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2020
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L., Bloom, H. L. & 31 others, Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Dunn, M. E., Engström, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Mordi, I. R., Morris, A. D., Morris, A. P., Palmer, C. N. A., Parry, H. M., Smith, N. L., Veluchamy, A., McMurray, J. J. V., Lang, C. C. & Lumbers, R. T., 9 Jan 2020, In : Nature Communications. 11, 1, p. 1-12 12 p., 163.

Research output: Contribution to journalArticle

Open Access
File
Mendelian Randomization Analysis
pathogenesis
genome
Heart Failure
Genes
11 Downloads (Pure)

The impact of phenotype, ethnicity and genotype on progression of Type 2 diabetes mellitus

Thakarakkattil Narayanan Nair, A., Donnelly, L. A., Dawed, A. Y., Gan, S., Anjana, R. M., Mohan, V., Palmer, C. & Pearson, E., 7 Jan 2020, In : Endocrinology, Diabetes & Metabolism. 11 p., e00108.

Research output: Contribution to journalArticle

Open Access
File
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Insulin Resistance
Genotype
Insulin
2019

ADRB2 haplotypes and risk of exacerbations in asthmatic children and young adults treated with long-acting beta 2-agonists: A meta-analysis in the PiCA consortium

Karimi, L., Vijverberg, S. J., Engelkes, M., Hernandez-Pacheco, N., Farzan, N., Soares, P., Francis, B. R., Pino-Yanes, M., Eng, C., Mukhopadhyay, S., Schieck, M., Kabesch, M., Burchard, E. G., Palmer, C. N. A., Turner, S. W., Janssens, H. M., Maitland-Van Der Zee, A-H. & Verhamme, K. M. C., 21 Nov 2019, In : European Respiratory Journal. 54, 63, PA5388.

Research output: Contribution to journalMeeting abstract

A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity

Meng, W., Chan, B., Ezeonwumelu, C., Hebert, H., Campbell, A., Soler, V. & Palmer, C., 2 Jul 2019, In : Ophthalmic Genetics. 40, 3, p. 252-258 7 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Visual Acuity
Health
Genes
Genome
20 Downloads (Pure)

Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine

Cowan, K., MacLuskie, G., Finch, M., Palmer, C. N. A., Hair, J., Bylesjo, M., Lynagh, S., Brankin, P., McNeil, M., Low, C., Mallinson, D., Gourlay, E. M., Child, H., Cheyne, L. & Bunton, D. C., 20 Dec 2019, In : PLoS ONE. 14, 12, p. 1-15 15 p., e0226564.

Research output: Contribution to journalArticle

Open Access
File
pharmacogenomics
Precision Medicine
Pharmacogenetics
Bioinformatics
Computational Biology
38 Downloads (Pure)

Associations of autozygosity with a broad range of human phenotypes

Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M. & 416 others, Baumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J-F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M-L., Chen, G., Chen, Y-D. I., Chen, Z., Chiu, Y-F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y-J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K-T., Khor, C. C., de Kleijn, D. P. V., Koh, W-P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I-T., Lee, W-J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P-E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H-H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y-C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J-M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C-Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C-K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O'connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E-S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D-A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T-Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 31 Oct 2019, In : Nature Communications. 10, 1, p. 1-17 17 p., 4957.

Research output: Contribution to journalArticle

Open Access
File
phenotype
Phenotype
Inbreeding
social factors
fertility
6 Citations (Scopus)
276 Downloads (Pure)

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 208-214 7 p.

Research output: Contribution to journalArticle

Open Access
File
Type 1 Diabetes Mellitus
Autoantibodies
Type 2 Diabetes Mellitus
Insulin
Therapeutics
31 Downloads (Pure)

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Romagnoni, A., Jégou, S., Van Steen, K., Wainrib, G. & Hugot, J-P., 17 Jul 2019, In : Scientific Reports. 9, 1, p. 1-18 18 p., 10351.

Research output: Contribution to journalArticle

Open Access
File
Crohn Disease
Genome
Logistic Models
ROC Curve
Area Under Curve
2 Citations (Scopus)

