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2006

Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors

Zhang, J., Raper, A., Sugita, N., Hingorani, R., Salio, M., Palmowski, M. J., Cerundolo, V. & Crocker, P. R., May 2006, In : Blood. 107, 9, p. 3600-3608 9 p.

Research output: Contribution to journalArticle

162 Citations (Scopus)
2002

Chromatin motion is constrained by association with nuclear compartments in human cells

Chubb, J. R., Boyle, S., Perry, P. & Bickmore, W. A., 2002, In : Current Biology. 12, 6, p. 439-445 7 p.

Research output: Contribution to journalArticle

417 Citations (Scopus)
2007

Classification and functional annotation of eukaryotic protein kinases

Miranda-Saavedra, D. & Barton, G. J., 2007, In : Proteins: Structure, Function, and Bioinformatics. 68, 4, p. 893-914 22 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)
2006

Global mapping of pharmacological space

Paolini, G. V., Shapland, R. H. B., Hoorn, W. P. V., Mason, J. S. & Hopkins, A. L., 2006, In : Nature Biotechnology. 24, 7, p. 805-815 11 p.

Research output: Contribution to journalArticle

614 Citations (Scopus)
2005

Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms

Kennedy, G., Spence, V. A., McLaren, M., Hill, A., Underwood, C. & Belch, J. J. F., Sep 2005, In : Free Radical Biology and Medicine. 39, 5, p. 584-589 6 p.

Research output: Contribution to journalArticle

217 Citations (Scopus)

p53 isoforms can regulate p53 transcriptional activity

Bourdon, J. C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K. & Lane, D. P., 15 Sep 2005, In : Genes & Development. 19, 18, p. 2122-2137 16 p.

Research output: Contribution to journalArticle

559 Citations (Scopus)
2002

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Multiple Leiomyoma Consortium, Tomlinson, I. P. M., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E. M., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A. & 12 others, Vilkki, S., Laiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V. & Aaltonen, L. A., 2002, In : Nature Genetics. 30, 4, p. 406-410 5 p.

Research output: Contribution to journalArticle

1002 Citations (Scopus)
2006

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

Pearson, E. R., Flechtner, I., Njolstad, P. R., Malecki, M. T., Flanagan, S. E., Larkin, B., Ashcroft, F. M., Klimes, I., Codner, E., Iotova, V., Slingerland, A. S., Shield, J., Robert, J-J., Holst, J. J., Clark, P. M., Ellard, S., Sovik, O., Polak, M. & Hattersley, A. T., 3 Aug 2006, In : New England Journal of Medicine. 355, 5, p. 467-477 11 p.

Research output: Contribution to journalArticle

668 Citations (Scopus)
2004

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

Gloyn, A. L., Pearson, E. R., Antcliff, J. F., Proks, P., Bruining, J., Slingerland, A. S., Howard, N., Srinivasan, S., Silva, J. M. C. L., Molnes, J., Edghill, E. L., Frayling, T. M., Temple, I. K., Mackay, D., Shield, J. P. H., Sumnik, Z., van Rhijn, A., Wales, J. K. H., Clark, P., Gorman, S. & 5 others, Aisenberg, J., Ellard, S., Njolstad, P. R., Ashcroft, F. M. & Hattersley, A. T., 2004, In : New England Journal of Medicine. 350, 18, p. 1838-1849 12 p.

Research output: Contribution to journalArticle

858 Citations (Scopus)

General practitioners' knowledge, confidence and attitudes in the diagnosis and management of dementia

Turner, S., Iliffe, S., Downs, M., Wilcock, J., Bryans, M., Levin, E., Keady, J. & O'Carroll, R., 2004, In : Age and Ageing. 33, 5, p. 461-467 7 p.

Research output: Contribution to journalArticle

238 Citations (Scopus)
2003

Evaluating computerised health information systems: hard lessons still to be learnt

Littlejohns, P., Wyatt, J. C. & Garvican, L., Apr 2003, In : BMJ. 326, 7394, p. 860-863 4 p.

