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Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

Ong, H. B., Sienkiewicz, N., Wyllie, S., Patterson, S. & Fairlamb, A. H., Oct 2013, In : Molecular Microbiology. 90, 2, p. 443-455 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Andrés, D. A., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J. S., Turner, C. M. R., Tait, A., MacLeod, A., Mäser, P., Barrett, M. P., Horn, D. & De Koning, H. P., 1 Mar 2014, In : Journal of Antimicrobial Chemotherapy. 69, 3, p. 651-663 13 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Trypanosoma brucei brucei: uptake and metabolism of pyridoxine and pyridoxal

Gray, A., May 1995, In : Experimental parasitology. 80, 3, p. 390-400 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Trypanosoma brucei brucei variant surface glycoprotein contains non-N-acetylated glucosamine

Strang, A-M., Williams, J. M., Ferguson, M. A. J., Holder, A. A. & Allen, A. K., 1 Mar 1986, In : Biochemical Journal. 234, 2, p. 481-484 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Trypanosoma brucei DHRF-TS revisited: characterisation of a bifunctional and highly unstable recombinant dihydrofolate reductase-thymidylate synthase

W. Gibson, M., Dewar, S., Ong, H. B., Sienkiewicz, N. & Fairlamb, A., 13 May 2016, In : PLoS Neglected Tropical Diseases. 10, 5, p. 1-20 20 p., e0004714.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
127 Downloads (Pure)

Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains

Atrih, A., Richardson, J. M., Prescott, A. R. & Ferguson, M. A. J., 14 Jan 2005, In : Journal of Biological Chemistry. 280, 2, p. 865-871 7 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Trypanosoma brucei GPEET-PARP is phosphorylated on six out of seven threonine residues

Mehlert, A., Treumann, A. & Ferguson, M. A. J., 25 Jan 1999, In : Molecular and Biochemical Parasitology. 98, 2, p. 291-296 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

Sienkiewicz, N., Ong, H. B. & Fairlamb, A. H., Aug 2010, In : Molecular Microbiology. 77, 3, p. 658-671 14 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
16 Citations (Scopus)

Trypanosoma brucei UDP-glucose:glycoprotein glucosyltransferase has unusual substrate specificity and protects the parasite from stress

Izquierdo, L., Atrih, A., Rodrigues, J. A., Jones, D. C. & Ferguson, M. A. J., Feb 2009, In : Eukaryotic Cell. 8, 2, p. 230-240 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Trypanosoma brucei variant surface glycoprotein has a sn-1,2-dimyristyl glycerol membrane anchor at its COOH terminus

Ferguson, M. A. J., Haldar, K. & Cross, G. A. M., 25 Apr 1985, In : Journal of Biological Chemistry. 260, 8, p. 4963-4968 6 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

Trypanosoma cruzi mucins: potential functions of a complex structure

Almeida, I. C., Gazzinelli, R., Ferguson, M. A. J. & Travassos, L. R., 1999, In : Memorias do Instituto Oswaldo Cruz. 94, Supplement 1, p. 173-176 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W., Torrie, L. S. & De Rycker, M., Oct 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-11 11 p., e01082-19.

Research output: Contribution to journalArticle

Open Access
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74 Downloads (Pure)

Trypanosoma cruzi trypanothione reductase: Crystallization, unit cell dimensions and structure solution

Zhang, Y., Bailey, S., Naismith, J. H., Bond, C. S., Habash, J., McLaughlin, P., Papiz, M. Z., Borges, A., Cunningham, M., Fairlamb, A. H. & Hunter, W. N., 20 Aug 1993, In : Journal of Molecular Biology. 232, 4, p. 1217-1220 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Trypanosomal histone γH2A and the DNA damage response

Glover, L. & Horn, D., May 2012, In : Molecular and Biochemical Parasitology. 183, 1, p. 78-83 6 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

Krieger, S., Schwarz, W., Arlyanayagam, M. R., Fairlamb, A. H., Krauth-Siegel, R. L. & Clayton, C., 19 Feb 2000, In : Molecular Microbiology. 35, 3, p. 542-552 11 p.

Research output: Contribution to journalArticle

281 Citations (Scopus)

Trypanothione biosynthesis in Leishmania major

Oza, S. L., Shaw, M. P., Wyllie, S. & Fairlamb, A. H., 1 Jan 2005, In : Molecular and Biochemical Parasitology. 139, 1, p. 107-116 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

Holloway, G. A., Charman, W. N., Fairlamb, A. H., Brun, R., Kaiser, M., Kostewicz, E., Novello, P. M., Parisot, J. P., Richardson, J., Street, I. P., Watson, K. G. & Baell, J. B., Jul 2009, In : Antimicrobial Agents and Chemotherapy. 53, 7, p. 2824-2833 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Tryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells

Ritchie, J. W. A. & Taylor, P. M., May 2010, In : Amino Acids. 38, 5, p. 1361-1367 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour

Rogers, R. D., Blackshaw, A. J., Middleton, H. C., Matthews, K., Hawtin, K., Crowley, C., Hopwood, A., Wallace, C., Deakin, J. F. W., Sahakian, B. J. & Robbins, T. W., Oct 1999, In : Psychopharmacology. 146, 4, p. 482-491 10 p.

