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  • Susan Wyllie
Article

8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi

Fersing, C., Boudot, C., Castera-Ducros, C., Pinault, E., Hutter, S., Paoli-Lombardo, R., Primas, N., Pedron, J., Seguy, L., Bourgeade-Delmas, S., Sournia-Saquet, A., Stigliani, J. L., Brossas, J. Y., Paris, L., Valentin, A., Wyllie, S., Fairlamb, A. H., Boutet-Robinet, É., Corvaisier, S., Since, M. & 8 others, Malzert-Fréon, A., Destere, A., Mazier, D., Rathelot, P., Courtioux, B., Azas, N., Verhaeghe, P. & Vanelle, P., 15 Sep 2020, In : European Journal of Medicinal Chemistry. 202, 15 p., 112558.

Research output: Contribution to journalArticle

Activation of bicyclic nitro-drugs by a novel nitroreductase (NTR2) in Leishmania

Wyllie, S., Roberts, A. J., Norval, S., Patterson, S., Foth, B. J., Berriman, M., Read, K. D. & Fairlamb, A. H., 3 Nov 2016, In : PLoS Pathogens. 12, 11, p. 1-22 22 p., e1005971.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
150 Downloads (Pure)

Antikinetoplastid SAR study in 3-nitroimidazopyridine series: identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties.

Fersing, C., Boudot, C., Paoli-Lombardo, R., Primas, N., Pinault, E., Hutter, S., Castera-Ducros, C., Kabri, Y., Pedron, J., Bourgeade-Delmas, S., Sournia-Saquet, A., Stigliani, J. L., Valentin, A., Azqueta, A., Muruzabal, D., Destere, A., Wyllie, S., Fairlamb, A. H., Corvaisier, S., Since, M. & 7 others, Malzert-Fréon, A., Di Giorgio, C., Rathelot, P., Azas, N., Courtioux, B., Vanelle, P. & Verhaeghe, P., 4 Aug 2020, In : European Journal of Medicinal Chemistry. 206, 20 p., 112668.

Research output: Contribution to journalArticle

Chemical Validation of Methionyl tRNA Synthetase (MetRS) as a Druggable Target in Leishmania donovani

Torrie, L., Brand, S., Robinson, D., Ko, E. J., Stojanovski, L., Simeons, F. R. C., Wyllie, S., Thomas, J., Ellis, L., Osuna-Cabello, M., Epemolu, R., Nuehs, A., Riley, J., MacLean, L., Manthri, S., Read, K., Gilbert, I., Fairlamb, A. & De Rycker, M., Oct 2017, In : ACS Infectious Diseases. 3, 10, p. 718-727 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
164 Downloads (Pure)

New 8-nitroquinolinone derivative displaying submicromolar in vitro activities against both Trypanosoma brucei and cruzi

Pedron, J., Boudot, C., Brossas, J., Pinault, E., Bourgeade-Delmas, S., Sournia-Saquet, A., Boutet-Robinet, E., Destere, A., Tronnet, A., Bergé, J., Bonduelle, C., Deraeve, C., Pratviel, G., Stigliani, J-L., Paris, L., Mazier, D., Corvaisier, S., Since, M., Malzert-Freon, A., Wyllie, S. & 5 others, Milne, R., Fairlamb, A. H., Valentin, A., Courtioux, B. & Verhaeghe, P., 9 Apr 2020, In : ACS Medicinal Chemistry Letters. 11, 4, p. 464-472 9 p.

Research output: Contribution to journalArticle

Open Access
File
40 Downloads (Pure)

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei

Wyllie, S., Foth, B. J., Kelner, A., Sokolova, A. Y., Berriman, M. & Fairlamb, A., Mar 2016, In : Journal of Antimicrobial Chemotherapy. 71, 3, p. 625-634 10 p.

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
183 Downloads (Pure)

Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Fersing, C., Basmaciyan, L., Boudot, C., Pedron, J., Hutter, S., Cohen, A., Castera-Ducros, C., Primas, N., Laget, M., Casanova, M., Bourgeade-Delmas, S., Piednoel, M., Sournia-Saquet, A., Belle Mbou, V., Courtioux, B., Boutet-Robinet, É., Since, M., Milne, R., Wyllie, S., Fairlamb, A. H. & 5 others, Valentin, A., Rathelot, P., Verhaeghe, P., Vanelle, P. & Azas, N., 10 Jan 2019, In : ACS Medicinal Chemistry Letters. 10, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
206 Downloads (Pure)

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

Bruhn, D. F., Wyllie, S., Rodríguez-Cortés, A., Carrillo, A. K., Rakesh, Guy, R. K., Fairlamb, A. H. & Lee, R. E., Apr 2016, In : Journal of Antimicrobial Chemotherapy. 71, 4, p. 956-963 8 p., dkv417.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Open Access
File
11 Citations (Scopus)
183 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
143 Downloads (Pure)

Setting our sights on infectious diseases

De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In : ACS Infectious Diseases. 6, p. 3-13 11 p.

Research output: Contribution to journalArticle

Open Access
File
70 Downloads (Pure)
Open Access
File
9 Citations (Scopus)
131 Downloads (Pure)

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

Patterson, S., Wyllie, S., Norval, S., Stojanovski, L., Simeons, F. R. C., Auer, J. L., Osuna-Cabello, M., Read, K. D. & Fairlamb, A. H., 24 May 2016, In : eLife. 5, p. 1-21 21 p., e09744.

Research output: Contribution to journalArticle

Open Access
File
41 Citations (Scopus)
194 Downloads (Pure)

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani: ACS Infectious Diseases

Wall, R. J., Carvalho, S., Milne, R., Bueren-Calabuig, J. A., Moniz, S., Cantizani-Perez, J., MacLean, L., Kessler, A., Cotillo, I., Sastry, L., Manthri, S., Patterson, S., Zuccotto, F., Thompson, S., Martin, J., Marco, M., Miles, T. J., De Rycker, M., Thomas, M. G., Fairlamb, A. H. & 2 others, Gilbert, I. H. & Wyllie, S., 13 Mar 2020, In : ACS Infectious Diseases. 6, 3, p. 515-528 14 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
45 Downloads (Pure)
Review article
Open Access
File
152 Citations (Scopus)
313 Downloads (Pure)