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Author

  • Alan Prescott
2020

A conserved ATG2-GABARAP family interaction is critical for phagophore formation

Bozic, M., van den Bekerom, L., Milne, B. A., Goodman, N., Roberston, L., Prescott, A., Macartney, T., Dawe, N. & McEwan, D., 4 Mar 2020, In : EMBO Reports. 21, 3, p. 1-17 17 p., e48412.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
55 Downloads (Pure)

Antibody RING-Mediated Destruction of Endogenous Proteins

Ibrahim, A. F. M., Shen, L., Tatham, M. H., Dickerson, D., Prescott, A. R., Abidi, N., Xirodimas, D. P. & Hay, R. T., 25 May 2020, In : Molecular Cell. 12 p.

Research output: Contribution to journalArticle

Open Access
File
17 Downloads (Pure)

Cold climate adaptation is a plausible cause for evolution of multicellular sporulation in Dictyostelia

Lawal, H. M., Schilde, C., Kin, K., Brown, M. W., James, J., Prescott, A. R. & Schaap, P., 29 May 2020, In : Scientific Reports. 10, 1, p. 1-9 9 p., 8797.

Research output: Contribution to journalArticle

Open Access
File
13 Downloads (Pure)

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation.

Research output: Contribution to journalArticle

Open Access
File
15 Downloads (Pure)
2019

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
179 Downloads (Pure)

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
4 Downloads (Pure)

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 1 Sep 2019, In : EMBO Reports. 20, 9, p. 1-19 19 p., e47495.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
88 Downloads (Pure)
Open Access
File
51 Downloads (Pure)

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.

Research output: Contribution to journalArticle

Open Access
File
56 Downloads (Pure)
Open Access
File
65 Downloads (Pure)

Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 17 May 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
155 Downloads (Pure)

Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages

Guo, M., Härtlova, A., Gierlinski, M., Prescott, A., Castellvi, J., Hernandez Losa, J., Petersen, S. K., Wenzel, U. A., Dill, B. D., Emmerich, C. H., Ramon Y Cajal, S., Russell, D. G. & Trost, M., 3 Jun 2019, In : EMBO Journal. 38, 11, p. 1-15 15 p., e100299.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
182 Downloads (Pure)
2018

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P. & Ganley, I. G., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 439-449.e5 17 p.

Research output: Contribution to journalArticle

Open Access
File
123 Citations (Scopus)
179 Downloads (Pure)

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Martinez-Fabregas, J., Prescott, A., van Kasteren, S., Leslie Pedrioli, D., McLean, W., Moles, A., Reinheckel, T., Poli, V. & Watts, C., 17 Dec 2018, In : Nature Communications. 9, 1, p. 1-16 16 p., 5343.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
129 Downloads (Pure)

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks

Malik, N., Macartney, T., Hornberger, A., Anderson, K., Tovell, H., Prescott, A. R. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 117-135 19 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
242 Downloads (Pure)

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
153 Downloads (Pure)

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 others, Smith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, p. 1-18 18 p., 181108.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
127 Downloads (Pure)
2017

Bifunctionality of a biofilm matrix protein controlled by redox state

Arnaouteli, S., Ferreira, A. S., Schor, M., Morris, R. J., Bromley, K. M., Jo, J., Cortez, K. L., Sukhodub, T., Prescott, A. R., Dietrich, L. E. P., MacPhee, C. E. & Stanley-Wall, N. R., 25 Jul 2017, In : Proceedings of the National Academy of Sciences. 114, 30, p. E6184-E6191 8 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
488 Downloads (Pure)
Open Access
File
6 Citations (Scopus)
171 Downloads (Pure)

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)

Logie, L., Van Aalten, L., Knebel, A., Force, T., Hastie, C. J., MacLauchlan, H., Campbell, D. G., Gourlay, R., Prescott, A., Davidson, J., Fuller, W. & Sutherland, C., 15 Dec 2017, In : Scientific Reports. 7, p. 1-14 14 p., 17682.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
171 Downloads (Pure)
2016

Deep intronic sequence variants in COL2A1 affect the alternative splicing efficiency of Exon 2, and may confer a risk for rhegmatogenous retinal detachment

Spickett, C., Hysi, P., Hammond, C. J., Prescott, A., Fincham, G. S., Poulson, A. V., McNinch, A. M., Richards, A. J. & Snead, M. P., 21 Aug 2016, In : Human Mutation. 37, 10, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
138 Downloads (Pure)

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

McWilliams, T., Prescott, A., Allen, G., Tamjar, J., Munson, M., Thomson, C., Muqit, M. & Ganley, I., 25 Jul 2016, In : Journal of Cell Biology. 214, 3, p. 333-345 13 p.

