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• Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

  Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

  Research output: Contribution to journal › Article › peer-review

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  91 Citations (Scopus)

  461 Downloads (Pure)

• Discovery of an RmlC/D fusion protein in the microalga Prymnesium parvum and its implications for NDP-β-L-rhamnose biosynthesis in microalgae

  Wagstaff, B., Rejzek, M., Kuhaudomlarp, S., Hill, L., Mascia, I., Nepogodiev, S. A., Dorfmueller, H. & Field, R. A., 7 Jun 2019, In: Journal of Biological Chemistry. 294, 23, p. 9172-9185 14 p.

  Research output: Contribution to journal › Article › peer-review

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  8 Citations (Scopus)

  161 Downloads (Pure)

• Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres

  Kobayashi, N., Suzuki, Y., Schoenfeld, L., Müller, C., Nieduszynski, C., Wolfe, K. & Tanaka, T., 3 Aug 2015, In: Current Biology. 25, 15, p. 2026-2033 8 p.

  Research output: Contribution to journal › Article › peer-review

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  29 Citations (Scopus)

  224 Downloads (Pure)

• Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221.

  Cohen, P. T. & Cohen, P., 15 Jun 1989, In: The Biochemical journal. 260, 3, p. 931-934 4 p.

  Research output: Contribution to journal › Article › peer-review
  95 Citations (Scopus)

• Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor

  Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R. & Gray, N. S., 14 May 2015, In: ACS Medicinal Chemistry Letters. 6, 5, p. 584-589 6 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

  Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A., & 7 othersGray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 10 Nov 2016, In: Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.

  Research output: Contribution to journal › Article › peer-review

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  46 Citations (Scopus)

  227 Downloads (Pure)

• Discovery of benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain

  Cipriano, A., Milite, C., Feoli, A., Viviano, M., Pepe, G., Campiglia, P., Sarno, G., Picaud, S., Imaide, S., Makukhin, N., Filippakopoulos, P., Ciulli, A., Castellano, S. & Sbardella, G., 19 Oct 2022, In: ChemMedChem. 17, 20, 14 p., e202200343.

  Research output: Contribution to journal › Article › peer-review

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  6 Downloads (Pure)

• Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

  Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H., & 30 othersRauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. & Franks, P. W., 1 Sep 2019, In: Diabetologia. 62, 9, p. 1601-1615 15 p.

  Research output: Contribution to journal › Article › peer-review

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  15 Citations (Scopus)

  27 Downloads (Pure)

• Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

  Koivula, R. W., Heggie, A., Barnett, A., Cederberg, H., Hansen, T. H., Koopman, A. D., Ridderstråle, M., Rutters, F., Vestergaard, H., Gupta, R., Herrgård, S., Heymans, M. W., Perry, M. H., Rauh, S., Siloaho, M., Teare, H. J. A., Thorand, B., Bell, J., Brunak, S., Frost, G., & 14 othersJablonka, B., Mari, A., McDonald, T. J., Dekker, J. M., Hansen, T., Hattersley, A., Laakso, M., Pedersen, O., Koivisto, V., Ruetten, H., Walker, M., Pearson, E., Franks, P. W. & DIRECT Consortium, Jun 2014, In: Diabetologia. 57, 6, p. 1132-1142 11 p.

  Research output: Contribution to journal › Article › peer-review

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  38 Citations (Scopus)

  210 Downloads (Pure)

• Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations

  Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K., 1 Nov 2011, In: Open Biology. 1, NOVEMBER, 110012.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• Discovery of common and rare genetic risk variants for colorectal cancer

  Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., Conti, D. V., Qu, C., Jeon, J., Edlund, C. K., Greenside, P., Wainberg, M., Schumacher, F. R., Smith, J. D., Levine, D. M., Nelson, S. C., Sinnott-Armstrong, N. A., Albanes, D., Alonso, M. H., Anderson, K., & 179 othersArnau-Collell, C., Arndt, V., Bamia, C., Banbury, B. L., Baron, J. A., Berndt, S. I., Bézieau, S., Bishop, D. T., Boehm, J., Boeing, H., Brenner, H., Brezina, S., Buch, S., Buchanan, D. D., Burnett-Hartman, A., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chirlaque, M-D., Cho, S. H., Connolly, C. M., Cross, A. J., Cuk, K., Curtis, K. R., de la Chapelle, A., Doheny, K. F., Duggan, D., Easton, D. F., Elias, S. G., Elliott, F., English, D. R., Feskens, E. J. M., Figueiredo, J. C., Fischer, R., FitzGerald, L. M., Forman, D., Gala, M., Gallinger, S., Gauderman, W. J., Giles, G. G., Gillanders, E., Gong, J., Goodman, P. J., Grady, W. M., Grove, J. S., Gsur, A., Gunter, M. J., Haile, R. W., Hampe, J., Hampel, H., Harlid, S., Hayes, R. B., Hofer, P., Hoffmeister, M., Hopper, J. L., Hsu, W-L., Huang, W-Y., Hudson, T. J., Hunter, D. J., Ibañez-Sanz, G., Idos, G. E., Ingersoll, R., Jackson, R. D., Jacobs, E. J., Jenkins, M. A., Joshi, A. D., Joshu, C. E., Keku, T. O., Key, T. J., Kim, H. R., Kobayashi, E., Kolonel, L. N., Kooperberg, C., Kühn, T., Küry, S., Kweon, S-S., Larsson, S. C., Laurie, C. A., Le Marchand, L., Leal, S. M., Lee, S. C., Lejbkowicz, F., Lemire, M., Li, C. I., Li, L., Lieb, W., Lin, Y., Lindblom, A., Lindor, N. M., Ling, H., Louie, T. L., Männistö, S., Markowitz, S. D., Martín, V., Masala, G., McNeil, C. E., Melas, M., Milne, R. L., Moreno, L., Murphy, N., Myte, R., Naccarati, A., Newcomb, P. A., Offit, K., Ogino, S., Onland-Moret, N. C., Pardini, B., Parfrey, P. S., Pearlman, R., Perduca, V., Pharoah, P. D. P., Pinchev, M., Platz, E. A., Prentice, R. L., Pugh, E., Raskin, L., Rennert, G., Rennert, H. S., Riboli, E., Rodríguez-Barranco, M., Romm, J., Sakoda, L. C., Schafmayer, C., Schoen, R. E., Seminara, D., Shah, M., Shelford, T., Shin, M-H., Shulman, K., Sieri, S., Slattery, M. L., Southey, M. C., Stadler, Z. K., Stegmaier, C., Su, Y-R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Thomas, S. S., Toland, A. E., Trichopoulou, A., Ulrich, C. M., Van Den Berg, D. J., van Duijnhoven, F. J. B., Van Guelpen, B., van Kranen, H., Vijai, J., Visvanathan, K., Vodicka, P., Vodickova, L., Vymetalkova, V., Weigl, K., Weinstein, S. J., White, E., Win, A. K., Wolf, C. R., Wolk, A., Woods, M. O., Wu, A. H., Zaidi, S. H., Zanke, B. W., Zhang, Q., Zheng, W., Scacheri, P. C., Potter, J. D., Bassik, M. C., Kundaje, A., Casey, G., Moreno, V., Abecasis, G. R., Nickerson, D. A., Gruber, S. B., Hsu, L. & Peters, U., 1 Jan 2019, In: Nature Genetics. 51, 1, p. 76-87 12 p.

  Research output: Contribution to journal › Article › peer-review

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  225 Citations (Scopus)

  268 Downloads (Pure)

• Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

  IMI DIRECT Consortium, Rasmussen, S. & Brunak, S., 2 Jan 2023, (E-pub ahead of print) In: Nature Biotechnology. 17 p.

