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  Loss-of-Function GRHL3 Variants Detected in African Patients with Isolated Cleft Palate

  Eshete, M. A., Liu, H., Li, M., Adeyemo, W. L., Gowans, L. J. J., Mossey, P. A., Busch, T., Deressa, W., Donkor, P., Olaitan, P. B., Aregbesola, B. S., Braimah, R. O., Oseni, G. O., Oginni, F., Audu, R., Onwuamah, C., James, O., Augustine-Akpan, E., Rahman, L. A., Ogunlewe, M. O., & 17 othersArthur, F. K. N., Bello, S. A., Agbenorku, P., Twumasi, P., Abate, F., Hailu, T., Demissie, Y., Hailu, A., Plange-Rhule, G., Obiri-Yeboah, S., Dunnwald, M. M., Gravem, P. E., Marazita, M. L., Adeyemo, A. A., Murray, J. C., Cornell, R. A. & Butali, A., 1 Jan 2018, In: Journal of Dental Research. 97, 1, p. 41-48 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  19 Citations (Scopus)

  27 Downloads (Pure)

• Loss-of-function mutations in APOC3, triglycerides, and coronary disease

  TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute & Kathiresan, S., 3 Jul 2014, In: New England Journal of Medicine. 371, 1, p. 22-31 10 p.

  Research output: Contribution to journal › Article › peer-review
  718 Citations (Scopus)

• Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads

  Lin, Z., Zhao, J., Nitoiu, D., Scott, C. A., Plagnol, V., Smith, F. J. D., Wilson, N. J., Cole, C., Schwartz, M. E., McLean, W. H. I., Wang, H., Feng, C., Duo, L., Zhou, E. Y., Ren, Y., Dai, L., Chen, Y., Zhang, J., Xu, X., O'Toole, E. A., & 2 othersKelsell, D. P. & Yang, Y., 5 Mar 2015, In: American Journal of Human Genetics. 96, 3, p. 440-447 8 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

  Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Collisson, E. A., Gordon, P. B., Jakkula, L., Pennypacker, S., Zou, Y., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Hur, J. S., Park, K., & 13 othersHuh, N., Kwok, P-Y., Arron, S. T., Massion, P. P., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W., Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., 25 Oct 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17761-17766 6 p.

  Research output: Contribution to journal › Article › peer-review
  321 Citations (Scopus)

• Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum

  Kezic, S., Kemperman, P. M. J. H., Koster, E. S., de Jongh, C. M., Thio, H. B., Campbell, L. E., Irvine, A. D., McLean, I. W. H., Puppels, G. J. & Caspers, P. J., 2008, In: Journal of Investigative Dermatology. 128, 8, p. 2117-9 3 p.

  Research output: Contribution to journal › Article › peer-review
  232 Citations (Scopus)

• Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

  Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L. E., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis-Jones, S., Arseculeratne, G., Munro, C. S., Sergeant, A., O'Regan, G., Bale, S. J., Compton, J. G., DiGiovanna, J. J., Presland, R. B., Fleckman, P. & McLean, W. H. I., 2006, In: Nature Genetics. 38, 3, p. 337-342 6 p.

  Research output: Contribution to journal › Article › peer-review
  789 Citations (Scopus)

• Loss-of-function mutations in the gene encoding filaggrin underlie a Japanese family with food-dependent exercise-induced anaphylaxis

  Mizuno, O., Nomura, T., Ohguchi, Y., Suzuki, S., Nomura, Y., Hamade, Y., Hoshina, D., Sandilands, A., Akiyama, M., McLean, W. H. I., Abe, R. & Shimizu, H., Apr 2015, In: Journal of the European Academy of Dermatology and Venereology. 29, 4, p. 805-808 4 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Loss-of-function mutations of CUL3, a high confidence gene for psychiatric disorders, lead to aberrant neurodevelopment in human induced pluripotent stem cells

