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  • Ewan Pearson
Article

4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation

Sipeky, C., Llerena, A., Manolopoulos, V. G., Pearson, E., Mlakar, V., Gozzo, L., Simmaco, M., Marchetti, P., Re, M. D., Stankovic, S., Meyer, U., Cascorbi, I., Ingelman-Sundberg, M., Suarez-Kurtz, G., Marc, J., Katsila, T., Paulmichl, M., Nofziger, C., Ansari, M., Drago, F. & 1 others, van Schaik, R. H., Oct 2019, In : Pharmacogenomics. 20, 15, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

A common missense variant of LILRB5 is associated with statin intolerance and myalgia

Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., Abelega, N-U., Carr, D., Bloch, K., Hallberg, P., Yue, Q-Y., Pearson, E. R., Colhoun, H., Morris, A. D., Dow, E., George, J., Pirmohamed, M., Ridker, P. M., Doney, A. S. F., Alfirevic, A. & 5 others, Wadelius, M., Maitland-van der Zee, A. H., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, 21 Dec 2017, In : European Heart Journal. 38, 48, p. 3569-3575 7 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
146 Downloads (Pure)

Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study

Connelly, P. J., Lonergan, M., Soto-Pedre, E., Donnelly, L., Zhou, K. & Pearson, E. R., 5 Jul 2017, In : Diabetes, Obesity & Metabolism. 19, 11, p. 1579-1586 7 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
164 Downloads (Pure)

Adherence to oral glucose-lowering therapies and associations with 1-year HbA1c: A retrospective cohort analysis in a large primary care database

Farmer, A. J., Rodgers, L. R., Lonergan, M., Shields, B., Weedon, M. N., Donnelly, L., Holman, R. R., Pearson, E. R. & Hattersley, A. T., 1 Feb 2016, In : Diabetes Care. 39, 2, p. 258-263 6 p.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
143 Downloads (Pure)

A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Wood, A. R., Jonsson, A., Jackson, A. U., Wang, N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., Stančáková, A., Boomsma, D. I., de Geus, E. J. C., Eekhoff, E. M. W., Fritsche, A., Kramer, M. H. H., Nijpels, G., Simonis-Bik, A. M. C., van Haeften, T. W., Mahajan, A. & 31 others, Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, K., Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, N., Eiberg, H., Pedersen, O., Chen, Y-D., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, T., Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M., 21 Jul 2017, In : Diabetes. 66, 8, p. 2296-2309 14 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
204 Downloads (Pure)

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 208-214 7 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
374 Downloads (Pure)

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

Shepherd, M. H., Shields, B. M., Hudson, M., Pearson, E. R., Hyde, C., Ellard, S., Hattersley, A. T. & Patel, K. A., Dec 2018, In : Diabetologia. 61, 12, p. 2520-2527 8 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
92 Downloads (Pure)

Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes

Noyes, J. D., Soto-Pedre, E., Donnelly, L. A. & Pearson, E., 14 Jan 2018, In : Diabetic Medicine. 35, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
147 Downloads (Pure)

Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes

Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. & Li, S., 3 Jan 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.

Research output: Contribution to journalArticle

Open Access
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40 Downloads (Pure)

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., Colhoun, H., Morris, A. D., George, J., Doney, A., Pirmohamed, M., Alfirevic, A., Wadelius, M., Maitland-van der Zee, A. H., Ridker, P. M., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, Aug 2017, In : Circulation: Cardiovascular Genetics. 10, 4, e001737 .

Research output: Contribution to journalArticle

3 Citations (Scopus)

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

Hébert, H. L., Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
213 Downloads (Pure)

Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study

Eibich, P., Green, A., Hattersley, A. T., Jennison, C., Lonergan, M., Pearson, E. R. & Gray, A. M., Oct 2017, In : Diabetes Therapy. 8, 5, p. 1031-1045 15 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
128 Downloads (Pure)

C-peptide decline in type 1 diabetes has two phases: An initial exponential fall and a subsequent stable phase

Shields, B. M., McDonald, T. J., Oram, R., Hill, A., Hudson, M., Leete, P., Pearson, E. R., Richardson, S. J., Morgan, N. G. & Hattersley, A. T., 1 Jul 2018, In : Diabetes Care. 41, 7, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
280 Downloads (Pure)

CYP2C8 and SLCO1B1 variants and therapeutic response to thiazolidinediones in patients with type 2 diabetes.