Research output: Contribution to journalArticle

235 Citations (Scopus)
2009

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, M. H. & Hiom, K., 21 May 2009, In : Nature. 459, 7245, p. 460-U184 5 p.

Research output: Contribution to journalArticle

319 Citations (Scopus)
2008

Elevated levels of oncogenic protein kinase pim-1 induce the p53 pathway in cultured cells and correlate with increased mdm2 in mantle cell lymphoma

Hogan, C., Hutchison, C., Marcar, L., Milne, D., Saville, M., Goodlad, J., Kernohan, N. & Meek, D., 27 Jun 2008, In : Journal of Biological Chemistry. 283, 26, p. 18012-18023 12 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

Dinkova-Kostova, A. T. & Talalay, P., Jun 2008, In : Molecular Nutrition & Food Research. 52, p. S128-S138 11 p.

Research output: Contribution to journalReview article

396 Citations (Scopus)
2001

Checklists for improving rigour in qualitative research: a case of the tail wagging the dog?

Barbour, R. S., May 2001, In : BMJ. 322, 7294, p. 1115-1117 3 p.

Research output: Contribution to journalArticle

1340 Citations (Scopus)
2011

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T., 6 Jul 2011, In : EMBO Journal. 30, 13, p. 2596-2609 14 p.

Research output: Contribution to journalArticle

Open Access
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74 Citations (Scopus)
129 Downloads (Pure)

AMPK and autophagy get connected

Hardie, D. G., 16 Feb 2011, In : EMBO Journal. 30, 4, p. 634-635 2 p.

Research output: Contribution to journalEditorial

104 Citations (Scopus)
2008

Wide variation in surgical outcomes for acromegaly in the UK

Bates, P. R., Carson, M. N., Trainer, P. J., Wass, J. A. H., Bevan, J. S., Atkinson, A. B., Peacey, S. R., Stewart, P. M., Sheppard, M. C., Dayan, C. M., Chatterjee, K., Scanlon, M. F., Leese, G. P., Walker, B. R., Patrick, A. W., Vaidya, B., Connell, J. M. C., Allan, B., Atkin, S. L., Orme, S. & 61 others, Howlett, T. A., Vora, J. P., Jenkins, P. J., Aylwin, S., Bouloux, P., Davis, J. R. E., Shalet, S., James, R. A., Howell, S. J., Vice, P. A., Newell-Price, J., Ross, R. J. M., Clayton, R. N., Jennings, P., Booth, A., Alexander, A., Holden, N., Jablonski, L., Wright, D., Hunt, M., Taheri, J., Holmes, C., Woods, E., Brown, T., Roberts, S., Carson, M., Goss, L., Revesz, S., Campbell, K., Grant, D., Smith, C., Cleary, S., Spink, C., Howlett, T., Chapman, M., Corlett, P., Morton, B., Whittingham, P., Conrich, L., Gaygon, C., Owusu-Antwi, S., Stobie, E., Walker-Scott, E., Gilbert, J., Drowley, T., Gibson, C., Roberts, M., Gebbie, J., Henderson, P., Johnstone, K., Murphy, A., Cowshill, C., Fazal-Sanderson, V., Smith, R., Parkington, S., Doane, A., Ibbotson, V., Lynch, R., Brown, M., Barry, E. & Brown, N., 2008, In : Clinical Endocrinology. 68, 1, p. 136-142 7 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2011

