gibson, J., Thomson, P. A., Hayward, C., Smith, B., Hocking, L. J., Padmanabhan, S., Deary, I. J., Porteous, D. J., & 4 othersMors, O., Mattheisen, M., Nicodemus, K. K. & McIntosh, A. M., Apr 2020, In: Pharmacogenomics Journal. 20, p. 329-341 13 p.

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• Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use

  PiCA and SysPharmPedia consortia, Hernandez-Pacheco, N., Vijverberg, S. J., Herrera-Luis, E., Li, J., Sio, Y. Y., Granell, R., Corrales, A., Maroteau, C., Lethem, R., Perez-Garcia, J., Farzan, N., Repnik, K., Gorenjak, M., Soares, P., Karimi, L., Schieck, M., Pérez-Méndez, L., Berce, V., Tavendale, R., & 18 othersEng, C., Sardon, O., Kull, I., Mukhopadhyay, S., Pirmohamed, M., Verhamme, K. M. C., Burchard, E. G., Kabesch, M., Hawcutt, D. B., Melén, E., Potočnik, U., Chew, F. T., Tantisira, K. G., Turner, S., Palmer, C. N., Flores, C., Pino-Yanes, M. & Maitland-van der Zee, A. H., May 2021, In: European Respiratory Journal. 57, 5, 2003388.

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  9 Citations (Scopus)

• Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

  Padmanabhan, S., Melander, O., Johnson, T., Di Blasio, A. M., Lee, W. K., Gentilini, D., Hastie, C. E., Menni, C., Monti, M. C., Delles, C., Laing, S., Corso, B., Navis, G., Kwakernaak, A. J., van der Harst, P., Bochud, M., Maillard, M., Burnier, M., Hedner, T., Kjeldsen, S., & 31 othersWahlstrand, B., Sjogren, M., Fava, C., Montagnana, M., Danese, E., Torffvit, O., Hedblad, B., Snieder, H., Connell, J. M. C., Brown, M., Samani, N. J., Farrall, M., Cesana, G., Mancia, G., Signorini, S., Grassi, G., Eyheramendy, S., Wichmann, H. E., Laan, M., Strachan, D. P., Sever, P., Shields, D. C., Stanton, A., Vollenweider, P., Teumer, A., Voelzke, H., Rettig, R., Newton-Cheh, C., Arora, P., Zhang, F. & Global BPgen Consortium, Oct 2010, In: PLoS Genetics. 6, 10, p. - 11 p., e1001177.

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  282 Citations (Scopus)

• Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

  Craddock, N., Hurles, M. E., Cardin, N., Pearson, R. D., Plagnol, V., Robson, S., Vukcevic, D., Barnes, C., Conrad, D. F., Giannoulatou, E., Holmes, C., Marchini, J. L., Stirrups, K., Tobin, M. D., Wain, L. V., Yau, C., Aerts, J., Ahmad, T., Andrews, T. D., Arbury, H., & 31 othersAttwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Byrnes, J., Caesar, S., Clee, C. M., Coffey, A. J., Connell, J. M. C., Cooper, J. D., Dominiczak, A. F., Downes, K., Morris, A. P., Mowat, C. & Wellcome Trust Case Control, 1 Apr 2010, In: Nature. 464, 7289, p. 713-U86 10 p.

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  641 Citations (Scopus)

• Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen

  SUMMIT Consortium, GENIE Consortium, Salem, R. M., Todd, J. N., Sandholm, N., Cole, J. B., Chen, W-M., Andrews, D., Pezzolesi, M. G., McKeigue, P. M., Hiraki, L. T., Qiu, C., Nair, V., Di Liao, C., Cao, J. J., Valo, E., Onengut-Gumuscu, S., Smiles, A. M., McGurnaghan, S. J., Haukka, J. K., & 33 othersHarjutsalo, V., Brennan, E. P., van Zuydam, N., Ahlqvist, E., Doyle, R., Ahluwalia, T. S., Lajer, M., Hughes, M. F., Park, J., Skupien, J., Spiliopoulou, A., Liu, A., Menon, R., Boustany-Kari, C. M., Kang, H. M., Nelson, R. G., Klein, R., Klein, B. E., Lee, K. E., Gao, X., Mauer, M., Maestroni, S., Caramori, M. L., de Boer, I. H., Miller, R. G., Guo, J., Boright, A. P., Tregouet, D., Gyorgy, B., Palmer, C. N. A., Colhoun, H. M., Paterson, A. D. & Florez, J. C., 1 Oct 2019, In: Journal of the American Society of Nephrology. 30, 10, p. 2000-2016 17 p.

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• Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)

  Deshmukh, H. A., Colhoun, H. M., Johnson, T., McKeigue, P. M., Betteridge, D. J., Durrington, P. N., Fuller, J. H., Livingstone, S., Charlton-Menys, V., Neil, A., Poulter, N., Sever, P., Shields, D. C., Stanton, A. V., Chatterjee, A., Hyde, C., Calle, R. A., DeMicco, D. A., Trompet, S., Postmus, I., & 5 othersFord, I., Jukema, J. W., Caulfield, M., Hitman, G. A. & PROSPER Investigators, ASCOT, CARDS, 2012, In: Journal of Lipid Research. 53, 5, p. 1000-1011 12 p.

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  88 Citations (Scopus)

• Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

  Hernandez-Pacheco, N., Farzan, N., Francis, B., Karimi, L., Repnik, K., Vijverberg, S. J., Soares, P., Schieck, M., Gorenjak, M., Forno, E., Eng, C., Oh, S. S., Pérez-Méndez, L., Berce, V., Tavendale, R., Samedy, L-A., Hunstman, S., Hu, D., Meade, K., Farber, H. J., & 21 othersAvila, P. C., Serebrisky, D., Thyne, S. M., Brigino-Buenaventura, E., Rodriguez-Cintron, W., Sen, S., Kumar, R., Lenoir, M., Rodriguez-Santana, J. R., Celedón, J. C., Mukhopadhyay, S., Potočnik, U., Pirmohamed, M., Verhamme, K. M., Kabesch, M., Palmer, C. N. A., Hawcutt, D. B., Flores, C., Maitland-van der Zee, A. H., Burchard, E. G. & Pino-Yanes, M., 3 Jun 2019, In: Clinical and Experimental Allergy. 49, 6, p. 789-798 10 p.

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• Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

  Strange, A., Bellenguez, C., Sim, X., Luben, R., Hysi, P. G., Ramdas, W. D., van Koolwijk, L. M., Freeman, C., Pirinen, M., Su, Z., Band, G., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, S. C., Tashakkori-Ghanbaria, A., Edkins, S., & 36 othersBumpstead, S. J., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J. A., Markus, H. S., Mathew, C. G., Palmer, C. N., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Wood, N. W., Barroso, I., Leena Peltonen, L. P., Healey, P., McGuffin, P., Topouzis, F., Klaver, C. C., van Duijn, C. M., Mackey, D. A., Young, T. L., Hammond, C. J., Khaw, K-T., Wareham, N., Wang, J. J., Wong, T. Y., Foster, P. J., Mitchell, P., Spencer, C. C., Donnelly, P., Viswanathan, A. C. & Pearson, R., 2013, In: Human Molecular Genetics. 22, 22, p. 4653-4660 8 p.

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  25 Citations (Scopus)

• Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank

  Meng, W., Adams, M. J., Palmer, C. N. A., 23andMe Research Team, Shi, J., Auton, A., Ryan, K. A., Jordan, J. M., Mitchell, B. D., Jackson, R. D., Yau, M. S., McIntosh, A. M. & Smith, B. H., 28 Aug 2019, In: Communications Biology. 2, p. 1-8 8 p., 321.

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