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2019
10 Downloads (Pure)

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression

Dixon, C. I., Walker, S. E., Swinny, J., Belelli, D., Lambert, J. J., King, S. L. & Stephens, D. N., Apr 2019, In : Behavioural Pharmacology. 30, 2-3, p. 272-281 10 p.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptors
Cocaine
Psychological Stress
Genotype
Cocaine-Related Disorders
21 Downloads (Pure)

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

Belelli, D., Hogenkamp, D., Gee, K. W. & Lambert, J. J., 23 Dec 2019, In : Neurobiology of Stress. 12, p. 1-11 11 p., 100207.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptors
Modulators
Neurotransmitter Agents
Steroids
Hypnotics and Sedatives
2018
3 Citations (Scopus)
99 Downloads (Pure)

An isotope dilution based-targeted and non-targeted carbonyl neurosteroid/steroid profiling

Sharp, S., Mitchell, S., Vallée, M., Kuzmanova, E., Cooper, M., Belelli, D., Lambert, J. & Huang, J., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5247-5255 9 p.

Research output: Contribution to journalArticle

Open Access
File
Isotopes
Dilution
Neurotransmitter Agents
Steroids
Brain
2 Citations (Scopus)
115 Downloads (Pure)

Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine

Mitchell, S. J., Maguire, E. P., Cunningham, L., Gunn, B. G., Linke, M., Zechner, U., Dixon, C. I., King, S. L., Stephens, D. N., Swinny, J. D., Belelli, D. & Lambert, J. J., Oct 2018, In : Neuropharmacology. 141, p. 98-112 15 p.

Research output: Contribution to journalArticle

Open Access
File
Nucleus Accumbens
GABA-A Receptors
Cocaine
Haplotypes
Cocaine-Related Disorders
5 Citations (Scopus)
113 Downloads (Pure)

Endogenous neurosteroids influence synaptic GABAA receptors during post-natal development

Belelli, D., Brown, A. R., Mitchell, S. J., Gunn, B. G., Herd, M. B., Phillips, G. D., Seifi, M., Swinny, J. D. & Lambert, J. J., 18 Feb 2018, In : Journal of Neuroendocrinology. 30, 2, p. 11-15 5 p., e12537.

Research output: Contribution to journalReview article

Open Access
File
Neurotransmitter Receptor
GABA-A Receptors
Neurotransmitter Agents
Synaptic Transmission
gamma-Aminobutyric Acid
10 Citations (Scopus)
105 Downloads (Pure)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J. J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. & 1 others, Stroh, A., 4 Sep 2018, In : eLife. 7, p. 1-32 32 p., e38744.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Huntington Disease
Animal Behavior
Aberrations
Visual Cortex
134 Downloads (Pure)

Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures

Monteiro, O., Chen, C., Bingham, R., Argyrou, A., Buxton, R., Jönsson, C. P., Jones, E., Bridges, A., Gatfield, K., Krauß, S., Lambert, J., Langston, R., Schweiger, S. & Uings, I., 23 Apr 2018, In : Neuroscience Letters. 673, p. 44-50 7 p.

Research output: Contribution to journalArticle

Open Access
File
Huntington Disease
Pharmacology
Peptides
Human Immunodeficiency Virus Proteins
S 6
2017
9 Citations (Scopus)
117 Downloads (Pure)

Behavioural pharmacology of the α5-GABAA receptor antagonist S44819: Enhancement and remediation of cognitive performance in preclinical models

Gacsályi, I., Móricz, K., Gigler, G., Wellmann, J., Nagy, K., Ling, I., Barkóczy, J., Haller, J., Lambert, J. J., Szénási, G., Spedding, M. & Antoni, F. A., Oct 2017, In : Neuropharmacology. 125, p. 30-38 9 p.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptor Antagonists
Pharmacology
Anti-Anxiety Agents
Antidepressive Agents
Fear
22 Citations (Scopus)
129 Downloads (Pure)

GABAA receptor subtype involvement in addictive behaviour

Stephens, D. N., King, S. L., Lambert, J. J., Belelli, D. & Duka, T., Jan 2017, In : Genes, Brain and Behavior. 16, 1, p. 149-184 36 p.

