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• Article

  Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

  Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Löchte, S., Stanly, T. A., Pulgar Prieto, K. D., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 Feb 2020, In: Science. 367, 6478, p. 643-652 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytokine Receptors
  • Dimerization
  • Janus Kinase 2
  • Mutation
  • Ligands
  23 Citations (Scopus)

  20 Downloads (Pure)

• Mechanism of hydrogen activation by [NiFe] hydrogenases

  Evans, R. M., Brooke, E. J., Wehlin, S. A. M., Nomerotskaia, E., Sargent, F., Carr, S. B., Phillips, S. E. V. & Armstrong, F. A., 30 Nov 2015, In: Nature Chemical Biology. 12, p. 46-50

  Research output: Contribution to journal › Article › peer-review

  • nickel-iron hydrogenase
  • Guanidine
  • Hydrogen
  • Nitrogen
  • Arginine
  67 Citations (Scopus)

• Mechanism of Hypoxia-Induced NF-kappa B

  Culver, C., Sundqvist, A., Mudie, S., Melvin, A., Xirodimas, D. & Rocha, S., 10 Oct 2010, In: Molecular and Cellular Biology. 30, 20, p. 4901-4921 21 p.

  Research output: Contribution to journal › Article › peer-review
  141 Citations (Scopus)

• Mechanism of hypoxia-induced NFκB

  Melvin, A., Mudie, S. & Rocha, S., 2011, In: Cell Cycle. 10, 6, p. 879-882 4 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone

  Simithy, J., Fuanta, N. R., Hobrath, J. V., Kochanowska-Karamyan, A., Hamann, M. T., Goodwin, D. C. & Calderón, A. I., May 2018, In: Biochimica et Biophysica Acta: General Subjects. 1866, 5-6, p. 731-739 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ilimaquinone
  • shikimate kinase
  • Mycobacterium tuberculosis
  • Adenosine Triphosphate
  • Antitubercular Agents
  5 Citations (Scopus)

  191 Downloads (Pure)

• Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy

  Fernyhough, P., Huang, T. J. & Verkhratsky, A., Dec 2003, In: Journal of the Peripheral Nervous System. 8, 4, p. 227-235 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Diabetic Neuropathies
  • Neurotrophin 3
  • Sensory Receptor Cells
  • Mitochondrial Membrane Potential
  • Insulin
  61 Citations (Scopus)

• Mechanism of structure-driven nonlinear instability of double tearing mode in reversed magnetic shear plasmas

  JANVIER, M., KISHIMOTO, Y. & LI, J., 2010, In: Plasma and Fusion Research. 5, p. 038-1 - 038-3 3 p.

  Research output: Contribution to journal › Article › peer-review

  • shear
  • magnetic islands
  • destabilization
  • energy sources
  • actuators

• Mechanism of ubiquitylation by dimeric RING ligase RNF4

  Plechanovova, A., Jaffray, E. G., McMahon, S. A., Johnson, K. A., Navratilova, I., Naismith, J. H. & Hay, R. T., Sep 2011, In: Nature Structural & Molecular Biology. 18, 9, p. 1052-1059 8 p.

  Research output: Contribution to journal › Article › peer-review
  106 Citations (Scopus)

• Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes

  Narlikar, G. J., Sundaramoorthy, R. & Owen-Hughes, T., 2013, In: Cell. 154, 3, p. 490-503 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromatin Assembly and Disassembly
  • Chromatin
  • Adenosine Triphosphate
  • Enzymes
  • Ancient DNA
  344 Citations (Scopus)

• Mechanisms contributing to the vaso-active effects of prilocaine in human skin

  Newton, D. J., Sur, E. L., Khan, F., McLeod, G. A. & Belch, J. J. F., 2003, In: Anaesthesia. 58, 1, p. 6-10 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Prilocaine
  • Prostaglandin-Endoperoxide Synthases
  • Skin
  • Nitric Oxide
  • Aspirin
  11 Citations (Scopus)

• Mechanisms for stabilisation and destabilisation of systems of reaction-diffusion equations

