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2020
4 Downloads (Pure)

Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes

Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. & Li, S., 3 Jan 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.

Research output: Contribution to journalArticle

Open Access
File
Thromboplastin
Type 1 Diabetes Mellitus
Healthy Volunteers
Blood Platelets
Endothelial Cells
16 Downloads (Pure)

The impact of phenotype, ethnicity and genotype on progression of Type 2 diabetes mellitus

Thakarakkattil Narayanan Nair, A., Donnelly, L. A., Dawed, A. Y., Gan, S., Anjana, R. M., Mohan, V., Palmer, C. & Pearson, E., 7 Jan 2020, In : Endocrinology, Diabetes & Metabolism. 11 p., e00108.

Research output: Contribution to journalArticle

Open Access
File
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Insulin Resistance
Genotype
Insulin
4 Downloads (Pure)

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

Koivula, R. W., Atabaki-Pasdar, N., Giordano, G. N., White, T., Adamski, J., Bell, J. D., Beulens, J., Brage, S., Brunak, S., De Masi, F., Dermitzakis, E. T., Forgie, I. M., Frost, G., Hansen, T., Hansen, T. H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M., Mari, A. & 14 others, McDonald, T. J., Pedersen, O., Rutters, F., Schwenk, J. M., Teare, H. J. A., Thomas, E. L., Vinuela, A., Mahajan, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E., Pavo, I. & Franks, P. W., 30 Jan 2020, In : Diabetologia. 13 p.

Research output: Contribution to journalArticle

Open Access
File
Type 2 Diabetes Mellitus
Homeostasis
Exercise
Research
Abdominal Fat
95 Downloads (Pure)
Open Access
File
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Diabetic Foot
Mortality
Diabetic Neuropathies
2019

4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation

Sipeky, C., Llerena, A., Manolopoulos, V. G., Pearson, E., Mlakar, V., Gozzo, L., Simmaco, M., Marchetti, P., Re, M. D., Stankovic, S., Meyer, U., Cascorbi, I., Ingelman-Sundberg, M., Suarez-Kurtz, G., Marc, J., Katsila, T., Paulmichl, M., Nofziger, C., Ansari, M., Drago, F. & 1 others, van Schaik, R. H., Oct 2019, In : Pharmacogenomics. 20, 15, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

Precision Medicine
Pharmacogenetics
Research
Sicily
Italy
6 Citations (Scopus)
283 Downloads (Pure)

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 208-214 7 p.

Research output: Contribution to journalArticle

Open Access
File
Type 1 Diabetes Mellitus
Autoantibodies
Type 2 Diabetes Mellitus
Insulin
Therapeutics
1 Citation (Scopus)
40 Downloads (Pure)

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

Lynam, A., McDonald, T., Hill, A., Dennis, J., Oram, R., Pearson, E., Weedon, M., Hattersley, A., Owen, K., Shields, B. & Jones, A., 26 Sep 2019, In : BMJ Open. 9, 9, p. 1-10 10 p., e031586.

Research output: Contribution to journalArticle

Open Access
File
Type 1 Diabetes Mellitus
Insulin
Area Under Curve
Therapeutics
ROC Curve
1 Citation (Scopus)
54 Downloads (Pure)

Diabetes: Is there a future for Pharmacogenomics guided treatment?

Pearson, E., Aug 2019, In : Clinical Pharmacology & Therapeutics. 106, 2, p. 329-337 9 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacogenetics
Clinical Decision Support Systems
Thiazolidinediones
Metformin
Hyperglycemia
20 Downloads (Pure)

Drug-drug-gene interactions and adverse drug reactions

Malki, M. A. & Pearson, E. R., 3 Dec 2019, In : Pharmacogenomics Journal. 12 p.

Research output: Contribution to journalReview article

Open Access
File
Drug-Related Side Effects and Adverse Reactions
Drug Interactions
Pharmaceutical Preparations
Genes
Polypharmacy
1 Citation (Scopus)
45 Downloads (Pure)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Wilman, H. R., Parisinos, C. A., Atabaki-Pasdar, N., Kelly, M., Thomas, E. L., Neubauer, S., Mahajan, A., Hingorani, A. D., Patel, R. S., Hemingway, H., Franks, P. W., Bell, J. D., Banerjee, R. & Yaghootkar, H., Sep 2019, In : Journal of Hepatology. 71, 3, p. 594-602 9 p.

