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2019
4 Citations (Scopus)
129 Downloads (Pure)

Dataset for the reporting of carcinoma of renal tubular origin: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Delahunt, B., Srigley, J. R., Judge, M. J., Amin, M. B., Billis, A., Camparo, P., Evans, A. J., Fleming, S., Griffiths, D. F., Lopez-Beltran, A., Martignoni, G., Moch, H., Nacey, J. N. & Zhou, M., Feb 2019, In : Histopathology. 74, 3, p. 377-390 14 p.

Research output: Contribution to journalReview article

Open Access
File
Adenocarcinoma
Kidney
Neoplasms
Pathology
Necrosis
2018
6 Citations (Scopus)

Challenges in Pathologic Staging of Renal Cell Carcinoma: A Study of Interobserver Variability Among Urologic Pathologists

Williamson, S. R., Rao, P., Hes, O., Epstein, J. I., Smith, S. C., Picken, M. M., Zhou, M., Tretiakova, M. S., Tickoo, S. K., Chen, Y-B., Reuter, V. E., Fleming, S., Maclean, F. M., Gupta, N. S., Kuroda, N., Delahunt, B., Mehra, R., Przybycin, C. G., Cheng, L., Eble, J. N. & 11 others, Grignon, D. J., Moch, H., Lopez, J. I., Kunju, L. P., Tamboli, P., Srigley, J. R., Amin, M. B., Martignoni, G., Hirsch, M. S., Bonsib, S. M. & Trpkov, K., Sep 2018, In : American Journal of Surgical Pathology. 42, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

Observer Variation
Renal Cell Carcinoma
Kidney
Blood Vessels
Neoplasms
2 Citations (Scopus)
71 Downloads (Pure)
Open Access
File
Adipokines
Prostatectomy
Prostate
Fats
Vascular Endothelial Growth Factor A
1 Citation (Scopus)
136 Downloads (Pure)

Phenotypic dissection of the mouse Ren-1(d) knockout by complementation with human renin

Buckley, C., Nelson, R. J., Mullins, L. J., Sharp, M. G. F., Fleming, S., Kenyon, C. J., Semprini, S., Steppan, D., Peti-Peterdi, J., Kurtz, A., Christian, H. & Mullins, J. J., 26 Jan 2018, In : Journal of Biological Chemistry. 293, 4, p. 1151-1162 12 p.

Research output: Contribution to journalArticle

Open Access
File
Dissection
Renin
Juxtaglomerular Apparatus
Renin-Angiotensin System
Angiotensins
2017
23 Citations (Scopus)
127 Downloads (Pure)

Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists

Williamson, S. R., Gadde, R., Trpkov, K., Hirsch, M. S., Srigley, J. R., Reuter, V. E., Cheng, L., Priya Kunju, L., Barod, R., Rogers, C. G., Delahunt, B., Hes, O., Eble, J. N., Zhou, M., McKenney, J. K., Martignoni, G., Fleming, S., Grignon, D. J., Moch, H. & Gupta, N. S., May 2017, In : Human Pathology. 63, p. 149-156 8 p.

Research output: Contribution to journalArticle

Open Access
File
Kidney Neoplasms
Oxyphilic Adenoma
Neoplasms
Renal Cell Carcinoma
Surveys and Questionnaires
83 Downloads (Pure)
Open Access
File
Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Macrophages
T-Lymphocytes
Kidney
6 Citations (Scopus)

Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography

Rossi, S. H., Hsu, R., Blick, C., Goh, V., Nathan, P., Nicol, D., Fleming, S., Sweeting, M., Wilson, E. C. F. & Stewart, G. D., May 2017, In : British Journal of Surgery. 104, 6, p. 648-659 12 p.

