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Author

  • Stewart Fleming
2019

Dataset for the reporting of carcinoma of renal tubular origin: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Delahunt, B., Srigley, J. R., Judge, M. J., Amin, M. B., Billis, A., Camparo, P., Evans, A. J., Fleming, S., Griffiths, D. F., Lopez-Beltran, A., Martignoni, G., Moch, H., Nacey, J. N. & Zhou, M., Feb 2019, In : Histopathology. 74, 3, p. 377-390 14 p.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
175 Downloads (Pure)

Periprostatic Fat Adipokines Expression Correlated with Prostate Cancer Aggressiveness in Men Undergoing Radical Prostatectomy for Clinically Localised Disease

Dahran, N., Szewczyk-Bieda, M., Vinnicombe, S., Fleming, S. & Nabi, G., Jun 2019, In : BJU International. 123, 6, p. 985-994 10 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
110 Downloads (Pure)
2018

Challenges in Pathologic Staging of Renal Cell Carcinoma: A Study of Interobserver Variability Among Urologic Pathologists

Williamson, S. R., Rao, P., Hes, O., Epstein, J. I., Smith, S. C., Picken, M. M., Zhou, M., Tretiakova, M. S., Tickoo, S. K., Chen, Y-B., Reuter, V. E., Fleming, S., Maclean, F. M., Gupta, N. S., Kuroda, N., Delahunt, B., Mehra, R., Przybycin, C. G., Cheng, L., Eble, J. N. & 11 others, Grignon, D. J., Moch, H., Lopez, J. I., Kunju, L. P., Tamboli, P., Srigley, J. R., Amin, M. B., Martignoni, G., Hirsch, M. S., Bonsib, S. M. & Trpkov, K., Sep 2018, In : American Journal of Surgical Pathology. 42, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Phenotypic dissection of the mouse Ren-1(d) knockout by complementation with human renin

Buckley, C., Nelson, R. J., Mullins, L. J., Sharp, M. G. F., Fleming, S., Kenyon, C. J., Semprini, S., Steppan, D., Peti-Peterdi, J., Kurtz, A., Christian, H. & Mullins, J. J., 26 Jan 2018, In : Journal of Biological Chemistry. 293, 4, p. 1151-1162 12 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
169 Downloads (Pure)
2017

Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists

Williamson, S. R., Gadde, R., Trpkov, K., Hirsch, M. S., Srigley, J. R., Reuter, V. E., Cheng, L., Priya Kunju, L., Barod, R., Rogers, C. G., Delahunt, B., Hes, O., Eble, J. N., Zhou, M., McKenney, J. K., Martignoni, G., Fleming, S., Grignon, D. J., Moch, H. & Gupta, N. S., May 2017, In : Human Pathology. 63, p. 149-156 8 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
180 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
116 Downloads (Pure)

Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography

Rossi, S. H., Hsu, R., Blick, C., Goh, V., Nathan, P., Nicol, D., Fleming, S., Sweeting, M., Wilson, E. C. F. & Stewart, G. D., May 2017, In : British Journal of Surgery. 104, 6, p. 648-659 12 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Multiple socioeconomic deprivation and impact on survival in patients with primary glomerulonephritis

McQuarrie, E. P., Mackinnon, B., Bell, S., Fleming, S., McNeice, V., Stewart, G., Fox, J. G., Geddes, C. C. & on behalf of the Scottish Renal Biopsy Registry, Feb 2017, In : Clinical Kidney Journal. 10, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
120 Downloads (Pure)

Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature

Aird, J. J., Nic An Riogh, A. U., Fleming, S., Hislop, R. G., Sweeney, P. & Mayer, N., 1 Dec 2017, In : International Journal of Surgical Pathology. 28, 8, p. 745-750 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Palmer, S., Litvinova, K., Dunaev, A., Fleming, S., McGloin, D. & Nabi, G., 7 Mar 2016, In : Biomedical Optics Express. 7, 4, p. 1193-2000 8 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
176 Downloads (Pure)

Microsatellite alteration and immunohistochemical expression profile of chromosome 9p21 in patients with sporadic renal cell carcinoma following surgical resection.

