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  • Miles Witham
2020

Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis: A pragmatic randomised, double-blind, placebo-controlled trial

Witham, M. D., Band, M., Ahmed, A. K., Almond, M. K., Balasubramaniam, G. S., Basnayake, K., Sumukadas, D., Chan, A., Chong, H. Y., Donnan, P. T., Duncan, N., Hampson, G., Hu, M. K., Kalra, P., Kennedy, G., Kirk, A., Lamb, E., Lambie, S., Littleford, R., McNamee, P. & 13 others, Mishra, B., Mitra, S., Nicholas, J., Plews, D., Rauchhaus, P., Soiza, R. L., Stevens, P. E., Sumukadas, D., Tse, W., Warwick, G., Wilkie, M., Winnett, G. & Avenell, A., 9 Apr 2020, In : Health Technology Assessment. 18, 16 p., 91 (2020).

Research output: Contribution to journalArticle

Open Access
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10 Downloads (Pure)

Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function: a randomised controlled trial

Witham, M. D., Clarke, C. L., Hutcheon, A., Gingles, C., Gandy, S., Priba, L., Nicholas, R. S., Cavin, I., Sumukadas, D., Struthers, A. D. & George, J., 21 Apr 2020, In : Age and Ageing. 8 p., afaa061.

Research output: Contribution to journalArticle

Open Access
File
6 Downloads (Pure)
Open Access
File
13 Downloads (Pure)

Sodium bicarbonate to improve physical function in patients over 60 years with advanced chronic kidney disease: the BiCARB RCT

Witham, M. D., Band, M., Chong, H., Donnan, P. T., Hampson, G., Hu, M. K., Littleford, R., Lamb, E., Kalra, P. A., Kennedy, G., McNamee, P., Plews, D., Rauchhaus, P., Soiza, R. L., Sumukadas, D., Warwick, G. & Avenell, A., Jun 2020, In : Health Technology Assessment. 24, 27, 120 p.

Research output: Contribution to journalArticle

Open Access
File
5 Downloads (Pure)
2019

Ability of verbal autopsy data to detect deaths due to uncontrolled hyperglycaemia: testing existing methods and development and validation of a novel weighted score

Blackstock, S., Witham, M. D., Wade, A. N., Crampin, A., Beran, D., Ogle, G. D. & Davies, J. I., 18 Oct 2019, In : BMJ Open. 9, 10, p. 1-8 8 p., e026331.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
62 Downloads (Pure)

Calcium Channel Blockers Are Associated With Improved Survival and Lower Cardiovascular Mortality in Patients With Renovascular Disease

Desmukh, H., Barker, E., Ambarasan, T., Levin, D., Bell, S., Witham, M. D. & George, J., 29 Jan 2019, In : Cardiovascular Therapeutics. 36, 6, p. 1-7 7 p., e12474.

Research output: Contribution to journalArticle

Open Access
File
64 Downloads (Pure)

Effect of vitamin K2 on postural sway in older people who fall: A Randomized Controlled Trial

Witham, M. D., Price, R. J. G., Band, M. M., Hannah, M. S., Fulton, R. L., Clarke, C. L., Donnan, P. T., McNamee, P., Cvoro, V. & Soiza, R. L., 15 Oct 2019, In : Journal of the American Geriatrics Society. 67, 10, p. 2102-2107 6 p.

Research output: Contribution to journalArticle

Open Access
File
97 Downloads (Pure)

External Validation of a Risk Score to Predict Aki in Either the Community or Hospital Setting

Bell, S., James, M., Farmer, C., Tan, Z., De Souza, N. & Witham, M., 13 Jun 2019, In : Nephrology Dialysis Transplantation. 34

Research output: Contribution to journalMeeting abstract

Impact of introducing electronic acute kidney injury alerts in primary care

Aiyegbusi, O., Witham, M., Lim, M., Gauld, G. & Bell, S., Apr 2019, In : Clinical Kidney Journal. 12, 2, p. 253-257 5 p.

Research output: Contribution to journalArticle

Open Access
File
96 Downloads (Pure)

Podiatry interventions to prevent falls in older people: a systematic review and meta-analysis

Wylie, G., Torrens, C., Campbell, P., Frost, H., Gordon, A. L., Menz, H. B., Skelton, D. A., Sullivan, F., Witham, M. D. & Morris, J., May 2019, In : Age and Ageing. 48, 3, p. 327-336 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
109 Downloads (Pure)

Serum sodium level variability as a prognosticator in older adults

Barma, M. A., Soiza, R. L., Donnan, P. T., McGilchrist, M. M., Frost, H. & Witham, M. D., 3 Jan 2019, In : Scandinavian Journal of Clinical and Laboratory Investigation. 78, 7-8, p. 632-638 7 p.