Research output: Contribution to journalReview article

Kidney Neoplasms
Renal Cell Carcinoma
Meta-Analysis
Ultrasonography
Kidney
5 Citations (Scopus)
95 Downloads (Pure)

Multiple socioeconomic deprivation and impact on survival in patients with primary glomerulonephritis

McQuarrie, E. P., Mackinnon, B., Bell, S., Fleming, S., McNeice, V., Stewart, G., Fox, J. G., Geddes, C. C. & on behalf of the Scottish Renal Biopsy Registry, Feb 2017, In : Clinical Kidney Journal. 10, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

Open Access
File
Glomerulonephritis
Survival
Renal Replacement Therapy
Economics
Kidney
5 Citations (Scopus)

Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature

Aird, J. J., Nic An Riogh, A. U., Fleming, S., Hislop, R. G., Sweeney, P. & Mayer, N., 1 Dec 2017, In : International Journal of Surgical Pathology. 28, 8, p. 745-750 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Molecular Biology
Chromosomes, Human, Pair 7
Osteosarcoma
Osteogenesis
2016
9 Citations (Scopus)
148 Downloads (Pure)

Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Palmer, S., Litvinova, K., Dunaev, A., Fleming, S., McGloin, D. & Nabi, G., 7 Mar 2016, In : Biomedical Optics Express. 7, 4, p. 1193-2000 8 p.

Research output: Contribution to journalArticle

Open Access
File
Organoids
bladder
muscles
Urinary Bladder Neoplasms
cancer
8 Citations (Scopus)
140 Downloads (Pure)

Microsatellite alteration and immunohistochemical expression profile of chromosome 9p21 in patients with sporadic renal cell carcinoma following surgical resection.

El-Mokadem, I., Alison, L., Kidd, T., Garret, K., Pratt, N., Batty, G. D., Fleming, S. & Nabi, G., 31 Jul 2016, In : BMC Cancer. 16, p. 1-10 10 p., 546.

Research output: Contribution to journalArticle

Open Access
File
Loss of Heterozygosity
Renal Cell Carcinoma
Microsatellite Repeats
Chromosomes
Neoplasms
1 Citation (Scopus)
116 Downloads (Pure)

Renal squamous cell carcinoma of a native kidney after renal transplant: a case report

Jakes, A., Jani, P., Menon, M., Adams, K., Edey, M., Fleming, S. & Bhandari, S., 2016, In : Transplantation Proceedings. 48, 1, p. 259-261 3 p.

Research output: Contribution to journalArticle

Open Access
File
Renal Cell Carcinoma
Squamous Cell Carcinoma
Transplants
Kidney
Infection
8 Citations (Scopus)
111 Downloads (Pure)

Tumour suppressor gene (CDKNA2) status on chromosome 9p in resected renal tissue improves prognosis of localised kidney cancer

El-Mokadem, I., Kidd, T., Pratt, N., Fleming, S. & Nabi, G., 22 Sep 2016, In : Oncotarget. 7, 45, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kidney Neoplasms
Tumor Suppressor Genes
Chromosomes
Fluorescence In Situ Hybridization
Kidney
2015
18 Citations (Scopus)

Acute tubulointerstitial nephritis in Scotland

Valluri, A., Hetherington, L., McQuarrie, E., Fleming, S., Kipgen, D., Geddes, C. C., Mackinnon, B. & Bell, S., 2015, In : QJM : an International Journal of Medicine. 108, 7, p. 527-532 6 p.

Research output: Contribution to journalArticle

Scotland
Biopsy
Creatinine
Adrenal Cortex Hormones
Pharmaceutical Preparations
7 Citations (Scopus)

Distal nephron neoplasms

Fleming, S., Mar 2015, In : Seminars in Diagnostic Pathology. 32, 2, p. 114-123 10 p.

Research output: Contribution to journalArticle

Nephrons
Oxyphilic Adenoma
Carcinoma
Phenotype
Mucinous Adenocarcinoma
1 Citation (Scopus)

Idiopathic hypocomplementemic interstitial nephritis

Kidder, D., Stewart, G. A., Furrie, E. & Fleming, S., Feb 2015, In : Kidney International. 87, 2, p. 485-486 2 p.

