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2019

CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high fat-fed C57BL/6 mice

Hasib, A., Hennayake, C., Bracy, D. P., Bugler-Lamb, A-R., Lantier, L., Khan, F., Ashford, M., McCrimmon, R., Wasserman, D. H. & Kang, L., 1 Dec 2019, In : American Journal of Physiology, Endocrinology and Metabolism. 317, 6, p. E973-E983 11 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Inbred C57BL Mouse
Insulin Resistance
Skeletal Muscle
Fats

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75]

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Jul 2019, In : Metabolism: Clinical and Experimental. 96, p. 101-102 2 p.

Research output: Contribution to journalArticle

Insulin
Inflammation
corrigendum
2018
8 Citations (Scopus)
149 Downloads (Pure)

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

Research output: Contribution to journalArticle

Open Access
File
Obese Mice
Leptin
Amyloid
Obesity
Homeostasis
2 Citations (Scopus)
93 Downloads (Pure)

Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

Smith, M. A., Katsouri, L., Virtue, S., Choudhury, A. I., Vidal-Puig, A., Ashford, M. L. J. & Withers, D. J., 9 Oct 2018, In : Cell Reports. 25, 2, p. 278-287.e4 15 p.

Research output: Contribution to journalArticle

Open Access
File
Pro-Opiomelanocortin
Calcium Channels
Leptin
Neurons
Glucose
29 Citations (Scopus)
122 Downloads (Pure)
Open Access
File
NF-E2-Related Factor 2
Fructose
Liver Cirrhosis
Fats
Endoplasmic Reticulum Stress
167 Citations (Scopus)
530 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journalArticle

Open Access
File
Alkylation
Anti-Inflammatory Agents
Interferon Type I
Cysteine
Lipopolysaccharides
14 Citations (Scopus)
77 Downloads (Pure)

Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30 Apr 2018, In : Clinical Science. 132, 8, p. 851-868 18 p.

Research output: Contribution to journalArticle

Open Access
File
Dementia
Chronic Disease
Cerebral Small Vessel Diseases
Education
Cerebrovascular Disorders
6 Citations (Scopus)
88 Downloads (Pure)

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Aug 2018, In : Metabolism. 85, p. 59-75 17 p.

Research output: Contribution to journalArticle

Open Access
File
Endoplasmic Reticulum Stress
Insulin Resistance
Insulin
Palmitates
Inflammation
9 Citations (Scopus)
102 Downloads (Pure)

The beta secretase BACE1 regulates the expression of the insulin receptor in the liver

Meakin, P., Mezzapesa, A., Benabou, E., Haas, M., Bonardo, B., Grino, M., Brunel, J-M., Biddinger, S. B., Desbois-Mouthon, C., Govers, R., Ashford, M. L. J. & Peiretti, F., 3 Apr 2018, In : Nature Communications. 9, p. 1-14 14 p., 1306.

Research output: Contribution to journalArticle

Open Access
File
Amyloid Precursor Protein Secretases
insulin
Insulin Receptor
liver
Liver
2017
8 Citations (Scopus)
199 Downloads (Pure)

AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner

Vlachaki Walker, J. M., Robb, J. L., Cruz, A. M., Malhi, A., Weightman Potter, P. G., Ashford, M. L. J., McCrimmon, R. J., Ellacott, K. L. J. & Beall, C., 21 Apr 2017, In : Diabetes, Obesity & Metabolism. 19, 7, p. 997-1005 9 p.

Research output: Contribution to journalArticle

Open Access
File
A 769662
AMP-Activated Protein Kinases
Astrocytes
Adenosine Triphosphate
Calcium
6 Citations (Scopus)
229 Downloads (Pure)
Open Access
File
Hypoglycemia
Hypoglycemic Agents
Rodentia
Type 1 Diabetes Mellitus
Brain-Derived Neurotrophic Factor
5 Citations (Scopus)
87 Downloads (Pure)

Oleate induces KATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge

Dadak, S., Beall, C., Vlachaki Walker, J. M., Soutar, M. P. M., McCrimmon, R. J. & Ashford, M. L. J., 27 Mar 2017, In : Neuroscience. 346, p. 29-42 14 p.

Research output: Contribution to journalArticle

Open Access
File
KATP Channels
Oleic Acid
Neurons
Glucose
Arcuate Nucleus of Hypothalamus
2016
2 Citations (Scopus)
144 Downloads (Pure)

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons

Hathorne, E., Hamilton, D. L., Findlay, J. A., Beall, C., McCrimmon, R. J. & Ashford, M. L. J., Dec 2016, In : Neuropharmacology. 111, p. 212-222 11 p.