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

Noordam, R., Young, W. J., Salman, R., Kanters, J. K., van den Berg, M. E., van Heemst, D., Lin, H. J., Barreto, S. M., Biggs, M. L., Biino, G., Catamo, E., Concas, M. P., Ding, J., Evans, D. S., Foco, L., Grarup, N., Lyytikäinen, L. P., Mangino, M., Mei, H., van der Most, P. J. & 83 others, Müller-Nurasyid, M., Nelson, C. P., Qian, Y., Repetto, L., Said, M. A., Shah, N., Schramm, K., Vidigal, P. G., Weiss, S., Yao, J., Zilhao, N. R., Brody, J. A., Braund, P. S., Brumat, M., Campana, E., Christofidou, P., Caulfield, M. J., De Grandi, A., Dominiczak, A. F., Doney, A. S. F., Eiriksdottir, G., Ellervik, C., Giatti, L., Gögele, M., Graff, C., Guo, X., van der Harst, P., Joshi, P. K., Kähönen, M., Kestenbaum, B., Lima-Costa, M. F., Linneberg, A., Maan, A. C., Meitinger, T., Padmanabhan, S., Pattaro, C., Peters, A., Petersmann, A., Sever, P., Sinner, M. F., Shen, X., Stanton, A., Strauch, K., Soliman, E. Z., Tarasov, K. V., Taylor, K. D., Thio, C. H. L., Uitterlinden, A. G., Vaccargiu, S., Waldenberger, M., Robino, A., Correa, A., Cucca, F., Cummings, S. R., Dörr, M., Girotto, G., Gudnason, V., Hansen, T., Heckbert, S. R., Juhl, C. R., Kääb, S., Lehtimäki, T., Liu, Y., Lotufo, P. A., Palmer, C. N. A., Pirastu, M., Pramstaller, P. P., Ribeiro, A. L. P., Rotter, J. I., Samani, N. J., Snieder, H., Spector, T. D., Stricker, B. H., Verweij, N., Wilson, J. F., Wilson, J. G., Jukema, J. W., Tinker, A., Newton-Cheh, C. H., Sotoodehnia, N., Mook-Kanamori, D. O., Munroe, P. B. & Warren, H. R., 25 Jun 2019, In : Journal of the American College of Cardiology. 73, 24, p. 3118-3131 14 p.

Research output: Contribution to journalArticle

Cardiac Electrophysiology
Magnesium
Electrolytes
Potassium
Calcium
1 Citation (Scopus)
43 Downloads (Pure)

Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis

Trenkwalder, T., Nelson, C. P., Musameh, M. D., Mordi, I. R., Kessler, T., Pellegrini, C., Debiec, R., Rheude, T., Lazovic, V., Zeng, L., Martinsson, A., Gustav Smith, J., Gådin, J. R., Franco-Cereceda, A., Eriksson, P., Nielsen, J. B., Graham, S. E., Willer, C. J., Hveem, K., Kastrati, A. & 9 others, Braund, P. S., Palmer, C. N. A., Aracil, A., Husser, O., Koenig, W., Schunkert, H., Lang, C. C., Hengstenberg, C. & Samani, N. J., 1 Feb 2019, In : International journal of cardiology. 276, p. 212-217 6 p.

Research output: Contribution to journalArticle

Open Access
File
Aortic Valve Stenosis
Coronary Artery Disease
Alleles
Meta-Analysis
21 Citations (Scopus)
64 Downloads (Pure)

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Flannick, J., Mercader, J. M., Fuchsberger, C., Udler, M. S., Mahajan, A., Wessel, J., Teslovich, T. M., Caulkins, L., Koesterer, R., Barajas-Olmos, F., Blackwell, T. W., Boerwinkle, E., Brody, J. A., Centeno-Cruz, F., Chen, L., Chen, S., Contreras-Cubas, C., Córdova, E., Correa, A., Cortes, M. & 30 others, DeFronzo, R. A., Dolan, L., Drews, K. L., Elliott, A., Floyd, J. S., Gabriel, S., Garay-Sevilla, M. E., García-Ortiz, H., Gross, M., Han, S., Heard-Costa, N. L., Jackson, A. U., Jørgensen, M. E., Kang, H. M., Kelsey, M., Kim, B-J., Koistinen, H. A., Kuusisto, J., Leader, J. B., Linneberg, A., Liu, C-T., Liu, J., Lyssenko, V., Manning, A. K., Marcketta, A., Malacara-Hernandez, J. M., Morris, A. D., Palmer, C. N. A., Scott, L. J. & Morris, A. P., Jun 2019, In : Nature. 570, 7759, p. 71-76 6 p.

Research output: Contribution to journalArticle

Open Access
File
Exome
Type 2 Diabetes Mellitus
Genes
Gene Knockout Techniques
Gene Frequency
39 Downloads (Pure)

Genetic correlations between pain phenotypes and depression and neuroticism

Meng, W., Adams, M. J., Reel, P., Rajendrakumar, A., Huang, Y., Deary, I. J., Palmer, C. N. A., McIntosh, A. M. & Smith, B. H., 29 Oct 2019, In : European Journal of Human Genetics. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Depression
Phenotype
Pain
Linkage Disequilibrium
Major Depressive Disorder
1 Citation (Scopus)
41 Downloads (Pure)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Wilman, H. R., Parisinos, C. A., Atabaki-Pasdar, N., Kelly, M., Thomas, E. L., Neubauer, S., Mahajan, A., Hingorani, A. D., Patel, R. S., Hemingway, H., Franks, P. W., Bell, J. D., Banerjee, R. & Yaghootkar, H., Sep 2019, In : Journal of Hepatology. 71, 3, p. 594-602 9 p.