Research output: Contribution to journalArticle

Interstitial Nephritis
Creatinine
Herbal Medicine
Alopecia
Arthralgia
18 Citations (Scopus)

Kidney biopsy findings in primary Sjogren syndrome

Kidder, D., Rutherford, E., Kipgen, D., Fleming, S., Geddes, C. & Stewart, G. A., 2015, In : Nephrology Dialysis Transplantation. 7 p.

Research output: Contribution to journalArticle

Sjogren's Syndrome
Kidney
Biopsy
Interstitial Nephritis
Glomerulonephritis
104 Citations (Scopus)

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Cardaci, S., Zheng, L., Mackay, G., van den Broek, N. J. F., MacKenzie, E. D., Nixon, C., Stevenson, D., Tumanov, S., Bulusu, V., Kamphorst, J. J., Vazquez, A., Fleming, S., Schiavi, F., Kalna, G., Blyth, K., Strathdee, D. & Gottlieb, E., 24 Aug 2015, In : Nature Cell Biology. 17, 10, p. 1317-1326 13 p.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Pyruvic Acid
Aspartic Acid
Growth
Pyruvate Carboxylase
62 Citations (Scopus)

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

Kovac, M., Navas, C., Horswell, S., Salm, M., Bardella, C., Rowan, A., Stares, M., Castro-Giner, F., Fisher, R., de Bruin, E. C., Kovacova, M., Gorman, M., Makino, S., Williams, J., Jaeger, E., Jones, A., Howarth, K., Larkin, J., Pickering, L., Gore, M. & 25 others, Nicol, D. L., Hazell, S., Stamp, G., O'Brien, T., Challacombe, B., Matthews, N., Phillimore, B., Begum, S., Rabinowitz, A., Varela, I., Chandra, A., Horsfield, C., Polson, A., Tran, M., Bhatt, R., Terracciano, L., Eppenberger-Castori, S., Protheroe, A., Maher, E., El Bahrawy, M., Fleming, S., Ratcliffe, P., Heinimann, K., Swanton, C. & Tomlinson, I., 19 Mar 2015, In : Nature Communications. 6, 11 p., 6336.

Research output: Contribution to journalArticle

Kidney Neoplasms
mutations
Tumors
Genes
cancer
2014
16 Citations (Scopus)
112 Downloads (Pure)

Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery

El-Mokadem, I., Fitzpatrick, J., Bondad, J., Rauchhaus, P., Cunningham, J., Pratt, N., Fleming, S. & Nabi, G., 23 Sep 2014, In : British Journal of Cancer. 111, 7, p. 1381-1390 10 p.

Research output: Contribution to journalArticle

Open Access
File
Chromosome Deletion
Renal Cell Carcinoma
Recurrence
Survival
Interphase
13 Citations (Scopus)

Evidence for aldosterone-dependent growth of renal cell carcinoma

King, S., Bray, S., Galbraith, S., Christie, L. & Fleming, S., Aug 2014, In : International Journal of Experimental Pathology. 95, 4, p. 244-250 7 p.

Research output: Contribution to journalArticle

Spironolactone
Kidney Neoplasms
Aldosterone
Renal Cell Carcinoma
Mineralocorticoid Receptors
36 Citations (Scopus)
133 Downloads (Pure)

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G., 2014, In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

Research output: Contribution to journalArticle

Open Access
File
Kidney Neoplasms
Tumor Biomarkers
Proteomics
Renal Cell Carcinoma
Proteins
51 Citations (Scopus)

Risk of AKI with gentamicin as surgical prophylaxis

Bell, S., Davey, P., Nathwani, D., Marwick, C., Vadiveloo, T., Sneddon, J., Patton, A., Bennie, M., Fleming, S. & Donnan, P. T., Nov 2014, In : Journal of the American Society of Nephrology. 25, 11, p. 2625-2632 8 p.