Research output: Contribution to journalArticle

Open Access
File
KATP Channels
Neurons
Glucose
Hypoglycemia
Hypoglycemic Agents
31 Citations (Scopus)
213 Downloads (Pure)

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C., 8 Aug 2016, In : Scientific Reports. 6, p. 1-17 17 p., 31159.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin
Cytokines
Oxidants
Polyubiquitin
Autoimmunity
13 Citations (Scopus)
113 Downloads (Pure)
Open Access
File
Type 1 Diabetes Mellitus
Hypoglycemia
Rodentia
Oxidative Stress
Inflammation
2015

BACE1 activity as a determining factor in atherosclerosis development?

Meakin, P., Hamilton, A., Jalicy, S., Khan, F. & Ashford, M., Jul 2015, In : Atherosclerosis. 241, 1, p. e13 1 p., EAS-0263.

Research output: Contribution to journalArticle

Atherosclerosis
Peptide Hydrolases
Enzymes
Temporal Arteries
Apolipoproteins E
6 Citations (Scopus)
133 Downloads (Pure)

BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid

Findlay, J. A., Hamilton, D. L. & Ashford, M. L., 1 Oct 2015, In : Frontiers in Cellular Neuroscience. 9, 14 p., 382.

Research output: Contribution to journalArticle

Open Access
File
Thioctic Acid
3-Hydroxybutyric Acid
Glucose
Alzheimer Disease
Enzymes
15 Citations (Scopus)
Caveolins
Proteomics
Adrenergic Receptors
Muscle Cells
Chemical activation
7 Citations (Scopus)
118 Downloads (Pure)

Mice lacking beta2-integrin function remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation

Meakin, P. J., Morrison, V. L., Sneddon, C. C., Savinko, T., Uotila, L., Jalicy, S. M., Gabriel, J. L., Kang, L., Ashford, M. L. J. & Fagerholm, S. C., 25 Sep 2015, In : PLoS ONE. 10, 9, 15 p., e0138872.

Research output: Contribution to journalArticle

Open Access
File
CD18 Antigens
Neutrophil Infiltration
Infiltration
insulin resistance
Insulin Resistance
62 Citations (Scopus)

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M. A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., Bilican, B., Chowdhry, S., Meakin, P. J., Ashford, M. L. J., Wyllie, D. J. A., Scannevin, R. H., Chandran, S., Hayes, J. D. & Hardingham, G. E., 13 May 2015, In : Nature Communications. 6, 15 p., 7066.

Research output: Contribution to journalArticle

Epigenetic Repression
NF-E2-Related Factor 2
antioxidants
Antioxidants
Neurons
22 Citations (Scopus)

Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. & Fuller, W., 2015, In : FASEB Journal. 12 p.

Research output: Contribution to journalArticle

Lipoylation
Membranes
Cysteine
Anchors
GTP-Binding Proteins
40 Citations (Scopus)

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Rzepecka, J., Pineda, M. A., Al-Riyami, L., Rodgers, D. T., Huggan, J. K., Lumb, F. E., Khalaf, A. I., Meakin, P. J., Corbet, M., Ashford, M. L., Suckling, C. J., Harnett, M. M. & Harnett, W., Jun 2015, In : Journal of Autoimmunity. 60, p. 59-73 15 p.

Research output: Contribution to journalArticle

Inflammasomes
Experimental Arthritis
Helminths
Interleukin-1
Rheumatoid Arthritis
2014
9 Citations (Scopus)
108 Downloads (Pure)

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes

Hamilton, D. L., Findlay, J. A., Montagut, G., Meakin, P. J., Bestow, D., Jalicy, S. M. & Ashford, M. L. J., Aug 2014, In : Diabetologia. 57, 8, p. 1684-1692 9 p.

Research output: Contribution to journalArticle

Open Access
File
Amyloid beta-Protein Precursor
Skeletal Muscle Fibers
Rodentia
Glucose
Enzymes
144 Citations (Scopus)
106 Downloads (Pure)

AMPK: regulating energy balance at the cellular and whole body levels

Hardie, D. G. & Ashford, M. L. J., Mar 2014, In : Physiology. 29, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenine Nucleotides
Energy Intake
Eukaryota
Energy Metabolism
8 Citations (Scopus)

Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle

Hamilton, D. L., Beall, C., Jeromson, S., Chevtzoff, C., Cuthbertson, D. J. & Ashford, M. L. J., Jan 2014, In : Journal of Physiological Sciences. 64, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Muscle Cells
Skeletal Muscle
Skeletal Muscle Fibers
Glucose

Regulation of the Cardiac Sodium/Calcium Exchanger by Protein Palmitoylation

Reilly, L., Hilgemann, D. W., Ashford, M. & Fuller, W., 28 Jan 2014, In : Biophysical Journal. 106, 2, Supplement 1, p. 581a 1 p., 2935-Pos B627.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Substrate recognition by the cell surface palmitoyl transferase DHHC5

Howie, J., Reilly, L., Fraser, N. J., Vlachaki Walker, J., Wypijewski, K. J., Ashford, M. L. J., Calaghan, S., McClafferty, H., Tian, L., Shipston, M. J., Boguslavskyi, A., Shattock, M. J. & Fuller, W., 9 Dec 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17534-17539 6 p.