  Fischer, S., Schlotthauer, I., Kizner, V., Macartney, T., Dorner-Ciossek, C. & Gillardon, F., 10 Nov 2020, In: Neuroscience. 448, p. 234-254 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  3 Citations (Scopus)

  66 Downloads (Pure)

• Loss of function of def selectively up-regulates Δ113p53 expression to arrest expansion growth of digestive organs in zebrafish

  Chen, J., Ruan, H., Ng, S. M., Gao, C., Soo, H. M., Wu, W., Zhang, Z., Wen, Z., Lane, D. & Peng, J., Dec 2005, In: Genes & Development. 19, 23, p. 2900-2911 12 p.

  Research output: Contribution to journal › Article › peer-review
  138 Citations (Scopus)

• Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

  Brown, S. J., Asai, Y., Cordell, H. J., Campbell, L. E., Zhao, Y., Liao, H., Northstone, K., Henderson, J., Alizadehfar, R., Ben-Shoshan, M., Morgan, K., Roberts, G., Masthoff, L. J. N., Pasmans, S. G. M. A., van den Akker, P. C., Wijmenga, C., Hourihane, J. OB., Palmer, C. N. A., Lack, G., Clarke, A., & 3 othersHull, P. R., Irvine, A. D. & McLean, W. H. I., Mar 2011, In: Journal of Allergy and Clinical Immunology. 127, 3, p. 661-667 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  326 Citations (Scopus)

  162 Downloads (Pure)

• Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families

  Ekelund, E., Lieden, A., Link, J., Lee, S. P., D'Amato, M., Palmer, C. N. A., Kockum, I. & Bradley, M., 2008, In: Acta Dermato-Venereologica. 88, 1, p. 15-19 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  47 Citations (Scopus)

  192 Downloads (Pure)

• Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

  Weidinger, S., Illig, T., Baurecht, H., Irvine, A. D., Rodriguez, E., Diaz-Lacava, A., Klopp, N., Wagenpfeil, S., Zhao, Y., Liao, H., Lee, S. P., Palmer, C. N. A., Jenneck, C., Maintz, L., Hagemann, T., Behrendt, H., Ring, J., Nothen, M. M., McLean, W. H. I. & Novak, N., 1 Jul 2006, In: Journal of Allergy and Clinical Immunology. 118, 1, p. 214-219 6 p.

  Research output: Contribution to journal › Article › peer-review
  491 Citations (Scopus)

• Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction

  Roche, S. L., Sherman, D. L., Dissanayake, K., Soucy, G., Desmazieres, A., Lamont, D. J., Peles, E., Julien, J-P., Wishart, T. M., Ribchester, R. R., Brophy, P. J. & Gillingwater, T. H., 17 Sep 2014, In: Journal of Neuroscience. 34, 38, p. 12904-12918 15 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• Loss of heterozygosity occurs at the D11S29 locus on chromosome 11q23 in invasive cervical carcinoma

  Bethwaite, P. B., Koreth, J., Herrington, C. S. & McGee, J. OD., Apr 1995, In: British Journal of Cancer. 71, 4, p. 814-818 5 p.

  Research output: Contribution to journal › Article › peer-review
  60 Citations (Scopus)

• Loss of iron triggers PINK1/Parkin-independent mitophagy

  Allen, G. F. G., Toth, R., James, J. & Ganley, I. G., 2013, In: EMBO Reports. 14, p. 1127-1135 9 p.

  Research output: Contribution to journal › Article › peer-review
  301 Citations (Scopus)

• Loss of Kindlin-1, a human homolog of the Caenorhabditis elegans actin–extracellular-matrix linker protein UNC-112, causes Kindler syndrome