Blood Pressure Loci Identified with a Gene-Centric Array

Johnson, T., Gaunt, T. R., Newhouse, S. J., Padmanabhan, S., Tomaszewski, M., Kumari, M., Morris, R. W., Tzoulaki, I., O'Brien, E. T., Poulter, N. R., Sever, P., Shields, D. C., Thom, S., Wannamethee, S. G., Whincup, P. H., Brown, M. J., Connell, J. M., Dobson, R. J., Howard, P. J., Mein, C. A. & 31 others, Onipinla, A., Shaw-Hawkins, S., Zhang, Y., Smith, G. D., Day, I. N. M., Lawlor, D. A., Goodall, A. H., Fowkes, F. G., Abecasis, G. R., Elliott, P., Gateva, V., Braund, P. S., Burton, P. R., Nelson, C. P., Tobin, M. D., van der Harst, P., Glorioso, N., Neuvrith, H., Salvi, E., Staessen, J. A., Stucchi, A., Devos, N., Jeunemaitre, X., Plouin, P-F., Tichet, J., Juhanson, P., Org, E., Putku, M., Sober, S., Veldre, G. & Global BPgen Consortium, Cardiogenics Consortium, 9 Dec 2011, In : American Journal of Human Genetics. 89, 6, p. 688-700 13 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)
2010

The Spen Family Protein FPA Controls Alternative Cleavage and Polyadenylation of RNA

Hornyik, C., Terzi, L. C. & Simpson, G. G., 16 Feb 2010, In : Developmental Cell. 18, 2, p. 203-213 11 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)
2011

Kinetochore-Dependent Microtubule Rescue Ensures Their Efficient and Sustained Interactions in Early Mitosis

Gandhi, S. R., Gierlinski, M., Mino, A., Tanaka, K., Kitamura, E., Clayton, L. & Tanaka, T. U., 15 Nov 2011, In : Developmental Cell. 21, 5, p. 920-933 14 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2008
135 Citations (Scopus)
2007

Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae

Kitamura, E., Tanaka, K., Kitamura, Y. & Tanaka, T. U., 15 Dec 2007, In : Genes & Development. 21, 24, p. 3319-3330 12 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
2010

Involvement of hydrogenases in the formation of highly catalytic Pd(0) nanoparticles by bioreduction of Pd(II) using Escherichia coli mutant strains

Deplanche, K., Caldelari, I., Mikheenko, I. P., Sargent, F. & Macaskie, L. E., Sep 2010, In : Microbiology. 156, 9, p. 2630-2640 11 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Health Status of Adults with Congenital Adrenal Hyperplasia: A Cohort Study of 203 Patients

Arlt, W., Willis, D. S., Wild, S. H., Krone, N., Doherty, E. J., Hahner, S., Han, T. S., Carroll, P. V., Conway, G. S., Rees, D. A., Stimson, R. H., Walker, B. R., Connell, J. M. C., Ross, R. J. & United Kingdom Congenital Adrenal, Nov 2010, In : Journal of Clinical Endocrinology & Metabolism. 95, 11, p. 5110-5121 12 p.

Research output: Contribution to journalArticle

232 Citations (Scopus)
2008

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K. & Hundal, H. S., 10 Oct 2008, In : Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)
2009

A method for genetically installing site-specific acetylation in recombinant histories defines the effects of H3 K56 acetylation

Neumann, H., Hancock, S. M., Buning, R., Routh, A., Chapman, L., Somers, J., Owen-Hughes, T., van Noort, J., Rhodes, D. & Chin, J. W., 9 Oct 2009, In : Molecular Cell. 36, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

308 Citations (Scopus)
2007

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress

Ge, X. Q., Jackson, D. A. & Blow, J. J., 15 Dec 2007, In : Genes & Development. 21, 24, p. 3331-3341 11 p.

Research output: Contribution to journalArticle

342 Citations (Scopus)

Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells

Johnson, C. E., Crawford, B. E., Stavridis, M., Ten Dam, G., Wat, A. L., Rushton, G., Ward, C. M., Wilson, V., van Kuppevelt, T. H., Esko, J. D., Smith, A., Gallagher, J. T. & Merry, C. L. R., Aug 2007, In : Stem Cells. 25, 8, p. 1913-23 11 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)
2005

Glutathione transferases

Hayes, J. D., Flanagan, J. U. & Jowsey, I. R., 2005, In : Annual Review of Pharmacology and Toxicology. 45, p. 51-88 38 p.