  Gourley, S. A., Britton, N. F., Chaplain, M. A. J. & Byrne, H. M., Sep 1996, In: Journal of Mathematical Biology. 34, 8, p. 857-877 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Reaction-diffusion Equations
  • Stabilization
  • diffusivity
  • Perturbation
  • Ecological Model
  9 Citations (Scopus)

• Mechanisms influencing the vasoactive effects of lidocaine in human skin

  Newton, D. J., McLeod, G. A., Khan, F. & Belch, J. J. F., 2007, In: Anaesthesia. 62, 2, p. 146-150 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Lidocaine
  • Skin
  • Prostaglandin-Endoperoxide Synthases
  • Adrenergic Receptors
  • Nitric Oxide
  46 Citations (Scopus)

• Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice

  Lipina, C., Kendall, H., McPherron, A. C., Taylor, P. M. & Hundal, H. S., 3 Jun 2010, In: FEBS Letters. 584, 11, p. 2403-2408 6 p.

  Research output: Contribution to journal › Article › peer-review
  54 Citations (Scopus)

• Mechanisms mitigating problems with multiple kinetochores on one microtubule in early mitosis

  Yue, Z., Komoto, S., Gierlinski, M., Pasquali, D., Kitamura, E. & Tanaka, T. U., 15 Jul 2017, In: Journal of Cell Science. 130, 14, p. 2266-2276 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kinetochores
  • Mitosis
  • Microtubules
  • Spindle Poles
  • Chromosome Segregation
  105 Downloads (Pure)

• Mechanisms of a change in the refractive index of an intensely pumped Yb:YAG crystal

  Antipov, O. L., Bredikhin, D. V., Eremeikin, O. N., Ivakin, E. V., Savikin, A. P., Sukhodolov, A. V. & Fedorova, K. A., May 2006, In: Quantum Electronics. 36, 5, p. 418-423 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Yttrium aluminum garnet
  • Refractive index
  • Crystals
  • yttrium-aluminum garnet
  • refractivity
  14 Citations (Scopus)

• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

  Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

  Research output: Contribution to journal › Article › peer-review

  • Cullin 1
  • SKP Cullin F-Box Protein Ligases
  • Kelch-Like ECH-Associated Protein 1
  • F-Box Proteins
  • Oxidation-Reduction
  377 Citations (Scopus)

• Mechanisms of anion conduction by coupled glutamate transporters

  Machtens, J-P., Kortzak, D., Lansche, C., Leinenweber, A., Kilian, P., Begemann, B., Zachariae, U., Ewers, D., de Groot, B. L., Briones, R. & Fahlke, C., 29 Jan 2015, In: Cell. 160, 3, p. 542-553 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Amino Acid Transport System X-AG
  • Anions
  • Amino Acid Transport Systems
  • Excitatory Amino Acids
  • Conformations
  73 Citations (Scopus)

• Mechanisms of cervical spine injury in rugby union: A systematic review of the literature

  Kuster, D., Abboud, R., Drew, T. & Gibson, A., 1 Jun 2012, In: British Journal of Sports Medicine. 46, 8, p. 550-554 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Football
  • Spine
  • Systematic Reviews
  • Wounds and Injuries
  • Neck
  36 Citations (Scopus)

• Mechanisms of changes in renal handling of sodium following transjugular intrahepatic portal systemic stent-shunt (TIPSS)

  Jalan, R., Redhead, D. N., Thomas, H. W., Henderson, N., Orourke, K., Dillon, J. F., Williams, B. C. & Hayes, P. C., 1996, In: European Journal of Gastroenterology & Hepatology. 8, 11, p. 1111-1116 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Stents
  • Sodium
  • Ascites
  • Kidney
  • Portal Pressure
  19 Citations (Scopus)

• Mechanisms of failure for shallow foundations under earthquake loading

  Knappett, J. A., Haigh, S. K. & Madabhushi, S. P. G., 2006, In: Soil Dynamics and Earthquake Engineering. 26, 2-4, p. 91-102 12 p.