Research output: Contribution to journalArticle

Gentamicins
Orthopedics
Antibiotic Prophylaxis
Urology
Gynecology
8 Citations (Scopus)

Signalling pathways in succinate dehydrogenase B-associated renal carcinoma

Fleming, S., Mayer, N. J., Vlatkovic, L. J., McLean, J., McConachie, M. & Baty, D., Mar 2014, In : Histopathology. 64, 4, p. 477-483 7 p.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Carcinoma
Kidney
Glycogen Synthase Kinase 3
Neoplasms
4 Citations (Scopus)
92 Downloads (Pure)

Significance of chromosome 9p status in renal cell carcinoma: a systematic review and quality of the reported studies

El-Mokadem, I., Fitzpatrick, J., Rai, B., Cunningham, J., Pratt, N., Fleming, S. & Nabi, G., 2014, In : BioMed Research International. 2014, 11 p., 521380.

Research output: Contribution to journalArticle

Open Access
File
Chromosomes
Renal Cell Carcinoma
Microsatellite Repeats
Standardization
Decision making
126 Citations (Scopus)
129 Downloads (Pure)

Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients

Gill, A. J., Hes, O., Papathomas, T., Sedivcová, M., Tan, P. H., Agaimy, A., Andresen, P. A., Kedziora, A., Clarkson, A., Toon, C. W., Sioson, L., Watson, N., Chou, A., Paik, J., Clifton-Bligh, R. J., Robinson, B. G., Benn, D. E., Hills, K., Maclean, F., Niemeijer, N. D. & 18 others, Vlatkovic, L., Hartmann, A., Corssmit, E. P. M., van Leenders, G. J. L. H., Przybycin, C., McKenney, J. K., Magi-Galluzzi, C., Yilmaz, A., Yu, D., Nicoll, K. D., Yong, J. L., Sibony, M., Yakirevich, E., Fleming, S., Chow, C. W., Miettinen, M., Michal, M. & Trpkov, K., Dec 2014, In : American Journal of Surgical Pathology. 38, 12, p. 1588-1602 15 p.

Research output: Contribution to journalArticle

Open Access
File
Succinate Dehydrogenase
Carcinoma
Kidney
Neoplasms
Germ-Line Mutation
2013

Complementation of juxtaglomerular cell granulation in Ren-1d null mice by human renin

Buckley, C., Nelson, R., Sharp, M., Flemming, S., Kenyon, C., Mullins, L., Steppan, D. & Mullins, J., Apr 2013, In : FASEB Journal. 27, Suppl., 1 p., 1165.20.

Research output: Contribution to journalMeeting abstract

15 Citations (Scopus)

Generation and characterisation of keratin 7 (K7) knockout mice

Sandilands, A., Smith, F. J. D., Lunny, D. P., Campbell, L. E., Davidson, K. M., MacCallum, S. F., Corden, L. D., Christie, L., Fleming, S., Lane, E. B. & McLean, W. H. I., 31 May 2013, In : PLoS ONE. 8, 5, 11 p., e64404.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations

Trpkov, K., Grignon, D. J., Bonsib, S. M., Amin, M. B., Billis, A., Lopez-Beltran, A., Samaratunga, H., Tamboli, P., Delahunt, B., Egevad, L., Montironi, R., Srigley, J. R. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1505–1517 13 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Pathology
Kidney
Neoplasms
Fats
103 Citations (Scopus)

Renal tumors: diagnostic and prognostic biomarkers

Tan, P. H., Cheng, L., Rioux-Leclercq, N., Merino, M. J., Netto, G., Reuter, V. E., Shen, S. S., Grignon, D. J., Montironi, R., Egevad, L., Srigley, J. R., Delahunt, B., Moch, H. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1518–1531 14 p.