Research output: Contribution to journalArticle

Open Access
File
Hepcidins
Iron
Liver
Genes
Abdominal Obesity
9 Citations (Scopus)
185 Downloads (Pure)

Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

Ji, Y., Yiorkas, A. M., Frau, F., Mook-Kanamori, D., Staiger, H., Thomas, E. L., Atabaki-Pasdar, N., Campbell, A., Tyrrell, J., Jones, S. E., Beaumont, R. N., Wood, A. R., Tuke, M. A., Ruth, K. S., Mahajan, A., Murray, A., Freathy, R. M., Weedon, M. N., Hattersley, A. T., Hayward, C. & 11 others, Machann, J., Häring, H-U., Franks, P., de Mutsert, R., Pearson, E., Stefan, N., Frayling, T. M., Allebrandt, K. V., Bell, J. D., Blakemore, A. I. & Yaghootkar, H., 1 Jan 2019, In : Diabetes. 68, 1, p. 207-219 13 p.

Research output: Contribution to journalArticle

Open Access
File
Adiposity
Type 2 Diabetes Mellitus
Heart Diseases
Fats
Alleles
47 Downloads (Pure)

Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals

McCreight, L., Mari, A., Coppin, L., Jackson, N., Umpleby, A. M. & Pearson, E., 22 Nov 2019, In : Diabetologia. 4 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
73 Downloads (Pure)

Motivations for data sharing-views of research participants from four European countries: A DIRECT study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 30 Jan 2019, In : European Journal of Human Genetics. 27, 5, p. 721-729 9 p.

Research output: Contribution to journalArticle

Open Access
File
Information Dissemination
Motivation
Research
Privacy
Biomedical Research
65 Downloads (Pure)

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease

Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P. K., Relan, D., Harris, S., Vaidya, S. S. ., Dhillon, B., Zhou, K., Pearson, E., Hayward, C., Polašek, O., Deary, I. J., MacGillivray, T. J., Wilson, J. F., Trucco, M., Palmer, C. & 1 others, Doney, A., Dec 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552 11 p.

Research output: Contribution to journalArticle

Open Access
File
Retinal Vessels
Genetic Loci
Coronary Artery Disease
Biomarkers
Genome-Wide Association Study
4 Citations (Scopus)
86 Downloads (Pure)

The effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study

Scottish Diabetes Research Network Epidemiology Group, McGurnaghan, S. J., Brierley, L., Caparrotta, T. M. ., McKeigue, P. M., Blackbourn, L. A. K., Wild, S. H., Leese, G., McCrimmon, R., McKnight, J. A., Pearson, E., Petrie, J. R., Sattar, N. & Colhoun, H. M., Apr 2019, In : Diabetologia. 62, 4, p. 621-632 12 p.

Research output: Contribution to journalArticle

Open Access
File
Type 2 Diabetes Mellitus
Observational Studies
Cardiovascular Diseases
Blood Pressure
Body Weight
4 Citations (Scopus)
79 Downloads (Pure)
Open Access
File
Type 2 Diabetes Mellitus
Primary Health Care
Blood Pressure
Pharmaceutical Preparations
Prescriptions
5 Citations (Scopus)
88 Downloads (Pure)

Type 2 diabetes: a multifaceted disease

Pearson, E., Jul 2019, In : Diabetologia. 62, 7, p. 1107-1112 6 p.

Research output: Contribution to journalReview article

Open Access
File
Type 2 Diabetes Mellitus
Insulin Resistance
Therapeutics
2 Citations (Scopus)
58 Downloads (Pure)

Variation in the plasma membrane monoamine transporter (PMAT) (encoded by SLC29A4) and organic cation transporter 1 (OCT1) (encoded by SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: An IMI direct study

Dawed, A., Zhou, K., van Leeuwen, N., Mahajan, A., Robertson, N. R., Koivula, R. W., Elders, P. J. M., Rauh, S. P., Jones, A. G., Holl, R. W. ., Stingl, J. C., Franks, P. W., McCarthy, M. I., 't Hart, L. M. & Pearson, E., 1 Jun 2019, In : Diabetes Care. 42, 6, p. 1027-1033 7 p.

