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  • Thomas MacDonald
2020

Chronotherapy in hypertension: the devil is in the details

Guthrie, G., TIME study Steering Committee, Poulter, N., Macdonald, T., Ford, I., Mackenzie, I., Findlay, E., Williams, B., Brown, M., Lang, C. & Webb, D., 21 Apr 2020, In : European Heart Journal. 41, 16, p. 1606-1607 2 p.

Research output: Contribution to journalComment/debate

Open Access
File
11 Downloads (Pure)

Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

Morales, D. R., Morant, S. V., MacDonald, T. M., Mackenzie, I. S., Doney, A. S. F., Mitchell, L., Bennie, M., Robertson, C., Hallas, J., Pottegard, A., Ernst, M. T., Wei, L., Nicholson, L., Morris, C., Herings, R. M. C., Overbeek, J. A., Smits, E. & Flynn, R. W. V., Mar 2020, In : Pharmacoepidemiology and Drug Safety. 29, 3, p. 296-305 10 p.

Research output: Contribution to journalArticle

Open Access
File
35 Downloads (Pure)

Reply

Gingles, C. R., Symon, R., Gandy, S. J., Struthers, A. D., Houston, G., MacDonald, T. M., Lang, C. C., Donnan, P. T. & George, J., 1 Jan 2020, In : Journal of Hypertension. 38, 1, p. 177-178 2 p.

Research output: Contribution to journalLetter

2019

Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension

Gingles, C., Symon, R., Gandy, S., Struthers, A., Houston, G., MacDonald, T., Lang, C., Donnan, P. & George, J., Dec 2019, In : Journal of Hypertension. 37, 12, p. 2481-2489 9 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
140 Downloads (Pure)

Cardiovascular Safety of Prucalopride in Patients with Chronic Constipation: A Multinational Population-Based Cohort Study

Gilsenan, A., Fortuny, J., Cainzos-Achirica, M., Cantero, O. F., Flynn, R. W. V., Garcia-Rodriguez, L., Harding, A., Kollhorst, B., Karlsson, P., Linnér, L., MacDonald, T. M., Odsbu, I., Plana, E., Ruigómez, A., Schink, T., Ziemiecki, R. & Andrews, E. B., Oct 2019, In : Drug Safety. 42, 10, p. 1179-1190 12 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
64 Downloads (Pure)
Open Access
File
107 Downloads (Pure)
2 Citations (Scopus)
124 Downloads (Pure)

Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study

Wei, L., Lai, E. C-C., Kao-Yang, Y-H., Walker, B. R., MacDonald, T. M. & Andrew, R., 10 Apr 2019, In : BMJ (Clinical research ed.). 365, p. 1-11 11 p., l1204.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
114 Downloads (Pure)

Lowering Uric Acid in Normouricaemic Hypertensive Patients Has an Adverse Effect on Left Ventricular Hypertrophy Regression: Mechanistic Proof of the Urate Paradox

Gingles, C., Symon, R., Gandy, S. J., Struthers, A. D., Houston, G., Macdonald, T. M., Lang, C. C., Donnan, P. T. & George, J., 1 Jul 2019, In : Journal of Hypertension. 37, p. e57

Research output: Contribution to journalMeeting abstract

Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350

Fortuny, J., Gilsenan, A., Cainzos-Achirica, M., Cantero, O. F., Flynn, R. W. V., Garcia-Rodriguez, L., Kollhorst, B., Karlsson, P., Linnér, L., MacDonald, T. M., Plana, E., Ruigómez, A., Schink, T., Ziemiecki, R. & Andrews, E. B., Oct 2019, In : Drug Safety. 42, 10, p. 1167-1177 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
115 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
46 Downloads (Pure)
2018

AB1029 Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease (ALL-HEART) study: baseline characteristics of the randomised patient population

Mackenzie, I., Ford, I., Hawkey, C., Begg, A., Taggar, J., Struthers, A., Wei, L., Avery, A., Walker, A., Duce, S., Barr, R., Dumbleton, J. & Macdonald, T., 12 Jun 2018, In : Annals of the Rheumatic Diseases. 77, suppl. 2, p. 1631.1-1631 1 p.