Research output: Contribution to journalArticle

Biomarkers
Kidney
Renal Cell Carcinoma
Neoplasms
Immunohistochemistry
306 Citations (Scopus)

The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters

Delahunt, B., Cheville, J. C., Martignoni, G., Humphrey, P. A., Magi-Galluzzi, C., McKenney, J., Egevad, L., Algaba, F., Moch, H., Grignon, D. J., Montrioni, R., Srigley, J. R. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1490–1504 15 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Pathology
Neoplasms
Carcinoma
Necrosis
530 Citations (Scopus)

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley, J. R., Delahunt, B., Eble, J. N., Egevad, L., Epstein, J. I., Grignon, D., Hes, O., Moch, H., Montironi, R., Tickoo, S. K., Zhou, M., Argani, P. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1469-89 21 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Pathology
Kidney
Neoplasms
Leiomyomatosis

The use of steroids in acute tubulo-interstitial nephritis. A multicentre retrospective study

Hetherington, L., Valluri, A., McQuarrie, E., Fleming, S., Geddes, C., Bell, S. & MacKinnon, B., May 2013, In : Nephrology Dialysis Transplantation. 28, supp. 1, p. i343-i343 1 p., MP145.

Research output: Contribution to journalMeeting abstract

3 Citations (Scopus)

Translocation renal cell carcinomas: an evolving entity and a member of the microphthalmia transcription factor-associated family of tumors

Bambury, R. M., Battley, J. E., McCarthy, A., Brady, C., O'Reilly, S., Kelly, P. J., O'Brien, F., Sweeney, P., Fleming, S., Mayer, N. J. & Power, D. G., Sep 2013, In : Clinical Genitourinary Cancer. 11, 3, p. 357-361 5 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Renal Cell Carcinoma
Transcription Factors
Neoplasms
Alveolar Soft Part Sarcoma
2012
45 Citations (Scopus)

Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B., 15 Feb 2012, In : Biochemical Journal. 442, p. 151-159 9 p.

Research output: Contribution to journalArticle

Phaeochromocytomas associated with PTEN mutation demonstarate tissue specificity in the anti-tumour effect of mTOR inhibition

Taggart, C. & Fleming, S., Sep 2012, In : Journal of Pathology. 228, Suppl. 1, p. S37-S37 1 p.

Research output: Contribution to journalMeeting abstract

65 Citations (Scopus)

Phenformin as prophylaxis and therapy in breast cancer xenografts

Appleyard, M. V. C. L., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R. & Thompson, A. M., 13 Mar 2012, In : British Journal of Cancer. 106, 6, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

2011
31 Citations (Scopus)

11 beta Hydroxysteroid Dehydrogenase Type 2 is a Key Component of Neoangiogenesis in Renal Carcinoma and Glioma

Galbraith, S., Gallacher, M., Smith, C., Christie, L. & Fleming, S., Jul 2011, In : Journal of Pathology. 224, S2, p. S33-S33 1 p.

Research output: Contribution to journalSpecial issue

A Comparison of WT1, PTEN and the AKT Pathway in Ovarian Serous Carcinoma vs. Colorectal Adenocarcinoma

Gallacher, M. A. & Fleming, S., Jul 2011, In : Journal of Pathology. 224, S2, p. S24-S24 1 p.

Research output: Contribution to journalSpecial issue

37 Citations (Scopus)

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

Miller, G., Matthews, S. P., Reinheckel, T., Fleming, S. & Watts, C., May 2011, In : FASEB Journal. 25, 5, p. 1606-1617 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L., 29 Mar 2011, In : British Journal of Cancer. 104, 7, p. 1116-1125 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R., Jan 2011, In : Disease Models & Mechanisms. 4, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Renal Tumors Associated With Germline SDHB Mutation Show Distinctive Morphology

Gill, A. J., Pachter, N. S., Chou, A., Young, B., Clarkson, A., Tucker, K. M., Winship, I. M., Earls, P., Benn, D. E., Robinson, B. G., Fleming, S. & Clifton-Bligh, R. J., Oct 2011, In : American Journal of Surgical Pathology. 35, 10, p. 1578-1585 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The D153del Mutation in GNB3 Gene Causes Tissue Specific Signalling Patterns and an Abnormal Renal Morphology in Rge Chickens

Tummala, H., Fleming, S., Hocking, P. M., Wehner, D., Naseem, Z., Ali, M., Inglehearn, C. F., Zhelev, N. & Lester, D. H., 22 Aug 2011, In : PLoS ONE. 6, 8, p. - 11 p., e21156.

Research output: Contribution to journalArticle