  Research output: Contribution to journal › Article › peer-review

  • earthquakes
  • failure mechanism
  • Earthquakes
  • particle image velocimetry
  • photogrammetry
  44 Citations (Scopus)

• Mechanisms of glutamine transport in rat adipocytes and acute regulation by cell swelling

  Ritchie, J. W. A., Baird, F. E., Christie, G. R., Stewart, A., Low, S. Y., Hundal, H. S. & Taylor, P. M., 2001, In: Cellular Physiology and Biochemistry. 11, 5, p. 259-270 12 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine

  Sancho, R., de la Vega, L., Macho, A., Appendino, G., Di Marzo, V. & Muñoz, E., 15 Sep 2005, In: Journal of Immunology. 175, 6, p. 3990-3999 10 p.

  Research output: Contribution to journal › Article › peer-review

  • arachidonyl dopamine
  • HIV-1
  • Lipids
  • HIV Long Terminal Repeat
  • NF-kappa B
  21 Citations (Scopus)

• Mechanisms of hydrogen sulfide removal by ground granulated blast furnace slag amended soil

  Xie, M., Leung, A. K. & Ng, C. W. W., May 2017, In: Chemosphere. 175, p. 425-430 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hydrogen Sulfide
  • Soil
  • hydrogen sulfide
  • blast furnace
  • Slags
  12 Citations (Scopus)

  225 Downloads (Pure)

• Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis

  Chalmers, J. D. & Hill, A. T., Aug 2013, In: Molecular Immunology. 55, 1, p. 27-34 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Bronchiectasis
  • Neutrophils
  • Fibrosis
  • Leukocyte Elastase
  • Phagocytosis
  97 Citations (Scopus)

• Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

  Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. & Hardie, D. G., 20 Jul 2017, In: Cell Chemical Biology. 24, 7, p. 813-824.e4 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SU 6656
  • Phosphorylation
  • AMP-activated protein kinase kinase
  • Sorafenib
  • Chemical activation
  27 Citations (Scopus)

  132 Downloads (Pure)

• Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

  Fang, W., Sanz, A. B., Galan Bartual, S., Wang, B., Ferenbach, A., Farkaš, V., Hurtado-Guerrero, R., Arroyo, J. & van Aalten, D., 10 Apr 2019, In: Nature Communications. 10, 1, p. 1-10 10 p., 1669.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Aspergillus
  • redundancy
  • Aspergillus fumigatus
  • Cell Wall
  • Chitin
  4 Citations (Scopus)

  76 Downloads (Pure)

• Mechanisms of root reinforcement in soils: An experimental methodology using four-dimensional X-ray computed tomography and digital volume correlation

  Bull, D. J., Smethurst, J. A., Sinclair, I., Pierron, F., Roose, T., Powrie, W. & Bengough, A. G., 27 May 2020, In: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences. 476, 2237, p. 1-23 23 p., 20190838.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • X-ray Tomography
  • Computed Tomography
  • Reinforcement
  • Soil
  • reinforcement
  1 Citation (Scopus)

  29 Downloads (Pure)

• Mechanisms of spontaneous calcium oscillations and action potentials in immortalized hypothalamic (GT1-7) neurons

  Charles, A. C. & Hales, T. G., Jan 1995, In: Journal of Neurophysiology. 73, 1, p. 56-64 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Signaling
  • Action Potentials
  • Neurons
  • Nifedipine
  • Caffeine
  78 Citations (Scopus)

• Mechanisms of switching on p53: a role for covalent modification?

  Meek, D. W., 13 Dec 1999, In: Oncogene. 18, 53, p. 7666-7675 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Proteins
  • Post Translational Protein Processing
  • Oncogenes
  • DNA Damage
  • Phosphorylation
  207 Citations (Scopus)

• Mechanisms of the antinatriuretic action of physiological doses of angiotensin II in man

  Seidelin, P. H., McMurray, J. J. & Struthers, A. D., Jun 1989, In: Clinical Science. 76, 6, p. 653-658 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Angiotensin II
  • Nephrons
  • Sodium
  • Accidental Falls
  • Aldosterone
  20 Citations (Scopus)