  Research output: Contribution to journal › Article › peer-review

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• Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

  Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H., 8 Oct 2015, In: Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

  Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In: ChemMedChem. 10, 11, p. 1809-1820 12 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Discovery of invariants through automated theory formation

  Llano, M. T., Ireland, A. & Pease, A., 17 Jun 2011, In: Electronic Proceedings in Theoretical Computer Science, EPTCS. 55, p. 1-19 19 p.

  Research output: Contribution to journal › Conference article › peer-review
  5 Citations (Scopus)

• Discovery of invariants through automated theory formation

  Llano, M. T., Ireland, A. & Pease, A., Oct 2012, In: Formal Aspects of Computing. n/a, p. 1-47 47 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

  Navratilova, I., Aristotelous, T., Picaud, S., Chaikuad, A., Knapp, S., Filappakopoulos, P. & Hopkins, A. L., 8 Dec 2016, In: ACS Medicinal Chemistry Letters. 7, 12, p. 1213-1218 6 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)

  Brasca, M. G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Casale, E., Ceccarelli, W., Colombo, N., De Ponti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E. R., Ferguson, R. D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L., & 4 othersSola, F., Visco, C., Zuccotto, F. & Fogliatto, G., 15 Nov 2013, In: Bioorganic & Medicinal Chemistry. 21, 22, p. 7047-7063 17 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists

  Jones, D. G., Liang, X., Stewart, E. L., Noe, R. A., Kallander, L. S., Madauss, K. P., Williams, S. P., Thompson, S. K., Gray, D. W. & Hoekstra, W. J., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 13, p. 3203-6 4 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Discovery of novel heart rate-associated loci using the Exome Chip

  van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Müller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikäinen, L-P., & 101 othersHall, L. M., van Setten, J., Trompet, S., Prins, B. P., Isaacs, A., Radmanesh, F., Marten, J., Entwistle, A., Kors, J. A., Silva, C. T., Alonso, A., Bis, J. C., de Boer, R. A., de Haan, H. G., de Mutsert, R., Dedoussis, G., Dominiczak, A. F., Doney, A. S. F., Ellinor, P. T., Eppinga, R. N., Felix, S. B., Guo, X., Hagemeijer, Y., Hansen, T., Harris, T. B., Heckbert, S. R., Huang, P. L., Hwang, S-J., Kähönen, M., Kanters, J. K., Kolcic, I., Launer, L. J., Li, M., Yao, J., Linneberg, A., Liu, S., Macfarlane, P. W., Mangino, M., Morris, A. D., Mulas, A., Murray, A. D., Nelson, C. P., Orrú, M., Padmanabhan, S., Peters, A., Porteous, D. J., Poulter, N. R., Psaty, B. M., Qi, L., Raitakari, O. T., Rivadeneira, F., Roselli, C., Rudan, I., Sattar, N., Sever, P., Sinner, M. F., Soliman, E. Z., Spector, T. D., Stanton, A. V., Stirrups, K. E., Taylor, K. D., Tobin, M. D., Uitterlinden, A. G., Vaartjes, I., Hoes, A. W., van der Meer, P., Völker, U., Waldenberger, M., Xie, Z., Zoledziewska, M., Tinker, A., Polasek, O., Rosand, J., Jamshidi, Y., van Duijn, C. M., Zeggini, E., Wouter Jukema, J., Asselbergs, F. W., Samani, N. J., Lehtimäki, T., Gudnason, V., Wilson, J., Lubitz, S. A., Kääb, S., Sotoodehnia, N., Caulfield, M. J., Palmer, C. N. A., Sanna, S., Mook-Kanamori, D. O., Deloukas, P., Pedersen, O., Rotter, J. I., Dörr, M., O'Donnell, C. J., Hayward, C., Arking, D. E., Kooperberg, C., van der Harst, P., Eijgelsheim, M., Stricker, B. H. C. & Munroe, P. B., 15 Jun 2017, In: Human Molecular Genetics. 26, 12, p. 2346-2363 18 p.