Research output: Contribution to journalArticle

Open Access
File
142 Downloads (Pure)
2018
Open Access
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1 Citation (Scopus)
71 Downloads (Pure)

Cardiovascular Disease Profile of the Oldest Adults in Rural South Africa: Data from the HAALSI Study (Health and Aging in Africa: Longitudinal Studies of INDEPTH Communities)

Jardim, T. V., Witham, M. D., Abrahams-Gessel, S., Gómez-Olivé, F. X., Tollman, S., Berkman, L. & Gaziano, T. A., 14 Nov 2018, In : Journal of the American Geriatrics Society. 66, 11, p. 2151-2157 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
File
3 Citations (Scopus)
138 Downloads (Pure)

Cross-sectional relationship between Haemoglobin concentration and measures of physical and cognitive function in an older rural South African population

Payne, C. F., Davies, J. I., Gomez-Olive, F. X., Hands, K. J., Kahn, K., Kobayashi, L. C., Tipping, B., Tollman, S., Wade, A. & Witham, M., 9 Aug 2018, In : Journal of Epidemiology and Community Health. 72, 9, p. 796-802 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
149 Downloads (Pure)

Effect of vitamin D supplementation on markers of vascular function: a systematic review and individual participant meta-analysis

Beveridge, L., Khan, F., Struthers, A., Armitage, J., Barchetta, I., Cavallo, M. G., Clarke, R., Dalan, R., Dreyer, G., Gepner, A. D., Forouhi, N. G., Harris, R. A. ., Hitman, G. A., Larsen, T., Khadgawat, R., Marckmann, P., Mose, F. H. ., Pilz, S., Scholze, A., Shargorodsky, M. & 4 others, Sokol, S. I., Stricker, H., Zoccali, C. & Witham, M., 5 Jun 2018, In : Journal of the American Heart Association. 7, 11, p. 1-21 21 p., e008273.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
133 Downloads (Pure)

Establishing a clinical phenotype for cachexia in end stage kidney disease: study protocol

Reid, J., Noble, H. R., Adamson, G., Davenport, A., Farrington, K., Fouque, D., Kalantar-Zadeh, K., Mallett, J., McKeaveney, C., Porter, S., Seres, D. S., Shields, J., Slee, A., Witham, M. D. & Maxwell, A. P., 13 Feb 2018, In : BMC Nephrology. 19, 1, p. 38 6 p., 38.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
166 Downloads (Pure)

Hypertension treatment for older people-navigating between Scylla and Charybdis

Conroy, S. P., Westendorp, R. G. J. & Witham, M. D., Jul 2018, In : Age and Ageing. 47, 4, p. 505-508 4 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
86 Downloads (Pure)

Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual-patient data meta-analysis of randomised trials

Taylor, R. S. ., Walker, S., Smart, N. A., Piepoli, M. F., Warren, F. C., Ciani, O., O'Connor, C. M., Whellan, D., Keteyian, S. J., Coats, A. J. S., Davos, C. H., Dalal, H. M., Dracup, K., Evangelista, L., Jolly, K., Myers, J., McKelvie, R. S., Nilsson, B. B., Passino, C., Witham, M. & 2 others, Yeh, G. Y. & Olsen Zwisler, A-D., 1 Dec 2018, In : European Journal of Heart Failure. 20, 12, p. 1735-1743 9 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
73 Downloads (Pure)

Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): study protocol for a randomised controlled trial

Band, M. M., Sumukadas, D., Struthers, A. D., Avenell, A., Donnan, P. T., Kemp, P. R., Smith, K. T., Hume, C. L., Hapca, A. & Witham, M. D., 1 Jan 2018, In : Trials. 19, p. 1-11 11 p., 6.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
156 Downloads (Pure)

Systematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocol

Gillies, K., Bower, P., Elliott, J., MacLennan, G., Newlands, R. S. N., Ogden, M., Treweek, S. P., Wells, M., Witham, M. D., Young, B. & Francis, J. J., 27 Mar 2018, In : Trials. 19, 1, p. 1-10 10 p., 197.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
154 Downloads (Pure)

The Addition of Vitamin D Supplementation to Interferon and Ribavirin in the Treatment of Hepatitis C Virus Infection: A Randomised Double-Blind PlaceboControlled Pilot Study

Coats, J. T., Hapca, A., Witham, M., Donnan, P., Heydtmann, M., Bathgate, A., Hayes, P. C., Fraser, A., Evans, M., Leen, C., Bramley, P., Barclay, S. T., Fox, R. & Dillon, J. F., 2018, In : Archives of Gastroenterology and Hepatology. 1, 2, p. 39-48 10 p.