Research output: Contribution to journalConference article

Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies

Williams, B., MacDonald, T. M., Morant, S. V., Webb, D. J., Sever, P., McInnes, G. T., Ford, I., Cruickshank, J. K., Caulfield, M. J., Padmanabhan, S., Mackenzie, I. S., Salsbury, J. & Brown, M. J., 1 Jun 2018, In : The Lancet Diabetes and Endocrinology. 6, 6, p. 464-475 12 p.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
103 Downloads (Pure)

Evaluation of pregnancy outcomes in patients with multiple sclerosis after fingolimod exposure

Geissbühler, Y., Vile, J., Koren, G., Guennec, M., Butzkueven, H., Tilson, H., MacDonald, T. M. & Hellwig, K., 2018, In : Therapeutic Advances in Neurological Disorders. 11, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
133 Downloads (Pure)

Ibuprofen and Paracetamol: Acceptably Safe for All?

Pigazzani, F., Mackenzie, I. & MacDonald, T. M., Nov 2018, In : Drug Safety. 41, 11, p. 999-1001 3 p.

Research output: Contribution to journalComment/debate

Open Access
File
2 Citations (Scopus)
150 Downloads (Pure)

In response to: 'Thyroid hormone replacement - a counterblast to guidelines'

Leese, G. P., Flynn, R. V., MacDonald, T. M., Schofield, C. & Mackie, A. D., Mar 2018, In : Journal of the Royal College of Physicians of Edinburgh. 48, 1, p. 93 1 p.

Research output: Contribution to journalLetter

Open Access

Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records

Tornio, A., Flynn, R., Morant, S., Velten, E., Palmer, C. N. A., MacDonald, T. M. & Doney, A. S. F., 1 Feb 2018, In : Clinical Pharmacology & Therapeutics. 103, 2, p. 281-286 6 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
156 Downloads (Pure)
Open Access
File
17 Downloads (Pure)
Open Access
File
120 Downloads (Pure)

The effect of changes to GOLD severity stage on long term morbidity and mortality in COPD

Flynn, R. W. V., MacDonald, T. M., Chalmers, J. D. & Schembri, S., 12 Dec 2018, In : Respiratory Research. 19, p. 1-10 10 p., 249.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
122 Downloads (Pure)
2017

Acid-suppression medications and bacterial gastroenteritis: a population-based cohort study

Wei, L., Ratnayake, L., Phillips, G., McGuigan, C. C., Morant, S. V., Flynn, R. W., Mackenzie, I. S. & MacDonald, T. M., Jun 2017, In : British Journal of Clinical Pharmacology. 83, 6, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
173 Downloads (Pure)

Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial

MacDonald, T. M., Williams, B., Webb, D. J., Morant, S., Caulfield, M., Cruickshank, J. K., Ford, I., Sever, P., Mackenzie, I. S., Padmanabhan, S., McCann, G. P., Salsbury, J., McInnes, G., Brown, M. J. & for The British Hypertension Society Programme of Prevention And Treatment of Hypertension With Algorithm‐based Therapy (PATHWAY), Nov 2017, In : Journal of the American Heart Association. 6, 11, p. 1-28 28 p., e006986.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
157 Downloads (Pure)
Open Access
File
8 Citations (Scopus)
307 Downloads (Pure)

Erratum: The British Society for Rheumatology Guideline for the Management of Gout

Hui, M., Carr, A., Cameron, S., Davenport, G., Doherty, M., Forrester, H., Jenkins, W., Jordan, K. M., Mallen, C. D., MacDonald, T., Nuki, G., Pywell, A., Zhang, W. & Roddy, E., 1 Jul 2017, In : Rheumatology. 56, 7, p. 1246 1 p.