  Research output: Contribution to journal › Article › peer-review

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  18 Citations (Scopus)

  163 Downloads (Pure)

• Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

  Wang, S., Midgley, C. A., Scaërou, F., Grabarek, J. B., Griffiths, G., Jackson, W., Kontopidis, G., McClue, S. J., McInnes, C., Meades, C., Mezna, M., Plater, A., Stuart, I., Thomas, M. P., Wood, G., Clarke, R. G., Blake, D. G., Zheleva, D. I., Lane, D. P., Jackson, R. C., & 2 othersGlover, D. M. & Fischer, P. M., 10 Jun 2010, In: Journal of Medicinal Chemistry. 53, 11, p. 4367-4378 12 p.

  Research output: Contribution to journal › Article › peer-review
  86 Citations (Scopus)

• Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1

  Osborne, J., Birchall, K., Tsagris, D. J., Lewis, S. J., Smiljanic-Hurley, E., Taylor, D. L., Levy, A., Alessi, D. & McIver, E. G., 15 Feb 2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 4, p. 668-673 6 p.

  Research output: Contribution to journal › Article › peer-review

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  7 Citations (Scopus)

  78 Downloads (Pure)

• Discovery of potent and selective covalent inhibitors of JNK

  Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. & Gray, N. S., 27 Jan 2012, In: Chemistry & Biology. 19, 1, p. 140-154 15 p.

  Research output: Contribution to journal › Article › peer-review
  239 Citations (Scopus)

• Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

  Cavazzuti, A., Paglietti, G., Hunter, W. N., Gamarro, F., Piras, S., Loriga, M., Alleca, S., Corona, P., McLuskey, K., Tulloch, L., Gibellini, F., Ferrari, S. & Costin, M. P., 5 Feb 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1448-1453 6 p.

  Research output: Contribution to journal › Article › peer-review
  119 Citations (Scopus)

• Discovery of powerful millisecond flares from Cygnus X-1

  Gierliński, M. & Zdziarski, A. A., 11 Aug 2003, In: Monthly Notices of the Royal Astronomical Society. 343, 3, p. L84-L88 5 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)

• Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

  LifeLines Cohort Study, EPIC-CVD Consortium, EPIC-InterAct Consortium, Understanding Society Scientific Group, Million Veteran Program, Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G., & 37 othersLiu, D. J., Prins, B. P., Stewart, I. D., Cabrera, C. P., Eales, J. M., Akbarov, A., Auer, P. L., Bielak, L. F., Bis, J. C., Braithwaite, V. S., Brody, J. A., Daw, E. W., Warren, H. R., Drenos, F., Nielsen, S. F., Faul, J. D., Fauman, E. B., Fava, C., Ferreira, T., Foley, C. N., Franceschini, N., Gao, H., Giannakopoulou, O., Giulianini, F., Gudbjartsson, D. F., Guo, X., Harris, S. E., Havulinna, A. S., Helgadottir, A., Huffman, J. E., Hwang, S-J., Kanoni, S., Smith, J. A., Palmer, C. N. A., Smith, B. H., Munroe, P. B. & Howson, J. M. M., Dec 2020, In: Nature Genetics. 52, 12, p. 1314-1332 19 p.

  Research output: Contribution to journal › Article › peer-review

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  39 Citations (Scopus)

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• Discovery of sarolaner: A novel, Orally administered, broad-spectrum, Isoxazoline ectoparasiticide for dogs

  McTier, T. L., Chubb, N., Curtis, M. P., Hedges, L., Inskeep, G. A., Knauer, C. S., Menon, S., Mills, B., Pullins, A., Zinser, E., Woods, D. J. & Meeus, P., 30 May 2016, In: Veterinary Parasitology. 222, p. 3-11 9 p.

  Research output: Contribution to journal › Article › peer-review

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  87 Citations (Scopus)

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• Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

  Diehl, C. J. & Ciulli, A., 19 Aug 2022, In: Chemical Society Reviews. 51, 19, p. 8216-8257 42 p.