Research output: Contribution to journalReview article

Open Access
File
Addictive Behavior
GABA-A Receptors
Protein Isoforms
Neurotransmitter Receptor
Brain
5 Citations (Scopus)
121 Downloads (Pure)
Open Access
File
Ventral Tegmental Area
mu Opioid Receptor
Morphine
Inhibitory Postsynaptic Potentials
Neurons
16 Citations (Scopus)
105 Downloads (Pure)

Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies

Kumar, N., Fagart, J., Liere, P., Mitchell, S. J., Knibb, A. R., Petit-Topin, I., Rame, M., El-Etr, M., Schumacher, M., Lambert, J. J., Rafestin-Oblin, M-E. & Sitruk-Ware, R., 1 Jan 2017, In : Endocrinology. 158, 1, p. 170-182 12 p.

Research output: Contribution to journalArticle

Open Access
File
Progestins
Structure-Activity Relationship
Contraception
Brain
GABA-A Receptors
8 Citations (Scopus)
73 Downloads (Pure)

Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

Weir, C. J., Mitchell, S. J. & Lambert, J. J., Dec 2017, In : British Journal of Anaesthesia. 119, Suppl. 1, p. i167-i175 9 p.

Research output: Contribution to journalArticle

Open Access
File
Intravenous Anesthetics
General Anesthetics
GABA-A Receptors
Anesthetics
Central Nervous System
13 Citations (Scopus)
98 Downloads (Pure)

Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent

Etherington, L-A., Mihalik, B., Pálvölgyi, A., Ling, I., Pallagi, K., Kertész, S., Varga, P., Gunn, B. G., Brown, A. R., Livesey, M. R., Monteiro, O., Belelli, D., Barkóczy, J., Spedding, M., Gacsályi, I., Antoni, F. A. & Lambert, J. J., Oct 2017, In : Neuropharmacology. 125, p. 353-364 12 p.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptors
Benzodiazepines
gamma-Aminobutyric Acid
Therapeutics
Central Nervous System
2016
7 Citations (Scopus)
100 Downloads (Pure)

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons

Brown, A. R., Mitchell, S., Peden, D. R., Herd, M. B., Seifi, M., Swinny, J. D., Belelli, D. & Lambert, J., Apr 2016, In : Neuropharmacology. 103, p. 163-173 11 p.

Research output: Contribution to journalArticle

Open Access
File
Synaptic Transmission
gamma-Aminobutyric Acid
Neurotransmitter Agents
Neurons
Pyramidal Cells
2015
15 Citations (Scopus)

A novel GABAA alpha 5 receptor inhibitor with therapeutic potential

Ling, I., Mihalik, B., Etherington, L-A., Kapus, G., Pálvölgyi, A., Gigler, G., Kertész, S., Gaál, A., Pallagi, K., Kiricsi, P., Szabó, É., Szénási, G., Papp, L., Hársing, L. G., Lévay, G., Spedding, M., Lambert, J. J., Belelli, D., Barkóczy, J., Volk, B. & 3 others, Simig, G., Gacsályi, I. & Antoni, F. A., 5 Oct 2015, In : European Journal of Pharmacology. 764, p. 497-507 11 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Benzodiazepines
gamma-Aminobutyric Acid
Blood-Brain Barrier
Hypnotics and Sedatives
13 Citations (Scopus)

Control of inhibition by the direct action of cannabinoids on GABAA receptors

Golovko, T., Min, R., Lozovaya, N., Falconer, C., Yatsenko, N., Tsintsadze, T., Tsintsadze, V., Ledent, C., Harvey, R. J., Belelli, D., Lambert, J. J., Rozov, A. & Burnashev, N., 1 Sep 2015, In : Cerebral Cortex. 25, 9, p. 2440-2455 16 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Cannabinoids
Pyramidal Cells
GABA-A Receptors
Interneurons
13 Citations (Scopus)

Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones

Brown, A. R., Herd, M. B., Belelli, D. & Lambert, J. J., 1 Jan 2015, In : Journal of Physiology. 593, 1, p. 267-284 37 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Synaptic Transmission
Neurotransmitter Agents
Neurons
Thalamus
67 Citations (Scopus)

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response

Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J. & Belelli, D., Jan 2015, In : Frontiers in Neuroendocrinology. 36, p. 28-48 21 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Neurotransmitter Agents
Mood Disorders
Life Change Events
Psychiatry
10 Citations (Scopus)

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus

Corteen, N. L., Carter, J. A., Rudolph, U., Belelli, D., Lambert, J. J. & Swinny, J. D., Sep 2015, In : Brain Structure and Function. 220, 5, p. 2739-2763 25 p.

Research output: Contribution to journalArticle

GABA Receptors
GABA-A Receptors
Serotonergic Neurons
Serotonin
Central Nervous System
2014
23 Citations (Scopus)

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol

Maguire, E. P., Mitchell, E. A., Greig, S. J., Corteen, N., Balfour, D. J. K., Swinny, J. D., Lambert, J. J. & Belelli, D., Apr 2014, In : Neuropsychopharmacology. 39, 5, p. 1232-1244 13 p.

Research output: Contribution to journalArticle

Glycine Receptors
Serotonergic Neurons
Rodentia
Ethanol
Strychnine
29 Citations (Scopus)

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon

Seifi, M., Brown, J. F., Mills, J., Bhandari, P., Belelli, D., Lambert, J. J., Rudolph, U. & Swinny, J. D., 2014, In : Journal of Neuroscience. 34, 31, p. 10361-10378 18 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Enteric Nervous System
GABA-A Receptors
Colon
Myenteric Plexus
13 Citations (Scopus)
110 Downloads (Pure)
Open Access
File
Etomidate
General Anesthetics
GABA-A Receptors
Neurons
Hypnotics and Sedatives
32 Citations (Scopus)

Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants

Maguire, E. P., Macpherson, T., Swinny, J. D., Dixon, C. I., Herd, M. B., Belelli, D., Stephens, D. N., King, S. L. & Lambert, J. J., 15 Jan 2014, In : Journal of Neuroscience. 34, 3, p. 823-838 16 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Neurons
Cocaine
Nucleus Accumbens
Dopamine
2013
8 Citations (Scopus)

5-chloroindole: a potent allosteric modulator of the 5-HT3 receptor

Newman, A. . S., Batis, N., Grafton, G., Caputo, F., Brady, C. A., Lambert, J. J., Peters, J. A., Gordon, J., Barnes, N. M., Brain, K. L., Powell, A. D. & Barnes, N. M., 2013, In : British Journal of Pharmacology. 169, 6, p. 1228-1238 11 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Serotonin Receptors
tropisetron
Quipazine
Biguanides
45 Citations (Scopus)

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors

Jensen, M. L., Wafford, K. A., Brown, A. R., Belelli, D., Lambert, J. J. & Mirza, N. R., 2013, In : British Journal of Pharmacology. 168, 5, p. 1118-1132 15 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress-response.

Gunn, B., Cunningham, L., Cooper, M. A., Corteen, N., Seifi, M., Swinny, J. D., Lambert, J. J. & Belelli, D., 11 Dec 2013, In : Journal of Neuroscience. 33, 50, p. 19534-19554 21 p.

Research output: Contribution to journalArticle

Psychological Stress
Neurotransmitter Agents
Neurons
Corticotropin-Releasing Hormone
GABA-A Receptors
45 Citations (Scopus)

Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus

Herd, M., Brown, A. R., Lambert, J. & Belelli, D., 11 Sep 2013, In : Journal of Neuroscience. 33, 37, p. 14850-14868

Research output: Contribution to journalArticle

GABA-A Receptors
Thalamus
Neurons
Ventral Thalamic Nuclei
Absence Epilepsy
53 Citations (Scopus)

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents

Wlodarczyk, A. I., Sylantyev, S., Herd, M. B., Kersanté, F., Lambert, J. J., Rusakov, D. A., Linthorst, A. C. E., Semyanov, A., Belelli, D., Pavlov, I. & Walker, M. C., 27 Feb 2013, In : Journal of Neuroscience. 33, 9, p. 3905-3914 10 p.