Research output: Contribution to journalArticle

Open Access
File
119 Citations (Scopus)
268 Downloads (Pure)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 22 Apr 2016, In : eLife. 5, p. 1-18 18 p., e12278.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
136 Downloads (Pure)
2015

A key role for PTP1B in dendritic cell maturation, migration, and T cell activation

Martin-Granados, C., Prescott, A. R., Le Sommer, S., Klaska, I. P., Yu, T., Muckersie, E., Giuraniuc, C. V., Grant, L., Delibegovic, M. & Forrester, J. V., Dec 2015, In : Journal of Molecular Cell Biology. 7, 6, p. 517-528 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. MK., 1 Aug 2015, In : EMBO Reports. 16, 8, p. 939-954 16 p.

Research output: Contribution to journalArticle

Open Access
File
91 Citations (Scopus)
142 Downloads (Pure)

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling

Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G. & Hundal, H., 1 Sep 2015, In : Biochemical Journal. 470, 2, p. 207-221

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
156 Downloads (Pure)

High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M., Sep 2015, In : Proteomics. 15, 18, p. 3169-3174 6 p.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
120 Downloads (Pure)

RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions

Pechenick Jowers, T., Featherstone, R. J., Reynolds, D. K., Brown, H. K., James, J., Prescott, A., Haga, I. R. & Beard, P. M., 15 Jan 2015, In : Virology. 475, p. 66-73 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P., 15 Jun 2015, In : Biochemical Journal. 468, 3, p. 363-372 10 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

Ozanne, J., Prescott, A. R. & Clark, K., 15 Jan 2015, In : Biochemical Journal. 465, 2, p. 271-279 9 p.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)

The PDK1-Rsk signaling pathway controls Langerhans cell proliferation and patterning

Zaru, R., Matthews, S. P., Edgar, A. J., Prescott, A. R., Gomez-Nicola, D., Hanauer, A. & Watts, C., 1 Nov 2015, In : Journal of Immunology. 195, 9, p. 4264-4272 9 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
134 Downloads (Pure)
2014

A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C., 1 Oct 2014, In : Journal of Cell Science. 127, 19, p. 4213-4224 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
Open Access
38 Citations (Scopus)
Open Access
File
104 Citations (Scopus)
178 Downloads (Pure)

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Banerjee, S., Buhrlage, S. J., Huang, H-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. & Gray, N. S., 1 Jan 2014, In : Biochemical Journal. 457, 1, p. 215-225 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
Open Access
File
53 Citations (Scopus)
130 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
140 Downloads (Pure)

Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking

Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E., 15 Feb 2014, In : Journal of Cell Science. 127, 4, p. 812-827 16 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
5 Citations (Scopus)
2013

A synthetic system for expression of components of a bacterial microcompartment

Sargent, F., Davidson, F. A., Kelly, C. L., Binny, R., Christodoulides, N., Gibson, D., Johansson, E., Kozyrska, K., Licandro Lado, L., MacCallum, J., Montague, R., Ortmann, B., Owen, R., Coulthurst, S. J., Dupuy, L., Prescott, A. R. & Palmer, T., Nov 2013, In : Microbiology. 159, 11, p. 2427-2436 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

Hobley, L., Ostrowski, A., Rao, F. V., Bromley, K. M., Porter, M., Prescott, A. R., Macphee, C. E., van Aalten, D. M. F. & Stanley-Wall, N. R., 13 Aug 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13600-13605 6 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P., 23 Aug 2013, In : Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
131 Downloads (Pure)

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S., 2013, In : Scientific Reports. 3, 1275.

Research output: Contribution to journalArticle

25 Citations (Scopus)

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

Groves, M. J., Johnson, C. E., James, J., Prescott, A. R., Cunningham, J., Haydock, S., Pepper, C., Fegan, C., Pirrie, L., Westwood, N. J., Coates, P. J., Ganley, I. G. & Tauro, S., 2013, In : British Journal of Cancer. 109, October, p. 2432=2444 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C., 15 Jan 2013, In : Journal of Immunology. 190, 2, p. 565-577 13 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. & Cohen, P. T. W., 1 Sep 2013, In : Cell Cycle. 12, 17, p. 2876-2887 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling

McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R., 14 Mar 2013, In : Blood. 121, 11, p. 2084-2094 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

Elliott, J. L., Perng, M. D., Prescott, A. R., Jansen, K. A., Koenderink, G. H. & Quinlan, R. A., 2013, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 368, 1617, 15 p., 20120375.

Research output: Contribution to journalArticle

29 Citations (Scopus)
20 Citations (Scopus)