  Research output: Contribution to journal › Review article › peer-review

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  4 Citations (Scopus)

  15 Downloads (Pure)

• Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

  Bell, M., Foley, D., Naylor, C., Wood, G., Robinson, C., Riley, J., Epemolu, R., Ellis, L., Scullion, S., Shishikura, Y., Osuna-Cabello, M., Ferguson, L., Pinto, E., Fletcher, D., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 341–347 7 p.

  Research output: Contribution to journal › Article › peer-review

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  3 Citations (Scopus)

  211 Downloads (Pure)

• Discovery of soticlestat, a potent and selective inhibitor for cholesterol 24-hydroxylase (CH24H)

  Koike, T., Yoshikawa, M., Ando, H. K., Farnaby, W., Nishi, T., Watanabe, E., Yano, J., Miyamoto, M., Kondo, S., Ishii, T. & Kuroita, T., 26 Aug 2021, In: Journal of Medicinal Chemistry. 64, 16, p. 12228-12244 17 p.

  Research output: Contribution to journal › Article › peer-review

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  14 Citations (Scopus)

• Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

  Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 15 Oct 2018, In: Bioorganic & Medicinal Chemistry Letters. 28, 19, p. 3255-3259 5 p.

  Research output: Contribution to journal › Article › peer-review

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  14 Citations (Scopus)

  243 Downloads (Pure)

• Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies

  Lucas, X., Simon, S., Schubert, R. & Günther, S., 9 Apr 2013, In: PLoS ONE. 8, 4, 8 p., e60679.

  Research output: Contribution to journal › Article › peer-review

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  7 Citations (Scopus)

  164 Downloads (Pure)

• Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

  Tan, L., Nomanbhoy, T., Gurbani, D., Patricelli, M., Hunter, J., Geng, J., Herhaus, L., Zhang, J., Pauls, E., Ham, Y., Choi, H. G., Xie, T., Deng, X., Buhrlage, S. J., Sim, T., Cohen, P., Sapkota, G., Westover, K. D. & Gray, N. S., 8 Jan 2015, In: Journal of Medicinal Chemistry. 58, 1, p. 183-196 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  53 Citations (Scopus)

• Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2

  Liu, X., Kalogeropulou, A. F., Domingos, S., Makukhin, N., Nirujogi, R., Singh, F., Shpiro, N., Saalfrank, A., Sammler, E., Ganley, I. G., Moreira, R., Alessi, D. R. & Ciulli, A., 21 Sep 2022, In: Journal of the American Chemical Society. 144, 37, p. 16930-16952 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  4 Citations (Scopus)

  67 Downloads (Pure)

• Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

  Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I., 2013, In: ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Discrete cell modelling

  Macklin, P., Edgerton, M. E., Lowengrub, J. S. & Cristini, V., 2010, Multiscale modeling of cancer: an integrated experimental and mathematical modeling approach. Cristini, V. & Lowengrub, J. (eds.). Cambridge University Press, p. 88-122 35 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Discrete Element Modeling of Compound Rockfall Fence Nets

  Previtali, M., Ciantia, M., Spadea, S., Castellanza, R. & Crosta, G. B., 2021, Challenges and Innovations in Geomechanics: Proceedings of the 16th International Conference of IACMAG - Volume 2. Barla, M., Di Donna, A. & Sterpi, D. (eds.). Switzerland: Springer , Vol. 2. p. 560-567 8 p. (Lecture Notes in Civil Engineering; vol. 126).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

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  5 Citations (Scopus)

  83 Downloads (Pure)

• Discrete element modelling of soil erosion

  Muir Wood, D., Maeda, K. & Nukudani, E., 2008, 4th International Conference on Scour and Erosion. Japanese Geotechnical Society, p. 491-496 6 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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• Discrete Element simulation of the response of a double-twisted mesh subject to cyclic loads

