Find Research Outputs

2019
1 Citation (Scopus)
68 Downloads (Pure)

An Owner-Independent Investigation of Diabetes Alert Dog Performance

Wilson, C., Morant, S., Kane, S., Pesterfield, C., Guest, C. & Rooney, N. J., 27 Mar 2019, In : Frontiers in Veterinary Science. 6, p. 1-11 11 p., 91.

Research output: Contribution to journalArticle

Open Access
File
Dogs
Hypoglycemic Agents
Television
Glucose
Critical Care
47 Downloads (Pure)

Antidepressant treatment with sertraline for adults with depressive symptoms in primary care: the PANDA research programme including RCT

Duffy, L., Lewis, G., Ades, A., Araya, R., Bone, J., Brabyn, S., Button, K., Churchill, R., Croudace, T., Derrick, C., Dixon, P., Dowrick, C., Fawsitt, C., Fusco, L., Gilbody, S., Harmer, C., Hobbs, C., Hollingworth, W., Jones, V., Kendrick, T. & 18 others, Kessler, D., Khan, N., Kounali, D., Lanham, P., Malpass, A., Munafo, M., Pervin, J., Peters, T., Riozzie, D., Robinson, J., Salaminios, G., Sharp, D., Thom, H., Thomas, L., Welton, N., Wiles, N., Woodhouse, R. & Lewis, G., Dec 2019, In : Programme Grants for Applied Research. 7, 10, 138 p.

Research output: Contribution to journalArticle

Open Access
File
Sertraline
Antidepressive Agents
Primary Health Care
Depression
Research
10 Citations (Scopus)
78 Downloads (Pure)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
Antigen Receptors
T-cells
Metabolism
Methionine
T-Lymphocytes
2 Citations (Scopus)
123 Downloads (Pure)

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis

Sibila, O., Perea, L., Cantó, E., Shoemark, A., Cassidy, D., Smith, A. H., Suarez-cuartin, G., Rodrigo-troyano, A., Keir, H. R., Oriano, M., Ong, S., Vidal, S., Blasi, F., Aliberti, S. & Chalmers, J. D., Sep 2019, In : Thorax. 74, 9, p. 835-842 8 p.

Research output: Contribution to journalArticle

Open Access
File
Secretory Leukocyte Peptidase Inhibitor
Bronchiectasis
Disease Progression
Peptides
Sputum
2 Citations (Scopus)

Anti-microbial Resistance In Atopic Dermatitis: Need for an Urgent Rethink

Harkins, C. P., Holden, M. T. G. & Irvine, A. D., 1 Mar 2019, In : Annals of Allergy, Asthma & Immunology. 122, 3, p. 236-240 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
97 Downloads (Pure)

A numerical model based on ALE formulation to predict crack propagation in sandwich structures

Funari, M. F., Greco, F., Lonetti, P. & Spadea, S., Jan 2019, In : Frattura ed Integrita Strutturale. 13, 47, p. 277-293 17 p.

Research output: Contribution to journalArticle

Open Access
File
Sandwich structures
Numerical models
Crack propagation
Debonding
Skin

A nurse-led FibroScan ® outreach clinic encourages socially deprived heavy drinkers to engage with liver services

Matthews, K., MacGilchrist, A., Coulter-Smith, M., Jones, J. & Cetnarskyj, R., Feb 2019, In : Journal of Clinical Nursing. 28, 3-4, p. 650-662 13 p.

Research output: Contribution to journalArticle

Nurses
Liver Diseases
Liver
Nurses' Practice Patterns
Referral and Consultation

Anxiety and fear management in paediatric dentistry using distraction techniques

Robertson, M., Araujo, M. & Innes, N., 28 Jun 2019, In : Evidence-Based Dentistry. 20, 2, p. 50-51 2 p.

Research output: Contribution to journalReview article

Pediatric Dentistry
Fear
Dental Anxiety
Tooth
Anxiety
27 Downloads (Pure)

A Participant-Centred Model for Citizen Observatories at Scale

Woods, M., Hemment, D. & Ajates Gonzalez, R., 7 Apr 2019, Geophysical Research Abstracts. European Geosciences Union, Vol. 21. 1 p. EGU2019-18970

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
observatory
soil moisture
citizen
environmental monitoring
innovation
66 Downloads (Pure)

A patient-centred intervention to improve the management of multimorbidity in general practice: the 3D RCT

Salisbury, C., Man, M-S., Chaplin, K., Mann, C., Bower, P., Brookes, S., Duncan, P., Fitzpatrick, B., Gardner, C., Gaunt, D. M., Guthrie, B., Hollinghurst, S., Kadir, B., Lee, V., McLeod, J., Mercer, S. W., Moffat, K. R., Moody, E., Rafi, I., Robinson, R. & 2 others, Shaw, A. & Thorn, J., Feb 2019, In : Health Services and Delivery Research. 7, 5, 276 p.