  Siegel, D. H., Ashton, G. H. S., Penagos, H. G., Lee, J. V., Feiler, H. S., Wilhelmsen, K. C., South, A. P., Smith, F., Prescott, A. R., Wessagowit, V., Oyama, N., Akiyama, M., Al Aboud, D., Al Aboud, K., Al Githami, A., Al Hawsawi, K., Al Ismaily, A., Al-Suwaid, R., Atherton, D. J., Caputo, R., & 22 othersFine, J-D., Frieden, I. J., Fuchs, E., Haber, R. M., Harada, T., Kitajima, Y., Mallory, S. B., Ogawa, H., Sahin, S., Shimizu, H., Suga, Y., Tadini, G., Tsuchiya, K., Wiebe, C. B., Wojnarowska, F., Zaghloul, A. B., Hamada, T., Mallipeddi, R., Eady, R. A. J., McLean, I., McGrath, J. A. & Epstein, E. H., 2003, In: American Journal of Human Genetics. 73, 1, p. 174-187 14 p.

  Research output: Contribution to journal › Article › peer-review
  262 Citations (Scopus)

• Loss of Mef2D function enhances TLR induced IL-10 production in macrophages

  Pattison, M. J., Naik, R. J., Reyskens, K. M. S. E. & Arthur, J. S. C., 21 Aug 2020, In: Bioscience Reports. 40, 8, 15 p., BSR20201859.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1 Citation (Scopus)

  36 Downloads (Pure)

• Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma

  Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In: Scientific Reports. 6, 7 p., 25804.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  26 Citations (Scopus)

  187 Downloads (Pure)

• Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

  Chowdhry, S., Nazmy, M. H., Meakin, P. J., Dinkova-Kostova, A. T., Walsh, S. V., Tsujita, T., Dillon, J. F., Ashford, M. L. J. & Hayes, J. D., 2010, In: Free Radical Biology and Medicine. 48, 2, p. 357-371 15 p.

  Research output: Contribution to journal › Article › peer-review
  187 Citations (Scopus)

• Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis

  Morris, H. T., Fort, L., Spence, H. J., Patel, R., Vincent, D. F., Park, J. H., Snapper, S. B., Carey, F. A., Sansom, O. J. & Machesky, L. M., Jul 2018, In: Journal of Pathology. 245, 3, p. 337-348 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  7 Citations (Scopus)

  145 Downloads (Pure)

• Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

  Muha, V., Authier, F., Szoke-Kovacs, Z., Johnson, S., Gallagher, J., McNeilly, A., McCrimmon, R., Teboul, L. & van Aalten, D., 2021, In: Journal of Biological Chemistry. 296, 15 p., 100439.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  6 Citations (Scopus)

  21 Downloads (Pure)

• Loss of Pikfyve causes Transdifferentiation of Dictyostelium Spores into Basal Disc Cells

  Yamada, Y., Forbes, G., Du, Q., Kawata, T. & Schaap, P., 19 Aug 2021, In: Frontiers in Cell and Developmental Biology. 9, 11 p., 692473.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1 Citation (Scopus)

  17 Downloads (Pure)

• Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling

  Lackey, J., Barnett, J., Davidson, L., Batty, I. H., Leslie, N. R. & Downes, C. P., Nov 2007, In: Oncogene. 26, 50, p. 7132-7142 11 p.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• Loss of retinoblastoma protein expression is frequent in small cell neuroendocrine carcinoma of the cervix and is unrelated to HPV type

  Herrington, C. S., Graham, D., Southern, S. A., Bramdev, A. & Chetty, R., 1999, In: Human Pathology. 30, 8, p. 906-910 5 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Loss of Rho function in the thymus is accompanied by the development of thymic lymphoma

  Cleverley, SC., Costello, PS., Henning, SW. & Cantrell, D. A., 6 Jan 2000, In: Oncogene. 19, 1, p. 13-20 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  38 Citations (Scopus)

• Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps - a putative role of semaphorins 3F and 3A

  Graf, N., McLean, M., Capellino, S., Schölmerich, J., Murray, G. I., El-Omar, E. M. & Straub, R. H., Feb 2012, In: Neurogastroenterology and Motility. 24, 2, p. 120-e83 10 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Loss of sequences on the short arm of chromosome 17 is a late event in squamous carcinoma of the cervix

