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  • Michael Ferguson
2020

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures

Galloway, A., Atrih, A., Grzela, R., Darzynkiewicz, E., Ferguson, M. A. J. & Cowling, V. H., 26 Feb 2020, In : Open Biology. 10, 2, p. 1-13 13 p., 190306.

Research output: Contribution to journalArticle

Open Access
File
32 Downloads (Pure)

Setting our sights on infectious diseases

De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In : ACS Infectious Diseases. 6, p. 3-13 11 p.

Research output: Contribution to journalArticle

Open Access
File
50 Downloads (Pure)

Treating age-related multimorbidity: the drug discovery challenge

Ermogenous, C., Green, C., Jackson, T., Ferguson, M. & Lord, J. M., 20 Jun 2020, In : Drug Discovery Today. 13 p.

Research output: Contribution to journalReview article

Open Access
2019

Organizational innovation for developing new medicines that target aging and age-related conditions

Ford, G. A., Lord, J. M., Ferguson, M. A. J., Bountra, C. & Le Couteur, D. G., 6 Mar 2019, In : The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 75, 1, p. 87-88 2 p., glz062.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
135 Downloads (Pure)

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

Open Access
File
6 Citations (Scopus)
170 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
126 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
63 Downloads (Pure)

Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix

Mattos, E. C., Canuto, G., Varón, N. C. M., Magalhães, R. D. M., Crozier, T. W. M., Lamont, D. J., Tavares, M. F. M., Colli, W., Ferguson, M. A. J. & Alves, M. J. M., 6 Feb 2019, In : PLoS Neglected Tropical Diseases. 13, 2, p. 1-27 27 p., e0007103.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
113 Downloads (Pure)

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W., Torrie, L. S. & De Rycker, M., Oct 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-11 11 p., e01082-19.

Research output: Contribution to journalArticle

Open Access
File
79 Downloads (Pure)
2018

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat

Pinger, J., Nešić, D., Ali, L., Aresta-Branco, F., Lilic, M., Chowdhury, S., Kim, H. S., Verdi, J., Raper, J., Ferguson, M. A. J., Papavasiliou, F. N. & Stebbins, C. E., Aug 2018, In : Nature Microbiology. 3, 8, p. 932-938 7 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
235 Downloads (Pure)

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In : Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
423 Downloads (Pure)

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

Kovarova, J., Nagar, R., Correia Faria, J., Ferguson, M., Barrett, M. P. & Horn, D., 27 Dec 2018, In : PLoS Pathogens. 14, 12, p. 1-22 22 p., e1007475.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
105 Downloads (Pure)

N-glycan microheterogeneity regulates interactions of plasma proteins

Wu, D., Struwe, W. B., Harvey, D. J., Ferguson, M. A. J. & Robinson, C. V., 28 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 35, p. 8763-8768 6 p., 201807439.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
120 Downloads (Pure)

Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei

Crozier, T. W. M., Tinti, M., Wheeler, R. J., Ly, T., Ferguson, M. A. J. & Lamond, A. I., 1 Jun 2018, In : Molecular & Cellular Proteomics. 17, 6, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
131 Downloads (Pure)

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. & Ferguson, M., 24 Jul 2018, In : PLoS ONE. 13, 7, p. 1-14 14 p., e0201263.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
115 Downloads (Pure)
2017
Open Access
File
134 Citations (Scopus)
286 Downloads (Pure)

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

Ivanova, I. M., Nepogodiev, S. A., Saalbach, G., O'Neill, E. C., Urbaniak, M. D., Ferguson, M. A. J., Gurcha, S. S., Besra, G. S. & Field, R. A., 13 Jan 2017, In : Carbohydrate Research. 438, p. 26-38 13 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
123 Downloads (Pure)

Genetic Metabolic Complementation establishes a requirement for GDP-fucose in Leishmania

Guo, H., Novozhilova, N. M., Bandini, G., Turco, S. J., Ferguson, M. A. J. & Beverley, S. M., 23 Jun 2017, In : Journal of Biological Chemistry. 292, 25, p. 10696-10708 13 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
116 Downloads (Pure)

Prediction of protein complexes in Trypanosoma brucei by protein correlation profiling mass spectrometry and machine learning

Crozier, T. W. M., Tinti, M., Larance, M., Lamond, A. I. & Ferguson, M. A. J., 1 Dec 2017, In : Molecular & Cellular Proteomics. 16, 12, p. 2254-2267 14 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
166 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
178 Downloads (Pure)
2016

A gene of the β3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei

Damerow, M., Graalfs, F., Guther, M. L. S., Mehlert, A., Izquierdo, L. & Ferguson, M. A. J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13834-13845 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
147 Downloads (Pure)

Evaluation of antigens for development of a serological test for Human African Trypanosomiasis

Biéler, S., Waltenberger, H., Barrett, M. P., McCulloch, R., Mottram, J. C., Carrington, M., Schwaeble, W., McKerrow, J., Phillips, M. A., Michels, P. A., Büscher, P., Sanchez, J-C., Bishop, R., Robinson, D. R., Bangs, J., Ferguson, M., Nerima, B., Albertini, A., Michel, G., Radwandska, M. & 1 others, Ndung'u, J. M., 9 Dec 2016, In : PLoS ONE. 11, 12, p. 1-23 23 p., e0168074.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
302 Downloads (Pure)

Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling

Larance, M., Kirkwood, K. J., Tinti, M., Brenes Murillo, A., Ferguson, M. & Lamond, A., 1 Jul 2016, In : Molecular & Cellular Proteomics. 15, 7, p. 2476-2490 15 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
120 Downloads (Pure)

Proteomic identification of immunodiagnostic antigens for Trypanosoma vivax infections in cattle and generation of a proof-of-concept lateral flow test diagnostic device

Fleming, J. R., Sastry, L., Wall, S. J., Sullivan, L. & Ferguson, M. A. J., 8 Sep 2016, In : PLoS Neglected Tropical Diseases. 10, 9, 11 p., e0004977.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
160 Downloads (Pure)
2015

Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. R., Lüder, C. G. K., Ferguson, M. A. J. & Routier, F. H., 3 Nov 2015, In : PLoS Neglected Tropical Diseases. 9, 11, e0004205.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
113 Downloads (Pure)

Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma brucei

Izquierdo, L., Acosta-Serrano, A., Mehlert, A. & Ferguson, M. A. J., 2015, In : Glycobiology. 25, 4, p. 438-447 50 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. F. R., Ferguson, M. A. J. & Routier, F. H., Oct 2015, In : International Journal for Parasitology. 45, 12, p. 783-790 8 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
159 Downloads (Pure)

Molecular control of irreversible bistability during trypanosome developmental commitment

Domingo-Sananes, M. R., Szöor, B., Ferguson, M. A. J., Urbaniak, M. D. & Matthews, K. R., 19 Oct 2015, In : Journal of Cell Biology. 211, 2, p. 455-468 14 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
132 Downloads (Pure)

Parasite Glycobiology: A Bittersweet Symphony

Rodrigues, J. A., Acosta-Serrano, A., Aebi, M., Ferguson, M. A. J., Routier, F. H., Schiller, I., Soares, S., Spencer, D., Titz, A., Wilson, I. B. H. & Izquierdo, L., 12 Nov 2015, In : PLoS Pathogens. 11, 11, e1005169.

Research output: Contribution to journalReview article

Open Access
File
19 Citations (Scopus)
115 Downloads (Pure)

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J. & 21 others, Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., 28 Jan 2015, In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2014

Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis

Sternberg, J. M., Gierlinski, M., Biéler, S., Ferguson, M. A. J. & Ndung'u, J. M., Dec 2014, In : PLoS Neglected Tropical Diseases. 8, 12, p. e3373 8 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
151 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
142 Downloads (Pure)
Open Access
File
53 Citations (Scopus)
130 Downloads (Pure)

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei

Damerow, M., Rodrigues, J. A., Wu, D., Güther, M. L. S., Mehlert, A. & Ferguson, M. A. J., 28 Mar 2014, In : Journal of Biological Chemistry. 289, 13, p. 9328-9339 12 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
122 Downloads (Pure)

Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

Sullivan, L., Fleming, J., Sastry, L., Mehlert, A., Wall, S. J. & Ferguson, M. A. J., 17 Jul 2014, In : PLoS Neglected Tropical Diseases. 8, 7, p. e2976

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
162 Downloads (Pure)
Open Access
File
31 Citations (Scopus)
88 Downloads (Pure)

Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H., Mar 2014, In : Organic and Biomolecular Chemistry. 12, 12, p. 1919-1934 16 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
155 Downloads (Pure)

Proteomic Selection of Immunodiagnostic Antigens for Trypanosoma congolense

Fleming, J. R., Sastry, L., Crozier, T. W. M., Napier, G. B., Sullivan, L. & Ferguson, M. A. J., 2014, In : PLoS Neglected Tropical Diseases. 8, 6, e2936.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
354 Downloads (Pure)

TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei

Nakanishi, M., Karasudani, M., Shiraishi, T., Hashida, K., Hino, M., Ferguson, M. A. J. & Nomoto, H., Jun 2014, In : Parasitology International. 63, 3, p. 513-518 6 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
156 Downloads (Pure)
21 Citations (Scopus)
2013

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sep 2013, In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Creation and characterization of glycosyltransferase mutants of trypanosoma brucei

Izquierdo, L., Güther, M. L. S. & Ferguson, M. A. J., 2013, Glycosyltransferases. Brockhausen, I. (ed.). Humana Press, p. 249-275 27 p. (Methods in Molecular Biology; vol. 1022).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

6 Citations (Scopus)

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Pizarro, J. C., Hills, T., Senisterra, G., Wernimont, A. K., Mackenzie, C., Norcross, N. R., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. & Hui, R., 17 Oct 2013, In : PLoS Neglected Tropical Diseases. 7, 10, e2492.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
126 Downloads (Pure)

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. & Van Aalten, D. M. F., 11 Jul 2013, In : Bioscience Reports. 33, 5, 11 p., e00063.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. & van Aalten, D. M. F., Aug 2013, In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
101 Citations (Scopus)

Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device

Sullivan, L., Wall, S. J., Carrington, M. & Ferguson, M. A. J., 28 Feb 2013, In : PLoS Neglected Tropical Diseases. 7, 2, 14 p., e2087.

Research output: Contribution to journalArticle

29 Citations (Scopus)