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Author

  • Iva Hopkins Navratilova
Article

A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development

Mariappa, D., Selvan, N., Borodkin, V. S., Alonso, J., Ferenbach, A. T., Shepherd, C., Navratilova, I. H. & Van Aalten, D. M. F., Sep 2015, In : Biochemical Journal. 470, 2, p. 255-262 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A mutant O-GlcNAcase enriches Drosophila developmental regulators

Selvan, N., Williamson, R., Mariappa, D., Campbell, D. G., Gourlay, R., Ferenbach, A. T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. & van Aalten, D. M. F., Aug 2017, In : Nature Chemical Biology. 13, 8, p. 882-887 8 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
178 Downloads (Pure)

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sep 2013, In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Biosensor-Based Approach to the Identification of Protein Kinase Ligands with Dual-Site Modes of Action

Navratilova, I., Macdonald, G., Robinson, C., Hughes, S., Mathias, J., Phillips, C. & Cook, A., Feb 2012, In : Journal of Biomolecular Screening. 17, 2, p. 183-193 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Development and applications of biosensor assays for fragment screening of wild-type GPCRs

Hopkins Navratilova, I. & Fagge, T., 2015, In : European Pharmaceutical Review. 20, 6, p. 29-31 3 p.

Research output: Contribution to journalArticle

Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

Navratilova, I., Aristotelous, T., Picaud, S., Chaikuad, A., Knapp, S., Filappakopoulos, P. & Hopkins, A. L., 8 Dec 2016, In : ACS Medicinal Chemistry Letters. 7, 12, p. 1213-1218 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I., 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Mousnier, A., Bell, A. S., Swieboda, D. P., Morales-Sanfrutos, J., Pérez-Dorado, I., Brannigan, J. A., Newman, J., Ritzefeld, M., Hutton, J. A., Guedán, A., Asfor, A. S., Robinson, S. W., Hopkins-Navratilova, I., Wilkinson, A. J., Johnston, S. L., Leatherbarrow, R. J., Tuthill, T. J., Solari, R. & Tate, E. W., Jun 2018, In : Nature Chemistry. 10, 6, p. 599-606 8 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
133 Downloads (Pure)

GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD)

van der Beek, S. L., Le Breton, Y., Ferenbach, A. T., Chapman, R. N., van Aalten, D. M. F., Hopkins Navratilova, I., Boons, G. J., Mciver, K. S., van Sorge, N. M. & Dorfmueller, H., 24 Nov 2015, In : Molecular Microbiology. 98, 5, p. 946-962 16 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
233 Downloads (Pure)

Inhibitors against Fungal Cell Wall Remodeling Enzymes

Delso, I., Valero-Gonzalez, J., Gomollón-Bel, F., Castro-López, J., Fang, W., Navratilova, I., van Aalten, D. M. F., Tejero, T., Merino, P. & Hurtado-Guerrero, R., 22 Jan 2018, In : ChemMedChem. 13, 2, p. 128-132 5 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
153 Downloads (Pure)

Mechanism of ubiquitylation by dimeric RING ligase RNF4

Plechanovova, A., Jaffray, E. G., McMahon, S. A., Johnson, K. A., Navratilova, I., Naismith, J. H. & Hay, R. T., Sep 2011, In : Nature Structural & Molecular Biology. 18, 9, p. 1052-1059 8 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R., 4 May 2011, In : EMBO Journal. 30, 9, p. 1730-1741 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry

Borodkin, V. S., Rafie, K., Selvan, N., Aristotelous, T., Navratilova, I., Ferenbach, A. T. & Van Aalten, D. M. F., 18 May 2018, In : ACS Chemical Biology. 13, 5, p. 1353-1360 8 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
145 Downloads (Pure)

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

Schimpl, M., Zheng, X., Borodkin, V. S., Blair, D. E., Ferenbach, A. T., Schüttelkopf, A. W., Navratilova, I., Aristotelous, T., Albarbarawi, O., Robinson, D. A., van Aalten, D. M. F. & Macnaughtan, M. A., 2012, In : Nature Chemical Biology.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Screening for GPCR Ligands Using Surface Plasmon Resonance

Hopkins Navratilova, I., Besnard, J. & Hopkins, A. L., Jul 2011, In : ACS Medicinal Chemistry Letters. 2, 7, p. 549-554 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F., 2 Oct 2013, In : Open Biology. 3, 130021.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates

Cahill, S. T., Tyrrell, J. M., Navratilova, I. H., Calvopiña, K., Robinson, S. W., Lohans, C. T., McDonough, M. A., Cain, R., Fishwick, C. W. G., Avison, M. B., Walsh, T. R., Schofield, C. J. & Brem, J., 1 Apr 2019, In : Biochimica et Biophysica Acta: General Subjects. 1863, 4, p. 742-748 7 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
49 Downloads (Pure)

Substrate and product analogues as human O-GlcNAc transferase inhibitors

Dorfmueller, H. C., Borodkin, V. S., Blair, D. E., Pathak, S., Navratilova, I. & van Aalten, D. M. F., Mar 2011, In : Amino Acids. 40, 3, p. 781-792 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Surveying GPCR solubilisation conditions using surface plasmon resonance

Navratilova, I. H., Aristotelous, T., Bird, L. E. & Hopkins, A. L., 1 Sep 2018, In : Analytical Biochemistry. 556, p. 23-34 12 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
14 Downloads (Pure)
Chapter (peer-reviewed)

Surface plasmon resonance analysis of seven-transmembrane receptors

Aristotelous, T., Hopkins, A. L. & Navratilova, I., 2015, Membrane proteins—production and functional characterization. Shukla, A. K. (ed.). Academic Press, p. 499-525 27 p. (Methods in Enzymology; vol. 556).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

14 Citations (Scopus)
Review article

Emerging role of surface plasmon resonance in fragment-based drug discovery

Navratilova, I. & Hopkins, A. L., Oct 2011, In : Future Medicinal Chemistry. 3, 14, p. 1809-1820 12 p.

Research output: Contribution to journalReview article

46 Citations (Scopus)