Research output: Contribution to journalArticle

Open Access
File

The effect of perindopril on postural instability in older people with a history of falls-a randomised controlled trial

Sumukadas, D., Price, R., McMurdo, M. E. T., Rauchhaus, P., Struthers, A., McSwiggan, S., Arnold, G., Abboud, R. & Witham, M., 1 Jan 2018, In : Age and Ageing. 47, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
181 Downloads (Pure)
2017

Association between bisphosphonate therapy and outcomes from rehabilitation in older people

Goodbrand, J. A., Hughes, L. D., Cochrane, L., Donnan, P., McGilchrist, M., Frost, H., McMurdo, M. & Witham, M., May 2017, In : Archives of Gerontology and Geriatrics. 70, p. 195-200 6 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
153 Downloads (Pure)

Bringing all together for research capacity building in LMICs - Authors' reply

Beran, D., Byass, P., Gbakima, A., Kahn, K., Sankoh, O., Tollman, S., Witham, M. & Davies, J., Sep 2017, In : The Lancet Global Health. 5, 9, p. e870 1 p.

Research output: Contribution to journalLetter

Open Access
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151 Downloads (Pure)

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

Petrie, J. R., Chaturvedi, N., Ford, I., Brouwers, M. C. G. J., Greenlaw, N., Tillin, T., Hramiak, I., Hughes, A. D., Jenkins, A. J., Klein, B. E. K., Klein, R., Ooi, T. C., Rossing, P., Stehouwer, C. D. A., Sattar, N. & Colhoun, H. M., 1 Aug 2017, In : The Lancet Diabetes and Endocrinology. 5, 8, p. 597-609 13 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)

Conducting and reporting trials for older people

Witham, M. D. & Stott, D. J., 1 Nov 2017, In : Age and Ageing. 46, 6, p. 889-894 6 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
104 Downloads (Pure)

Factors associated with change in objectively measured physical activity in older people: data from the Physical Activity Cohort Scotland study

Clarke, C., Sniehotta, F. F., Vadiveloo, T., Argo, I., Donnan, P., McMurdo, M. & Witham, M., 14 Aug 2017, In : BMC Geriatrics. 17, p. 1-9 9 p., 180.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
163 Downloads (Pure)

Hospital-acquired pneumonia surveillance-an unmet need

Ewan, V. C., Witham, M. D., Kiernan, M. A. & Simpson, A. J., Oct 2017, In : The Lancet Respiratory Medicine. 5, 10, p. 771-772 2 p.

Research output: Contribution to journalComment/debate

Open Access
File
5 Citations (Scopus)
169 Downloads (Pure)

Interventions to Enhance Medication Adherence in Older Heart Failure Patients - A Systematic Review

Fulton, R., Kroll, T., McMurdo, M., Molloy, G. J. & Witham, M., 16 May 2017, In : Age and Ageing. 46, Supplement 1, p. i25 1 p.

Research output: Contribution to journalMeeting abstract

Interventions to improve medication adherence in heart failure: A systematic review

Fulton, R. L., Kroll, T., McMurdo, M., Molloy, G. J. & Witham, M. D., 2017, In : Journal of Preventive Cardiology. 6, 3, p. 1048-1056 9 p.

Research output: Contribution to journalReview article

Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial

REMOVAL Trial Team, Petrie, J. R., Chaturvedi, N., Ford, I., Hramiak, I., Hughes, A. D., Jenkins, A. J., E. Klein, B., Klein, R., Ooi, T. C., Rossing, P., Sattar, N. & Stehouwer, C. D. A., 1 Apr 2017, In : Diabetes, Obesity and Metabolism. 19, 4, p. 509-516 8 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
90 Downloads (Pure)

Podiatry interventions to reduce falls in older people

Morris, J., Witham, M., Campbell, P., Frost, H., Torrens, C. & Wylie, G., 2017, In : PROSPERO.

Research output: Contribution to journalReview article

Prevalence and correlates of frailty in an older rural African population: findings from the HAALSI cohort study

Payne, C. F., Wade, A., Kabudula, C. W., Davies, J. I., Change, A. Y., Gomez-Olive, F. X., Kahn, K., Berkman, L. F., Tollman, S., Salomon, J. A. & Witham, M., 28 Dec 2017, In : BMC Geriatrics. 17, p. 1-10 10 p., 293.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
155 Downloads (Pure)

Research capacity building-obligations for global health partners

Beran, D., Byass, P., Gbakima, A., Kahn, K., Sankoh, O., Tollman, S., Witham, M. & Davies, J., Jun 2017, In : The Lancet Global Health. 5, 6, p. e567-e568 2 p.

Research output: Contribution to journalComment/debate

Open Access
File
29 Citations (Scopus)
137 Downloads (Pure)

Selecting Potential Pharmacological Interventions in Sarcopenia

Kilsby, A. J., Sayer, A. A. & Witham, M. D., Apr 2017, In : Drugs & Aging. 34, 4, p. 223-240 8 p.