Research output: Contribution to journalArticle

Open Access
File
Organic Cation Transporter 1
Membrane Transport Proteins
Metformin
Type 2 Diabetes Mellitus
Cell Membrane
3 Citations (Scopus)
83 Downloads (Pure)

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

MASTERMIND consortium, McGovern, A. P., Dennis, J. M., Shields, B. M., Hattersley, A. T., Pearson, E. R. & Jones, A. G., 12 Apr 2019, In : BMC Medicine. 17, 1, p. 1-17 17 p., 79.

Research output: Contribution to journalArticle

Open Access
File
Therapeutics
Type 2 Diabetes Mellitus
Glucose
Propensity Score
Cohort Studies
2018
9 Citations (Scopus)
68 Downloads (Pure)

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

Shepherd, M. H., Shields, B. M., Hudson, M., Pearson, E. R., Hyde, C., Ellard, S., Hattersley, A. T. & Patel, K. A., Dec 2018, In : Diabetologia. 61, 12, p. 2520-2527 8 p.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Type 2 Diabetes Mellitus
Prospective Studies
Insulin
Therapeutics
7 Citations (Scopus)
114 Downloads (Pure)

Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes

Noyes, J. D., Soto-Pedre, E., Donnelly, L. A. & Pearson, E., 14 Jan 2018, In : Diabetic Medicine. 35, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Open Access
File
Type 2 Diabetes Mellitus
HDL Cholesterol
Reading
Therapeutics
Logistic Models
9 Citations (Scopus)
174 Downloads (Pure)

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

Hébert, H. L., Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
184 Downloads (Pure)

C-peptide decline in type 1 diabetes has two phases: An initial exponential fall and a subsequent stable phase

Shields, B. M., McDonald, T. J., Oram, R., Hill, A., Hudson, M., Leete, P., Pearson, E. R., Richardson, S. J., Morgan, N. G. & Hattersley, A. T., 1 Jul 2018, In : Diabetes Care. 41, 7, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Open Access
File
C-Peptide
Type 1 Diabetes Mellitus
Creatinine
Cell Survival
Research Design
26 Citations (Scopus)
162 Downloads (Pure)

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Neonatal Diabetes International Collaborative Group, Bowman, P., Sulen, Å., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M., Iafusco, D. & 2 others, Hattersley, A. T. & Njølstad, P. R., 1 Aug 2018, In : The Lancet Diabetes and Endocrinology. 6, 8, p. 637-646 10 p.

Research output: Contribution to journalArticle

Open Access
File
Cohort Studies
Safety
Mutation
Therapeutics
Insulin
1 Citation (Scopus)
54 Downloads (Pure)

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: A joint modelling approach

MASTERMIND consortium, Dennis, J. M., Shields, B. M., Jones, A. G., Pearson, E., Hattersley, A. T. & Henley, W. E., 14 Dec 2018, In : Clinical Epidemiology. 10, p. 1869-1877 9 p.

Research output: Contribution to journalArticle

Open Access
File
Type 2 Diabetes Mellitus
Joints
Drug Therapy
Metformin
Pharmaceutical Preparations
19 Citations (Scopus)
117 Downloads (Pure)

First Genome Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Cousminer, D. L., Ahlqvist, E., Mishra, R., Andersen, M. K., Chesi, A., Hawa, M. I., Davis, A., Hodge, K. M., Bradfield, J. P., Zhou, K., Guy, V. C., Åkerlund, M., Wod, M., Fritsche, L. G., Vestergaard, H., Snyder, J., Højlund, K., Linneberg, A., Käräjämäki, A., Brandslund, I. & 33 others, Kim, C. E., Witte, D. R., Sørgjerd, E. P., Brillon, D. J., Pedersen, O., Beck-Nielsen, H., Grarup, N., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Melander, O., Harris, R. I., Varvel, S., Grill, V. E. R., Hakonarson, H. H., Froguel, P., Lonsdale, J. T., Mauricio, D., Schloot, N. C., Khunti, K., Greenbaum, C. J., Asvold, B. O., Yderstræde, K. B., Pearson, E., Schwartz, S., Voight, B. F., Hansen, T., Tuomi, T., Boehm, B. O., Groop, L. C., Leslie, R. D. & Grant, S. F. A., 1 Nov 2018, In : Diabetes Care. p. 2396-2403 7 p.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Population Control
Latent Autoimmune Diabetes in Adults
12 Citations (Scopus)
125 Downloads (Pure)

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O’Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C., Pearson, E., Scott, R. A., van Heel, D. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 711.