Research output: Contribution to journalArticle

GABA-A Receptors
gamma-Aminobutyric Acid
GABA-A Receptor Antagonists
Picrotoxin
Neurotransmitter Receptor
10 Citations (Scopus)

Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor

Carland, J. E., Cooper, M. A., Livesey, M. R., Hales, T. G., Lambert, J. J. & Peters, J. A., 1 Nov 2013, In : Journal of Biological Chemistry. 288, 44, p. 31592-31601 10 p.

Research output: Contribution to journalArticle

Cysteine
Arginine
Torpedo
Structural Models
Nicotinic Receptors
26 Citations (Scopus)

Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition

Anstee, Q., Knapp, S., Maguire, E. P., Hosie, A. M., Thomas, P., Mortensen, M., Bhome, R., Martinez, A., Walker, S. E., Dixon, C. I., Ruparelia, K., Montagnese, S., Kuo, Y-T., Herlihy, A., Bell, J. D., Robinson, I., Guerrini, I., McQuillin, A., Fisher, E. M. C., Ungless, M. A. & 8 others, Gurling, H. M. D., Morgan, M. Y., Brown, S. D. M., Stephens, D. N., Belelli, D., Lambert, J., Smart, T. G. & Thomas, H. C., 26 Nov 2013, In : Nature Communications. 4, 2816.

Research output: Contribution to journalArticle

mutations
Alcohol Drinking
genes
alcohols
Genes
20 Citations (Scopus)
Cysteine Loop Ligand-Gated Ion Channel Receptors
Neurotransmitter Receptor
Structural integrity
2012

5-HT3 receptors

Peters, J., Cooper, M., Livesey, M., Carland, J. & Lambert, J., 22 Mar 2012, Ion Channels: From Structure to Function. Kew, J. & Davies, C. (eds.). Oxford: Oxford University Press, p. 232-251 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

45 Citations (Scopus)

Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule

Zhang, H., Etherington, L-A., Hafner, A-S., Belelli, D., Coussen, F., Delagrange, P., Chaouloff, F., Spedding, M., Lambert, J. J., Choquet, D. & Groc, L., 2012, In : Molecular Psychiatry. 18, p. 471-484 14 p.

Research output: Contribution to journalArticle

Nootropic Agents
tianeptine
Neuronal Plasticity
AMPA Receptors
Antidepressive Agents
2011
84 Citations (Scopus)

Distinct mechanisms regulate GABA(A) receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells

Panzanelli, P., Gunn, B. G., Schlatter, M. C., Benke, D., Tyagarajan, S. K., Scheiffele, P., Belelli, D., Lambert, J. J., Rudolph, U. & Fritschy, J-M., 15 Oct 2011, In : Journal of Physiology. 589, 20, p. 4959-4980 22 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
91 Downloads (Pure)

Neurosteroids and GABAA receptor interactions: A focus on stress

Gunn, B. G., Brown, A. R., Lambert, J. J. & Belelli, D., 5 Dec 2011, In : Frontiers in Neuroscience. 5, p. 1-20 20 p., 131.

Research output: Contribution to journalReview article

Open Access
File
GABA-A Receptors
Neurotransmitter Agents
Steroids
Central Nervous System Depressants
Advance Directives
12 Citations (Scopus)

Rings of Charge within the Extracellular Vestibule Influence Ion Permeation of the 5-HT(3)A Receptor

Livesey, M. R., Cooper, M. A., Lambert, J. J. & Peters, J. A., 6 May 2011, In : Journal of Biological Chemistry. 286, 18, p. 16008-16017 10 p.

Research output: Contribution to journalArticle

The actions of neurosteroids at alpha 2-GABAA receptors in stress-sensitive neuronal targets

Belelli, D., Gunn, B. G., Maguire, E. P. & Lambert, J. J., May 2011, In : Alcohol. 45, 3, p. 287-287 1 p., S85.

Research output: Contribution to journalBook/Film/Article review