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2019
NF-E2 Transcription Factor
NF-E2-Related Factor 2
Air Pollutants
Transcription Factors
Antioxidants
1 Citation (Scopus)
7 Downloads (Pure)

New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology

Pi, J., Hayes, J. D. & Yamamoto, M., 15 Mar 2019, In : Toxicology and Applied Pharmacology. 367, p. 33-35 3 p.

Research output: Contribution to journalEditorial

Open Access
File
69 Citations (Scopus)
111 Downloads (Pure)

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
File
Chronic Disease
NF-E2-Related Factor 2
Ubiquitin-Protein Ligases
Cytoprotection
Neurodegenerative Diseases
2018
13 Citations (Scopus)
148 Downloads (Pure)

A partnership with the proteasome: the destructive nature of GSK3

Robertson, H., Hayes, J. D. & Sutherland, C., Jan 2018, In : Biochemical Pharmacology. 147, p. 77-92 16 p.

Research output: Contribution to journalArticle

Open Access
File
Glycogen Synthase Kinase 3
Proteasome Endopeptidase Complex
beta-Transducin Repeat-Containing Proteins
Phosphorylation
Proteins
28 Citations (Scopus)
121 Downloads (Pure)
Open Access
File
NF-E2-Related Factor 2
Fructose
Liver Cirrhosis
Fats
Endoplasmic Reticulum Stress
5 Citations (Scopus)
72 Downloads (Pure)
Open Access
File
Cullin Proteins
NF-E2-Related Factor 2
Zinc
Transcription Factors
Switches
2017
8 Citations (Scopus)
106 Downloads (Pure)

Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice

Crawford, D. R., Ilic, Z., Guest, I., Milne, G. L., Hayes, J. D. & Sell, S., Jul 2017, In : Carcinogenesis. 38, 7, p. 717-727 11 p.

Research output: Contribution to journalArticle

Open Access
File
Aflatoxin B1
Glutathione Transferase
Knockout Mice
Cell Proliferation
Liver
1 Citation (Scopus)

Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In : British Journal of Cancer. 117, 1 p., e1.

Research output: Contribution to journalArticle

20 Citations (Scopus)
178 Downloads (Pure)

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In : Oncogene. 36, 44, p. 6204-6212 9 p.

Research output: Contribution to journalArticle

Open Access
File
Homeodomain Proteins
Protein Kinases
Neoplasms
Phosphotransferases
Oncogenes
3 Citations (Scopus)
208 Downloads (Pure)
Open Access
File
Epigenomics
Antioxidants
Tumor Suppressor Proteins
Acetylation
Oxidation-Reduction
6 Citations (Scopus)
146 Downloads (Pure)
Open Access
File
Oncogenes
Oncogene Proteins
Ligases
Ubiquitin
Genes
2016
13 Citations (Scopus)
111 Downloads (Pure)
Open Access
File
Type 1 Diabetes Mellitus
Hypoglycemia
Rodentia
Oxidative Stress
Inflammation
6 Citations (Scopus)
227 Downloads (Pure)

Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In : Current Opinion in Toxicology. 1, p. 92-103 12 p.

Research output: Contribution to journalReview article

Open Access
File
NF-E2-Related Factor 2
Basic-Leucine Zipper Transcription Factors
Glycogen Synthase Kinase 3
diethyl maleate
Fibroblasts
2015
47 Citations (Scopus)
NF-E2 Transcription Factor
NF-E2-Related Factor 2
Glycogen Synthase Kinase 3
Proto-Oncogene Proteins c-akt
Phosphorylation
258 Citations (Scopus)

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

Research output: Contribution to journalArticle

SKP Cullin F-Box Protein Ligases
F-Box Proteins
Nutrients
Oxidation-Reduction
Cues
62 Citations (Scopus)

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M. A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., Bilican, B., Chowdhry, S., Meakin, P. J., Ashford, M. L. J., Wyllie, D. J. A., Scannevin, R. H., Chandran, S., Hayes, J. D. & Hardingham, G. E., 13 May 2015, In : Nature Communications. 6, 15 p., 7066.