Research output: Contribution to journalArticle

Open Access
File
General Practice
Comorbidity
Patient-Centered Care
Quality of Life
Cost of Illness
1 Citation (Scopus)
53 Downloads (Pure)

APETALA2 control of barley internode elongation

Patil, V., McDermott, H. I., Mcallister, T., Cummins, M., Clara Silva, J., Mollison, E., Meikle, R., Morris, J. A., Hedley, P. E., Waugh, R., Dockter, C., Hansson, M. & McKim, S., 12 Jun 2019, In : Development. 146, 11, p. 1-16 16 p., 170373.

Research output: Contribution to journalArticle

Open Access
File
Gibberellins
Hordeum
Inflorescence
Growth
MicroRNAs
21 Downloads (Pure)

A platform for target prediction of phenotypic screening hit molecules

Homeyer, N., van Deursen, R., Ochoa-Montaño, B., Heikamp, K., Ray, P., Zuccotto, F., Blundell, T. L. & Gilbert, I. H., 24 Oct 2019, In : Journal of Molecular Graphics & Modelling. 95, p. 1-9 9 p., 107485.

Research output: Contribution to journalArticle

Open Access
File
Screening
screening
platforms
Ligands
Proteins
2 Citations (Scopus)

A point of care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

Shoemark, A., Cant, E., Carreto, L., Smith, A., Oriano, M., Keir, H. R., Perea, L., Canto, E., Terranova, L., Vidal, S., Moffitt, K., Aliberti, S., Sibila, O. & Chalmers, J. D., 1 Jun 2019, In : European Respiratory Journal. 53, 6, 1900303.

Research output: Contribution to journalArticle

Point-of-Care Systems
Leukocyte Elastase
Bronchiectasis
Sputum
Infection

Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity

Phenwan, T., Sattayakhom, A., Palipoch, S., Punsawad, C., Na-Ek, P., Poonsawat, W., Kumanee, N. & Koomhin, P., 27 Mar 2019.

Research output: Contribution to conferencePoster

Apolipoproteins E
Dementia
Alzheimer Disease
Population
Genes
25 Downloads (Pure)

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 26 Jul 2019, In : Nucleic Acids Research. 47, 13, p. 7063-7077 15 p.

Research output: Contribution to journalArticle

Open Access
File
Regulon
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma brucei brucei
RNA-Binding Proteins
25 Downloads (Pure)
Open Access
File
Opiate Substitution Treatment
Hepatitis C
Primary Health Care
Motivation
Patient Acceptance of Health Care
77 Downloads (Pure)

Application of a Sensitive and Reproducible Label-Free Proteomic Approach to Explore the Proteome of Individual Meiotic-Phase Barley Anthers

Lewandowska, D., Zhang, R., Colas, I., Uzrek, N. & Waugh, R., 2 Apr 2019, In : Frontiers in Plant Science. 10, p. 1-15 15 p., 393.

Research output: Contribution to journalArticle

Open Access
File
proteome
proteomics
anthers
meiosis
barley
1 Citation (Scopus)
88 Downloads (Pure)

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

Research output: Contribution to journalArticle

Open Access
File
ellipticine
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Oxidoreductases
14 Citations (Scopus)

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., Anand, A., Boeddinghaus, J., Nestelberger, T., Badertscher, P., Mokhtari, A., Pickering, J. W., Troughton, R. W., Greenslade, J., Parsonage, W., Mueller-Hennessen, M., Gori, T., Jernberg, T., Morris, N., Liebetrau, C. & 34 others, Hamm, C., Katus, H. A., Münzel, T., Landmesser, U., Salomaa, V., Iacoviello, L., Ferrario, M. M., Giampaoli, S., Kee, F., Thorand, B., Peters, A., Borchini, R., Jørgensen, T., Söderberg, S., Sans, S., Tunstall-Pedoe, H., Kuulasmaa, K., Renné, T., Lackner, K. J., Worster, A., Body, R., Ekelund, U., Kavsak, P. A., Keller, T., Lindahl, B., Wild, P., Giannitsis, E., Than, M., Cullen, L. A., Mills, N. L., Mueller, C., Zeller, T., Westermann, D. & Blankenberg, S., 27 Jun 2019, In : New England Journal of Medicine. 380, 26, p. 2529-2540 12 p.