• Mechanisms of the Enhanced Antibacterial Effect of Ag-TiO₂ Coatings

  Liu, C., Geng, L., Yu, Y., Zhang, Y., Zhao, B. & Zhao, Q., 7 Feb 2018, In: Biofouling. 34, 2, p. 190-199 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • titanium dioxide
  • surface energy
  • coating
  • coatings
  • Electrons
  10 Citations (Scopus)

  235 Downloads (Pure)

• Mechanisms of water retention in cement pastes containing a self-curing agent

  Dhir, R. K., Hewlett, P. C. & Dyer, T. D., 1 Mar 1998, In: Magazine of Concrete Research. 50, 1, p. 85-90 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Ointments
  • Curing
  • Cements
  • Vapor pressure
  • Hydration
  31 Citations (Scopus)

• Mechanism-specific signatures for small-molecule p53 activators

  van Leeuwen, I. M. M., Higgins, M., Campbell, J., Brown, C. J., McCarthy, A. R., Pirrie, L., Westwood, N. J. & Lain, S., 15 May 2011, In: Cell Cycle. 10, 10, p. 1590-1598 9 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

  Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G. D., Waigh, R. D., Tate, R. J., Harvey, A. L. & Furman, B. L., 2008, In: British Journal of Pharmacology. 153, 8, p. 1669-1677 9 p.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)

• Mechanistic aspects of the DNA junction-resolving enzyme T7 endonuclease I.

  Liu, J., Déclais, A-C. & Lilley, D. M. J., Mar 2006, In: Biochemistry. 45, 12, p. 3934-3942

  Research output: Contribution to journal › Article › peer-review

  • Deoxyribonuclease I
  • Hydrolysis
  • methylphosphonic acid
  • Metal ions
  • Catalytic Domain
  12 Citations (Scopus)

• Mechanistic dichotomy in the asymmetric allylation of aldehydes with allyltrichlorosilanes catalyzed by chiral pyridine N-oxides

  Malkov, A. V., Stončius, S., Bell, M., Castelluzzo, F., Ramírez-López, P., Biedermannová, L., Langer, V., Rulíšek, L. & Kočovský, P., 2013, In: Chemistry: a European Journal. 19, 28, p. 9167-9185 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Allylation
  • pyridine N-oxide
  • Pyridine
  • Catalyst selectivity
  • Aldehydes
  27 Citations (Scopus)

• Mechanistic framework to link root growth models with weather and soil physical properties, including example applications to soybean growth in Brazil

  De Moraes, M. T., Bengough, A. G., Debiasi, H., Franchini, J. C., Levien, R., Schnepf, A. & Leitner, D., Jul 2018, In: Plant and Soil. 428, 1-2, p. 67-92 26 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • soil physical properties
  • growth models
  • soybean
  • root growth
  • weather
  17 Citations (Scopus)

  132 Downloads (Pure)

• Mechanistic Insight into Control of CFTR by AMPK

  Kongsuphol, P., Cassidy, D., Hieke, B., Treharne, K. J., Schreiber, R., Mehta, A. & Kunzelmann, K., 27 Feb 2009, In: Journal of Biological Chemistry. 284, 9, p. 5645-5653 9 p.

  Research output: Contribution to journal › Article › peer-review
  59 Citations (Scopus)

• Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

  Alpi, A. F., Pace, P. E., Babu, M. M. & Patel, K. J., 26 Dec 2008, In: Molecular Cell. 32, 6, p. 767-777 11 p.

  Research output: Contribution to journal › Article › peer-review
  142 Citations (Scopus)

• Mechanistic Insight into the Regulation of Lipoxygenase-Driven Lipid Peroxidation Events in Human Spermatozoa and Their Impact on Male Fertility

  Walters, J. L. H., Anderson, A. L., Martins da Silva, S. J., Aitken, R. J., De Iuliis, G. N., Sutherland, J. M., Nixon, B. & Bromfield, E. G., 31 Dec 2020, In: Antioxidants . 10, 1, 17 p., 43.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 4-hydroxy-2-nonenal
  • Lipoxygenase
  • Fertility
  • Lipid Peroxidation
  • Spermatozoa
  6 Downloads (Pure)