El-Mokadem, I., Alison, L., Kidd, T., Garret, K., Pratt, N., Batty, G. D., Fleming, S. & Nabi, G., 31 Jul 2016, In : BMC Cancer. 16, p. 1-10 10 p., 546.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
170 Downloads (Pure)

Renal squamous cell carcinoma of a native kidney after renal transplant: a case report

Jakes, A., Jani, P., Menon, M., Adams, K., Edey, M., Fleming, S. & Bhandari, S., 2016, In : Transplantation Proceedings. 48, 1, p. 259-261 3 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
168 Downloads (Pure)

Tumour suppressor gene (CDKNA2) status on chromosome 9p in resected renal tissue improves prognosis of localised kidney cancer

El-Mokadem, I., Kidd, T., Pratt, N., Fleming, S. & Nabi, G., 22 Sep 2016, In : Oncotarget. 7, 45, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
141 Downloads (Pure)
2015

Acute tubulointerstitial nephritis in Scotland

Valluri, A., Hetherington, L., McQuarrie, E., Fleming, S., Kipgen, D., Geddes, C. C., Mackinnon, B. & Bell, S., 2015, In : QJM : an International Journal of Medicine. 108, 7, p. 527-532 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Distal nephron neoplasms

Fleming, S., Mar 2015, In : Seminars in Diagnostic Pathology. 32, 2, p. 114-123 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Idiopathic hypocomplementemic interstitial nephritis

Kidder, D., Stewart, G. A., Furrie, E. & Fleming, S., Feb 2015, In : Kidney International. 87, 2, p. 485-486 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Kidney biopsy findings in primary Sjogren syndrome

Kidder, D., Rutherford, E., Kipgen, D., Fleming, S., Geddes, C. & Stewart, G. A., 2015, In : Nephrology Dialysis Transplantation. 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Cardaci, S., Zheng, L., Mackay, G., van den Broek, N. J. F., MacKenzie, E. D., Nixon, C., Stevenson, D., Tumanov, S., Bulusu, V., Kamphorst, J. J., Vazquez, A., Fleming, S., Schiavi, F., Kalna, G., Blyth, K., Strathdee, D. & Gottlieb, E., 24 Aug 2015, In : Nature Cell Biology. 17, 10, p. 1317-1326 13 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

Kovac, M., Navas, C., Horswell, S., Salm, M., Bardella, C., Rowan, A., Stares, M., Castro-Giner, F., Fisher, R., de Bruin, E. C., Kovacova, M., Gorman, M., Makino, S., Williams, J., Jaeger, E., Jones, A., Howarth, K., Larkin, J., Pickering, L., Gore, M. & 25 others, Nicol, D. L., Hazell, S., Stamp, G., O'Brien, T., Challacombe, B., Matthews, N., Phillimore, B., Begum, S., Rabinowitz, A., Varela, I., Chandra, A., Horsfield, C., Polson, A., Tran, M., Bhatt, R., Terracciano, L., Eppenberger-Castori, S., Protheroe, A., Maher, E., El Bahrawy, M., Fleming, S., Ratcliffe, P., Heinimann, K., Swanton, C. & Tomlinson, I., 19 Mar 2015, In : Nature Communications. 6, 11 p., 6336.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2014

Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery

El-Mokadem, I., Fitzpatrick, J., Bondad, J., Rauchhaus, P., Cunningham, J., Pratt, N., Fleming, S. & Nabi, G., 23 Sep 2014, In : British Journal of Cancer. 111, 7, p. 1381-1390 10 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
140 Downloads (Pure)