Research output: Contribution to journalArticle

Transferases
Lipoylation
Acyltransferases
Cysteine
phospholemman
82 Citations (Scopus)
190 Downloads (Pure)
Open Access
File
NF-E2-Related Factor 2
Unfolded Protein Response
High Fat Diet
Fatty Liver
Insulin Resistance
2013
12 Citations (Scopus)

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J., Jun 2013, In : Journal of Bioenergetics and Biomembranes. 45, 3, p. 229-241 13 p.

Research output: Contribution to journalArticle

KATP Channels
AMP-Activated Protein Kinases
Insulin-Secreting Cells
Glucose
Adenylate Kinase
21 Citations (Scopus)

Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression

Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. & Ashford, M. L. J., Feb 2013, In : NeuroSignals. 21, 1-2, p. 28-41 14 p.

Research output: Contribution to journalArticle

Agouti-Related Protein
Sirolimus
Hormones
Messenger RNA
AMP-Activated Protein Kinases

Beta-secretase 1 (BACE1) inhibition improves obese and diabetic phenotypes in a leptin dependent manner

Meakin, P. J., Jalicy, S. M., Irvine, S. W. & Ashford, M. L. J., Mar 2013, In : Diabetic Medicine. 30, Suppl. 1, p. 41-41 1 p., P43.

Research output: Contribution to journalMeeting abstract

Beta-secretase 1 (BACE1) inhibition improves obese and diabetic phenotypes in a leptin dependent manner

Meakin, P. J., Jalicy, S. M., Irvine, S. W. & Ashford, M. L. J., 2013.

Research output: Contribution to conferencePoster

2 Citations (Scopus)

Continuous hypothalamic KATP channel activation blunts glucose counter-regulation in vivo in rats and supresses KATP conductance in vitro

Beall, C., Haythorne, E., Fan, X., Du, Q., Jovanovic, S., Sherwin, R., Ashford, M. L. J. & McCrimmon, R., Sep 2013, In : Diabetologia. 56, 9, p. 2088-2092 5 p.

Research output: Contribution to journalArticle

KATP Channels
Hypoglycemia
Glucose
Sulfonylurea Receptors
Epinephrine
2012

Hypoglycaemia: exercise for the brain?

Ashford, M., Beall, C. & McCrimmon, R., Oct 2012, In : Journal of Neuroendocrinology. 24, 10, p. 1365-1366 2 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour

Beall, C., Hamilton, D. L., Gallagher, J., Logie, L., Wright, K., Soutar, M. P., Dadak, S., Ashford, F. B., Haythorne, E., Du, Q., Jovanovic, A., McCrimmon, R. J. & Ashford, M. L. J., Sep 2012, In : Diabetologia. 55, 9, p. 2432-2444 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Nrf2 orchestrates fuel partitioning for cell proliferation

Hayes, J. D. & Ashford, M. L. J., 2012, In : Cell Metabolism. 16, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

Purine Nucleotides
Phosphatidylinositol 3-Kinases
Hypertrophy
Transcription Factors
Up-Regulation
56 Citations (Scopus)
131 Downloads (Pure)

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Meakin, P. J., Harper, A. J., Hamilton, D. L., Gallagher, J., McNeilly, A. D., Burgess, L. A., Vaanholt, L. M., Bannon, K. A., Latcham, J., Hussain, I., Speakman, J. R., Howlett, D. R. & Ashford, M. L. J., 1 Jan 2012, In : Biochemical Journal. 441, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

2011
30 Citations (Scopus)

Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

Claret, M., Smith, M. A., Knauf, C., Al-Qassab, H., Woods, A., Heslegrave, A., Piipari, K., Emmanuel, J. J., Colom, A., Valet, P., Cani, P. D., Begum, G., White, A., Mucket, P., Peters, M., Mizuno, K., Batterham, R. L., Giese, K. P., Ashworth, A., Burcelin, R. & 3 others, Ashford, M. L., Carling, D. & Withers, D. J., Mar 2011, In : Diabetes. 60, 3, p. 735-745 11 p.

Research output: Contribution to journalArticle