• Mechanistic insights into the cure of prion disease by novel antiprion compounds

  Webb, S., Lekishvili, T., Loeschner, C., Sellarajah, S., Prelli, F., Wisniewski, T., Gilbert, I. H. & Brown, D. R., Oct 2007, In: Journal of Virology. 81, 19, p. 10729-10741 13 p.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• Mechanistic Insights Into the Therapeutic Use of High-Dose Allopurinol in Angina Pectoris

  Rajendra, N. S., Ireland, S., George, J., Belch, J. J. F., Lang, C. C. & Struthers, A. D., 16 Aug 2011, In: Journal of the American College of Cardiology. 58, 8, p. 820-828 9 p.

  Research output: Contribution to journal › Article › peer-review
  92 Citations (Scopus)

• Mechanistic interplay between ceramide and insulin resistance

  Reali, F., Morine, M. J., Kahramanoä Ullarl, O., Raichur, S., Schneider, H. C., Crowther, D. & Priami, C., 23 Jan 2017, In: Scientific Reports. 7, 9 p., 41231.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ceramides
  • dihydroceramide desaturase
  • Insulin Resistance
  • N-palmitoylsphingosine
  • Serine C-Palmitoyltransferase
  20 Citations (Scopus)

  71 Downloads (Pure)

• Mechanoaccumulative elements of the mammalian actin cytoskeleton

  Schiffhauer, E. S., Luo, T., Mohan, K., Srivastava, V., Qian, X., Griffis, E. R., Iglesias, P. A. & Robinson, D. N., 6 Jun 2016, In: Current Biology. 26, 11, p. 1473-1479 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Filamins
  • Myosin Type II
  • Actinin
  • microfilaments
  • Actin Cytoskeleton
  41 Citations (Scopus)

  330 Downloads (Pure)

• MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain

  Lagger, S., Connelly, J. C., Schweikert, G., Webb, S., Selfridge, J., Ramsahoye, B. H., Yu, M., He, C., Sanguinetti, G., Sowers, L. C., Walkinshaw, M. D. & Bird, A., 12 May 2017, In: PLoS Genetics. 13, 5, e1006793.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytosine
  • cytosine
  • brain
  • Nucleotides
  • transcription (genetics)
  56 Citations (Scopus)

  57 Downloads (Pure)

• Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo

  Miles, W. O., Jaffray, E., Campbell, S. G., Takeda, S., Bayston, L. J., Basu, S. P., Li, M., Raftery, L. A., Ashe, M. P., Hay, R. T. & Ashe, H. L., 15 Sep 2008, In: Genes & Development. 22, 18, p. 2578-2590 13 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Mediating the flow of Professional Capital: The Potential of Technology for Rural Teachers Professional Learning in Scotland

  Coker, H., 10 Nov 2019, In: Australian and International Journal of Rural Education. 29, 3, p. 39-55 17 p.

  Research output: Contribution to journal › Article › peer-review

  • rural area
  • teacher
  • Internet
  • learning
  • video conference

• Medical education and disability studies

  Campbell, F. K., Dec 2009, In: Journal of Medical Humanities. 30, 4, p. 221-235 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Disability Studies
  • Medical Education
  • disability studies
  • Medical Students
  • disability
  28 Citations (Scopus)

• Medical educators' metaphoric talk about their assessment relationships with students: 'you don't want to sort of be the one who sticks the knife in them'

  Rees, C. E., Knight, L. V. & Cleland, J. A., 1 Jan 2009, In: Assessment & Evaluation in Higher Education. 34, 4, p. 455-467 13 p.

  Research output: Contribution to journal › Article › peer-review

  • metaphor
  • educator
  • student
  • medical student
  • cognition
  37 Citations (Scopus)

• Medical educators' social acts of explaining passing underperformance in students: a qualitative study

  Monrouxe, L. V., Rees, C. E., Lewis, N. J. & Cleland, J. A., May 2011, In: Advances in Health Sciences Education. 16, 2, p. 239-252 14 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)