  Previtali, M., Ciantia, M., Spadea, S., Castellanza, R. & Crosta, G. B., May 2022, Proceedings of the 20th International Conference on Soil Mechanics and Geotechnical Engineering, Sydney 2021. Sydney: Australian Geomechanics Society, p. 667-672 6 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Discrete Model for Dynamic Structure-Soil-Structure Interaction

  Aldaikh, H., Alexander, N. & Ibraim, E., 2012, Proceedings of the 15th World Conference of Earthquake Engineering (15WCEE): Proceedings of a meeting held 24-28 September 2012, Lisbon, Portugal.. Red Hook, NY: International Association for Earthquake Engineering , Vol. 24. p. 19433-19442 10 p. 3386

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

• Discrete modelling of vertical track-soil coupling for vehicle-track dynamics

  Kouroussis, G., Gazetas, G., Anastasopoulos, I., Conti, C. & Verlinden, O., Dec 2011, In: Soil Dynamics and Earthquake Engineering. 31, 12, p. 1711-1723 13 p.

  Research output: Contribution to journal › Article › peer-review
  77 Citations (Scopus)

• Discretion not to quash permission despite breach of Habitats Directive

  Reid, C., Aug 2019, Scottish Planning and Environmental Law, 194, p. 93-93 1 p.

  Research output: Contribution to specialist publication › Article

• Discretised eigenvalue problems, LBB constants and stabilization

  Griffiths, D., Griffiths, D. (ed.) & Watson, A. (ed.), 1995

  Research output: Non-textual form › Digital or Visual Products

• Discretization provides a conceptually simple tool to build expression networks

  Vass, J. K., Higham, D. J., Mudaliar, M. A. V., Mao, X. & Crowther, D. J., 18 Apr 2011, In: PLoS ONE. 6, 4, p. 1-12 12 p., e18634.

  Research output: Contribution to journal › Article › peer-review

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  4 Citations (Scopus)

  90 Downloads (Pure)

• Discriminant analysis of mandibular measurements for the estimation of sex in a modern Brazilian sample

  Lopez-Capp, T. T., Rynn, C., Wilkinson, C., de Paiva, L. A. S., Michel-Crosato, E. & Biazevic, M. G. H., May 2018, In: International Journal of Legal Medicine. 132, 3, p. 843-851 9 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Discriminating between barley genotypes using microsatellite markers

  Russell, J., Fuller, J., Young, G., Thomas, B., Macaulay, M., Waugh, R., Powell, W. & Taramino, G., Aug 1997, In: Genome. 40, 4, p. 442-450 9 p.

  Research output: Contribution to journal › Article › peer-review
  140 Citations (Scopus)

• Discriminating dysplasia: optical tomographic texture analysis of colorectal polyps

  Li, W., Coats, M., Zhang, J. & McKenna, S., Dec 2015, In: Medical Image Analysis. 26, 1, p. 57-69 13 p.

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  10 Citations (Scopus)

  341 Downloads (Pure)

• Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry

  Nenutil, R., Smardova, J., Pavlova, S., Hanzelkova, Z., Muller, P., Fabian, P., Hrstka, R., Janotova, P., Radina, M., Lane, D. P., Coates, P. J. & Vojtesek, B., 2005, In: Journal of Pathology. 207, 3, p. 251-259 9 p.

  Research output: Contribution to journal › Article › peer-review
  118 Citations (Scopus)

• Discrimination of bladder cancer cells from normal urothelial cells with high specificity and sensitivity: combined application of AFM and modulated Raman spectroscopy

  Canetta, E., Riches, A., Borger, E., Herrington, S., Dholakia, K. & Adya, A. K., May 2014, In: Acta Biomaterialia. 10, 5, p. 2043-2055

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Discrimination of closely homologous HPV types by nonisotopic in situ hybridization: definition and derivation of tissue melting temperatures

  Herrington, C. S., Graham, A. K., Flannery, D. M. J., Burns, J. & McGee, J. OD., 1990, In: Histochemical Journal. 22, 10, p. 545-554 10 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)