Dawed, A. Y., Donnelly, L., Tavendale, R., Carr, F., Leese, G., Palmer, C. N. A., Pearson, E. & Zhou, K., Nov 2016, In : Diabetes Care. 39, 11, p. 1902-1908 7 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
199 Downloads (Pure)

Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial

Singh, J. S. S., Mordi, I. R., Vickneson, K., Fathi, A., Donnan, P. T., Mohan, M., Choy, A. M. J., Gandy, S., George, J., Khan, F., Pearson, E. R., Houston, J. G., Struthers, A. D. & Lang, C. C., 1 Jun 2020, In : Diabetes Care. 43, 6, p. 1356-1359 4 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
62 Downloads (Pure)

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

Lynam, A., McDonald, T., Hill, A., Dennis, J., Oram, R., Pearson, E., Weedon, M., Hattersley, A., Owen, K., Shields, B. & Jones, A., 26 Sep 2019, In : BMJ Open. 9, 9, p. 1-10 10 p., e031586.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
70 Downloads (Pure)

Diabetes: Is there a future for Pharmacogenomics guided treatment?

Pearson, E., 12 Jul 2019, In : Clinical Pharmacology & Therapeutics. 106, 2, p. 329-337 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
86 Downloads (Pure)

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

Eriksen, R., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Prehn, C., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J. & 18 others, Kokkola, T., Rutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G., Aug 2020, In : EBioMedicine. 58, 9 p., 102932.

Research output: Contribution to journalArticle

Open Access
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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H. & 30 others, Rauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. & Franks, P. W., 1 Sep 2019, In : Diabetologia. 62, 9, p. 1601-1615 15 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
12 Downloads (Pure)

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Neonatal Diabetes International Collaborative Group, Bowman, P., Sulen, Å., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M., Iafusco, D. & 2 others, Hattersley, A. T. & Njølstad, P. R., 1 Aug 2018, In : The Lancet Diabetes and Endocrinology. 6, 8, p. 637-646 10 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
196 Downloads (Pure)

Effect of Serotonin Transporter 5HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study

Dujic, T., Zhou, K., Tavendale, R., Palmer, C. & Pearson, E., 1 Nov 2016, In : Diabetes Care. 39, 11, p. 1896-1901 6 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
162 Downloads (Pure)

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: A joint modelling approach

MASTERMIND consortium, Dennis, J. M., Shields, B. M., Jones, A. G., Pearson, E., Hattersley, A. T. & Henley, W. E., 14 Dec 2018, In : Clinical Epidemiology. 10, p. 1869-1877 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
76 Downloads (Pure)

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes

Dawed, A. Y., Ali, A., Zhou, K., Pearson, E. R. & Franks, P. W., Nov 2017, In : Diabetologia. 60, 11, p. 2231-2239 8 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
149 Downloads (Pure)

First Genome Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Cousminer, D. L., Ahlqvist, E., Mishra, R., Andersen, M. K., Chesi, A., Hawa, M. I., Davis, A., Hodge, K. M., Bradfield, J. P., Zhou, K., Guy, V. C., Åkerlund, M., Wod, M., Fritsche, L. G., Vestergaard, H., Snyder, J., Højlund, K., Linneberg, A., Käräjämäki, A., Brandslund, I. & 33 others, Kim, C. E., Witte, D. R., Sørgjerd, E. P., Brillon, D. J., Pedersen, O., Beck-Nielsen, H., Grarup, N., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Melander, O., Harris, R. I., Varvel, S., Grill, V. E. R., Hakonarson, H. H., Froguel, P., Lonsdale, J. T., Mauricio, D., Schloot, N. C., Khunti, K., Greenbaum, C. J., Asvold, B. O., Yderstræde, K. B., Pearson, E., Schwartz, S., Voight, B. F., Hansen, T., Tuomi, T., Boehm, B. O., Groop, L. C., Leslie, R. D. & Grant, S. F. A., 1 Nov 2018, In : Diabetes Care. p. 2396-2403 7 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
162 Downloads (Pure)

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O’Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C., Pearson, E., Scott, R. A., van Heel, D. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 711.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
156 Downloads (Pure)

Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease

Yaghootkar, H., Lotta, L. A., Tyrrell, J., Smit, R. A. J., Jones, S. E., Donnelly, L., Beaumont, R., Campbell, A., Tuke, M. A., Hayward, C., Ruth, K. S., Padmanabhan, S., Jukema, J. W., Palmer, C. C., Hattersley, A., Freathy, R. M., Langenberg, C., Wareham, N. J., Wood, A. R., Murray, A. & 5 others, Weedon, M. N., Sattar, N., Pearson, E., Scott, R. A. & Frayling, T. M., Aug 2016, In : Diabetes. 65, 8, p. 2448-2460 13 p.