Research output: Contribution to journalArticle

Open Access
File
inference
catalogs
resources
Genotype
3 Citations (Scopus)
68 Downloads (Pure)

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes

Rotroff, D. M., Yee, S. W., Zhou, K., Marvel, S. W., Shah, H. S., Jack, J. R., Havener, T. M., Hedderson, M. M., Kubo, M., Herman, M. A., Gao, H., Mychaleckyi, J. C., McLeod, H. L., Doria, A., Giacomini, K. M., Pearson, E. R., Wagner, M. J., Buse, J. B., Motsinger-Reif, A. A. & MetGen Investigators and the ACCORD/ACCORDion Investigators, Jul 2018, In : Diabetes. 67, 7, p. 1428-1440 13 p.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Type 2 Diabetes Mellitus
Glucose
Feeding Behavior
Knockout Mice
3 Citations (Scopus)
119 Downloads (Pure)

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

Gudmundsdottir, V., Pedersen, H. K., Allebrandt, K. V., Brorsson, C., van Leeuwen, N., Banasik, K., Mahajan, A., Groves, C. J., van de Bunt, M., Dawed, A. Y., Fritsche, A., Staiger, H., Simonis-Bik, A. M. C., Deelen, J., Kramer, M. H. H., Dietrich, A., Hübschle, T., Willemsen, G., Häring, H-U., de Geus, E. J. C. & 8 others, Boomsma, D. I., Eekhoff, E. M. W., Ferrer, J., McCarthy, M. I., Pearson, E. R., Gupta, R., Brunak, S. & 't Hart, L. M., 2 Jan 2018, In : PLoS ONE. 13, 1, p. 1-19 19 p., e0189886.

Research output: Contribution to journalArticle

Open Access
File
glucagon-like peptide 1
Biological Phenomena
Glucagon-Like Peptide 1
insulin secretion
Electric network analysis
4 Citations (Scopus)
141 Downloads (Pure)

Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study

Siddiqui, M. K., Kennedy, G., Carr, F., Doney, A., Pearson, E., Morris, A., Johnson, T., McLaughlin, M. M., Williams, R. E. & Palmer, C., Jun 2018, In : Diabetologia. 61, 6, p. 1344-1353 10 p.

Research output: Contribution to journalArticle

Open Access
File
1-Alkyl-2-acetylglycerophosphocholine Esterase
Diabetic Retinopathy
Disease Progression
Scotland
Survival Analysis
11 Citations (Scopus)
117 Downloads (Pure)

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

Molnos, S., Wahl, S., Haid, M., Eekhoff, E. M. W., Pool, R., Floegel, A., Deelen, J., Much, D., Prehn, C., Breier, M., Draisma, H. H. M., van Leeuwen, N., Simonis-Bik, A. M. C., Jonsson, A., Willemsen, G., Bernigau, W., Wang-Sattler, R., Suhre, K., Peters, A., Thorand, B. & 24 others, Herder, C., Rathmann, W., Roden, M., Gieger, C., Kramer, M. H. H., van Heemst, D., Pedersen, H. K., Gudmundsdottir, V., Schulze, M. B., Pischon, T., de Geus, E. J. C., Boeing, H., Boomsma, D. I., Ziegler, A. G., Slagboom, P. E., Hummel, S., Beekman, M., Grallert, H., Brunak, S., McCarthy, M. I., Gupta, R., Pearson, E. R., Adamski, J. & 't Hart, L. M., Jan 2018, In : Diabetologia. 61, 1, p. 117-129 13 p.

Research output: Contribution to journalArticle

Open Access
File
Type 2 Diabetes Mellitus
Glucose Tolerance Test
Biomarkers
Glucagon-Like Peptide 1
Arginine
9 Citations (Scopus)
76 Downloads (Pure)

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J-L., Demine, S., Schiavo, A. A., Pachera, N., Deglasse, J-P., Jonas, J-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M., 2 Nov 2018, In : Nucleic Acids Research. 46, 19, p. 10302-10318 17 p.

