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2019
2 Citations (Scopus)
54 Downloads (Pure)

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Interactions
Clinical Trials
Pharmaceutical Preparations
Pharmacokinetics
Cytochrome P-450 CYP3A
1 Citation (Scopus)
90 Downloads (Pure)

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

Research output: Contribution to journalArticle

Open Access
File
ellipticine
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Oxidoreductases
1 Citation (Scopus)
90 Downloads (Pure)

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes

McMahon, M., Ding, S., Acosta-Jimenez, L., Terranova, R., Gerard, M-A., Vitobello, A., Moggs, J. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2019, In : Molecular Pharmacology. 95, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Open Access
File
Transcriptional Activation
Chromatin
Hepatocytes
Xenobiotics
constitutive androstane receptor
2 Citations (Scopus)
Open Access
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A1
Knockout Mice
Pharmaceutical Preparations
Enzyme Inhibitors
28 Citations (Scopus)
111 Downloads (Pure)

Discovery of common and rare genetic risk variants for colorectal cancer

Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., Conti, D. V., Qu, C., Jeon, J., Edlund, C. K., Greenside, P., Wainberg, M., Schumacher, F. R., Smith, J. D., Levine, D. M., Nelson, S. C., Sinnott-Armstrong, N. A., Albanes, D., Alonso, M. H., Anderson, K. & 179 others, Arnau-Collell, C., Arndt, V., Bamia, C., Banbury, B. L., Baron, J. A., Berndt, S. I., Bézieau, S., Bishop, D. T., Boehm, J., Boeing, H., Brenner, H., Brezina, S., Buch, S., Buchanan, D. D., Burnett-Hartman, A., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chirlaque, M-D., Cho, S. H., Connolly, C. M., Cross, A. J., Cuk, K., Curtis, K. R., de la Chapelle, A., Doheny, K. F., Duggan, D., Easton, D. F., Elias, S. G., Elliott, F., English, D. R., Feskens, E. J. M., Figueiredo, J. C., Fischer, R., FitzGerald, L. M., Forman, D., Gala, M., Gallinger, S., Gauderman, W. J., Giles, G. G., Gillanders, E., Gong, J., Goodman, P. J., Grady, W. M., Grove, J. S., Gsur, A., Gunter, M. J., Haile, R. W., Hampe, J., Hampel, H., Harlid, S., Hayes, R. B., Hofer, P., Hoffmeister, M., Hopper, J. L., Hsu, W-L., Huang, W-Y., Hudson, T. J., Hunter, D. J., Ibañez-Sanz, G., Idos, G. E., Ingersoll, R., Jackson, R. D., Jacobs, E. J., Jenkins, M. A., Joshi, A. D., Joshu, C. E., Keku, T. O., Key, T. J., Kim, H. R., Kobayashi, E., Kolonel, L. N., Kooperberg, C., Kühn, T., Küry, S., Kweon, S-S., Larsson, S. C., Laurie, C. A., Le Marchand, L., Leal, S. M., Lee, S. C., Lejbkowicz, F., Lemire, M., Li, C. I., Li, L., Lieb, W., Lin, Y., Lindblom, A., Lindor, N. M., Ling, H., Louie, T. L., Männistö, S., Markowitz, S. D., Martín, V., Masala, G., McNeil, C. E., Melas, M., Milne, R. L., Moreno, L., Murphy, N., Myte, R., Naccarati, A., Newcomb, P. A., Offit, K., Ogino, S., Onland-Moret, N. C., Pardini, B., Parfrey, P. S., Pearlman, R., Perduca, V., Pharoah, P. D. P., Pinchev, M., Platz, E. A., Prentice, R. L., Pugh, E., Raskin, L., Rennert, G., Rennert, H. S., Riboli, E., Rodríguez-Barranco, M., Romm, J., Sakoda, L. C., Schafmayer, C., Schoen, R. E., Seminara, D., Shah, M., Shelford, T., Shin, M-H., Shulman, K., Sieri, S., Slattery, M. L., Southey, M. C., Stadler, Z. K., Stegmaier, C., Su, Y-R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Thomas, S. S., Toland, A. E., Trichopoulou, A., Ulrich, C. M., Van Den Berg, D. J., van Duijnhoven, F. J. B., Van Guelpen, B., van Kranen, H., Vijai, J., Visvanathan, K., Vodicka, P., Vodickova, L., Vymetalkova, V., Weigl, K., Weinstein, S. J., White, E., Win, A. K., Wolf, C. R., Wolk, A., Woods, M. O., Wu, A. H., Zaidi, S. H., Zanke, B. W., Zhang, Q., Zheng, W., Scacheri, P. C., Potter, J. D., Bassik, M. C., Kundaje, A., Casey, G., Moreno, V., Abecasis, G. R., Nickerson, D. A., Gruber, S. B., Hsu, L. & Peters, U., 1 Jan 2019, In : Nature Genetics. 51, 1, p. 76-87 12 p.