Research output: Contribution to journalArticle

Open Access
File
Hepcidins
Iron
Liver
Genes
Abdominal Obesity
2 Citations (Scopus)
32 Downloads (Pure)

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen

SUMMIT Consortium, GENIE Consortium, Salem, R. M., Todd, J. N., Sandholm, N., Cole, J. B., Chen, W-M., Andrews, D., Pezzolesi, M. G., McKeigue, P. M., Hiraki, L. T., Qiu, C., Nair, V., Di Liao, C., Cao, J. J., Valo, E., Onengut-Gumuscu, S., Smiles, A. M., McGurnaghan, S. J., Haukka, J. K. & 33 others, Harjutsalo, V., Brennan, E. P., van Zuydam, N., Ahlqvist, E., Doyle, R., Ahluwalia, T. S., Lajer, M., Hughes, M. F., Park, J., Skupien, J., Spiliopoulou, A., Liu, A., Menon, R., Boustany-Kari, C. M., Kang, H. M., Nelson, R. G., Klein, R., Klein, B. E., Lee, K. E., Gao, X., Mauer, M., Maestroni, S., Caramori, M. L., de Boer, I. H., Miller, R. G., Guo, J., Boright, A. P., Tregouet, D., Gyorgy, B., Palmer, C. N. A., Colhoun, H. M., Paterson, A. D. & Florez, J. C., 1 Oct 2019, In : Journal of the American Society of Nephrology. 30, 10, p. 2000-2016 17 p.

Research output: Contribution to journalArticle

Open Access
File
Glomerular Basement Membrane
Genome-Wide Association Study
Diabetic Nephropathies
Collagen
Albuminuria
2 Citations (Scopus)
9 Downloads (Pure)

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

Hernandez-Pacheco, N., Farzan, N., Francis, B., Karimi, L., Repnik, K., Vijverberg, S. J., Soares, P., Schieck, M., Gorenjak, M., Forno, E., Eng, C., Oh, S. S., Pérez-Méndez, L., Berce, V., Tavendale, R., Samedy, L. A., Hunstman, S., Hu, D., Meade, K., Farber, H. J. & 21 others, Avila, P. C., Serebrisky, D., Thyne, S. M., Brigino-Buenaventura, E., Rodriguez-Cintron, W., Sen, S., Kumar, R., Lenoir, M., Rodriguez-Santana, J. R., Celedón, J. C., Mukhopadhyay, S., Potočnik, U., Pirmohamed, M., Verhamme, K. M., Kabesch, M., Palmer, C. N. A., Hawcutt, D. B., Flores, C., van der Zee, A. H. M., Burchard, E. G. & Pino-Yanes, M., Jun 2019, In : Clinical and Experimental Allergy. 49, 6, p. 789-798 10 p.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Adrenal Cortex Hormones
Asthma
Hispanic Americans
Population
53 Downloads (Pure)

Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank

Meng, W., Adams, M. J., Palmer, C. N. A., 23andMe Research Team, Shi, J., Auton, A., Ryan, K. A., Jordan, J. M., Mitchell, B. D., Jackson, R. D., Yau, M. S., McIntosh, A. M. & Smith, B. H., 28 Aug 2019, In : Communications Biology. 2, p. 1-8 8 p., 321.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Knee
Pain
Osteoarthritis
Knee Osteoarthritis

Investigating the Relationship Between Type 2 Diabetes and Dementia Using Electronic Medical Records in the GoDARTS Bioresource

Doney, A. S. F., Bonney, W., Jefferson, E., Walesby, K. E., Bittern, R., Trucco, E., Connelly, P., McCrimmon, R. J. & Palmer, C. N. A., Oct 2019, In : Diabetes Care. 42, 10, p. 1973-1980 8 p.

Research output: Contribution to journalArticle

Electronic Health Records
Scotland
Type 2 Diabetes Mellitus
Dementia
Vascular Dementia

Meta-analysis of inhaled corticosteroids response in children with asthma

Hernandez-Pacheco, N., Vijverberg, S. J., Gorenjak, M., Flores, C., Francis, B., Farzan, N., Corrales, A., Karimi, L., Maroteau, C., Schieck, M., Repnik, K., Perez-Mendez, L., Soares, P., Berce, V., Tavendale, R., Sardon, O., Corcuera, P., Korta, J., Mukhopadhyay, S., Pirmohamed, M. & 8 others, Mc Verhamme, K., Kabesch, M., Hawcutt, D. B., Turner, S., Palmer, C. N., Potocnik, U., Maitland-Van Der Zee, A. H. & Pino-Yanes, M., 28 Sep 2019, In : European Respiratory Journal. 54, 63, PA5434.

Research output: Contribution to journalMeeting abstract

3 Citations (Scopus)
45 Downloads (Pure)

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S., Boehnke, M. & 32 others, Bots, M. L., Brazel, D. M., Chambers, J. C., Chang-Claude, J., Chen, C., Corley, J., Chou, Y. L., David, S. P., de Boer, R. A., de Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Smith, J. A., Zhou, K., Palmer, C. N. A., Liu, D. J. & Howson, J. M. M., 7 Jan 2019, In : Molecular Psychiatry. p. 1-18 18 p.