Research output: Contribution to journalComment/debate

Open Access
File
6 Citations (Scopus)
164 Downloads (Pure)

The emergence of sarcopenia as an important entity in older people

Offord, N. J. & Witham, M. D., 1 Aug 2017, In : Clinical Medicine - Journal of the Royal College of Physicians of London. 17, 4, p. 363-366 4 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
109 Downloads (Pure)

Turning predator into prey: the problem of predatory journal

Witham, M. D. & Runcie, H., Mar 2017, In : Journal of the Royal College of Physicians of Edinburgh. 47, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

Open Access
File
4 Citations (Scopus)
120 Downloads (Pure)

Validation of the AX3 triaxial accelerometer in older functionally impaired people

Clarke, C. C., Taylor, J., Crighton, L. J., Goodbrand, J. A., McMurdo, M. E. T. & Witham, M. D., Jun 2017, In : Aging Clinical and Experimental Research. 29, 3, p. 451-457 7 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
349 Downloads (Pure)

Variations in disability and quality of life with age and sex between eight Lower and Middle Income Countries: data from the INDEPTH WHO-SAGE collaboration

Gomez-Olive, F. X., Schröders, J., Aboderin, I., Byass, P., Chatterji, S., Kahn, K., Kowal, P., Nathan, R., Ng, N., Razzaque, A., Sankoh, O., Streatfield, P. K., Tollman, S., Wilopo, S. A. & Witham, M. D., 20 Dec 2017, In : BMJ Global Health . 2, 4, 12 p., e000508.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
101 Downloads (Pure)
2016

A good death for the oldest old

Witham, M. D. & Hockley, J., 27 Apr 2016, In : Age and Ageing. 45, 3, p. 329-331 3 p.

Research output: Contribution to journalEditorial

Open Access
File
3 Citations (Scopus)
89 Downloads (Pure)

Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation

Orriss, I. R., Arnett, T. R., George, J. & Witham, M. D., 15 Mar 2016, In : Experimental Cell Research. 342, 2, p. 166-174 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
135 Downloads (Pure)

An evaluation of the psychometric properties of the Indicator of Relative Need (IoRN) instrument

Canny, A., Robertson, F., Knight, P., Redpath, A. & Witham, M. D., 28 Jul 2016, In : BMC Geriatrics. 16, 10 p., 147.

Research output: Contribution to journalArticle

Open Access
File
203 Downloads (Pure)

Association between allopurinol use and hip fracture in older patients

Basu, U., Goodbrand, J., McMurdo, M. E. T., Donnan, P. T., McGilchrist, M., Frost, H., George, J. & Witham, M. D., Mar 2016, In : Bone. 84, p. 189-193 5 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
124 Downloads (Pure)

Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Barma, M., Khan, F., Price, R. J. G., Donnan, P. T., Messow, C. M., Ford, I., McConnachie, A., Struthers, A. D., McMurdo, M. E. T. & Witham, M. D., 2016, In : Aging Clinical and Experimental Research. 29, 5, p. 1055-1059 5 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
151 Downloads (Pure)

Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial

Fulton, R. L., McMurdo, M. E. T., Hill, A., Abboud, R. J., Arnold, G. P., Struthers, A. D., Khan, F., Vermeer, C., Knapen, M. H. J., Drummen, N. E. A. & Witham, M. D., Mar 2016, In : Journal of Nutrition Health & Aging. 20, 3, p. 325-333 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Hospital-acquired pneumonia incidence and diagnosis in older patients

Burton, L. A., Price, R., Barr, K. E., McAuley, S. M., Allen, J. B., Clinton, A. M., Phillips, G., Marwick, C. A., McMurdo, M. E. T. & Witham, M. D., Jan 2016, In : Age and Ageing. 45, 1, p. 171-174 4 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
223 Downloads (Pure)

Introduction to the Age and Ageing Sarcopenia collection

Witham, M. & Sayer, A. A., 2 Nov 2016, In : Age and Ageing. 45, 6, p. 752-753 2 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
167 Downloads (Pure)

Should chronic metabolic acidosis be treated in older people with chronic kidney disease?

Witham, M. D. & Lamb, E. J., Nov 2016, In : Nephrology Dialysis Transplantation. 31, 11, p. 1796-1802 7 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
129 Downloads (Pure)

Slower Decline in C-Reactive Protein after an Inflammatory Insult Is Associated with Longer Survival in Older Hospitalised Patients

Barma, M., Goodbrand, J. A., Donnan, P. T., McGilchrist, M. M., Frost, H., McMurdo, M. E. T. & Witham, M. D., 28 Jul 2016, In : PLoS ONE. 11, 7, 10 p., e0159412.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
189 Downloads (Pure)