Research output: Contribution to journalArticle

Open Access
File
Colorectal Neoplasms
Long Noncoding RNA
Preclinical Drug Evaluations
Genome-Wide Association Study
Haplotypes
38 Downloads (Pure)

Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

Vitobello, A., Perner, J., Beil, J., Zhu, J., Del Río-Espínola, A., Morawiec, L., Westphal, M., Dubost, V., Altorfer, M., Naumann, U., Mueller, A., Kapur, K., Borowsky, M., Henderson, C., Wolf, C. R., Schwarz, M., Moggs, J. & Terranova, R., Oct 2019, In : Life Science Alliance. 2, 5, p. 1-18 18 p., e201900461.

Research output: Contribution to journalArticle

Open Access
File
phenobarbital
liver neoplasms
Phenobarbital
tumor
Liver
2018
13 Citations (Scopus)
113 Downloads (Pure)

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5 /P450 reductase null (HBRN) mice

Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., Apr 2018, In : Archives of Toxicology. 92, 4, p. 1625-1638 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Metabolism
Cytochrome P-450 Enzyme System
Oxidoreductases
7 Citations (Scopus)
106 Downloads (Pure)

Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In : Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

Open Access
File
Lung Neoplasms
Cytochrome P-450 CYP3A
Therapeutics
Pharmaceutical Preparations
Cytochrome P-450 CYP1A2
2 Citations (Scopus)
152 Downloads (Pure)

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Sheth, H., Northwood, E., Ulrich, C. M., Scherer, D., Elliott, F., Barrett, J. H., Forman, D., Wolf, C. R., Smith, G., Jackson, M. S., Santibanez-Koref, M., Haile, R., Casey, G., Jenkins, M., Win, A. K., Hopper, J. L., Marchand, L. L., Lindor, N. M., Thibodeau, S. N., Potter, J. D. & 2 others, Burn, J. & Bishop, D. T., 9 Feb 2018, In : PLoS ONE. 13, 2, p. 1-17 17 p., e0192223.

Research output: Contribution to journalArticle

Open Access
File
aspirin
Metabolic Networks and Pathways
case-control studies
Polymorphism
colorectal neoplasms
3 Citations (Scopus)
77 Downloads (Pure)

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

McMahon, M., Ding, S., Acosta-Jimenez, L. P., Frangova, T. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2018, In : Journal of Physiology. 596, 1, p. 105-127 23 p.

Research output: Contribution to journalArticle

Open Access
File
Heme Oxygenase (Decyclizing)
Oxidative Stress
Galactosidases
Firefly Luciferases
Toxicology
2017
3 Citations (Scopus)
98 Downloads (Pure)
Open Access
File
Cytochrome P-450 CYP2D6
Tamoxifen
Drug Interactions
Cytochrome P-450 Enzyme System
Antidepressive Agents
20 Citations (Scopus)
167 Downloads (Pure)

Aryl hydrocarbon receptor is required for optimal B-cell proliferation

Villa, M., Gialitakis, M., Tolaini, M., Ahlfors, H., Henderson, C. J., Wolf, C. R., Brink, R. & Stockinger, B., 4 Jan 2017, In : EMBO Journal. 36, 1, p. 116-128 13 p.