Research output: Contribution to journalArticle

Troponin
Myocardial Infarction
Troponin I
Hospital Emergency Service
Troponin T
3 Citations (Scopus)
14 Downloads (Pure)

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

Brunner, F. J., Waldeyer, C., Ojeda, F., Salomaa, V., Kee, F., Sans, S., Thorand, B., Giampaoli, S., Brambilla, P., Tunstall-Pedoe, H., Moitry, M., Iacoviello, L., Veronesi, G., Grassi, G., Mathiesen, E. B., Söderberg, S., Linneberg, A., Brenner, H., Amouyel, P., Ferrières, J. & 20 others, Tamosiunas, A., Nikitin, Y. P., Drygas, W., Melander, O., Jöckel, K-H., Leistner, D. M., Shaw, J. E., Panagiotakos, D. B., Simons, L. A., Kavousi, M., Vasan, R. S., Dullaart, R. P. F., Wannamethee, S. G., Risérus, U., Shea, S., de Lemos, J. A., Omland, T., Kuulasmaa, K., Landmesser, U. & Blankenberg, S., 14 Dec 2019, In : Lancet. 394, 10215, p. 2173-2183 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cardiovascular Diseases
Cholesterol
Population
Risk Reduction Behavior
Lipids
20 Downloads (Pure)

Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine

Cowan, K., MacLuskie, G., Finch, M., Palmer, C. N. A., Hair, J., Bylesjo, M., Lynagh, S., Brankin, P., McNeil, M., Low, C., Mallinson, D., Gourlay, E. M., Child, H., Cheyne, L. & Bunton, D. C., 20 Dec 2019, In : PLoS ONE. 14, 12, p. 1-15 15 p., e0226564.

Research output: Contribution to journalArticle

Open Access
File
pharmacogenomics
Precision Medicine
Pharmacogenetics
Bioinformatics
Computational Biology

Application of Three-dimensional IGN-2 Equations to Wave Diffraction Problems

Zhao, B., Zhang, T., Duan, W., Ertekin, R. C. & Hayatdavoodi, M., 16 Dec 2019, In : Journal of Ocean Engineering and Marine Energy. 13 p.

Research output: Contribution to journalArticle

wave diffraction
Diffraction
nonlinear wave
diffraction
prediction
21 Downloads (Pure)
Open Access
File
Observational Studies
Hemoglobins
Colonoscopy
Feces
Colorectal Neoplasms
1 Citation (Scopus)
88 Downloads (Pure)

Approaches to communication assessment with children and adults with profound intellectual and multiple disabilities

Chadwick, D., Buell, S. & Goldbart, J., 1 Mar 2019, In : Journal of Applied Research in Intellectual Disabilities. 32, 2, p. 336-358 23 p.

Research output: Contribution to journalArticle

Open Access
File
multiple disabilities
Intellectual Disability
Communication
communication
Evidence-Based Practice
1 Citation (Scopus)

Appropriate referring

Wight, A. J., Jun 2019, In : British Dental Journal. 226, 12, p. 911

Research output: Contribution to journalLetter

A Practical Guide to Barley Crossing

Thomas, W. T. B., Bull, H., Booth, A., Hamilton, R., Forster, B. P. & Franckowiak, J. D., 1 Jan 2019, Barley: Methods and Protocols. Harwood, W. A. (ed.). New York: Humana Press, Vol. 1900. p. 21-36 16 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Hordeum
Inbreeding
Pollen
Seeds
144 Downloads (Pure)
Open Access
File
Orthopedics
Fasting
Cohort Studies
Prospective Studies
Wounds and Injuries

A prospective observational study of the utility of early diagnostic laparoscopy for right lower abdominal pain: a safe and effective diagnostic and therapeutic tool

Guthrie, G. J. K., Johnston, T., Ewing, A., Mullen, R., Suttie, S. A. & Patil, P. V., 1 May 2019, In : Scottish Medical Journal. 64, 2, p. 49-55 7 p.

Research output: Contribution to journalArticle

Laparoscopy
Abdominal Pain
Observational Studies
Prospective Studies
Appendicitis

A prospective questionnaire-based study on staff awareness of intimate partner violence (IPV) in orthopaedic trauma patients

Downie, S., Madden, K., Bhandari, M. & Jariwala, A., Aug 2019, In : Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 17, 4, p. 207-214 8 p.