  Herrington, C. S., Worsham, M., Southern, S. A., Mackowiak, P. & Wolman, S. R., Jun 2001, In: Molecular Pathology. 54, 3, p. 160-164 5 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Loss of Tet1-associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer

  Thomson, J. P., Ottaviano, R., Unterberger, E. B., Lempiäinen, H., Muller, A., Terranova, R., Illingworth, R. S., Webb, S., Kerr, A. R. W., Lyall, M. J., Drake, A. J., Wolf, C. R., Moggs, J. G., Schwarz, M. & Meehan, R. R., 15 May 2016, In: Cancer Research. 76, 10, p. 3097-3108 12 p.

  Research output: Contribution to journal › Article › peer-review
  62 Citations (Scopus)

• Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

  Rasmussen, K. D., Jia, G., Johansen, J. V., Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, B. T., Bernard, O. A., Christensen, J. & Helin, K., 1 May 2015, In: Genes and Development. 29, 9, p. 910-922 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  174 Citations (Scopus)

  91 Downloads (Pure)

• Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

  Chanas, S. A., Jiang, Q., McMahon, M., McWalter, G. K., McLellan, L. I., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moffat, G. J., Itoh, K., Yamamoto, M. & Hayes, J. D., 2002, In: Biochemical Journal. 365, Pt 2, p. 405-16 12 p.

  Research output: Contribution to journal › Article › peer-review
  360 Citations (Scopus)

• Loss of the Polyketide Synthase StlB Results in Stalk Cell Over production in Polysphondylium violaceum

  Narita, T. B., Kawabe, Y., Kin, K., Gibbs, R. A., Kuspa, A., Muzny, D., Richards, S., Strassmann, J. E., Sucgang, R., Worley, K. C. & Schaap, P., May 2020, In: Genome Biology and Evolution. 12, 5, p. 674-683 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  3 Citations (Scopus)

  30 Downloads (Pure)

• Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage

  Maure, J. F., Moser, S. C., Jaffray, E. G., Alpi, A. F. & Hay, R. T., 17 May 2016, In: Scientific Reports. 6, 10 p., 26178.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  10 Citations (Scopus)

  150 Downloads (Pure)

• Lost containers tell no tales. Time to worry

  Cobley, A., 24 May 2016, The Register.

  Research output: Contribution to specialist publication › Article

• Lost in translation: pitfalls in deciphering plant alternative splicing transcripts

  Brown, J. W. S., Simpson, C. G., Marquez, Y., Gadd, G. M., Barta, A. & Kalyna, M., Aug 2015, In: The Plant Cell. 27, 8, p. 2083-2087 5 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Lost in Translation: the English Policeman through a German monocle, 1848-1914

  Johansen, A., Dec 2013, In: History. 98, 333, p. 750-768 19 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Love in a Time of Colic: Mobilizing Professional Love in Relationships with Children and Young People to Promote Their Resilience and Wellbeing

  Purcell, M. E., Page, J. & Reid, J., 8 Oct 2020, (E-pub ahead of print) In: Child and Youth Services. 26 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  43 Downloads (Pure)

• Love is what people say it is: Performativity and narrativity in critical love studies

  Gratzke, M., 12 Apr 2017, In: Journal of Popular Romance Studies. 6, p. 1-20 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Love thy neighbour ( but not their front lawn)

  Comerford, E., 2014, In: Scottish Planning and Environmental Law. 162, p. 29-31 3 p.