Research output: Contribution to journalArticle

Open Access
File
Aryl Hydrocarbon Receptors
Cell proliferation
B-Lymphocytes
Cell Proliferation
Cells
1 Citation (Scopus)

Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In : British Journal of Cancer. 117, 1 p., e1.

Research output: Contribution to journalArticle

104 Citations (Scopus)
137 Downloads (Pure)

Feedback control of AHR signalling regulates intestinal immunity

Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W. & Stockinger, B., 9 Feb 2017, In : Nature. 542, 7640, p. 242-245 4 p.

Research output: Contribution to journalLetter

Open Access
File
Aryl Hydrocarbon Receptors
Immunity
Ligands
Cytochromes
Epithelial Cells

Genetically Humanized Animal Models

Samuelsson, K., Scheer, N., Wilson, I., Wolf, C. & Henderson, C. J., 13 Jun 2017, Comprehensive Medicinal Chemistry III. Chackalamannil, S., Rotella, D. P. & Ward, S. E. (eds.). Elsevier, p. 130-149 20 p. (Reference Module in Chemistry, Molecular Sciences and Chemical Engineering).

Research output: Chapter in Book/Report/Conference proceedingChapter

Animal Models
Drug-Related Side Effects and Adverse Reactions
Drug Discovery
Hepatocytes
Pharmacokinetics
10 Citations (Scopus)
96 Downloads (Pure)
Open Access
File
Cytochrome P-450 CYP1A1
Poisons
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Glutathione Transferase
Premature Mortality
7 Citations (Scopus)

Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis

Terranova, R., Vitobello, A., Del Rio Espinola, A., Wolf, C. R., Schwarz, M., Thomson, J. M., Meehan, R. & Moggs, J. G., Apr 2017, In : Current Opinion in Toxicology. 3, p. 62-70 9 p.

Research output: Contribution to journalReview article

Xenobiotics
Epigenomics
Carcinogenesis
Tissue
Animals
2 Citations (Scopus)
130 Downloads (Pure)

Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver

Pouché, L., Vitobello, A., Römer, M., Glogovac, M., MacLeod, A. K., Ellinger-Ziegelbauer, H., Westphal, M., Dubost, V., Stiehl, D. P., Dumotier, B., Fekete, A., Moulin, P., Zell, A., Schwarz, M., Moreno, R., Huang, J. T. J., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moggs, J. G. & 1 others, Terranova, R., Aug 2017, In : Toxicological Sciences. 158, 2, p. 367-378 11 p.

Research output: Contribution to journalArticle

Open Access
File
Untranslated RNA
Xenobiotics
Liver
Carcinogenesis
Biomarkers
2016
16 Citations (Scopus)
173 Downloads (Pure)

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Henderson, C. J. & Wolf, C. R., 6 Dec 2016, In : British Journal of Cancer. 115, 12, p. 1530-1539 10 p.

Research output: Contribution to journalArticle

Open Access
File
Non-Small Cell Lung Carcinoma
Biomarkers
Squamous Cell Carcinoma
Neoplasms
Cell Line

Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs

Wolf, C. R., Kapelyukh, Y., Scheer, N. & Henderson, C. J., 20 Nov 2016, New Horizons in Predictive drug Metabolism and Pharmocokentics. 49 ed. Royal Society of Chemistry, Vol. 2016-January. p. 152-176 25 p. (RSC Drug Discovery Series; vol. 2016-January, no. 49).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetically Modified Animals
Drug and Narcotic Control
Pharmaceutical Preparations
Animal Models
Genes
150 Downloads (Pure)

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π

McMillan, D. H., van der Velden, J. L. J., Lahue, K. G., Quan, X., Schneider, R. W., Iberg, M. S., Nolin, J. D., Abdalla, S., Casey, D. T., Tew, K. D., Townsend, D. M., Henderson, C. J., Wolf, C. R., Butnor, K. J., Taatjes, D. J., Budd, R. C., Irvin, C. G., van der Vliet, A., Flemer, S., Anathy, V. & 1 others, Janssen-Heininger, Y. M. W., 2 Jun 2016, In : JCI Insight. 1, 8, 16 p., e85717.