Evidence for aldosterone-dependent growth of renal cell carcinoma

King, S., Bray, S., Galbraith, S., Christie, L. & Fleming, S., Aug 2014, In : International Journal of Experimental Pathology. 95, 4, p. 244-250 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G., 2014, In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
160 Downloads (Pure)

Risk of AKI with gentamicin as surgical prophylaxis

Bell, S., Davey, P., Nathwani, D., Marwick, C., Vadiveloo, T., Sneddon, J., Patton, A., Bennie, M., Fleming, S. & Donnan, P. T., Nov 2014, In : Journal of the American Society of Nephrology. 25, 11, p. 2625-2632 8 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Signalling pathways in succinate dehydrogenase B-associated renal carcinoma

Fleming, S., Mayer, N. J., Vlatkovic, L. J., McLean, J., McConachie, M. & Baty, D., Mar 2014, In : Histopathology. 64, 4, p. 477-483 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Significance of chromosome 9p status in renal cell carcinoma: a systematic review and quality of the reported studies

El-Mokadem, I., Fitzpatrick, J., Rai, B., Cunningham, J., Pratt, N., Fleming, S. & Nabi, G., 2014, In : BioMed Research International. 2014, 11 p., 521380.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
114 Downloads (Pure)

Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients

Gill, A. J., Hes, O., Papathomas, T., Sedivcová, M., Tan, P. H., Agaimy, A., Andresen, P. A., Kedziora, A., Clarkson, A., Toon, C. W., Sioson, L., Watson, N., Chou, A., Paik, J., Clifton-Bligh, R. J., Robinson, B. G., Benn, D. E., Hills, K., Maclean, F., Niemeijer, N. D. & 18 others, Vlatkovic, L., Hartmann, A., Corssmit, E. P. M., van Leenders, G. J. L. H., Przybycin, C., McKenney, J. K., Magi-Galluzzi, C., Yilmaz, A., Yu, D., Nicoll, K. D., Yong, J. L., Sibony, M., Yakirevich, E., Fleming, S., Chow, C. W., Miettinen, M., Michal, M. & Trpkov, K., Dec 2014, In : American Journal of Surgical Pathology. 38, 12, p. 1588-1602 15 p.

Research output: Contribution to journalArticle

Open Access
File
133 Citations (Scopus)
152 Downloads (Pure)
2013

Complementation of juxtaglomerular cell granulation in Ren-1d null mice by human renin

Buckley, C., Nelson, R., Sharp, M., Flemming, S., Kenyon, C., Mullins, L., Steppan, D. & Mullins, J., Apr 2013, In : FASEB Journal. 27, Suppl., 1 p., 1165.20.

Research output: Contribution to journalMeeting abstract

Generation and characterisation of keratin 7 (K7) knockout mice

Sandilands, A., Smith, F. J. D., Lunny, D. P., Campbell, L. E., Davidson, K. M., MacCallum, S. F., Corden, L. D., Christie, L., Fleming, S., Lane, E. B. & McLean, W. H. I., 31 May 2013, In : PLoS ONE. 8, 5, 11 p., e64404.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations

Trpkov, K., Grignon, D. J., Bonsib, S. M., Amin, M. B., Billis, A., Lopez-Beltran, A., Samaratunga, H., Tamboli, P., Delahunt, B., Egevad, L., Montironi, R., Srigley, J. R. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1505–1517 13 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Renal tumors: diagnostic and prognostic biomarkers

Tan, P. H., Cheng, L., Rioux-Leclercq, N., Merino, M. J., Netto, G., Reuter, V. E., Shen, S. S., Grignon, D. J., Montironi, R., Egevad, L., Srigley, J. R., Delahunt, B., Moch, H. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1518–1531 14 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters

Delahunt, B., Cheville, J. C., Martignoni, G., Humphrey, P. A., Magi-Galluzzi, C., McKenney, J., Egevad, L., Algaba, F., Moch, H., Grignon, D. J., Montrioni, R., Srigley, J. R. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1490–1504 15 p.