Research output: Contribution to journalArticle

Randomised trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: The Standard care versus Celecoxib Outcome Trial (SCOT)

MacDonald, T., Hawkey, C. J., Ford, I., McMurray, J. J. V., Scheiman, J. M., Hallas, J., Findlay, E., Grobbee, D. E., Hobbs, FD. R., Ralston, S. H., Reid, D. M., Walters, M., Webster, J., Ruschitzka, F., Ritchie, L. D., Perez-Gutthann, S., Connolly, E., Greenlaw, N., Wilson, A., Wei, L. & 1 others, Mackenzie, I., 14 Jun 2017, In : European Heart Journal. 38, 23, p. 1843-1850 9 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
136 Downloads (Pure)

Spironolactone use and risk of incident cancers: a retrospective, matched cohort study

Mackenzie, I. S., Morant, S. V., Wei, L., Thompson, A. M. & MacDonald, T. M., 14 Feb 2017, In : British Journal of Clinical Pharmacology. 83, 3, p. 653-663 11 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
163 Downloads (Pure)

Study protocol for statin web-based investigation of side effects (StatinWISE): a series of randomised controlled N-of-1 trials comparing atorvastatin and placebo in UK primary care

Herrett, E., Williamson, E., Beaumont, D., Prowse, D., Youssouf, N., Brack, K., Armitage, J., Goldacre, B., MacDonald, T., Staa, T. V., Roberts, I., Shakur-Still, H. & Smeeth, L., 1 Dec 2017, In : BMJ Open. 7, 12, p. 1-8 8 p., e016604.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
117 Downloads (Pure)

Successful recruitment to a large online randomised trial: the TIME study

Rogers, A., Mackenzie, I., Rorie, D. & MacDonald, T., 2 May 2017, Trials: Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials. Supplement 1 ed. United Kingdom: BioMed Central, Vol. 18. p. 222-223 2 p. 089. (Trials; vol. 18, no. Suppl. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
579 Downloads (Pure)

The British Society for Rheumatology Guideline for the Management of Gout

Hui, M., Carr, A., Cameron, S., Davenport, G., Doherty, M., Forrester, H., Jenkins, W., Jordan, K. M., Mallen, C. D., MacDonald, T., Nuki, G., Pywell, A., Zhang, W. & Roddy, E., Jul 2017, In : Rheumatology. 56, 7, p. 1056-1059 4 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
146 Downloads (Pure)

The British Society For Rheumatology guideline for the management of gout

Hui, M., Carr, A., Cameron, S., Davenport, G., Doherty, M., Forrester, H., Jenkins, W., Jordan, K. M., Mallen, C. D., MacDonald, T., Nuki, G., Pywell, A., Zhang, W. & Roddy, E., Jul 2017, In : Rheumatology. 56, 7, p. e1-e20

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
128 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
146 Downloads (Pure)
2016
Open Access
File
1 Citation (Scopus)
183 Downloads (Pure)

Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial

Brown, M. J., Williams, B., Morant, S. V., Webb, D. J., Caulfield, M. J., Cruickshank, J. K., Ford, I., McInnes, G., Sever, P., Salsbury, J., Mackenzie, I. S., Padmanabhan, S., MacDonald, T. M. & for the British Hypertension Society's Prevention, Treatment of Hypertension with Algorithm-based Therapy (PATHWAY) Studies Group, Feb 2016, In : The Lancet: Diabetes and Endocrinology. 4, 2, p. 136-147 12 p.

Research output: Contribution to journalArticle

Open Access
File
47 Citations (Scopus)
134 Downloads (Pure)

Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study

Rorie, D. A., Rogers, A., Mackenzie, I. S., Ford, I., Webb, D. J., Willams, B., Brown, M., Poulter, N., Findlay, E., Saywood, W. & MacDonald, T. M., 9 Feb 2016, In : BMJ Open. 6, 2, e010313.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
139 Downloads (Pure)

Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study

Mackenzie, I. S., Ford, I., Walker, A., Hawkey, C., Begg, A., Avery, A., Taggar, J., Wei, L., Struthers, A. D., MacDonald, T. M. & ALL-HEART study group, 8 Sep 2016, In : BMJ Open. 6, 9, p. 1-9 9 p., e013774.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
207 Downloads (Pure)