Research output: Contribution to journalArticle

Open Access
File
Idiopathic Pulmonary Fibrosis
Glutathione Transferase
Fibrosis
Lung
Protein S
55 Citations (Scopus)
164 Downloads (Pure)

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

Takahashi, S., Fukami, T., Masuo, Y., Brocker, C. N., Xie, C., Krausz, K. W., Wolf, C. R., Henderson, C. J. & Gonzalez, F. J., Dec 2016, In : Journal of Lipid Research. 57, p. 2130-2037 8 p.

Research output: Contribution to journalArticle

Open Access
File
Chenodeoxycholic Acid
Ursodeoxycholic Acid
Bile Acids and Salts
Metabolism
Taurine
35 Citations (Scopus)

Loss of Tet1-associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer

Thomson, J. P., Ottaviano, R., Unterberger, E. B., Lempiäinen, H., Muller, A., Terranova, R., Illingworth, R. S., Webb, S., Kerr, A. R. W., Lyall, M. J., Drake, A. J., Wolf, C. R., Moggs, J. G., Schwarz, M. & Meehan, R. R., 15 May 2016, In : Cancer Research. 76, 10, p. 3097-3108 12 p.

Research output: Contribution to journalArticle

Liver Neoplasms
CpG Islands
Neoplasms
Liver
DNA Methylation
7 Citations (Scopus)
254 Downloads (Pure)

Olaparib, monotherapy or with ionizing radiation, exacerbates DNA damage in normal tissues: insights from a new p21 reporter mouse

McMahon, M., Frangova, T. G., Henderson, C. J. & Wolf, C. R., Dec 2016, In : Molecular Cancer Research. 14, 12, p. 1195-1203 9 p.

Research output: Contribution to journalArticle

Open Access
File
Ionizing Radiation
DNA Damage
Galactosidases
Cisplatin
Firefly Luciferases
20 Citations (Scopus)

The role of protein-protein and protein-membrane Interactions on P450 function

Scott, E. E., Wolf, C. R., Otyepka, M., Humphreys, S. C., Reed, J. R., Henderson, C. J., McLaughlin, L. A., Paloncyova, M., Navratilova, V., Berka, K., Anzenbacher, P., Dahal, U. P., Barnaba, C., Brozik, J. A., Jones, J. P., Estrada, F., Laurence, J. S., Park, J. W. & Backes, W. L., Apr 2016, In : Drug Metabolism and Disposition. 44, 4, p. 576-590 15 p.

Research output: Contribution to journalArticle

Membrane Proteins
NADPH-Ferrihemoprotein Reductase
Membranes
Lyases
Mixed Function Oxygenases
2015
12 Citations (Scopus)

Activation status of the Pregnane X Receptor influences Vemurafenib availability in humanized mouse models

MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., 1 Nov 2015, In : Cancer Research. 75, 21, p. 4573-4581 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
PLX4032
pregnane X receptor
Drug and Narcotic Control
Liver Microsomes
21 Citations (Scopus)
Protein S
Acetaminophen
Glutathione S-Transferase pi
Oxidative Stress
Glutamate-Cysteine Ligase
8 Citations (Scopus)

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes

MacLeod, A. K., Fallon, P. G., Sharp, S., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., Mar 2015, In : Molecular & Cellular Proteomics. 14, 3, p. 750-760 11 p.