Research output: Contribution to journalArticle

331 Citations (Scopus)

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley, J. R., Delahunt, B., Eble, J. N., Egevad, L., Epstein, J. I., Grignon, D., Hes, O., Moch, H., Montironi, R., Tickoo, S. K., Zhou, M., Argani, P. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1469-89 21 p.

Research output: Contribution to journalArticle

612 Citations (Scopus)

The use of steroids in acute tubulo-interstitial nephritis. A multicentre retrospective study

Hetherington, L., Valluri, A., McQuarrie, E., Fleming, S., Geddes, C., Bell, S. & MacKinnon, B., May 2013, In : Nephrology Dialysis Transplantation. 28, supp. 1, p. i343-i343 1 p., MP145.

Research output: Contribution to journalMeeting abstract

Translocation renal cell carcinomas: an evolving entity and a member of the microphthalmia transcription factor-associated family of tumors

Bambury, R. M., Battley, J. E., McCarthy, A., Brady, C., O'Reilly, S., Kelly, P. J., O'Brien, F., Sweeney, P., Fleming, S., Mayer, N. J. & Power, D. G., Sep 2013, In : Clinical Genitourinary Cancer. 11, 3, p. 357-361 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2012

Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B., 15 Feb 2012, In : Biochemical Journal. 442, p. 151-159 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Phaeochromocytomas associated with PTEN mutation demonstarate tissue specificity in the anti-tumour effect of mTOR inhibition

Taggart, C. & Fleming, S., Sep 2012, In : Journal of Pathology. 228, Suppl. 1, p. S37-S37 1 p.

Research output: Contribution to journalMeeting abstract

Phenformin as prophylaxis and therapy in breast cancer xenografts

Appleyard, M. V. C. L., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R. & Thompson, A. M., 13 Mar 2012, In : British Journal of Cancer. 106, 6, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2011

11 beta Hydroxysteroid Dehydrogenase Type 2 is a Key Component of Neoangiogenesis in Renal Carcinoma and Glioma

Galbraith, S., Gallacher, M., Smith, C., Christie, L. & Fleming, S., Jul 2011, In : Journal of Pathology. 224, S2, p. S33-S33 1 p.

Research output: Contribution to journalSpecial issue

32 Citations (Scopus)

A Comparison of WT1, PTEN and the AKT Pathway in Ovarian Serous Carcinoma vs. Colorectal Adenocarcinoma

Gallacher, M. A. & Fleming, S., Jul 2011, In : Journal of Pathology. 224, S2, p. S24-S24 1 p.

Research output: Contribution to journalSpecial issue

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

Miller, G., Matthews, S. P., Reinheckel, T., Fleming, S. & Watts, C., May 2011, In : FASEB Journal. 25, 5, p. 1606-1617 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L., 29 Mar 2011, In : British Journal of Cancer. 104, 7, p. 1116-1125 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R., Jan 2011, In : Disease Models & Mechanisms. 4, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Renal Tumors Associated With Germline SDHB Mutation Show Distinctive Morphology

Gill, A. J., Pachter, N. S., Chou, A., Young, B., Clarkson, A., Tucker, K. M., Winship, I. M., Earls, P., Benn, D. E., Robinson, B. G., Fleming, S. & Clifton-Bligh, R. J., Oct 2011, In : American Journal of Surgical Pathology. 35, 10, p. 1578-1585 8 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

The D153del Mutation in GNB3 Gene Causes Tissue Specific Signalling Patterns and an Abnormal Renal Morphology in Rge Chickens

Tummala, H., Fleming, S., Hocking, P. M., Wehner, D., Naseem, Z., Ali, M., Inglehearn, C. F., Zhelev, N. & Lester, D. H., 22 Aug 2011, In : PLoS ONE. 6, 8, p. - 11 p., e21156.

Research output: Contribution to journalArticle

7 Citations (Scopus)