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  • 2020
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Author

  • Tom Owen-Hughes
Article

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
73 Downloads (Pure)

Efficient Analysis of Mammalian Polysomes in cells and tissues using Ribo Mega-SEC

Yoshikawa, H., Larance, M., Harney, D. J., Sundaramoorthy, R., Ly, T., Owen-Hughes, T. & Lamond, A. I., 10 Aug 2018, In : eLife. 7, 7, p. 1-26 26 p., e36530.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
139 Downloads (Pure)

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

Hauer, M. H., Seeber, A., Singh, V., Thierry, R., Sack, R., Amitai, A., Kryzhanovska, M., Eglinger, J., Holcman, D., Owen-Hughes, T. & Gasser, S. M., Feb 2017, In : Nature Structural & Molecular Biology. 24, 2, p. 99-107 13 p.

Research output: Contribution to journalArticle

Open Access
File
84 Citations (Scopus)
311 Downloads (Pure)

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

Gali, V. K., Dickerson, D., Katou, Y., Fujiki, K., Shirahige, K., Owen-Hughes, T., Kubota, T. & Donaldson, A. D., Nov 2018, In : PLoS Genetics. 14, 11, p. 1-20 20 p., e1007783.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
133 Downloads (Pure)

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., Mcconnell, D. B. & Ciulli, A., 2 Jul 2019, In : Nature Chemical Biology. 15, 8, p. 846 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

Sundaramoorthy, R., Hughes, A. L., Singh, V., Wiechens, N., Ryan, D. P., El-Mkami, H., Petoukhov, M., Svergun, D. I., Treutlein, B., Quack, S., Fischer, M., Michaelis, J., Bottcher, B., Norman, D. G. & Owen-Hughes, T., 13 Apr 2017, In : eLife. 6, 28 p., e22510.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
172 Downloads (Pure)

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In : eLife. 2018, 7, p. 1-28 28 p., e35720.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
163 Downloads (Pure)

The Face of Chromatin Variants

Flaus, A. & Owen-Hughes, T., 5 Sep 2019, In : Cell. 178, 6, p. 1284-1286 3 p.

Research output: Contribution to journalArticle

Open Access
File
10 Downloads (Pure)

Unlocking the nucleosome

Flaus, A. & Owen-Hughes, T., 20 Jan 2017, In : Science. 355, 6322, p. 245-246 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
Comment/debate

Deciphering Subunit-Specific Functions within SWI/SNF Complexes

Hughes, A. & Owen-Hughes, T., 28 Feb 2017, In : Cell Reports. 18, 9, p. 2075-2076 2 p.

Research output: Contribution to journalComment/debate

Open Access
File
3 Citations (Scopus)
152 Downloads (Pure)
Review article

Chromatin remodelling comes into focus

Sundaramoorthy, R. & Owen-Hughes, T., 20 Aug 2020, In : F1000Research. 9, 14 p., 1011.

Research output: Contribution to journalReview article

Open Access
File
10 Downloads (Pure)