Research output: Contribution to journalArticle

Isotope Labeling
Cell culture
Metabolism
Isotopes
Labeling
10 Citations (Scopus)
23 Downloads (Pure)
Open Access
File
Metabolism
Liver
Biological Availability
Pharmaceutical Preparations
Nelfinavir
20 Citations (Scopus)

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo

Henderson, C. J., McLaughlin, L. A., Scheer, N., Stanley, L. A. & Wolf, C. R., Apr 2015, In : Molecular Pharmacology. 87, 4, p. 733-739 7 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
14 Citations (Scopus)

Defining human pathways of drug metabolism in vivo through the development of a multiple humanized mouse model

Scheer, N., Kapelyukh, Y., Rode, A., Oswald, S., Busch, D., McLaughlin, L. A., Lin, D., Henderson, C. J. & Wolf, C. R., Nov 2015, In : Drug Metabolism and Disposition. 43, 11, p. 1679-1690 12 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Polypharmacy
Oxygenases
Androgen Receptors
4 Citations (Scopus)

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability

Henderson, C. J., Cameron, A. R., Chatham, L., Stanley, L. A. & Wolf, C. R., May 2015, In : Toxicological Sciences. 145, 1, p. 138-148 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Carcinogens
Oxidative Stress
Liver
Phenobarbital
44 Citations (Scopus)

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and-independent mechanisms

Amankwatia, E. B., Chakravarty, P., Carey, F. A., Weidlich, S., Steele, R. J. C., Munro, A. J., Wolf, C. R. & Smith, G., 28 Apr 2015, In : British Journal of Cancer. 112, 9, p. 1480-1490 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Fluorouracil
Colorectal Neoplasms
Adenoma
HCT116 Cells
5 Citations (Scopus)

Model systems for understanding mechanisms of non-genotoxic carcinogenesis: response

Braeuning, A., Henderson, C. J., Wolf, C. R. & Schwarz, M., Oct 2015, In : Toxicological Sciences. 147, 2, p. 299-300 2 p.

Research output: Contribution to journalLetter

19 Citations (Scopus)

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

McGarry, D. J., Chen, W., Chakravarty, P., Lamont, D. L., Wolf, C. R. & Henderson, C. J., Jun 2015, In : Biochemical Journal. 469, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Protein S
Proteome
Liver
Animals
Glutathione S-Transferase pi
15 Citations (Scopus)
115 Downloads (Pure)

Recurrent Coding Sequence Variation Explains only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Timofeeva, M. N., Kinnersley, B., Farrington, S. M., Whiffin, N., Palles, C., Svinti, V., Lloyd, A., Gorman, M., Ooi, L. Y., Hosking, F., Barclay, E., Zgaga, L., Dobbins, S., Martin, L., Theodoratou, E., Broderick, P., Tenesa, A., Smillie, C., Grimes, G., Hayward, C. & 41 others, Campbell, A., Porteous, D., Deary, I. J., Harris, S. E., Northwood, E. L., Barrett, J. H., Smith, G., Wolf, R., Forman, D., Morreau, H., Ruano, D., Tops, C., Wijnen, J., Schrumpf, M., Boot, A., Vasen, H. F. A., Hes, F. J., Van Wezel, T., Franke, A., Lieb, W., Schafmayer, C., Hampe, J., Buch, S., Propping, P., Hemminki, K., Försti, A., Westers, H., Hofstra, R., Pinheiro, M., Pinto, C., Teixeira, M., Ruiz-Ponte, C., Fernández-Rozadilla, C., Carracedo, A., Castells, A., Castellví-Bel, S., Campbell, H., Bishop, D. T., Tomlinson, I. P. M., Dunlop, M. G. & Houlston, R. S., 10 Nov 2015, In : Scientific Reports. 5, 10 p., 16286.

Research output: Contribution to journalArticle

Open Access
File
Colorectal Neoplasms
Genes
Exome
DNA Mismatch Repair
Nucleic Acid Regulatory Sequences
10 Citations (Scopus)
Environmental Pollutants
Metabolism
Toxicity
Oxidoreductases
Cytochromes b5
Compartment Model
Transgenic Mice
cytochrome
Null
Mouse
2014
12 Citations (Scopus)

A role for cytochrome b5 in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice

Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y. & Wolf, C. R., Jan 2014, In : Drug Metabolism and Disposition. 42, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Neoplasms
Cytochromes
6 Citations (Scopus)
73 Downloads (Pure)

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

Macleod, A. K., Zang, T., Riches, Z., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., 7 Feb 2014, In : Journal of Proteome Research. 13, 2, p. 866-874 9 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolism
Enzymes
Drug interactions
Pharmaceutical Preparations
Ions
32 Citations (Scopus)