Research output: Contribution to journalArticle

Open Access
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44 Citations (Scopus)
178 Downloads (Pure)
Open Access
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4 Downloads (Pure)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Wilman, H. R., Parisinos, C. A., Atabaki-Pasdar, N., Kelly, M., Thomas, E. L., Neubauer, S., Mahajan, A., Hingorani, A. D., Patel, R. S., Hemingway, H., Franks, P. W., Bell, J. D., Banerjee, R. & Yaghootkar, H., Sep 2019, In : Journal of Hepatology. 71, 3, p. 594-602 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
74 Downloads (Pure)

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes

Rotroff, D. M., Yee, S. W., Zhou, K., Marvel, S. W., Shah, H. S., Jack, J. R., Havener, T. M., Hedderson, M. M., Kubo, M., Herman, M. A., Gao, H., Mychaleckyi, J. C., McLeod, H. L., Doria, A., Giacomini, K. M., Pearson, E. R., Wagner, M. J., Buse, J. B., Motsinger-Reif, A. A. & MetGen Investigators and the ACCORD/ACCORDion Investigators, Jul 2018, In : Diabetes. 67, 7, p. 1428-1440 13 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
88 Downloads (Pure)

Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

Ji, Y., Yiorkas, A. M., Frau, F., Mook-Kanamori, D., Staiger, H., Thomas, E. L., Atabaki-Pasdar, N., Campbell, A., Tyrrell, J., Jones, S. E., Beaumont, R. N., Wood, A. R., Tuke, M. A., Ruth, K. S., Mahajan, A., Murray, A., Freathy, R. M., Weedon, M. N., Hattersley, A. T., Hayward, C. & 11 others, Machann, J., Häring, H-U., Franks, P., de Mutsert, R., Pearson, E., Stefan, N., Frayling, T. M., Allebrandt, K. V., Bell, J. D., Blakemore, A. I. & Yaghootkar, H., 1 Jan 2019, In : Diabetes. 68, 1, p. 207-219 13 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
286 Downloads (Pure)

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

Gudmundsdottir, V., Pedersen, H. K., Allebrandt, K. V., Brorsson, C., van Leeuwen, N., Banasik, K., Mahajan, A., Groves, C. J., van de Bunt, M., Dawed, A. Y., Fritsche, A., Staiger, H., Simonis-Bik, A. M. C., Deelen, J., Kramer, M. H. H., Dietrich, A., Hübschle, T., Willemsen, G., Häring, H-U., de Geus, E. J. C. & 8 others, Boomsma, D. I., Eekhoff, E. M. W., Ferrer, J., McCarthy, M. I., Pearson, E. R., Gupta, R., Brunak, S. & 't Hart, L. M., 2 Jan 2018, In : PLoS ONE. 13, 1, p. 1-19 19 p., e0189886.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
159 Downloads (Pure)
Open Access
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10 Citations (Scopus)
144 Downloads (Pure)

Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study

Siddiqui, M. K., Kennedy, G., Carr, F., Doney, A., Pearson, E., Morris, A., Johnson, T., McLaughlin, M. M., Williams, R. E. & Palmer, C., Jun 2018, In : Diabetologia. 61, 6, p. 1344-1353 10 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
185 Downloads (Pure)

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

Molnos, S., Wahl, S., Haid, M., Eekhoff, E. M. W., Pool, R., Floegel, A., Deelen, J., Much, D., Prehn, C., Breier, M., Draisma, H. H. M., van Leeuwen, N., Simonis-Bik, A. M. C., Jonsson, A., Willemsen, G., Bernigau, W., Wang-Sattler, R., Suhre, K., Peters, A., Thorand, B. & 24 others, Herder, C., Rathmann, W., Roden, M., Gieger, C., Kramer, M. H. H., van Heemst, D., Pedersen, H. K., Gudmundsdottir, V., Schulze, M. B., Pischon, T., de Geus, E. J. C., Boeing, H., Boomsma, D. I., Ziegler, A. G., Slagboom, P. E., Hummel, S., Beekman, M., Grallert, H., Brunak, S., McCarthy, M. I., Gupta, R., Pearson, E. R., Adamski, J. & 't Hart, L. M., Jan 2018, In : Diabetologia. 61, 1, p. 117-129 13 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
147 Downloads (Pure)

Metformin and the gastrointestinal tract

McCreight, L. J., Bailey, C. J. & Pearson, E. R., Mar 2016, In : Diabetologia. 59, 3, p. 426-435 10 p.

Research output: Contribution to journalArticle

Open Access
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184 Citations (Scopus)
161 Downloads (Pure)

Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals

McCreight, L., Mari, A., Coppin, L., Jackson, N., Umpleby, A. M. & Pearson, E., 22 Nov 2019, In : Diabetologia. 4 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
80 Downloads (Pure)

Motivations for data sharing-views of research participants from four European countries: A DIRECT study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 30 Jan 2019, In : European Journal of Human Genetics. 27, 5, p. 721-729 9 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
105 Downloads (Pure)

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease

Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P. K., Relan, D., Harris, S., Vaidya, S. S. ., Dhillon, B., Zhou, K., Pearson, E., Hayward, C., Polašek, O., Deary, I. J., MacGillivray, T. J., Wilson, J. F., Trucco, M., Palmer, C. & 1 others, Doney, A., Dec 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552 11 p.