  Research output: Contribution to journal › Article

• Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART)

  Williams, M. C., Kwiecinski, J., Doris, M., McElhinney, P., D'Souza, M. S., Cadet, S., Adamson, P. D., Moss, A. J., Alam, S., Hunter, A., Shah, A. S. V., Mills, N. L., Pawade, T., Wang, C., Weir McCall, J., Bonnici-Mallia, M., Murrills, C., Roditi, G., van Beek, E. J. R., Shaw, L. J., & 6 othersNicol, E. D., Berman, D. S., Slomka, P. J., Newby, D. E., Dweck, M. R. & Dey, D., 11 May 2020, In: Circulation. 141, 18, p. 1452-1462 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  141 Citations (Scopus)

  75 Downloads (Pure)

• Low back pain: An assessment using positional MRI and MDT

  Hedberg, K., Alexander, L. A., Cooper, K., Hancock, E., Smith, F. W. & Ross, J., 2012, In: Manual Therapy.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Low Cell Number Proteomic Analysis Using In-Cell Protease Digests Reveals a Robust Signature for Cell Cycle State Classification

  Kelly, V., Al-Rawi, A., Lewis, D., Kustatscher, G. & Ly, T., 1 Jan 2022, In: Molecular & Cellular Proteomics. 21, 1, 19 p., 100169.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Citations (Scopus)

  37 Downloads (Pure)

• Low-complexity user pairing and power allocation algorithm for 5G cellular network non-orthogonal multiple access

  He, J. & Tang, Z., 1 May 2017, In: Electronics Letters. 53, 9, p. 626-627 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Citations (Scopus)

• Low-cost air-stable perovskite solar cells by incorporating inorganic materials

  Heshmati, N., Mohammadi, M. R., Abachi, P. & Martinez-Chapa, S. O., 14 Jan 2021, In: New Journal of Chemistry. 45, 2, p. 788-795 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  1 Citation (Scopus)

  73 Downloads (Pure)

• Low-cost high sensitivity pulsed endomicroscopy to visualize tricolor optical signatures

  Krstajić, N., Mills, B., Murray, I., Marshall, A., Norberg, D., Craven, T. H., Emanuel, P., Choudhary, T. R., Williams, G. O. S., Scholefield, E., Akram, A. R., Davie, A., Hirani, N., Bruce, A., Moore, A., Bradley, M. & Dhaliwal, K., 10 Jul 2018, In: Journal of Biomedical Optics. 23, 7, 12 p., 076005.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  13 Citations (Scopus)

  205 Downloads (Pure)

• Low-cost optical manipulation using hanging droplets of PDMS

  McDonald, C. & McGloin, D., 2015, In: RSC Advances. 5, 68, p. 55561-55565 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  11 Citations (Scopus)

  178 Downloads (Pure)

• Low-dimensional bifurcation phenomena in Taylor–Couette flow with discrete azimuthal symmetry

  Kobine, J. J. & Mullin, T., Sep 1994, In: Journal of Fluid Mechanics. 275, p. 379-405 27 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Low-dimensional Bose liquids: beyond the Gross-Pitaevskii approximation

  Kolomeisky, E. B., Newman, T. J., Straley, J. P. & Qi, X., 7 Aug 2000, In: Physical Review Letters. 85, 6, p. 1146-1149 4 p.

  Research output: Contribution to journal › Article › peer-review
  287 Citations (Scopus)

• Low dose atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) with spironolactone in the treatment of ascites

  Reynolds, N., Dillon, J. F., Pennington, C. R. & Struthers, A. D., 1998, In: Gut. 42, Suppl. 1, p. A20-A20 1 p., F78.

  Research output: Contribution to journal › Article › peer-review

• Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery

  Belch, J. J. F., Lowe, G. D., Pollock, J. G., Forbes, C. D. & Prentice, C. R., 1980, In: Thrombosis and Haemostasis. 42, 5, p. 1429-33 5 p.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)

• Low-dose phase contrast mammography with conventional x-ray sources

  Olivo, A., Gkoumas, S., Endrizzi, M., Hagen, C. K., Szafraniec, M. B., Diemoz, P. C., Munro, P. R. T., Ignatyev, K., Johnson, B., Horrocks, J. A., Vinnicombe, S. J., Jones, J. L. & Speller, R. D., 2013, In: Medical Physics. 40, 9

  Research output: Contribution to journal › Article › peer-review
  87 Citations (Scopus)