PATHWAY-2: Spironolactone for resistant hypertension - Authors' reply

Williams, B., MacDonald, T. M., Morant, S. V. & Brown, M. J., 2 Apr 2016, In : Lancet. 387, 10026, p. 1373-1374 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)
Open Access
File
4 Citations (Scopus)
134 Downloads (Pure)

Treatment in the Morning versus Evening (TIME) Study: Feasibility of an Online Study

Rorie, D. A., Rogers, A., Mackenzie, I. S., Findlay, E., MacDonald, T. M., Ford, I., Webb, D. J., Williams, B., Brown, M. & Poulter, N. R., 21 Sep 2016, In : Journal of Clinical Trials. 6, 5, p. 1-7 7 p., 1000281.

Research output: Contribution to journalArticle

Open Access
File
113 Downloads (Pure)
2015
7 Citations (Scopus)

Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension

Brown, M. J., Williams, B., MacDonald, T. M., Caulfield, M., Cruickshank, J. K., McInnes, G., Sever, P., Webb, D. J., Salsbury, J., Morant, S. & Ford, I., 7 Aug 2015, In : BMJ Open. 5, 8, 8 p., e008086.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
185 Downloads (Pure)

Does offering an incentive payment improve recruitment to clinical trials and increase the proportion of socially deprived and elderly participants?

Jennings, C. G., MacDonald, T. M., Wei, L., Brown, M. J., McConnachie, L. & Mackenzie, I. S., 7 Mar 2015, In : Trials. 16, 9 p., 80.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
120 Downloads (Pure)

Exaggerated exercise blood pressure response and future cardiovascular disease

Tzemos, N., Lim, P. O., Mackenzie, I. S. & Macdonald, T. M., Nov 2015, In : Journal of Clinical Hypertension . 17, 11, p. 837-844 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Home blood pressure monitoring

George, J. & MacDonald, T., 2015, In : European Cardiology Review. 10, 2, p. 95-101 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial

MacDonald, T. M., Williams, B., Caulfield, M., Cruickshank, J. K., McInnes, G., Sever, P., Webb, D. J., Mackenzie, I. S., Salsbury, J., Morant, S., Ford, I. & Brown, M. J., 7 Aug 2015, In : BMJ Open. 5, 8, 7 p., e007645.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
134 Downloads (Pure)

Pioglitazone and bladder cancer risk: a multipopulation pooled, cumulative exposure analysis

Levin, D., Bell, S., Sund, R., Hartikainen, S. A., Tuomilehto, J., Pukkala, E., Keskimäki, I., Badrick, E., Renehan, A. G., Buchan, I. E., Bowker, S. L., Minhas-Sandhu, J. K., Zafari, Z., Marra, C., Johnson, J. A., Stricker, B. H., Uitterlinden, A. G., Hofman, A., Ruiter, R., de Keyser, C. E. & 5 others, MacDonald, T. M., Wild, S. H., McKeigue, P. M., Colhoun, H. M. & on behalf of the Scottish Diabetes Research Network Epidemiology Group and the Diabetes and Cancer Research Consortium, Mar 2015, In : Diabetologia. 58, 3, p. 493-504 12 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension

Williams, B., MacDonald, T. M., Caulfield, M., Cruickshank, J. K., McInnes, G., Sever, P., Webb, D. J., Salsbury, J., Morant, S., Ford, I. & Brown, M. J., 7 Aug 2015, In : BMJ Open. 5, 8, 13 p., e008951.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
178 Downloads (Pure)

Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial

Williams, B., MacDonald, T. M., Morant, S., Webb, D. J., Sever, P., McInnes, G., Ford, I., Cruickshank, J. K., Caulfield, M. J., Salsbury, J., Mackenzie, I., Padmanabhan, S., Brown, M. J. & or The British Hypertension Society's PATHWAY Studies Group, 21 Nov 2015, In : Lancet. 386, 10008, p. 2059-2068 10 p.

Research output: Contribution to journalArticle

435 Citations (Scopus)