Research output: Contribution to journalArticle

235 Citations (Scopus)

Tryptophan switch for a photoactivated platinum anticancer complex

Butler, J. S., Woods, J. A., Farrer, N. J., Newton, M. E. & Sadler, P. J., 10 Oct 2012, In : Journal of the American Chemical Society. 134, 40, p. 16508-16511 4 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

TSC22 in mammary gland development and breast cancer

Huser, C., Heath, V., Pringle, M-A., Bell, A. K., Crighton, D., Ryan, K., Inman, G., Stein, T. & Gusterson, B., 2008, In : Breast Cancer Research. 10, p. S11 1 p.

Research output: Contribution to journalMeeting abstract

TSIS: an R package to infer alternative splicing isoform switches for time-series data

Guo, W., Calixto, C. P. G., Brown, J. W. S. & Zhang, R., 15 Oct 2017, In : Bioinformatics. 33, 20, p. 3308-3310 3 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
162 Downloads (Pure)

Tsunami sedimentology

Costa, P. J. M. & Dawson, S., 23 Dec 2015, Encyclopedia of Complexity and Systems Science. Meyers, R. A. (ed.). Springer , p. 1-17 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R., 2011, In : Biochemical Journal. 437, p. 157-167 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Tuberculosis immunodiagnosis: delving below the surface

Lalvani, A. & Connell, D. W., Mar 2013, In : Thorax. 68, 3, p. 204-206 3 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

Tuberculosis of spleen

Tang, B. & Yang, J., 1995, In : Acta Aacademiae Medical Qingdao Universitatis. 1, p. 60 1 p.

Research output: Contribution to journalArticle

Tubular Carcinoma of the Breast: Further Evidence to Support Its Excellent Prognosis

Rakha, E. A., Lee, A. H. S., Evans, A. J., Menon, S., Assad, N. Y., Hodi, Z., Macmillan, D., Blamey, R. W. & Ellis, I. O., 1 Jan 2010, In : Journal of Clinical Oncology. 28, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)
31 Citations (Scopus)

Tumor chemosensitivity and chemoresistance assays

Cree, I. A., Petty, R. D., Kurbacher, C. M. & Untch, M., 1 Nov 1996, In : Cancer. 78, 9, p. 2031-2032 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

Nelson, S. A., Li, Z., Newton, I. P., Fraser, D., Milne, R. E., Martin, D. M. A., Schiffmann, D., Yang, X., Dormann, D., Weijer, C. J., Appleton, P. L. & Nathke, I. S., Nov 2012, In : Disease Models & Mechanisms. 5, 6, p. 940-947 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Tumor localization in tissue microarrays using rotation invariant superpixel pyramids

Akbar, S., Jordan, L., Thompson, A. M. & McKenna, S. J., 2015, 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI 2015). IEEE, p. 1292-1295 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
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7 Citations (Scopus)
218 Downloads (Pure)

Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment

Anderson, A. R. A., Weaver, A. M., Cummings, P. T. & Quaranta, V., 2006, In : Cell. 127, 5, p. 905-915 11 p.

Research output: Contribution to journalArticle

474 Citations (Scopus)

Tumor Necrosis Factor-mediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection

Shinde, P. V., Xu, H. C., Maney, S. K., Kloetgen, A., Namineni, S., Zhuang, Y., Honke, N., Shaabani, N., Bellora, N., Doerrenberg, M., Trilling, M., Pozdeev, V. I., van Rooijen, N., Scheu, S., Pfeffer, K., Crocker, P. R., Tanaka, M., Duggimpudi, S., Knolle, P., Heikenwalder, M. & 9 others, Ruland, J., Mak, T. W., Brenner, D., Pandyra, A. A., Hoell, J. I., Borkhardt, A., Häussinger, D., Lang, K. S. & Lang, P. A., Feb 2018, In : Journal of Virology. 92, 3, p. 1-18 18 p., e01637-17.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
167 Downloads (Pure)

Tumor Risks and Genotype-Phenotype-Proteotype Analysis in 358 Patients With Germline Mutations in SDHB and SDHD

Ricketts, C. J., Forman, J. R., Rattenberry, E., Bradshaw, N., Lalloo, F., Izatt, L., Cole, T. R., Armstrong, R., Kumar, V. K. A., Morrison, P. J., Atkinson, A. B., Douglas, F., Ball, S. G., Cook, J., Srirangalingam, U., Killick, P., Kirby, G., Aylwin, S., Woodward, E. R., Evans, D. G. R. & 7 others, Hodgson, S. V., Murday, V., Chew, S. L., Connell, J. M., Blunde, T. L., MacDonald, F. & Maher, E. R., Jan 2010, In : Human Mutation. 31, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

248 Citations (Scopus)

Tumor segmentation from magnetic resonance imaging by learning via one-class support vector machine

