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• Article

  Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

  Deng, P., Khan, A., Jacobson, D., Sambrani, N., McGurk, L., Li, X., Jayasree, A., Hejatko, J., Shohat-Ophir, G., O'Connell, M. A., Li, J. B. & Keegan, L. P., 27 Mar 2020, In: Nature Communications. 11, 1, p. 1580 1580.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • editing
  • RNA Editing
  • Drosophila
  • Adenosine
  • brain
  7 Citations (Scopus)

  52 Downloads (Pure)

• Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

  Khan, A., Paro, S., McGurk, L., Sambrani, N., Hogg, M. C., Brindle, J., Pennetta, G., Keegan, L. P. & O'Connell, M. A., 14 Feb 2020, In: BMC Biology. 18, 1, 16 p., 15.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Synaptic Membranes
  • adenosine deaminase
  • Adenosine Deaminase
  • autophagy
  • mutant
  3 Citations (Scopus)

  51 Downloads (Pure)

• Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

  McGurk, L., Mojsilovic-Petrovic, J., Van Deerlin, V. M., Shorter, J., Kalb, R. G., Lee, V. M., Trojanowski, J. Q., Lee, E. B. & Bonini, N. M., 29 Aug 2018, In: Acta Neuropathologica Communications. 6, 1, p. 1-15 15 p., 84.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Poly Adenosine Diphosphate Ribose
  • Amyotrophic Lateral Sclerosis
  • veliparib
  • Spinal Cord
  • Nuclear RNA
  26 Citations (Scopus)

  71 Downloads (Pure)

• Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

  McGurk, L., Gomes, E., Guo, L., Shorter, J. & Bonini, N. M., 26 Dec 2018, In: Biochemistry. 57, 51, p. 6923-6926 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Poly Adenosine Diphosphate Ribose
  • Agglomeration
  • Prions
  • Biopolymers
  • DNA-Binding Proteins
  9 Citations (Scopus)

• Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

  McGurk, L., Gomes, E., Guo, L., Mojsilovic-Petrovic, J., Tran, V., Kalb, R. G., Shorter, J. & Bonini, N. M., 6 Sep 2018, In: Molecular Cell. 71, 5, p. 703-717.e9 24 p.

  Research output: Contribution to journal › Article › peer-review

  • Tankyrases
  • Poly Adenosine Diphosphate Ribose
  • Amyotrophic Lateral Sclerosis
  • Phosphorylation
  • Poly(ADP-ribose) Polymerases
  95 Citations (Scopus)

• TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2

  McGurk, L., Rifai, O. & Bonini, N. M., 23 Jun 2020, In: Journal of Cell Science. 133, 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tankyrases
  • Amyotrophic Lateral Sclerosis
  • Poly(ADP-ribose) Polymerases
  • RNA-Binding Proteins
  • DNA-Binding Proteins
  1 Citation (Scopus)

  19 Downloads (Pure)
• Comment/debate

  First person - Leeanne McGurk

  McGurk, L., Jun 2020, In: Journal of Cell Science. 133, 12, 2 p., jcs.248773.

  Research output: Contribution to journal › Comment/debate › peer-review
• Review article

  Poly(ADP-Ribosylation) in Age-Related Neurological Disease

  McGurk, L., Rifai, O. M. & Bonini, N. M., Aug 2019, In: Trends in Genetics. 35, 8, p. 601-613 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Poly ADP Ribosylation
  • Neurodegenerative Diseases
  • Proteins
  • Poly Adenosine Diphosphate Ribose
  • Amyotrophic Lateral Sclerosis
  3 Citations (Scopus)