Research output: Contribution to journalArticle

Open Access
File
RNA, Transfer, Gln
Transfer RNA
tRNA Methyltransferases
Guanosine
Induced Pluripotent Stem Cells
4 Citations (Scopus)
143 Downloads (Pure)

Performance of Cardiovascular Disease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register

Scottish Diabetes Research Network Epidemiology Group, Read, S. H., van Diepen, M., Colhoun, H. M., Halbesma, N., Lindsay, R. S., McKnight, J. A., McAllister, D. A., Pearson, E. R., Petrie, J. R., Philip, S., Sattar, N., Woodward, M. & Wild, S. H., 1 Sep 2018, In : Diabetes Care. 41, 9, p. 2010-2018 9 p.

Research output: Contribution to journalArticle

Open Access
File
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Calibration
Death Certificates
Hospital Records
5 Citations (Scopus)
129 Downloads (Pure)

Pharmacogenetics and target identification in diabetes

Pearson, E. R., 1 Jun 2018, In : Current Opinion in Genetics & Development. 50, p. 68-73 6 p.

Research output: Contribution to journalReview article

Open Access
File
Metformin
Pharmacogenetics
Mutation
Electronic Health Records
Patient Care
5 Citations (Scopus)
145 Downloads (Pure)

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

McCreight, L., Stage, T. B., Connelly, P., Lonergan, M., Nielsen, F., Prehn, C., Adamski, J., Brosen, K. & Pearson, E. R., 1 Jul 2018, In : Diabetes, Obesity & Metabolism. 20, 7, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Pharmacokinetics
Bile Acids and Salts
Lactic Acid
Serotonin
18 Citations (Scopus)
195 Downloads (Pure)

Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-Term Glycemic Response to DPP-4 Inhibitor Therapy

Dennis, J. M., Shields, B. M., Hill, A. V., Knight, B. A., McDonald, T. J., Rodgers, L. R., Weedon, M. N., Henley, W. E., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Jones, A. G. & MASTERMIND consortium, Apr 2018, In : Diabetes Care. 41, 4, p. 705-712 8 p.

Research output: Contribution to journalArticle

Open Access
File
Dipeptidyl-Peptidase IV Inhibitors
Precision Medicine
Type 2 Diabetes Mellitus
Incretins
Insulin Resistance
2 Citations (Scopus)
146 Downloads (Pure)

Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers-validation of technique and implications for clinical studies

Marzetti, M., Brunton, T., McCreight, L., Pearson, E., Docherty, S. & Gandy, S. J., 17 May 2018, In : British Journal of Radiology. 91, 1087, 7 p., 20180025.

Research output: Contribution to journalArticle

Open Access
File
Abdomen
Adipose Tissue
Healthy Volunteers
Body Mass Index
Subcutaneous Fat
33 Downloads (Pure)
Open Access
File
Sulfonamides
Hypoglycemia
Typhoid Fever
Pharmaceutical Preparations
Research Personnel
14 Citations (Scopus)
184 Downloads (Pure)

Sex and BMI alter the benefits and risks of sulfonylureas and thiazolidinediones in type 2 diabetes: A framework for evaluating stratification using routine clinical and individual trial data

Dennis, J. M., Henley, W. E., Weedon, M. N., Lonergan, M., Rodgers, L. R., Jones, A. G., Hamilton, W. T., Sattar, N., Janmohamed, S., Holman, R. R., Pearson, E. R., Shields, B. M. & Hattersley, A. T., 1 Sep 2018, In : Diabetes Care. 41, 9, p. 1844-1853 10 p.

Research output: Contribution to journalArticle

Open Access
File
Thiazolidinediones
Type 2 Diabetes Mellitus
Clinical Trials
rosiglitazone
Metformin
4 Citations (Scopus)
193 Downloads (Pure)

Sharing data for future research-engaging participants' views about data governance beyond the original project: a DIRECT Study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 28 Sep 2018, In : Genetics in Medicine. 21, p. 1131-1138 8 p.

Research output: Contribution to journalArticle

Open Access
File
Information Dissemination
Research Personnel
Patient Advocacy
Denmark
Research
94 Downloads (Pure)

The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project

Teare, H. J. A., de Masi, F., Banasik, K., Barnett, A., Herrgard, S., Jablonka, B., Postma, J. W. M., McDonald, T. J., Forgie, I., Chmura, P. J., Rydzka, E. K., Gupta, R., Brunak, S., Pearson, E. & Kaye, J., 4 Sep 2018, In : Life Sciences, Society and Policy. 14, 1, p. 1-17 17 p., 20.