Zhang, J., Ma, K-K., Er, M. H. & Chong, V., 2004, Proceedings from 7th International Workshop on Advanced Image Technology (IWAIT04). NUS School of Computing [and] NTU School of Computer Engineering, p. 207-211 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene

Dudgeon, C., Kek, C., Demidov, O. N., Saito, S., Fernandes, K., Diot, A., Bourdon, J-C., Lane, D. P., Appella, E., Fornace, A. J. & Bulavin, D. V., 15 Mar 2006, In : Cancer Research. 66, 6, p. 2928-2936 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Tumor transcriptome reveals the predictive and prognostic impact of lysosomal protease inhibitors in non-small-cell lung cancer

Petty, R. D., Kerr, K. M., Murray, G. I., Nicolson, M. C., Rooney, P. H., Bissett, D. & Collie-Duguid, E. S. R., 5 Apr 2006, In : Journal of Clinical Oncology. 24, 11, p. 1729-1744 16 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Tumour angiogenesis

Schor, A. M. & Schor, S. L., Nov 1983, In : Journal of Pathology. 141, 3, p. 385-413 29 p.

Research output: Contribution to journalReview article

147 Citations (Scopus)

Tumour-associated macrophages and oncolytic virotherapies: a mathematical investigation into a complex dynamics

Eftimie, R. & Eftimie, G., 6 Feb 2018, In : Letters in Biomathematics. 5, sup1, p. S6-S35

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
151 Downloads (Pure)

Tumour bed clip localisation for targeted breast radiotherapy: Compliance is proportional to trial-related research activity: Tumour bed clip localisation in breast radiotherapy

Kirwan, C. C., Al Sarakbi, W., Loncaster, J., Chan, H. Y., Thompson, A. M. & Wishart, G. C., Feb 2014, In : European Journal of Surgical Oncology. 40, 2, p. 158-162

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tumour biomarkers: association with heart failure outcomes

Shi, C., van der Wal, H. H., Silljé, H. H. W., Dokter, M. M., van den Berg, F., Huizinga, L., Vriesema, M., Post, J., Anker, S. D., Cleland, J. G., Ng, L. L., Samani, N. J., Dickstein, K., Zannad, F., Lang, C. C., van Haelst, P. L., Gietema, J. A., Metra, M., Ameri, P., Canepa, M. & 3 others, van Veldhuisen, D. J., Voors, A. A. & de Boer, R. A., 5 May 2020, In : Journal of Internal Medicine. 12 p.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)
Open Access
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32 Citations (Scopus)
210 Downloads (Pure)

Tumour cell membrane poration and ablation by pulsed low-intensity electric field with carbon nanotubes

Wang, L., Liu, D., Zhou, R., Wang, Z. & Cuschieri, A., Apr 2015, In : International Journal of Molecular Sciences. 16, 4, p. 6890-6901 12 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
163 Downloads (Pure)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., Mckiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, K., Nanthakumaran, S., Grabsch, H. I., Tan, P., Welch, A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M. & Petty, R. D., 18 Mar 2014, In : British Journal of Cancer. 110, 6, p. 1525-1534 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., Mckiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, J. K., Nanthakumaran, S., Grabsch, H. I., Tan, S. P., Welch, L. A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M., Matula, K. M. & 1 others, Petty, R. D., 2015, In : British Journal of Cancer. 113, 11, p. 1641 1 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., Mckiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, J. K., Nanthakumaran, S., Matula, K. M., Grabsch, H. I., Tan, S. P., Welch, L. A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M. & 1 others, Petty, R. D., 14 Jun 2016, In : British Journal of Cancer. 114, 12, p. e18 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Tumour microenvironment is implicated by dermal fibroblast expression profiling in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. & South, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S83-S83 1 p.

Research output: Contribution to journalBook/Film/Article review

Tumour necrosis factor a decreases glucose-6-phosphatase gene expression by activation of nuclear factor kB

Grempler, R., Kienitz, A., Werner, T., Meyer, M., Barthel, A., Ailett, F., Sutherland, C., Walther, R. & Schmoll, D., 2004, In : Biochemical Journal. 382, p. 471-479 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD

Andrews, K. A., Ascher, D. B., Pires, D. E. V., Barnes, D. R., Vialard, L., Casey, R. T., Bradshaw, N., Adlard, J., Aylwin, S., Brennan, P., Brewer, C., Cole, T., Cook, J. A., Davidson, R., Donaldson, A., Fryer, A., Greenhalgh, L., Hodgson, S. V., Irving, R., Lalloo, F. & 17 others, McConachie, M., McConnell, V. P. M., Morrison, P. J., Murday, V., Park, S-M., Simpson, H. L., Snape, K., Stewart, S., Tomkins, S. E., Wallis, Y., Izatt, L., Goudie, D., Lindsay, R. S., Perry, C. G., Woodward, E. R., Antoniou, A. C. & Maher, E. R., Jun 2018, In : Journal of Medical Genetics. 55, p. 384-394 11 p.

Research output: Contribution to journalArticle

Open Access
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44 Citations (Scopus)
162 Downloads (Pure)