Research output: Contribution to journalArticle

Epigenetic Repression
NF-E2-Related Factor 2
antioxidants
Antioxidants
Neurons
7 Citations (Scopus)

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Agathanggelou, A., Weston, V. J., Perry, T., Davies, N. J., Skowronska, A., Payne, D. T., Fossey, J. S., Oldreive, C. E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, S. J., Hole, P. S., Darley, R. L., McMahon, M., Hayes, J. D., Moss, P., Stewart, G., Taylor, A. M. R. & 1 others, Stankovic, T., Aug 2015, In : Haematologica. 100, 8, p. 1076-1085 10 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
B-Cell Chronic Lymphocytic Leukemia
Reactive Oxygen Species
Phenotype
Oxidation-Reduction
86 Citations (Scopus)
197 Downloads (Pure)

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

O'Connell, M. A. & Hayes, J. D., Aug 2015, In : Biochemical Society Transactions. 43, 4, p. 687-689 3 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolism
Oxidation-Reduction
NF-E2 Transcription Factor
Endoplasmic Reticulum-Associated Degradation
Health
19 Citations (Scopus)
240 Downloads (Pure)

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

Zhang, Y., Li, S., Xiang, Y., Qiu, L., Zhao, H. & Hayes, J. D., 13 Aug 2015, In : Scientific Reports. 5, 30 p., 12983.

Research output: Contribution to journalArticle

Open Access
File
2014
6 Citations (Scopus)

3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention

Nagle, A. A., Reddy, S. A., Bertrand, H., Tajima, H., Dang, T-M., Wong, S-C., Hayes, J. D., Wells, G. & Chew, E-H., 2014, In : ChemMedChem. 9, 8, p. 1763-1774 12 p.

Research output: Contribution to journalArticle

Chemoprevention
Fibroblasts
Anti-Inflammatory Agents
Lead compounds
Derivatives
13 Citations (Scopus)

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 in astrocytes

Deighton, R. F., Márkus, N. M., Al-Mubarak, B., Bell, K. F. S., Papadia, S., Meakin, P. J., Chowdhry, S., Hayes, J. & Hardingham, G. E., 2014, In : Proceedings of the National Academy of Sciences USA. 111, 18, p. E1818-1820 3 p., 24753562.

Research output: Contribution to journalLetter

32 Citations (Scopus)

Phosphoinositide 3-kinases upregulate system xc- via eukaryotic initiation factor 2α and activating transcription factor 4-A pathway active in glioblastomas and epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M-A., Halatsch, M-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., Aronica, E., Smolders, I., Ludolph, A. C., Methner, A., Conrad, M., Massie, A., Hardingham, G. E. & Maher, P., 28 May 2014, In : Antioxidants & Redox Signaling. 20, 18, p. 2907-2922 16 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 4
Eukaryotic Initiation Factor-2
1-Phosphatidylinositol 4-Kinase
Glioblastoma
Phosphatidylinositols
82 Citations (Scopus)
183 Downloads (Pure)
Open Access
File
NF-E2-Related Factor 2
Unfolded Protein Response
High Fat Diet
Fatty Liver
Insulin Resistance
660 Citations (Scopus)
Metabolism
Oxidation-Reduction
Pentose Phosphate Pathway
Lipogenesis
NADP
23 Citations (Scopus)
55 Downloads (Pure)

Transcription factor Nrf1 Is topologically repartitioned across membranes to enable target gene transactivation through Its acidic glucose-responsive domains

Zhang, Y., Ren, Y., Li, S. & Hayes, J. D., Apr 2014, In : PLoS ONE. 9, 4, 17 p., e93458.

Research output: Contribution to journalArticle

Open Access
File
transcriptional activation
endoplasmic reticulum
Transcriptional Activation
Transcription Factors
transcription factors
41 Citations (Scopus)

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

Tsujita, T., Peirce, V., Baird, L., Matsuyama, Y., Takaku, M., Walsh, S. V., Griffin, J. L., Uruno, A., Yamamoto, M. & Hayes, J. D., Oct 2014, In : Molecular and Cellular Biology. 34, 20, p. 3800-3816 17 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 1
Amino Acid Transport System X-AG
Cystine
Transcription Factors
Lipids
2013
26 Citations (Scopus)

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

Gan, F-F., Leng, H., Ang, X., Reddy, S. A., Lee, S. S-H., Yang, H., Tan, S-H., Hayes, J. D., Chui, W-K. & Chew, E-H., 1 Nov 2013, In : Toxicology and Applied Pharmacology. 272, 3, p. 852-862 11 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Cells
Modulation
Inflammation
Neoplasms
104 Citations (Scopus)

RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

Wang, H., Liu, K., Geng, M., Gao, P., Wu, X., Hai, Y., Li, Y., Li, Y., Luo, L., Hayes, J. D., Wang, X. J. & Tang, X., 2013, In : Cancer Research. 73, 10, p. 3097-3108 12 p.