Research output: Contribution to journalArticle

Open Access
File
Genetic Loci
Meta-Analysis
Smoking
Nucleotides
Exome
6 Citations (Scopus)
179 Downloads (Pure)

Multiethnic Genome-wide Association Study of Diabetic Retinopathy using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Pollack, S., Igo, R. P., Jensen, R. A., Christiansen, M., Li, X., Cheng, C-Y., Ng, M. C. Y., Smith, A. V., Rossin, E. J., Segrè, A. V., Davoudi, S., Tan, G. S., Ida Chen, Y-D., Kuo, J. Z., Dimitrov, L. M., Stanwyck, L. K., Meng, W., Hosseini, S. M., Imamura, M., Nousome, D. & 33 others, Kim, J., Hai, Y., Jia, Y., Ahn, J., Leong, A., Shah, K., Park, K. H., Guo, X., Ipp, E., Taylor, K. D., Adler, S. G., Sedor, J. R., Freedman, B. I., Lee, I-T., H-H Sheu, W., Kubo, M., Takahashi, A., Hadjadj, S., Marre, M., Tregouet, D-A., Mckean-Cowdin, R., Varma, R., McCarthy, M. I., Groop, L., Ahlqvist, E., Morris, A., Doney, A., Colhoun, H. M., Mitchell, P., Paterson, A. D., Palmer, C., Price, A. & Sobrin, L., 21 Jan 2019, In : Diabetes. 68, 2, p. 441-456 16 p.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Diabetic Retinopathy
Gene Regulatory Networks
Hispanic Americans
African Americans
59 Downloads (Pure)

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease

Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P. K., Relan, D., Harris, S., Vaidya, S. S. ., Dhillon, B., Zhou, K., Pearson, E., Hayward, C., Polašek, O., Deary, I. J., MacGillivray, T. J., Wilson, J. F., Trucco, M., Palmer, C. & 1 others, Doney, A., Dec 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552 11 p.

Research output: Contribution to journalArticle

Open Access
File
Retinal Vessels
Genetic Loci
Coronary Artery Disease
Biomarkers
Genome-Wide Association Study
3 Citations (Scopus)
36 Downloads (Pure)

Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes

McKeigue, P. M., Spiliopoulou, A., McGurnaghan, S., Colombo, M., Blackbourn, L., McDonald, T. J., Onengut-Gomuscu, S., Rich, S. S., Palmer, C. N. A., McKnight, J. A., Strachan, M. W. J., Patrick, A. W., Chalmers, J., Lindsay, R. S., Petrie, J. R., Thekkepat, S., Collier, A., MacRury, S. & Colhoun, H. M., 23 Aug 2019, In : BMC Medicine. 17, 1, p. 1-11 11 p., 165.

Research output: Contribution to journalArticle

Open Access
File
C-Peptide
Type 1 Diabetes Mellitus
Age of Onset
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
1 Citation (Scopus)
43 Downloads (Pure)

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing

PREDICTION-ADR Consortium, EUDRAGENE, Floyd, J. S., Bloch, K. M., Brody, J. A., Maroteau, C., Siddiqui, M. K., Gregory, R., Carr, D. F., Molokhia, M., Liu, X., Bis, J. C., Ahmed, A., Liu, X., Hallberg, P., Yue, Q., Magnusson, P. K. E., Brisson, D., Wiggins, K. L., Morrison, A. C. & 23 others, Khoury, E., McKeigue, P., Stricker, B. H., Lapeyre-Mestre, M., Heckbert, S. R., Gallagher, A. M., Chinoy, H., Gibbs, R. A., Bondon-Guitton, E., Tracy, R., Boerwinkle, E., Gaudet, D., Conforti, A., Van Staa, T., Sitlani, C. M., Rice, K. M., Maitland-van der Zee, A., Wadelius, M., Morris, A. P., Pirmohamed, M., Palmer, C. N. A., Psaty, B. M. & Alfirevic, A., 26 Jun 2019, In : PLoS ONE. 14, 6, p. 1-13 13 p., e0218115.

Research output: Contribution to journalArticle

Open Access
File
pharmacogenomics
Exome
Hydroxymethylglutaryl-CoA Reductase Inhibitors
muscular diseases
Pharmacogenetics
22 Downloads (Pure)

PheGWAS: A new dimension to visualize GWAS across multiple phenotypes

George, G., Gan, S., Huang, Y., Appleby, P., Nar, A. S., Venkatesan, R., Mohan, V., Palmer, C. N. A. & Doney, A. S. F., 20 Dec 2019, In : Bioinformatics. 8 p., btz944.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Lipids
Phenotype
Genes
Single Nucleotide Polymorphism
1 Citation (Scopus)

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Harold, D., Connolly, S., Riley, B. P., Kendler, K. S., McCarthy, S. E., McCombie, W. R., Richards, A., Owen, M. J., O'Donovan, M. C., Walters, J., Wellcome Trust Case Control Consortium 2, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Donohoe, G., Gill, M., Corvin, A. & Morris, D. W., Apr 2019, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 223-231 9 p.

Research output: Contribution to journalArticle

Exome
Haplotypes
Genome-Wide Association Study
Schizophrenia
Population

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A. & 43 others, Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T., Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Campbell, P. T., Evangelou, E., Li, J., Mitchell, P., Morris, A. D., Morris, A. D., Palmer, C. N. A., Roberts, D. J., Scott, R. A., Wood, A. R., Hirschhorn, J. N. & Loos, R. J. F., 3 Jun 2019, In : Nature Genetics. 51, p. 1191-1192 2 p.