Research output: Contribution to journalArticle

2463 Citations (Scopus)
2003

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

Ying, Q-L., Stavridis, M., Griffiths, D., Li, M. & Smith, A., 2003, In : Nature Biotechnology. 21, 2, p. 183-6 4 p.

Research output: Contribution to journalArticle

1048 Citations (Scopus)
2013

The role of healthcare support workers in providing palliative and end-of-life care in the community: a systematic literature review

Herber, O. R. & Johnston, B. M., May 2013, In : Health and Social Care in the Community. 21, 3, p. 225-235 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2003

Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi

Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., Wolf, C. R. & Park, B. K., 20 Jun 2003, In : Journal of Biological Chemistry. 278, 25, p. 22243-22249 7 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)
2012

G2019s leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

Papkovskaia, T. D., Chau, K-Y., Inesta-vaquera, F., Papkovsky, D. B., Healy, D. G., Nishio, K., Staddon, J., Duchen, M. R., Hardy, J., Schapira, A. H. V. & Cooper, J. M., 2012, In : Human Molecular Genetics. 21, 19, p. 4201-4213 13 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)
2004

Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates

McWalter, G. K., Higgins, L. G., McLellan, L. I., Henderson, C. J., Song, L., Thornalley, P. J., Itoh, K., Yamamoto, M. & Hayes, J. D., 1 Dec 2004, In : Journal of Nutrition. 134, 12, p. 3499S-3506S

Research output: Contribution to journalArticle

161 Citations (Scopus)
2007

Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity

Cavin, C., Delatour, T., Marin-Kuan, M., Holzhäuser, D., Higgins, L., Bezençon, C., Guignard, G., Junod, S., Richoz-Payot, J., Gremaud, E., Hayes, J. D., Nestler, S., Mantle, P. & Schilter, B., 2007, In : Toxicological Sciences. 96, 1, p. 30-9 10 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)
2003

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

Nioi, P., McMahon, M., Itoh, K., Yamamoto, M. & Hayes, J. D., 2003, In : Biochemical Journal. 374, Pt 2, p. 337-48 12 p.

Research output: Contribution to journalArticle

346 Citations (Scopus)
2005

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

Katoh, Y., Iida, K., Kang, M-I., Kobayashi, A., Mizukami, M., Tong, K. I., McMahon, M., Hayes, J. D., Itoh, K. & Yamamoto, M., 2005, In : Archives of Biochemistry and Biophysics. 433, 2, p. 342-50 9 p.

Research output: Contribution to journalArticle

136 Citations (Scopus)
2016

Factors influencing withdrawal from dialysis: a national registry study

Findlay, M. D., Donaldson, K., Doyle, A., Fox, J. G., Khan, I., McDonald, J., Metcalfe, W., Peel, R. K., Shilliday, I., Spalding, E., Stewart, G. A., Traynor, J. P., Mackinnon, B. & on behalf of the Scottish Renal Registry (SRR), 21 Apr 2016, In : Nephrology Dialysis Transplantation. 31, 12, p. 2041-2048 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Chromosome Duplication in Saccharomyces cerevisiae

Bell, S. P. & Labib, K., 6 Jul 2016, In : Genetics. 203, 3, p. 1027-1067 41 p.

Research output: Contribution to journalArticle

Open Access
File
112 Citations (Scopus)
131 Downloads (Pure)
2015

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

Brough, H. A., Liu, A. H., Sicherer, S., Makinson, K., Douiri, A., Brown, S. J., Stephens, A. C., McLean, W. H. I., Turcanu, V., Wood, R. A., Jones, S. M., Burks, W., Dawson, P., Stablein, D., Sampson, H. & Lack, G., Jan 2015, In : Journal of Allergy and Clinical Immunology. 135, 1, p. 164-170.e4 11 p.