Research output: Contribution to journalArticle

Orthopedics
Wounds and Injuries
Disclosure
Orthopedic Nursing
Intimate Partner Violence
39 Downloads (Pure)
Open Access
File
Othering
Emotion work
European Union
Exclusion
Solidarity
1 Citation (Scopus)
55 Downloads (Pure)

A qualitative exploration of memory cuing by personal items in the home

Zijlema, A., van den Hoven, E. & Eggen, B., Aug 2019, In : Memory Studies. 12, 4, p. 377-397 21 p.

Research output: Contribution to journalArticle

Open Access
File
Holidays
holidays
event
holiday

A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The 'VaSera' trial testing dietary nitrate and spironolactone

Mills, C. E., Govoni, V., Faconti, L., Casagrande, M-L., Morant, S. V., Crickmore, H., Iqbal, F., Maskell, P., Masani, A., Nanino, E., Webb, A. J. & Cruickshank, J. K., 13 Dec 2019, In : British Journal of Clinical Pharmacology. 35 p.

Research output: Contribution to journalArticle

Spironolactone
Vascular Stiffness
Doxazosin
Nitrates
Blood Pressure
3 Citations (Scopus)
41 Downloads (Pure)

A randomized clinical trial of the effectiveness of 0.018-inch and 0.022-inch slot orthodontic bracket systems: part 3 - biological side-effects of treatment

El-Angbawi, A. M., Yassir, Y. A., McIntyre, G. T., Revie, G. F. & Bearn, D. R., Apr 2019, In : European Journal of Orthodontics. 41, 2, p. 154-164 11 p., cjy039.

Research output: Contribution to journalArticle

Open Access
File
Orthodontic Brackets
Pain Perception
Randomized Controlled Trials
Therapeutics
Oral Hygiene
6 Citations (Scopus)
33 Downloads (Pure)

A randomized clinical trial of the effectiveness of 0.018-inch and 0.022-inch slot orthodontic bracket systems: part 2 - quality of treatment

Yassir, Y. A., El-Angbawi, A. M., McIntyre, G. T., Revie, G. & Bearn, D. R., Apr 2019, In : European Journal of Orthodontics. 41, 2, p. 143-153 11 p., cyj038.

Research output: Contribution to journalArticle

Open Access
File
Orthodontic Brackets
Incisor
Randomized Controlled Trials
Esthetics
Index of Orthodontic Treatment Need
4 Citations (Scopus)
48 Downloads (Pure)

A randomized clinical trial of the effectiveness of 0.018-inch and 0.022-inch slot orthodontic bracket systems: part 1 - duration of treatment

Yassir, Y. A., El-Angbawi, A. M., McIntyre, G. T., Revie, G. F. & Bearn, D. R., Apr 2019, In : European Journal of Orthodontics. 41, 2, p. 133-142 10 p., cjy037.

Research output: Contribution to journalArticle

Open Access
File
Orthodontic Brackets
Randomized Controlled Trials
Appointments and Schedules
Therapeutics
Angle Class II Malocclusion
9 Citations (Scopus)
58 Downloads (Pure)

A Randomized Controlled Trial of Metformin on Left Ventricular Hypertrophy in Patients with Coronary Artery Disease without Diabetes: The MET-REMODEL Trial

Mohan, M., Al-Talabany, S., McKinnie, A., Mordi, I., Singh, J., Gandy, S., Baig, F., Hussain, M. S. ., Bhalraam, U., Khan, F., Choy, A., Matthew, S., Houston, G., Struthers, A., George, J. & Lang, C. C., 1 Nov 2019, In : European Heart Journal. 40, 41, p. 3409-3417 9 p.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Left Ventricular Hypertrophy
Coronary Artery Disease
Randomized Controlled Trials
Insulin Resistance
15 Citations (Scopus)
52 Downloads (Pure)

A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects

Tyagi, H., Apergis-Schoute, A. M., Akram, H., Foltynie, T., Limousin, P., Drummond, L. M., Fineberg, N. A., Matthews, K., Jahanshahi, M., Robbins, T. W., Sahakian, B. J., Zrinzo, L., Hariz, M. & Joyce, E. M., 1 May 2019, In : Biological Psychiatry. 85, 9, p. 726-734 9 p.

Research output: Contribution to journalArticle

Open Access
File
Anterior Thalamic Nuclei
Subthalamic Nucleus
Deep Brain Stimulation
Obsessive-Compulsive Disorder
Capsules
2 Citations (Scopus)

A rapid technique for the direct metallization of PDMS substrates for flexible and stretchable electronics applications

Ryspayeva, A., Jones, T. D. A., Esfahani, M. N., Shuttleworth, M. P., Harris, R. A., Kay, R. W., Desmulliez, M. P. Y. & Marques-Hueso, J., 15 Mar 2019, In : Microelectronic Engineering. 209, p. 35-40 6 p.