Research output: Contribution to journalArticle

Energy Intake
Energy Metabolism
Body Mass Index
Obesity
Proteins

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, Liu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journalMeeting abstract

Ireland
Metformin
Blood Pressure
Physicians
Left Ventricular Hypertrophy
12 Citations (Scopus)
103 Downloads (Pure)

Serum kidney injury molecule 1 and β2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes

Colombo, M., Looker, H. C., Farran, B., Hess, S., Groop, L., Palmer, C. N. A., Brosnan, M. J., Dalton, R. N., Wong, M., Turner, C., Ahlqvist, E., Dunger, D., Agakov, F., Durrington, P., Livingstone, S., Betteridge, D. J., McKeigue, P. M. & Colhoun, H. M., 1 Jan 2019, In : Diabetologia. 62, 1, p. 156-168 13 p.

Research output: Contribution to journalArticle

Open Access
File
Type 2 Diabetes Mellitus
Biomarkers
Kidney
Wounds and Injuries
Serum
3 Citations (Scopus)
98 Downloads (Pure)

Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium

Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., Direk, K., Åkerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehlschlegel, J. D., Allayee, H., Almgren, P., Alver, M., Baranova, E. V., Behlouli, H., Boeckx, B., Braund, P. S., Breitling, L. P. & 161 others, Delgado, G., Duarte, N. E., Dubé, M-P., Dufresne, L., Eriksson, N., Foco, L., Scholz, M., Gijsberts, C. M., Glinge, C., Gong, Y., Hartiala, J., Heydarpour, M., Hubacek, J. A., Kleber, M., Kofink, D., Kotti, S., Kuukasjärvi, P., Lee, V-V., Leiherer, A., Lenzini, P. A., Levin, D., Lyytikäinen, L-P., Martinelli, N., Mons, U., Nelson, C. P., Nikus, K., Pilbrow, A. P., Ploski, R., Sun, Y. V., Tanck, M. W. T., Tang, W. H. W., Trompet, S., van der Laan, S. W., Van Setten, J., Vilmundarson, R. O., Viviani Anselmi, C., Vlachopoulou, E., Al Ali, L., Boerwinkle, E., Briguori, C., Carlquist, J. F., Carruthers, K. F., Casu, G., Deanfield, J., Deloukas, P., Dudbridge, F., Engström, T., Fitzpatrick, N., Fox, K., Gigante, B., James, S., Lokki, M-L., Lotufo, P. A., Marziliano, N., Mordi, I. R., Muhlestein, J. B., Newton-Cheh, C., Pitha, J., Saely, C. H., Samman-Tahhan, A., Sandesara, P. B., Teren, A., Timmis, A., Van de Werf, F., Wauters, E., Wilde, A. A. M., Ford, I., Stott, D. J., Algra, A., Andreassi, M. G., Ardissino, D., Arsenault, B. J., Ballantyne, C. M., Bergmeijer, T. O., Bezzina, C. R., Body, S. C., Boersma, E. H., Bogaty, P., Bots, M., Brenner, H., Brugts, J. J., Burkhardt, R., Carpeggiani, C., Condorelli, G., Cooper-DeHoff, R. M., Cresci, S., Danchin, N., de Faire, U., Doughty, R. N., Drexel, H., Engert, J. C., Fox, K. A. A., Girelli, D., Grobbee, D. E., Hagström, E., Hazen, S. L., Held, C., Hemingway, H., Hoefer, I. E., Hovingh, G. K., Jabbari, R., Johnson, J. A., Jukema, J. W., Kaczor, M. P., Kähönen, M., Kettner, J., Kiliszek, M., Klungel, O. H., Lagerqvist, B., Lambrechts, D., Laurikka, J. O., Lehtimäki, T., Lindholm, D., Mahmoodi, B. K., Maitland-van der Zee, A. H., McPherson, R., Melander, O., Metspalu, A., Niemcunowicz-Janica, A., Olivieri, O., Opolski, G., Palmer, C. N., Pasterkamp, G., Pepine, C. J., Pereira, A. C., Pilote, L., Quyyumi, A. A., Richards, A. M., Sanak, M., Siegbahn, A., Simon, T., Sinisalo, J., Smith, J. G., Spertus, J. A., Stender, S., Stewart, A. F. R., Szczeklik, W., Szpakowicz, A., Tardif, J-C., Ten Berg, J. M., Tfelt-Hansen, J., Thanassoulis, G., Thiery, J., Torp-Pedersen, C., van der Graaf, Y., Visseren, F. L. J., Waltenberger, J., Weeke, P. E., Van der Harst, P., Lang, C. C., Sattar, N., Cameron, V. A., Anderson, J. L., Brophy, J. M., Paré, G., Horne, B. D., März, W., Wallentin, L., Samani, N. J., Hingorani, A. D. & Asselbergs, F. W., Apr 2019, In : Circulation: Genomic and Precision Medicine. 12, 4, p. 145-160 16 p., e002470.