Research output: Contribution to journalArticle

Open Access
File
Private Sector
Information Dissemination
Public Sector
Sexual Partners
medicine

The search for predictive metabolic biomarkers for incident T2DM

Pearson, E. & Adamski, J., 18 Jun 2018, In : Nature Reviews Endocrinology. 14, 8, p. 444-446 3 p.

Research output: Contribution to journalComment/debate

Biomarkers
Metabolomics
Phenylalanine
Glycine
Type 2 Diabetes Mellitus
8 Citations (Scopus)

Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes

Patel, K. A., Weedon, M. N., Shields, B. M., Pearson, E. R., Hattersley, A. T. & McDonald, T. J., 8 Nov 2018, In : Diabetes Care. 42, 2, p. e1-e2 2 p.

Research output: Contribution to journalLetter

2017
11 Citations (Scopus)
115 Downloads (Pure)

A common missense variant of LILRB5 is associated with statin intolerance and myalgia

Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., Abelega, N-U., Carr, D., Bloch, K., Halberg, P., Yue, Q-Y., Pearson, E. R., Colhoun, H. M., Morris, A. D., Dow, E., George, J., Pirmohamed, M., Ridker, P. M., Doney, A. S. F., Alfirevic, A. & 5 others, Wadelius, M., Maitland-van der Zee, A. H., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, 21 Dec 2017, In : European Heart Journal. 38, 48, p. 3569-3575 7 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Myalgia
Immunogenetics
Muscles
Electronic Health Records
15 Citations (Scopus)
127 Downloads (Pure)

Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study

Connelly, P. J., Lonergan, M., Soto-Pedre, E., Donnelly, L., Zhou, K. & Pearson, E. R., 5 Jul 2017, In : Diabetes, Obesity & Metabolism. 19, 11, p. 1579-1586 7 p.

Research output: Contribution to journalArticle

Open Access
File
Lactic Acidosis
Metformin
Acute Kidney Injury
Lactic Acid
Type 2 Diabetes Mellitus
27 Citations (Scopus)
171 Downloads (Pure)

A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Wood, A. R., Jonsson, A., Jackson, A. U., Wang, N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., Stančáková, A., Boomsma, D. I., de Geus, E. J. C., Eekhoff, E. M. W., Fritsche, A., Kramer, M. H. H., Nijpels, G., Simonis-Bik, A. M. C., van Haeften, T. W., Mahajan, A. & 31 others, Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, K., Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, N., Eiberg, H., Pedersen, O., Chen, Y-D., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, T., Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M., 21 Jul 2017, In : Diabetes. 66, 8, p. 2296-2309 14 p.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Type 2 Diabetes Mellitus
Insulin
Alleles
Fasting
2 Citations (Scopus)

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., Colhoun, H., Morris, A. D., George, J., Doney, A., Pirmohamed, M., Alfirevic, A., Wadelius, M., Maitland-van der Zee, A. H., Ridker, P. M., Chasman, D. I., Palmer, C. N. A. & PREDICTION-ADR Consortium, Aug 2017, In : Circulation: Cardiovascular Genetics. 10, 4, e001737 .

Research output: Contribution to journalArticle

Myalgia
Creatine Kinase
Scotland
Gene Frequency
MM Form Creatine Kinase
1 Citation (Scopus)
84 Downloads (Pure)

Clarifying the relationship between metformin, acute kidney injury and lactic acidosis

Bell, S., Soto-Pedre, E., Connelly, P., Livingstone, S. & Pearson, E., 13 Dec 2017, In : Nature Reviews Nephrology. 14, 1 p., 70.

Research output: Contribution to journalLetter

Open Access
File
1 Citation (Scopus)
96 Downloads (Pure)

Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study

Eibich, P., Green, A., Hattersley, A. T., Jennison, C., Lonergan, M., Pearson, E. R. & Gray, A. M., Oct 2017, In : Diabetes Therapy. 8, 5, p. 1031-1045 15 p.

Research output: Contribution to journalArticle

Open Access
File
Health Care Costs
Type 2 Diabetes Mellitus
Cohort Studies
Costs and Cost Analysis
Therapeutics