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

Stiborová, M., Moserová, M., Černá, V., Indra, R., Dračínský, M., Šulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M., 6 Apr 2014, In : Toxicology. 318, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cytochromes b5
NADP
Cytochrome P-450 Enzyme System
Cytochromes b
15 Citations (Scopus)

Deletion of 30 Murine Cytochrome p450 Genes Results In Viable Mice With Compromised Drug Metabolism

Scheer, N., McLaughlin, L. A., Rode, A., MacLeod, A. K., Henderson, C. J. & Wolf, C. R., Jun 2014, In : Drug Metabolism and Disposition. 42, 6, p. 1022-1030 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Genes
Multigene Family
Liver
34 Citations (Scopus)

Epigenetic profiles as defined signatures of xenobiotic exposure

Thomson, J. P., Moggs, J. G., Wolf, C. R. & Meehan, R. R., Apr 2014, In : Mutation Research: Genetic Toxicology and Environmental Mutagenesis. 764-765, p. 3-9 7 p.

Research output: Contribution to journalArticle

Xenobiotics
Epigenomics
Carcinogens
Genome
Crowns
39 Citations (Scopus)
147 Downloads (Pure)

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

Sawers, L., Ferguson, M. J., Ihrig, B. R., Young, H. C., Chakravarty, P., Wolf, C. R. & Smith, G., 9 Sep 2014, In : British Journal of Cancer. 111, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Open Access
File
Platinum
Glutathione Transferase
Tumor Cell Line
Pharmaceutical Preparations
Ovarian Neoplasms
9 Citations (Scopus)
131 Downloads (Pure)

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

McMahon, M., Campbell, K. H., MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., 26 Nov 2014, In : PLoS ONE. 9, 11, e114055.

Research output: Contribution to journalArticle

Open Access
File
Histone Deacetylase Inhibitors
Cytotoxins
Tumors
Cells
drugs
16 Citations (Scopus)

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

Henderson, C. J., McLaren, A. W. & Wolf, C. R., 15 Aug 2014, In : Cancer Research. 74, 16, p. 4378-4387 10 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Ethoxyquin
Epithelium
Genetic Transcription
Butylated Hydroxyanisole
38 Citations (Scopus)

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane X receptors

Luisier, R., Lempiäinen, H., Scherbichler, N., Braeuning, A., Geissler, M., Dubost, V., Müller, A., Scheer, N., Chibout, S-D., Hara, H., Picard, F., Theil, D., Couttet, P., Vitobello, A., Grenet, O., Grasl-Kraupp, B., Ellinger-Ziegelbauer, H., Thomson, J. P., Meehan, R. R., Elcombe, C. R. & 6 others, Henderson, C. J., Wolf, C. R., Schwarz, M., Moulin, P., Terranova, R. & Moggs, J. G., 2014, In : Toxicological Sciences. 139, 2, p. 501-511 11 p.

Research output: Contribution to journalArticle

Phenobarbital
Liver
Cell Cycle
Cells
Untranslated RNA
39 Citations (Scopus)
126 Downloads (Pure)

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

Braeuning, A., Gavrilov, A., Brown, S., Wolf, C. R., Henderson, C. J. & Schwarz, M., 1 Aug 2014, In : Toxicological Sciences. 140, 2, p. 259-70 12 p.

Research output: Contribution to journalArticle

Open Access
File
Phenobarbital
Transgenic Mice
Tumors
Liver
Neoplasms
2013
8 Citations (Scopus)

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet (PUVA) sensitivity

Deeni, Y. Y., Ibbotson, S. H., Woods, J. A., Wolf, C. R. & Smith, G., 2013, In : PLoS ONE. 8, 9, e75494.

Research output: Contribution to journalArticle

psoralen
methoxsalen
Methoxsalen
Ficusin
cytochrome P-450
37 Citations (Scopus)
Cytochrome Reductases
Cytochromes b5
Cytochrome P-450 Enzyme System
Electrons
Liver