Research output: Contribution to journalArticle

Open Access
File
Coronary Disease
Sex Ratio
Acute Coronary Syndrome
Secondary Prevention
Biomarkers
15 Citations (Scopus)
202 Downloads (Pure)

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Understanding Society Scientific Group, Giri, A., Hellwege, J. N., Keaton, J. M., Park, J., Qiu, C., Warren, H. R., Torstenson, E. S., Kovesdy, C. P., Sun, Y. V., Wilson, O. D., Robinson-Cohen, C., Roumie, C. L., Chung, C. P., Birdwell, K. A., Damrauer, S. M., DuVall, S. L., Klarin, D., Cho, K., Wang, Y. & 33 others, Evangelou, E., Cabrera, C. P., Wain, L. V., Shrestha, R., Mautz, B. S., Akwo, E. A., Sargurupremraj, M., Debette, S., Boehnke, M., Scott, L. J., Luan, J., Zhao, J-H., Willems, S. M., Thériault, S., Shah, N., Oldmeadow, C., Almgren, P., Li-Gao, R., Verweij, N., Boutin, T. S., Mangino, M., Ntalla, I., Feofanova, E., Surendran, P., Cook, J. P., Karthikeyan, S., Lahrouchi, N., Liu, C., Sepúlveda, N., Palmer, C. N. A., Wilson, P. W. F., Hung, A. M. & Edwards, T. L., Jan 2019, In : Nature Genetics. 51, 1, p. 51-62 12 p.

Research output: Contribution to journalArticle

Open Access
File
Blood Pressure
Veterans
Kidney Tubules
Genes
RNA Sequence Analysis
2018
5 Citations (Scopus)
98 Downloads (Pure)

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use

Farzan, N., Vijverberg, S. J., Hernandez-Pacheco, N., Bel, E. H. D., Berce, V., Bønnelykke, K., Bisgaard, H., Burchard, E. G., Canino, G., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Forno, E., Francis, B., Hawcutt, D. B., Herrera-Luis, E., Kabesch, M., Karimi, L., Melén, E. & 19 others, Mukhopadhyay, S., Merid, S. K., Palmer, C. N., Pino-Yanes, M., Munir, P., Potočnik, U., Repnik, K., Schieck, M., Sevelsted, A., Yang Yie, S., Smyth, R. L., Soares, P., Söderhäll, C., Tantisira, K. G., Tavendale, R., Sze Man, T., Turner, S., Verhamme, K. M. & Maitland-van der Zee, A-H., Oct 2018, In : Allergy. 73, 10, p. 2083-2088 6 p.

Research output: Contribution to journalLetter

Open Access
File
30 Citations (Scopus)
69 Downloads (Pure)

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Finnish Diabetic Nephropathy Study (FinnDiane), Surrogate Markers for Micro- and Macro-Vascular Hard Endpoints for Innovative Diabetes Tools (SUMMIT) Study Group, GENIE (GEnetics of Nephropathy an International Effort) Consortium, Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, Van Zuydam, N. R., Ahlqvist, E., Sandholm, N., Deshmukh, H., Rayner, N. W., Abdalla, M., Ladenvall, C., Ziemek, D., Fauman, E., Robertson, N. R., McKeigue, P. M., Valo, E., Forsblom, C., Harjutsalo, V., Perna, A., Rurali, E. & 65 others, Marcovecchio, M. L., Igo, R. P., Salem, R. M., Perico, N., Lajer, M., Käräjämäki, A., Imamura, M., Kubo, M., Takahashi, A., Sim, X., Liu, J., Van Dam, R. M., Jiang, G., Tam, C. H. T., Luk, A. O. Y., Lee, H. M., Lim, C. K. P., Szeto, C. C., So, W. Y., Chan, J. C. N., Ang, S. F., Dorajoo, R., Wang, L., Clara, T. S. H., McKnight, A. J., Duffy, S., Pezzolesi, M. G., Marre, M., Gyorgy, B., Hadjadj, S., Hiraki, L. T., Ahluwalia, T. S., Almgren, P., Schulz, C-A., Orho-Melander, M., Linneberg, A., Christensen, C., Witte, D. R., Grarup, N., Brandslund, I., Melander, O., Paterson, A. D., Trégouët, D-A., Maxwell, A. P., Lim, S. C., Ma, R. C. W., Tai, E. S., Maeda, S., Lyssenko, V., Tuomi, T., Krolewski, A., Rich, S. S., Hirschhorn, J. N., Florez, J. C., Dunger, D., Pedersen, O., Hansen, T., Rossing, P., Remuzzi, G., Brosnan, M. J., Palmer, C. N. A., Groop, P-H., Colhoun, H. M., Groop, L. C. & McCarthy, M. I., Jul 2018, In : Diabetes. 67, 7, p. 1414-1427 14 p.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Diabetic Nephropathies
Type 2 Diabetes Mellitus
Phenotype
Sample Size
10 Citations (Scopus)
98 Downloads (Pure)

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes

Meng, W., Shah, K. P., Pollack, S., Toppila, L., Hebert, H., McCarthy, M. I., Groop, L. C., Ahlqvist, E., Lyssenko, V., Argardh, E., Daniell, M., Kaidonis, G., Craig, J. E., Mitchell, P., Liew, G., Kifley, A., Wang, J. J., Jensen, R. A., Penman, A., Hancock, H. & 19 others, Chen, C. J., Correa, A., Kuo, J. Z., Li, X., Chen, Y-D. I., Rotter, J. I., Klein, R., Klein, B. E., Wong, T. Y., Morris, A. D., Doney, A. S. F., Colhoun, H. M., Price, A. L., Burdon, K. P., Groop, P-H., Sandholm, N., Grassi, M. A., Sobrin, L. & Palmer, C., 1 Nov 2018, In : Acta Ophthalmologica. 96, 7, p. e811-e819 9 p.

