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  • 2020
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Author

  • Michael Ashford
Article

AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner

Vlachaki Walker, J. M., Robb, J. L., Cruz, A. M., Malhi, A., Weightman Potter, P. G., Ashford, M. L. J., McCrimmon, R. J., Ellacott, K. L. J. & Beall, C., 21 Apr 2017, In : Diabetes, Obesity & Metabolism. 19, 7, p. 997-1005 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
254 Downloads (Pure)

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
178 Downloads (Pure)

Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

Smith, M. A., Katsouri, L., Virtue, S., Choudhury, A. I., Vidal-Puig, A., Ashford, M. L. J. & Withers, D. J., 9 Oct 2018, In : Cell Reports. 25, 2, p. 278-287.e4 15 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
126 Downloads (Pure)

CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high fat-fed C57BL/6 mice

Hasib, A., Hennayake, C., Bracy, D. P., Bugler-Lamb, A-R., Lantier, L., Khan, F., Ashford, M., McCrimmon, R., Wasserman, D. H. & Kang, L., Dec 2019, In : American Journal of Physiology, Endocrinology and Metabolism. 317, 6, p. E973-E983 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons

Hathorne, E., Hamilton, D. L., Findlay, J. A., Beall, C., McCrimmon, R. J. & Ashford, M. L. J., Dec 2016, In : Neuropharmacology. 111, p. 212-222 11 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
175 Downloads (Pure)

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75]

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Jul 2019, In : Metabolism: Clinical and Experimental. 96, p. 101-102 2 p.

Research output: Contribution to journalArticle

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C., 8 Aug 2016, In : Scientific Reports. 6, p. 1-17 17 p., 31159.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
279 Downloads (Pure)

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation. 15 p.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)
Open Access
File
42 Citations (Scopus)
145 Downloads (Pure)
Open Access
File
9 Citations (Scopus)
271 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journalArticle

Open Access
File
243 Citations (Scopus)
645 Downloads (Pure)
Open Access
File
15 Citations (Scopus)
137 Downloads (Pure)

Oleate induces KATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge

Dadak, S., Beall, C., Vlachaki Walker, J. M., Soutar, M. P. M., McCrimmon, R. J. & Ashford, M. L. J., 27 Mar 2017, In : Neuroscience. 346, p. 29-42 14 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
110 Downloads (Pure)

Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30 Apr 2018, In : Clinical Science. 132, 8, p. 851-868 18 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
112 Downloads (Pure)

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Aug 2018, In : Metabolism. 85, p. 59-75 17 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
121 Downloads (Pure)