Research output: Contribution to journalArticle

copper
electronics
adhesion
metals
photolithography

Architectural identity and community formation: the case study of modernist Claremont Court housing scheme.

Costa Santos, S., Nov 2019, AHRA 2019: Architecture & Collective Life.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

housing
community
resident
narrative
grant

Archived in the landscape? Community, family and partnership: promoting heritage and community priorities through the Argyll estate papers

Tindley, A., Gibbard, M. & Diamond, A., 2019, In : Archives and Records. 40, 1, p. 5-20 16 p.

Research output: Contribution to journalArticle

Estate
Heritage
Economics
Rural Areas
Local Communities
34 Downloads (Pure)
Open Access
File
Dementia
Emergencies
Mortality
Memantine
Cholinesterase Inhibitors
89 Downloads (Pure)

Area under the curve analysis of blood pressure reveals increased spontaneous locomotor activity in SPAK knock-in mice: relevance for hypotension induced by SPAK inhibition?

Burgess, K., Jovanović, S., Sudhir, R. & Jovanović, A., 3 Feb 2019, In : Physiological Reports. 7, 3, p. 1-12 12 p., e13997.

Research output: Contribution to journalArticle

Open Access
File
Controlled Hypotension
Locomotion
Area Under Curve
Blood Pressure
PAS domain kinases
36 Downloads (Pure)

Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?

Savaridas, S. L., Sim, Y. T., Vinnicombe, S. J., Purdie, C. A., Thompson, A. M. & Evans, A., 21 Oct 2019, In : Cancer Imaging. 19, 1, p. 1-7 7 p., 67.

Research output: Contribution to journalArticle

Open Access
File
Breast Neoplasms
Drug Therapy
Calcinosis
Neoplasms
Biopsy
12 Downloads (Pure)

Are there differences between those doctors who apply for a training post in Foundation Year 2 and those who take time out of the training pathway? A UK multicohort study

Cleland, J. A., Prescott, G., Walker, K. A., Kumwenda, B. & Johnston, P. W., 24 Nov 2019, In : BMJ Open. 9, 11, 12 p.

Research output: Contribution to journalArticle

Open Access
File
Medical Schools
Information Storage and Retrieval
Internship and Residency
Medical Education
Medical Students
Periapical Tissue
Primary Health Care
Hospitalization
Periapical Abscess
Tooth

A retrospective documentary analysis of forensic dental cases over the past 30 years in Scotland

Rajan, E. K., Manica, S. & Revie, G., 2019, In : Dental Historian. 64, 2, p. 67-71 5 p.

Research output: Contribution to journalArticle

dentist
methodology
science
literature
time
23 Downloads (Pure)

A Retrospective Observational Study to Determine Baseline Characteristics and Early Prescribing Patterns for Patients Receiving Alirocumab in UK Clinical Practice

Reynolds, T., Carey, P., George, J., Konidaris, G., Narayanan, D., Ramachandran, S., Saunders, L., Viljoen, A. & Ferns, G., Dec 2019, In : Drugs - real world outcomes. 6, 4, p. 205-213 9 p.

Research output: Contribution to journalArticle

Open Access
File
Observational Studies
Retrospective Studies
LDL Cholesterol
Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
79 Downloads (Pure)

A review of online platforms in training and surgical education

El Boghdady, M., Ewalds-Kvist, B. M. & Alijani, A., 1 Apr 2019, In : European Surgery. 51, 2, p. 41-48 8 p.

Research output: Contribution to journalReview article

Open Access
File
Education
Learning
Teaching
Technology
Professional Education

A Review of the Role of Facilitators in Community-Based, Design-Led Planning and Placemaking Events

Al Waer, H. & Cooper, I., 2019, In : Built Environment. 45, 2, p. 190-211 22 p.

Research output: Contribution to journalArticle

planning
event
community
planning process
critic
1 Citation (Scopus)
92 Downloads (Pure)

Argumentation in the 2016 US Presidential Elections: Annotated corpora of television debates and social media reaction

Visser, J., Konat, B., Duthie, R., Koszowy, M., Budzynska, K. & Reed, C., 9 Feb 2019, In : Language Resources and Evaluation. 32 p.

Research output: Contribution to journalArticle

Open Access
File
presidential election
argumentation
social media
television
discourse analysis