Research output: Contribution to journalArticle

Open Access
File
NADPH Oxidase
Genome-Wide Association Study
Diabetic Retinopathy
Type 2 Diabetes Mellitus
Scotland
1 Citation (Scopus)
57 Downloads (Pure)

Candidate long-range regulatory sites acting on the IL17-pathway genes TRAF3IP2 and IL17RA are associated with psoriasis

Nititham, J., Fergusson, C., Palmer, C., Liao, W. & Foerster, J., 4 Aug 2018, In : Experimental Dermatology. 27, 11, p. 1294-1297 4 p.

Research output: Contribution to journalArticle

Open Access
File
Psoriasis
Genes
Mutation
Feedback
Sequence Alignment
9 Citations (Scopus)
171 Downloads (Pure)

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

Hébert, H. L., Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
138 Downloads (Pure)

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Blue Mountains Eye Study—GWAS group, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 & Souzeau, E., 1 Dec 2018, In : Nature Communications. 9, 1, p. 1864 11 p., 1864.

Research output: Contribution to journalArticle

Open Access
File
eye diseases
Eye Diseases
genome
Genome-Wide Association Study
Keratoconus
87 Downloads (Pure)

DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain

Pascal, M. M. V., Themistocleous, A. C., Baron, R., Binder, A., Bouhassira, D., Crombez, G., Finnerup, N. B., Gierthmühlen, J., Granovsky, Y., Groop, L., Hebert, H. L., Jensen, T. S., Johnsen, K., McCarthy, M. I., Meng, W., Palmer, C. N. A., Rice, A. S. C., Serra, J., Solà, R., Yarnitsky, D. & 3 others, Smith, B. H., Attal, N. & Bennett, D. L. H., 29 May 2018, In : Wellcome Open Research. 3, p. 1-16 16 p., 63.

Research output: Contribution to journalArticle

File
Neuralgia
Observational Studies
Network protocols
Ethics Committees
Chemotherapy
3 Citations (Scopus)
26 Downloads (Pure)

DOLORisk: Study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved]

Pascal, M. M. V., Themistocleous, A. C., Baron, R., Binder, A., Bouhassira, D., Crombez, G., Finnerup, N. B., Gierthmühlen, J., Granovsky, Y., Groop, L., Hebert, H. L., Jensen, T. S., Johnsen, K., McCarthy, M. I., Meng, W., Palmer, C. N. A., Rice, A. S. C., Serra, J., Solà, R., Yarnitsky, D. & 3 others, Smith, B. H., Attal, N. & Bennett, D. L. H., 29 May 2018, In : Wellcome Open Research. 3, p. 1-23 23 p., 63.

Research output: Contribution to journalArticle

File
Neuralgia
Observational Studies
Network protocols
Ethics Committees
Neural Conduction
96 Citations (Scopus)

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., Cook, J. P., Schmidt, E. M., Wuttke, M., Sarnowski, C., Mägi, R., Nano, J., Gieger, C., Trompet, S., Lecoeur, C., Preuss, M. H. & 30 others, Prins, B. P., Guo, X., Bielak, L. F., Below, J. E., Bowden, D. W., Chambers, J. C., Kim, Y. J., Ng, M. C. Y., Petty, L. E., Sim, X., Zhang, W., Bennett, A. J., Bork-Jensen, J., Brummett, C. M., Canouil, M., Ec kardt, K. U., Fischer, K., Kardia, S. L. R., Kronenberg, F., Läll, K., Liu, C. T., Locke, A. E., Luan, J., Ntalla, I., Nylander, V., Schönherr, S., Schurmann, C., Morris, A. D., Palmer, C. N. A. & McCarthy, M. I., 8 Oct 2018, In : Nature Genetics. 50, 11, p. 1505-1513 9 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Gene Frequency
Genome-Wide Association Study
Epigenomics
Genome
12 Citations (Scopus)
122 Downloads (Pure)

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O’Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C., Pearson, E., Scott, R. A., van Heel, D. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 711.

Research output: Contribution to journalArticle

Open Access
File
inference
catalogs
resources
Genotype
53 Citations (Scopus)

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., Cho, K., Gaziano, J. M. & 31 others, Wilson, P. W. F., Tsao, P. S., Kovesdy, C. P., Esko, T., Mägi, R., Milani, L., Almgren, P., Boutin, T., Debette, S., Ding, J., Giulianini, F., Holliday, E. G., Jackson, A. U., Li-Gao, R., Lin, W-Y., Luan, J., Mangino, M., Oldmeadow, C., Prins, B. P., Qian, Y., Sargurupremraj, M., Shah, N., Surendran, P., Thériault, S., Verweij, N., Willems, S. M., Connell, J., Morris, A. D., Palmer, C. N. A., Elliott, P. & Caulfield, M. J., Oct 2018, In : Nature Genetics. 50, p. 1412-1425 14 p.