Research output: Contribution to journalArticle

Open Access
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103 Downloads (Pure)

Obesity, clinical, and genetic predictors for glycemic progression in Chinese patients with type 2 diabetes: A cohort study using the Hong Kong Diabetes Register and Hong Kong Diabetes Biobank

Jiang, G., Luk, A. O., Tam, C. H. T., Lau, E. S., Ozaki, R., Chow, E. Y. K., Kong, A. P. S., Lim, C. K. P., Lee, K. F., Siu, S. C., Hui, G., Tsang, C. C., Lau, K. P., Leung, J. Y. Y., Tsang, M-W., Kam, G., Lau, I. T., Li, J. K., Yeung, V. T., Lau, E. & 8 others, Lo, S., Fung, S. K. S., Cheng, Y. L., Chow, C. C., Pearson, E. R., So, W. Y., Chan, J. C. N. & Ma, R. C. W., 28 Jul 2020, In : PLoS Medicine. 17, 7, 19 p., e100329.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes

Dujic, T., Causevic, A., Bego, T., Malenica, M., Velija-Asimi, Z., Pearson, E. R. & Semiz, S., Apr 2016, In : Diabetic Medicine. 33, 4, p. 511-514 4 p., 13040.

Research output: Contribution to journalArticle

Open Access
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52 Citations (Scopus)
140 Downloads (Pure)

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J-L., Demine, S., Schiavo, A. A., Pachera, N., Deglasse, J-P., Jonas, J-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M., 2 Nov 2018, In : Nucleic Acids Research. 46, 19, p. 10302-10318 17 p.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
105 Downloads (Pure)

Performance of Cardiovascular Disease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register

Scottish Diabetes Research Network Epidemiology Group, Read, S. H., van Diepen, M., Colhoun, H. M., Halbesma, N., Lindsay, R. S., McKnight, J. A., McAllister, D. A., Pearson, E. R., Petrie, J. R., Philip, S., Sattar, N., Woodward, M. & Wild, S. H., 1 Sep 2018, In : Diabetes Care. 41, 9, p. 2010-2018 9 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
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Personalized medicine in diabetes: The role of 'omics' and biomarkers

Pearson, E. R., 1 Jun 2016, In : Diabetic Medicine. 33, 6, p. 712-717 6 p.

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Pharmacogenetics in type 2 diabetes: Influence on response to oral hypoglycemic agents

Dawed, A. Y., Zhou, K. & Pearson, E. R., 6 Apr 2016, In : Pharmacogenomics and Personalized Medicine. 9, p. 17-29 13 p.

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Pharmacokinetics of metformin in patients with gastrointestinal intolerance

McCreight, L., Stage, T. B., Connelly, P., Lonergan, M., Nielsen, F., Prehn, C., Adamski, J., Brosen, K. & Pearson, E. R., 1 Jul 2018, In : Diabetes, Obesity & Metabolism. 20, 7, p. 1593-1601 9 p.

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Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients

Shields, B. M., Shepherd, M. H., Hudson, M. M., McDonald, T. J., Colclough, K., Peters, J., Knight, B., Hyde, C., Ellard, S., Pearson, E. R., Hattersley, A. T. & on behalf of the UNITED study team, Aug 2017, In : Diabetes Care. 40, 8, p. 1017-1025 9 p.

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Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W., 19 Jun 2020, In : Diabetologia. 23 p.

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Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W., Jul 2020, In : Diabetes Care. 43, 7, p. 1617-1635 19 p.

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Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-Term Glycemic Response to DPP-4 Inhibitor Therapy

Dennis, J. M., Shields, B. M., Hill, A. V., Knight, B. A., McDonald, T. J., Rodgers, L. R., Weedon, M. N., Henley, W. E., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Jones, A. G. & MASTERMIND consortium, Apr 2018, In : Diabetes Care. 41, 4, p. 705-712 8 p.

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Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E. & 43 others, Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M-G., Elders, P. J. M., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R. S., Sharma, S., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., 't Hart, L. M., Adamski, J., Musholt, P. B., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A. T., Walker, M., Beulens, J. W. J., Mari, A., Schwenk, J. M., Gupta, R., McCarthy, M. I., Pearson, E. R., Bell, J. D., Pavo, I. & Franks, P. W., 19 Jun 2020, In : PLoS Medicine. 17, 6, p. 1-27 27 p., e1003149.

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