Research output: Contribution to journalArticle

Antioxidant Response Elements
Gene Expression
Genes
Transcription Factors
Neoplasms
87 Citations (Scopus)
Gasotransmitters
NF-E2-Related Factor 2
Hydrogen Sulfide
Ligases
Ubiquitin
23 Citations (Scopus)
Behavior Control
Post Translational Protein Processing
Transcriptional Activation
Membranes
Endoplasmic Reticulum
2012
22 Citations (Scopus)

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics

Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., Hayes, J. & Park, B. K., 2012, In : Pharmacological Reports. 64, 3, p. 680-697 18 p.

Research output: Contribution to journalArticle

Proteomics
Gels
Liver
Antioxidant Response Elements
Proteins
47 Citations (Scopus)

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

Gupta, K., Patani, R., Baxter, P., Serio, A., Story, D., Tsujita, T., Hayes, J. D., Pedersen, R. A., Hardingham, G. E. & Chandran, S., May 2012, In : Cell Death & Differentiation. 19, 5, p. 779-787 9 p.

Research output: Contribution to journalArticle

239 Citations (Scopus)

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A. & Hayes, J. D., 2012, In : Oncogene. 32, p. 3765-3781 17 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Glycogen Synthase Kinase 3
Proto-Oncogene Proteins c-akt
1-Phosphatidylinositol 4-Kinase
Binding Sites
24 Citations (Scopus)

Nrf2 orchestrates fuel partitioning for cell proliferation

Hayes, J. D. & Ashford, M. L. J., 2012, In : Cell Metabolism. 16, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

Purine Nucleotides
Phosphatidylinositol 3-Kinases
Hypertrophy
Transcription Factors
Up-Regulation
77 Citations (Scopus)

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction

Hancock, R., Bertrand, H. C., Tsujita, T., Naz, S., El-Bakry, A., Laoruchupong, J., Hayes, J. D. & Wells, G., 15 Jan 2012, In : Free Radical Biology and Medicine. 52, 2, p. 444-451 8 p.

Research output: Contribution to journalArticle

139 Citations (Scopus)

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP Axis

Rada, P., Rojo, A. I., Evrard-Todeschi, N., Innamorato, N. G., Cotte, A., Jaworski, T., Tobón-Velasco, J. C., Devijver, H., García-Mayoral, M. F., Van Leuven, F., Hayes, J. D., Bertho, G. & Cuadrado, A., 2012, In : Molecular and Cellular Biology. 32, 17, p. 3486-99 14 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Glycogen Synthase Kinase 3
Electrophoresis, Gel, Two-Dimensional
Heme Oxygenase-1
Ubiquitin-Protein Ligases
2011
121 Citations (Scopus)

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

Higgins, L. G. & Hayes, J. D., May 2011, In : Drug Metabolism Reviews. 43, 2, p. 92-137 46 p.

Research output: Contribution to journalReview article

88 Citations (Scopus)

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., Hayes, J. D. & Hardingham, G. E., 4 Jan 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 1, p. E1-E2 2 p.

Research output: Contribution to journalLetter

Nrf2-mediated induction of antioxidant response element-driven gene expression by flavonoids is dependent on their chemical structure

Xiao, H., Hourihan, J. M., Brown, L., McMahon, M., Stewart, D. & Hayes, J. D., 18 Dec 2011, In : Toxicology. 290, 2-3, p. 126-127 2 p.

Research output: Contribution to journalBook/Film/Article review

317 Citations (Scopus)

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D. & Cuadrado, A., Mar 2011, In : Molecular and Cellular Biology. 31, 6, p. 1121-1133 13 p.

Research output: Contribution to journalArticle