Research output: Contribution to journalArticle

Blood Pressure
Cardiovascular Diseases
Genetic Association Studies
Life Style
Hypertension
8 Citations (Scopus)
122 Downloads (Pure)

Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD

Dicker, A. J., Crichton, M. L., Cassidy, A. J., Brady, G., Hapca, A., Tavendale, R., Einarsson, G. G., Furrie, E., Elborn, J. S., Schembri, S., Marshall, S. E., Palmer, C. N. A. & Chalmers, J. D., Jun 2018, In : Thorax. 73, 6, p. 510-518 9 p.

Research output: Contribution to journalArticle

Open Access
File
Microbiota
Chronic Obstructive Pulmonary Disease
Mannose-Binding Lectin
Lung
Mortality
2 Citations (Scopus)
102 Downloads (Pure)

Individuals with filaggrin-related eczema and asthma have increased long-term medication and hospital admission costs

Soares, P., Fidler, K., Felton, J., Tavendale, R., Hövels, A., Bremner, S. A., Palmer, C. N. A. & Mukhopadhyay, S., 17 Sep 2018, In : British Journal of Dermatology. 179, 3, p. 717-723 7 p.

Research output: Contribution to journalArticle

Open Access
File
Hospital Costs
Eczema
Asthma
Mutation
Confidence Intervals
4 Citations (Scopus)
125 Downloads (Pure)

Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records

Tornio, A., Flynn, R., Morant, S., Velten, E., Palmer, C. N. A., MacDonald, T. M. & Doney, A. S. F., 1 Feb 2018, In : Clinical Pharmacology & Therapeutics. 103, 2, p. 281-286 6 p.

Research output: Contribution to journalArticle

Open Access
File
clopidogrel
Electronic Health Records
Pharmacogenetics
Stroke
Confidence Intervals
3 Citations (Scopus)
137 Downloads (Pure)

Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study

Siddiqui, M. K., Kennedy, G., Carr, F., Doney, A., Pearson, E., Morris, A., Johnson, T., McLaughlin, M. M., Williams, R. E. & Palmer, C., Jun 2018, In : Diabetologia. 61, 6, p. 1344-1353 10 p.

Research output: Contribution to journalArticle

Open Access
File
1-Alkyl-2-acetylglycerophosphocholine Esterase
Diabetic Retinopathy
Disease Progression
Scotland
Survival Analysis
4 Citations (Scopus)
76 Downloads (Pure)

MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer

Rose, A. M., Krishan, A., Chakarova, C. F., Moya, L., Chambers, S., Hollands, M., Illingworth, J. C., Williams, S. M. G., James, H. E., Shah, A. Z., Palmer, C. N. A., Chakravarti, A., Berg, J. N., Batra, J. & Bhattacharya, S. S., May 2018, In : Annals of Oncology. 29, 5, p. 1292-1303 12 p.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Breast Neoplasms
Gene Expression
Alleles
Switch Genes
51 Citations (Scopus)
98 Downloads (Pure)

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

Dicker, A. J., Crichton, M. L., Pumphrey, E. G., Cassidy, A. J., Suarez-Cuartin, G., Sibila, O., Furrie, E., Fong, C. J., Ibrahim, W., Brady, G., Einarsson, G. G., Elborn, J. S., Schembri, S., Marshall, S. E., Palmer, C. N. A. & Chalmers, J. D., Jan 2018, In : Journal of Allergy and Clinical Immunology. 141, 1, p. 117-127 11 p.

Research output: Contribution to journalArticle

Open Access
File
Microbiota
Chronic Obstructive Pulmonary Disease
Sputum
Neutrophils
Pancreatic Elastase
11 Citations (Scopus)

N-Glycan Profile and Kidney Disease in Type 1 Diabetes

Bermingham, M. L., Colombo, M., McGurnaghan, S. J., Blackbourn, L. A. K., Vučković, F., Pučić Baković, M., Trbojević-Akmačić, I., Lauc, G., Agakov, F., Agakova, A. S., Hayward, C., Klarić, L., Palmer, C. N. A., Petrie, J. R., Chalmers, J., Collier, A., Green, F., Lindsay, R. S., Macrury, S., McKnight, J. A. & 6 others, Patrick, A. W., Thekkepat, S., Gornik, O., McKeigue, P. M., Colhoun, H. M. & on behalf of the SDRN Type 1 Bioresource Investigators, Jan 2018, In : Diabetes Care. 41, 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

Kidney Diseases
Type 1 Diabetes Mellitus
Polysaccharides
Diabetic Nephropathies
Albumins
6 Citations (Scopus)
80 Downloads (Pure)

Pharmacogenetics of inhaled long-acting beta2-agonists in asthma: a systematic review

Slob, E. M. A., Vijverberg, S. J. H., Palmer, C. N. A., Zazuli, Z., Farzan, N., Oliveri, N. M. B., Pijnenburg, M. W., Koppelman, G. H. & Maitland van der Zee, A. H., Nov 2018, In : Pediatric Allergy and Immunology. 29, 7, p. 705-714 10 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacogenetics
Asthma
PubMed
Adrenergic Receptors
Genes