Research output: Contribution to journalArticle

Open Access
File
156 Citations (Scopus)
305 Downloads (Pure)

The Top 10 oomycete pathogens in molecular plant pathology

Kamoun, S., Furzer, O., Jones, J. D. G., Judelson, H. S., Ali, G. S., Dalio, R. J. D., Roy, S. G., Schena, L., Zambounis, A., Panabières, F., Cahill, D., Ruocco, M., Figueiredo, A., Chen, X. R., Hulvey, J., Stam, R., Lamour, K., Gijzen, M., Tyler, B. M., Grünwald, N. J. & 14 others, Mukhtar, M. S., Tomé, D. F. A., Tör, M., Van Den Ackerveken, G., McDowell, J., Daayf, F., Fry, W. E., Lindqvist-Kreuze, H., Meijer, H. J. G., Petre, B., Ristaino, J., Yoshida, K., Birch, P. R. J. & Govers, F., May 2015, In : Molecular Plant Pathology. 16, 4, p. 413-434 22 p.

Research output: Contribution to journalArticle

233 Citations (Scopus)

Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

Branigan, E., Plechanovova, A., Jaffray, E. G., Naismith, J. H. & Hay, R. T., Aug 2015, In : Nature Structural & Molecular Biology. 22, 8, p. 597-602 6 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
140 Downloads (Pure)

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Aung, T., Ozaki, M., Mizoguchi, T., Allingham, R. R., Li, Z., Haripriya, A., Nakano, S., Uebe, S., Harder, J. M., Chan, A. S. Y., Lee, M. C., Burdon, K. P., Astakhov, Y. S., Abu-Amero, K. K., Zenteno, J. C., Nilgün, Y., Zarnowski, T., Pakravan, M., Safieh, L. A., Jia, L. & 30 others, Wang, Y. X., Williams, S., Paoli, D., Schlottmann, P. G., Huang, L., Sim, K. S., Foo, J. N., Nakano, M., Ikeda, Y., Kumar, R. S., Ueno, M., Manabe, S., Hayashi, K., Kazama, S., Ideta, R., Mori, Y., Miyata, K., Sugiyama, K., Higashide, T., Chihara, E., Inoue, K., Ishiko, S., Yoshida, A., Yanagi, M., Kiuchi, Y., Aihara, M., Ohashi, T., Sakurai, T., Sugimoto, T. & Wellcome Trust Case Control Consortium 2, Apr 2015, In : Nature Genetics. 47, 4, p. 387-392 6 p.

Research output: Contribution to journalLetter

44 Citations (Scopus)
2012

A hybrid discrete-continuum model of tumour induced angiogenesis

Anderson, A. R. A., Chaplain, M. A. J. & McDougall, S., 2012, Modeling tumor vasculature: molecular, cellular, and tissue level aspects and implications. Jackson, T. L. (ed.). New York: Springer , p. 105-133 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)
2014

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

Nijenhuis, W., Vallardi, G., Teixeira, A., Kops, G. J. P. L. & Saurin, A. T., Dec 2014, In : Nature Cell Biology. 16, 12, p. 1257-1264 8 p.

Research output: Contribution to journalLetter

Open Access
File
93 Citations (Scopus)
107 Downloads (Pure)
2002

AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat

McCrimmon, R. J., Evans, M. L., Jacob, R. J., Fan, X., Zhu, Y., Shulman, G. I. & Sherwin, R. S., Nov 2002, In : American Journal of Physiology, Endocrinology and Metabolism. 283, 5, p. E1076-E1083 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2005

Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function

Ferguson, S. C., Blane, A., Wardlaw, J., Frier, B. M., Perros, P., McCrimmon, R. J. & Deary, I. J., Jun 2005, In : Diabetes Care. 28, 6, p. 1431-1437 7 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)
2015

Reflective writing: the student nurse's perspective on reflective writing and poetry writing

Coleman, D. & Willis, D. S., Jul 2015, In : Nurse Education Today. 35, 7, p. 906-911 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Downregulation of miRNA-424: a sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma

Boldrup, L., Coates, P. J., Laurell, G., Wilms, T., Fahraeus, R. & Nylander, K., 26 May 2015, In : British Journal of Cancer. 112, 11, p. 1760-1765 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)